{"title":"Diagnosis of congestive heart failure by combining echocardiography and blood biomarkers in cats with cardiomyopathy","authors":"T. Shimoda , T. Osuga , K. Nakamura","doi":"10.1016/j.jvc.2025.05.007","DOIUrl":"10.1016/j.jvc.2025.05.007","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>In cats with cardiomyopathy, echocardiographic indices and blood biomarkers such as atrial natriuretic peptide (ANP), cardiac troponin I (cTnI), and N-terminal pro-B-type natriuretic peptide (NTproBNP) are useful in diagnosing congestive heart failure (CHF). However, the improvement in diagnostic accuracy by combining these indicators remains unclear.</div></div><div><h3>Animals, materials and methods</h3><div>Twenty-six cats diagnosed with cardiomyopathy using echocardiography were included in this study. They were classified into CHF and non-CHF groups according to the presence of pulmonary oedema or pleural effusion and response to heart failure treatment. The discriminative ability of each index for the presence of CHF was evaluated using a receiver operating characteristic curve.</div></div><div><h3>Results</h3><div>The left atrial-to-aortic root ratio (LA/Ao) had the highest area under the curve of 0.952 (95% confidence interval [CI]: 0.878–1.0), followed by ANP 0.915 (95% CI 0: 0.808–1.0), cTnI 0.861 (95% CI: 0.722–0.999), and NTproBNP 0.830 (95% CI: 0.672–0.988). Adding NTproBNP and ANP to the LA/Ao did not improve the discriminative ability. Limited by the combination of blood biomarkers, ANP and cTnI showed the highest discriminative ability.</div></div><div><h3>Study Limitations</h3><div>Following were the limitations to this study: lack of standardised medication, inability to calculate true correlation for NTproBNP values >1500 pmol/L, marked difference in disease severity between groups, inclusion of various cardiomyopathy types, reliance solely on LA/Ao for left atrial size assessment, and small sample size.</div></div><div><h3>Conclusions</h3><div>This study indicates that if LA/Ao can be measured accurately, the significance of measuring cardiac biomarkers for diagnosing CHF in cats with cardiomyopathy is low.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 70-78"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Divided left atrium (Cor Triatriatum Sinister) with atresia of the right pulmonary veins in a cat","authors":"P. Savarino , M. Borgarelli , T. Massimiliano","doi":"10.1016/j.jvc.2025.05.008","DOIUrl":"10.1016/j.jvc.2025.05.008","url":null,"abstract":"<div><div>A nine-month-old, female Maine Coon cat was referred for acute respiratory distress. Echocardiography revealed the presence of a membrane dividing the left atrium into two chambers, suggestive of cor triatriatum sinister (CTS). Due to poor prognosis, the owner elected for humane euthanasia. At necropsy, a transverse fibromuscular membrane containing an orifice dividing the left atrium into two chambers was observed, confirming the diagnosis of CTS, or divided left atrium. Moreover, atresia of the outflow of right pulmonary veins into the left atrium was identified. This study reports the rare instance of CTS associated with anomalies of the pulmonary venous connection.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 23-29"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B.J. Sutherland , M. Kraus , C. Barr , L. Aronson , D. Holt , S. Fuller
{"title":"Open atrial septal defect repair in a dog using fresh autologous pericardium","authors":"B.J. Sutherland , M. Kraus , C. Barr , L. Aronson , D. Holt , S. Fuller","doi":"10.1016/j.jvc.2025.05.004","DOIUrl":"10.1016/j.jvc.2025.05.004","url":null,"abstract":"<div><div>A one-year-old standard poodle was presented for evaluation of exercise intolerance with suspicion for a large atrial septal defect. Transthoracic echocardiography identified an unrestricted 2-cm secundum-type atrial septal defect with a peak left-to-right flow of 1 m/s yielding a Qp/Qs ratio of 2.1:1 and moderate right-sided chamber dilation. Based on clinical signs and echocardiographic findings, closure was recommended. Transesophageal echocardiography was subsequently performed to help determine the most appropriate closure method, which revealed insufficient posterior rim, and hence, surgical repair was recommended. The defect was closed using fresh autologous pericardium under normothermic cardiopulmonary bypass. Surgery and immediate postoperative recovery were relatively uncomplicated. Intra-operative epicardial and postoperative transthoracic echocardiography showed no residual atrial septal defect. The patient was closely monitored in the intensive care unit until discharge eight days after the procedure with no cardiac medications. Follow-up echocardiogram was performed three weeks postoperatively, showing an intact patch, no evidence of interatrial shunting, and decrease in right-sided chamber size. At six months, echocardiography showed an intact septum, normal right atrial and ventricular size, and resolution of clinical signs. This is the first known report of the use of fresh autologous pericardium as a durable and safe patch choice for atrial septal defect repair in a dog. Autologous pericardium is cost-effective and readily available. It is commonly employed to repair many cardiovascular defects in humans including atrial septal defects, right ventricular outflow tract enlargement, and pulmonary artery augmentation. This report also highlights the benefit of multi-modal imaging in clinical decision-making.