Current Osteoporosis Reports最新文献_第3页

The Impact of Non-bone Metastatic Cancer on Musculoskeletal Health. 非骨转移癌症对肌肉骨骼健康的影响。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-22 DOI: 10.1007/s11914-024-00872-4

Fabiola Galiana-Melendez, Joshua R. Huot

引用次数: 0

Correction: Practical Compass of Single-Cell RNA-Seq Analysis. 更正：单细胞 RNA-Seq 分析的实用指南针。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 DOI: 10.1007/s11914-024-00861-7

Hiroyuki Okada, Ung-Il Chung, Hironori Hojo

引用次数: 0

Regulation of FGF23 Production in Osteocytes. 调节骨细胞中 FGF23 的产生

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-02-09 DOI: 10.1007/s11914-024-00860-8

Seiji Fukumoto

引用次数: 0

Extracellular Vesicles and Exosomes in the Control of the Musculoskeletal Health. 控制肌肉骨骼健康的细胞外小泡和外泌体。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-03-01 DOI: 10.1007/s11914-024-00866-2

Fabio Penna, Lorena Garcia-Castillo, Paola Costelli

引用次数: 0

Diagnosing Osteoporosis in Diabetes-A Systematic Review on BMD and Fractures. 诊断糖尿病骨质疏松症--关于 BMD 和骨折的系统综述。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-03-21 DOI: 10.1007/s11914-024-00867-1

Inge Agnete Gerlach Brandt, Jakob Starup-Linde, Sally Søgaard Andersen, Rikke Viggers

{"title":"Diagnosing Osteoporosis in Diabetes-A Systematic Review on BMD and Fractures.","authors":"Inge Agnete Gerlach Brandt, Jakob Starup-Linde, Sally Søgaard Andersen, Rikke Viggers","doi":"10.1007/s11914-024-00867-1","DOIUrl":"10.1007/s11914-024-00867-1","url":null,"abstract":"Purpose of review: Recently, the American Diabetes Association updated the 2024 guidelines for Standards of Care in Diabetes and recommend that a T-score of - 2.0 in patients with diabetes should be interpreted as equivalent to - 2.5 in people without diabetes. We aimed to evaluate the most recent findings concerning the bone mineral density (BMD)-derived T-score and risk of fractures related to osteoporosis in subjects with diabetes.Recent findings: The dual-energy X-ray absorptiometry (DXA) scan is the golden standard for evaluating BMD. The BMD-derived T-score is central to fracture prediction and signifies both diagnosis and treatment for osteoporosis. However, the increased fracture risk in diabetes is not sufficiently explained by the T-score, complicating the identification and management of fracture risk in these patients. Recent findings agree that subjects with type 2 diabetes (T2D) have a higher T-score and higher fracture risk compared with subjects without diabetes. However, the actual number of studies evaluating the direct association of higher fracture risk at higher T-score levels is scant. Some studies support the adjustment based on the 0.5 BMD T-score difference between subjects with T2D and subjects without diabetes. However, further data from longitudinal studies is warranted to validate if the T-score treatment threshold necessitates modification to prevent fractures in subjects with diabetes.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interfacial Tissue Regeneration with Bone. 骨界面组织再生。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-02-15 DOI: 10.1007/s11914-024-00859-1

Stephanie S Steltzer, Adam C Abraham, Megan L Killian

{"title":"Interfacial Tissue Regeneration with Bone.","authors":"Stephanie S Steltzer, Adam C Abraham, Megan L Killian","doi":"10.1007/s11914-024-00859-1","DOIUrl":"10.1007/s11914-024-00859-1","url":null,"abstract":"Purpose of review: Interfacial tissue exists throughout the body at cartilage-to-bone (osteochondral interface) and tendon-to-bone (enthesis) interfaces. Healing of interfacial tissues is a current challenge in regenerative approaches because the interface plays a critical role in stabilizing and distributing the mechanical stress between soft tissues (e.g., cartilage and tendon) and bone. The purpose of this review is to identify new directions in the field of interfacial tissue development and physiology that can guide future regenerative strategies for improving post-injury healing.Recent findings: Cues from interfacial tissue development may guide regeneration including biological cues such as cell phenotype and growth factor signaling; structural cues such as extracellular matrix (ECM) deposition, ECM, and cell alignment; and mechanical cues such as compression, tension, shear, and the stiffness of the cellular microenvironment. In this review, we explore new discoveries in the field of interfacial biology related to ECM remodeling, cellular metabolism, and fate. Based on emergent findings across multiple disciplines, we lay out a framework for future innovations in the design of engineered strategies for interface regeneration. Many of the key mechanisms essential for interfacial tissue development and adaptation have high potential for improving outcomes in the clinic.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteocytes and Paget's Disease of Bone. 骨细胞与骨质疏松症

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-03-08 DOI: 10.1007/s11914-024-00863-5

Hirofumi Tenshin, Jesus Delgado-Calle, Jolene J Windle, G David Roodman, John M Chirgwin, Noriyoshi Kurihara