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 30-35"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ventriculophasic response in a horse with atrioventricular block","authors":"J. Liu, R. Baumwart, S. Kwon","doi":"10.1016/j.jvc.2025.05.005","DOIUrl":"10.1016/j.jvc.2025.05.005","url":null,"abstract":"<div><div>Ventriculophasic response (VR) in atrioventricular nodal (AVN) block is characterized by a shortening of the sinoatrial cycle length when a QRS complex is interposed between two P waves. This has been well documented in humans and dogs with AVN blocks but not in horses. Herein, we describe a horse with second-degree AVN blocks and constant PR intervals that exhibited 5:3 conduction and suspected VR at rest but less consistently after submaximal exercise. Proposed VR mechanisms include (1) inhibition of the Bezold-Jarisch reflex from reduced end-systolic volume during ventricular contraction; (2) vagal inhibition from increased intra-atrial pressure (Bainbridge reflex); and (3) accelerated sinus node discharge from changes in sinus nodal blood supply during ventricular contraction. This case exhibited some electrocardiogram characteristics of the first two mechanisms to explain the PP interval alteration and suspected VR. Horses often exhibit physiologic AVN blocks, and clinicians should consider VR when interpreting equine electrocardiograms.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 46-49"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ciccozzi, C.D. Stauthammer, C. Coats, S. Oberholtzer, A. Masters, E. Gavic, A. Rendahl, A. Tobias
{"title":"Transcatheter Amplatz canine duct occluder placement for patent ductus arteriosus occlusion: A retrospective analysis of outcomes and complications in 200 dogs","authors":"M. Ciccozzi, C.D. Stauthammer, C. Coats, S. Oberholtzer, A. Masters, E. Gavic, A. Rendahl, A. Tobias","doi":"10.1016/j.jvc.2025.05.002","DOIUrl":"10.1016/j.jvc.2025.05.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The Amplatz canine duct occluder (ACDO) is routinely used for patent ductus arteriosus (PDA) occlusion. Limited data are available on clinical outcomes and success rates with ACDO device placement. This study aimed to determine procedural outcome and complications for PDA occlusion with the ACDO in a large cohort of dogs.</div></div><div><h3>Animals, Materials, and Methods</h3><div>A retrospective study of 200 dogs that underwent ACDO placement for PDA occlusion between March 2007- and September 2023 was conducted. Transthoracic echocardiography was performed prior to occlusion, 24 h after occlusion, and during follow-up recheck visits. Procedural success was defined as successful device placement as determined based on fluoroscopy at the time of the PDA occlusion procedure and survival after the procedure.</div></div><div><h3>Results</h3><div>Dogs had a median weight of 6.5 kg and required a median device size of 6 mm. At 24 h post- occlusion, 5% of dogs had trivial flow through the device. Persistent trivial flow was noted on recheck in 5.5% of patients with a median follow-up time of 96 days. Minor complications occurred in 2.5% of dogs. Major complications occurred in 4% of dogs including device embolization in 2% of dogs. Procedural mortality rate was 0.5%. There was a statistically significant reduction in left ventricular and left atrial size at the 24-h postocclusion recheck echocardiogram (P<0.001) and at follow-up rechecks (P<0.001). There was a statistical difference (P<0.050) between echocardiographic and angiographicderived measurements and ratios when selecting device size.</div></div><div><h3>Conclusions</h3><div>The high procedural success and low complication rates support use of the ACDO device as a safe and effective method of PDA occlusion in dogs.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 36-45"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left atrial size in healthy Cavalier King Charles spaniels: a comparison to dogs of other breeds and previously published reference intervals","authors":"D. Caivano , P. Ferrari , M. Rishniw","doi":"10.1016/j.jvc.2025.04.003","DOIUrl":"10.1016/j.jvc.2025.04.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Recently, investigators have suggested that Cavalier King Charles spaniels have smaller left atrial-to-aortic ratios (LA:Aos) than other breeds.</div></div><div><h3>Animals, Materials and Methods</h3><div>This study comprised apparently healthy adult Cavalier King Charles spaniels (n = 218) and apparently healthy adult dogs of other breeds (n = 379), imaged by the same observers, for inclusion in the Osservatorio Veterinario Italiano Cardiopatie. Left atrial and aortic measurements, obtained from two-dimensional images at the closing of the aortic valve, and left ventricular internal dimensions in diastole, obtained from M-mode images, were both obtained from the right parasternal short-axis view. Furthermore, left atrial and aortic measurements were indexed allometrically and compared to data obtained by the same observers. Measurements obtained by multiple observers were compared for systematic bias. Reference limits were created for the LA:Ao and normalized left ventricular diastolic dimensions.</div></div><div><h3>Results</h3><div>Reference limits agreed with previously published limits for other dogs, with the upper reference limit for Cavalier King Charles spaniels approximating 1.6. Cavalier King Charles spaniels had allometrically indexed left atrial and aortic measurements that were not smaller than those in other dogs.</div></div><div><h3>Study Limitations</h3><div>Retrospective study with multiple independent observers, not specifically instructed to measure the LA:Ao.</div></div><div><h3>Conclusions</h3><div>Cavalier King Charles spaniels have an LA:Ao not smaller than other breeds. Furthermore, the left atrial linear dimension obtained in the right parasternal short-axis view and normalized to bodyweight does not appear to be smaller. Consequently, current generic reference intervals for left atrial dimensions apply to Cavalier King Charles spaniels.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutting and high-pressure balloon angioplasty in a dog with concurrent pulmonary valvar and infundibular stenosis","authors":"R.L. Winter, K.L. Maneval, C.S. Ferrel","doi":"10.1016/j.jvc.2025.05.006","DOIUrl":"10.1016/j.jvc.2025.05.006","url":null,"abstract":"<div><div>A two-year-old, 7.7-kg female spayed Cocker spaniel dog was presented for further evaluation of severe pulmonary stenosis. Transthoracic echocardiography revealed severe concentric hypertrophy and dilation of the right ventricle, and two distinct levels of obstruction were observed. A discrete level of obstruction was observed at the crista supraventricularis. This lesion was hyperechoic and located roughly 11 mm away from the pulmonary annulus. Additionally, pulmonary leaflets were elongated and demonstrated systolic doming. These findings were consistent with concurrent pulmonary valvar and infundibular stenosis. The peak systolic pressure gradient across the pulmonary annulus assessed by continuous-wave Doppler interrogation was 190 mmHg. The following day, pulmonary balloon angioplasty was performed successfully with cutting and high-pressure balloon catheters. The day after intervention, echocardiography revealed that the peak systolic pressure gradient across the pulmonary annulus had decreased to 65 mmHg. This pressure gradient had further decreased to 30 mmHg nine months later.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 50-56"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Occurrence and distribution of left ventricular bands and normal anatomical features in 78 feline hearts” [J Vet Cardiol 59 (2025) 81–92]","authors":"N. Kiessling , S. Rørvig , J. Häggström","doi":"10.1016/j.jvc.2025.05.001","DOIUrl":"10.1016/j.jvc.2025.05.001","url":null,"abstract":"","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 10-13"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Journal title page and editorial board","authors":"","doi":"10.1016/S1760-2734(25)00068-2","DOIUrl":"10.1016/S1760-2734(25)00068-2","url":null,"abstract":"","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Page i"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitral annular disjunction prevalence in 403 dogs referred for cardiac assessment (the MAD dog study).","authors":"N Pereira, M Wyler","doi":"10.1016/j.jvc.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.jvc.2025.06.007","url":null,"abstract":"<p><strong>Introduction/objectives: </strong>Mitral annular disjunction (MAD) is common in humans and is associated with myxomatous mitral valve disease (MMVD), mitral valve prolapse, and arrhythmias. It is poorly described in dogs, and its prevalence is unknown. The objective of this study is to establish the prevalence of MAD in a population of dogs referred for cardiac examination.</p><p><strong>Animals, methods and materials: </strong>A total of 415 dogs were screened. Over one year, dogs referred for cardiac assessment were prospectively enrolled. Age, breed, body weight, electrocardiography, and echocardiography were recorded. Dogs with systolic loss of continuity between the basal segment of the left ventricular posterior wall and the mitral valve (in right parasternal long-axis echocardiography) were considered to suffer from MAD.</p><p><strong>Results: </strong>Four hundred three dogs were included in the study. Seven dogs exhibited MAD. All MAD dogs had MMVD. No normal dogs exhibited MAD. The overall prevalence of MAD was 1.7%. The prevalence of MAD in dogs with MMVD was 2.5%. The prevalence of MAD in dogs with mitral valve prolapse was also 2.5%. No MAD dogs exhibited arrhythmias. The presence of MAD was associated with lower body weight.</p><p><strong>Study limitations: </strong>Single-operator bias and evolving diagnostic criteria for MAD in people complicate the interpretation of study results.</p><p><strong>Conclusions: </strong>Mitral annular disjunction is uncommon in dogs referred for cardiac evaluation and could only be identified in dogs suffering from MMVD. No arrhythmias were found in MAD dogs.</p>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}