{"title":"Osteocytes and Paget's Disease of Bone.","authors":"Hirofumi Tenshin, Jesus Delgado-Calle, Jolene J Windle, G David Roodman, John M Chirgwin, Noriyoshi Kurihara","doi":"10.1007/s11914-024-00863-5","DOIUrl":"10.1007/s11914-024-00863-5","url":null,"abstract":"Purpose of review: To describe the contributions of osteocytes to the lesions in Paget's disease, which are characterized by locally overactive bone resorption and formation.Recent findings: Osteocytes, the most abundant cells in bone, are altered in Paget's disease lesions, displaying increased size, decreased canalicular length, incomplete differentiation, and less sclerostin expression compared to controls in both patients and mouse models. Pagetic lesions show increased senescent osteocytes that express RANK ligand, which drives osteoclastic bone resorption. Abnormal osteoclasts in Paget's disease secrete abundant IGF1, which enhances osteocyte senescence, contributing to lesion formation. Recent data suggest that osteocytes contribute to lesion formation in Paget's disease by responding to high local IGF1 released from abnormal osteoclasts. Here we describe the characteristics of osteocytes in Paget's disease and their role in bone lesion formation based on recent results with mouse models and supported by patient data.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat as a Friend or Foe of the Bone. 脂肪是骨头的朋友还是敌人？

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-02-28 DOI: 10.1007/s11914-024-00864-4

Elodie Gruneisen, Richard Kremer, Gustavo Duque

{"title":"Fat as a Friend or Foe of the Bone.","authors":"Elodie Gruneisen, Richard Kremer, Gustavo Duque","doi":"10.1007/s11914-024-00864-4","DOIUrl":"10.1007/s11914-024-00864-4","url":null,"abstract":"Purpose of review: The objective of this review is to summarize the literature on the prevalence and diagnosis of obesity and its metabolic profile, including bone metabolism, focusing on the main inflammatory and turnover bone mediators that better characterize metabolically healthy obesity phenotype, and to summarize the therapeutic interventions for obesity with their effects on bone health.Recent findings: Osteoporosis and fracture risk not only increase with age and menopause but also with metabolic diseases, such as diabetes mellitus. Thus, patients with high BMI may have a higher bone fragility and fracture risk. However, some obese individuals with healthy metabolic profiles seem to be less at risk of bone fracture. Obesity has become an alarming disease with growing prevalence and multiple metabolic comorbidities, resulting in a significant burden on healthcare and increased mortality. The imbalance between increased food ingestion and decreased energy expenditure leads to pathological adipose tissue distribution and function, with increased secretion of proinflammatory markers and harmful consequences for body tissues, including bone tissue. However, some obese individuals seem to have a healthy metabolic profile and may not develop cardiometabolic disease during their lives. This healthy metabolic profile also benefits bone turnover and is associated with lower fracture risk.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophils in Inflammatory Bone Diseases. 炎症性骨病中的中性粒细胞

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.1007/s11914-024-00865-3

Carmelo Carmona-Rivera, Mariana J Kaplan, Liam J O'Neil

{"title":"Neutrophils in Inflammatory Bone Diseases.","authors":"Carmelo Carmona-Rivera, Mariana J Kaplan, Liam J O'Neil","doi":"10.1007/s11914-024-00865-3","DOIUrl":"10.1007/s11914-024-00865-3","url":null,"abstract":"Purpose of review: In this review, we summarize the current evidence that suggests that neutrophils play a key role in facilitating damage to local bone structures.Recent findings: Neutrophil infiltration is a hallmark of inflammatory bone diseases such as rheumatoid arthritis (RA) and periodontitis disease (PD). Both of these human diseases are marked by an imbalance in bone homeostasis, favoring the degradation of local bone which ultimately leads to erosions. Osteoclasts, a multinucleated resident bone cell, are responsible for facilitating the turnover of bone and the bone damage observed in these diseases. The involvement of neutrophils and neutrophil extracellular trap formation have recently been implicated in exacerbating osteoclast function through direct and indirect mechanisms. We highlight a recent finding that NET proteins such as histones and elastase can generate non-canonical, inflammatory osteoclasts, and this process is mediated by post-translational modifications such as citrullination and carbamylation, both of which act as autoantigens in RA. It appears that NETs, autoantibodies, modified proteins, cytokines, and osteoclasts all ultimately contribute to local and permanent bone damage in RA and PD. However, more studies are needed to fully understand the role of neutrophils in inflammatory bone diseases.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11061041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Skeletal Imaging and Image-Based Modeling in Pediatric Orthopaedics. 小儿骨科中的骨骼定量成像和基于图像的建模。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-02-01 Epub Date: 2024-01-20 DOI: 10.1007/s11914-023-00845-z

Melissa R Requist, Megan K Mills, Kristen L Carroll, Amy L Lenz

{"title":"Quantitative Skeletal Imaging and Image-Based Modeling in Pediatric Orthopaedics.","authors":"Melissa R Requist, Megan K Mills, Kristen L Carroll, Amy L Lenz","doi":"10.1007/s11914-023-00845-z","DOIUrl":"10.1007/s11914-023-00845-z","url":null,"abstract":"Purpose of review: Musculoskeletal imaging serves a critical role in clinical care and orthopaedic research. Image-based modeling is also gaining traction as a useful tool in understanding skeletal morphology and mechanics. However, there are fewer studies on advanced imaging and modeling in pediatric populations. The purpose of this review is to provide an overview of recent literature on skeletal imaging modalities and modeling techniques with a special emphasis on current and future uses in pediatric research and clinical care.Recent findings: While many principles of imaging and 3D modeling are relevant across the lifespan, there are special considerations for pediatric musculoskeletal imaging and fewer studies of 3D skeletal modeling in pediatric populations. Improved understanding of bone morphology and growth during childhood in healthy and pathologic patients may provide new insight into the pathophysiology of pediatric-onset skeletal diseases and the biomechanics of bone development. Clinical translation of 3D modeling tools developed in orthopaedic research is limited by the requirement for manual image segmentation and the resources needed for segmentation, modeling, and analysis. This paper highlights the current and future uses of common musculoskeletal imaging modalities and 3D modeling techniques in pediatric orthopaedic clinical care and research.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139503155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0