Current Osteoporosis Reports最新文献_第2页

Lateral Compression Fragility Fractures of the Pelvis: Diagnosis, Classifications, and Modern Management. 骨盆侧方压缩性脆性骨折：诊断、分类和现代管理。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-09-23 DOI: 10.1007/s11914-024-00891-1

Joseph T Patterson, Joshua A Parry

{"title":"Lateral Compression Fragility Fractures of the Pelvis: Diagnosis, Classifications, and Modern Management.","authors":"Joseph T Patterson, Joshua A Parry","doi":"10.1007/s11914-024-00891-1","DOIUrl":"https://doi.org/10.1007/s11914-024-00891-1","url":null,"abstract":"Purpose of review: To describe the diagnosis, classification, and modern management of lateral compression fragility fractures of the pelvis.Recent findings: Practice patterns are shifting toward early operative treatment of fragility fractures of the pelvis among patients who are unable to mobilize or whose injuries demonstrate occult instability on stress imaging. Early internal fixation appears to decrease pain, facilitate mobilization, accelerate hospital discharge, and minimize morbidity in this population. Lateral compression pelvic ring injuries are the most common type of fragility fracture of the pelvis. Similar to fragility fractures of the hip, lateral compression fragility fractures of the pelvis are typically sustained in a ground level fall. These injuries are associated with long acute hospital and post-acute facility admissions, loss of physical function, loss of independence, mortality, anxiety, sleep disturbance, and caregiver burnout. Unlike hip fractures, for which urgent operative treatment and early mobilization reduce mortality, lateral compression fragility fractures of the pelvis are commonly treated without surgery. Recommendations for nonoperative management of these injuries in older adults may be inappropriately generalized from studies of younger patient populations with high-energy mechanisms of pelvis fracture. However, strong evidence to support early internal fixation of these injuries practice is lacking. High quality investigations of early surgical intervention for lateral compression fragility fractures of the pelvis are needed to guide care for these patients.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air Pollution and Osteoporosis. 空气污染与骨质疏松症。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-09-20 DOI: 10.1007/s11914-024-00889-9

Olivia Allen, Martin M Knight, Stefaan W Verbruggen

{"title":"Air Pollution and Osteoporosis.","authors":"Olivia Allen, Martin M Knight, Stefaan W Verbruggen","doi":"10.1007/s11914-024-00889-9","DOIUrl":"https://doi.org/10.1007/s11914-024-00889-9","url":null,"abstract":"Purpose of review: The purpose of this review is to provide a background of osteoporosis and air pollution, discussing increasing incidence of the disease with exposure to pollutants and the role that inflammation may play in this process.Recent findings: Osteoporosis-related fractures are one of the most pressing challenges for the ageing global population, with significant increases in mortality known to occur after major osteoporotic fractures in the elderly population. Recent studies have established a firm correlative link between areas of high air pollution and increased risk of osteoporosis, particularly alarming given the increasingly urban global population. While the culprit pollutants and molecular mechanisms underlying this phenomenon have not yet been elucidated, initial studies suggest a role for inflammatory cascades in this phenomenon. While much more research is required to identify the most damaging air pollutants and to delineate the specific inflammatory molecular mechanisms, it is clear from the literature that shedding light on these pathways would unveil potential therapeutic targets to treat bone diseases, including osteoporosis. Major deficiencies of current animal models highlight the need for complex human in vitro models such as organ-on-a-chip technology to better understand the impact of air pollution.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lignans from Sambucus williamsii Protect Bone Via Microbiome. 三叶草中的木酚素通过微生物组保护骨骼

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-09-05 DOI: 10.1007/s11914-024-00883-1

Hui-Hui Xiao, Daniel Kam-Wah Mok, Xin-Sheng Yao, Man-Sau Wong

{"title":"Lignans from Sambucus williamsii Protect Bone Via Microbiome.","authors":"Hui-Hui Xiao, Daniel Kam-Wah Mok, Xin-Sheng Yao, Man-Sau Wong","doi":"10.1007/s11914-024-00883-1","DOIUrl":"https://doi.org/10.1007/s11914-024-00883-1","url":null,"abstract":"Purpose of review: Traditional Chinese Medicine has a unique system to diagnose and treat bone diseases with symptoms similar to those of osteoporosis. Sambucus williamsii Hance (SWH), a folk medicine in northern part of China for fractures healing and pain alleviation, has been demonstrated to exert bone anabolic effects in ovariectomized (OVX) rat and mice models in our previous studies. Lignans were identified to be the main bioactive fractions of SWH. However, pharmacokinetics study showed that the levels of lignan were too low to be detected in rat serum even upon taking 15 times of the effective dose of lignan-rich fraction from SWH. We hypothesize that lignans from SWH might exert its bone protective effect via the gut microbiome.Recent findings: Our study revealed that the lignan-rich fraction of SWH did not influence the diversity of gut microbiota in OVX rats, but significantly increased the abundance of a few phyla, in particular, the restoration of the abundance of several genera that was directly correlated with bone mineral density (BMD). In addition, a subsequent metabolomic study indicated that serotonin, a neurotransmitter synthesized in the intestine and influenced by gut microbiota, may be involved in mediating the bone protective action of the lignans. Gut-derived serotonin is thought to inhibit bone growth. Based on this finding, several inhibitors that suppressed the synthesis of serotonin were identified from the lignans of SWH. Our studies suggested that microbiome is an indispensable factor for lignans derived from S. willimasii to exert bone beneficial effects.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss. 骨质流失发病机制中的骨髓脂肪细胞衰老

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-08-01 Epub Date: 2024-06-03 DOI: 10.1007/s11914-024-00875-1

Mitchell N Froemming, Sundeep Khosla, Joshua N Farr

引用次数: 0

2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS). 骨细胞空洞的二维与三维评估--方法、推荐参数和挑战：欧洲钙化组织协会（ECTS）的叙述性综述。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-08-01 Epub Date: 2024-07-09 DOI: 10.1007/s11914-024-00877-z

Annika Vom Scheidt, Johannes Krug, Patricia Goggin, Astrid Diana Bakker, Björn Busse

{"title":"2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS).","authors":"Annika Vom Scheidt, Johannes Krug, Patricia Goggin, Astrid Diana Bakker, Björn Busse","doi":"10.1007/s11914-024-00877-z","DOIUrl":"10.1007/s11914-024-00877-z","url":null,"abstract":"Purpose of review: Quantification of the morphology of osteocyte lacunae has become a powerful tool to investigate bone metabolism, pathologies and aging. This review will provide a brief overview of 2D and 3D imaging methods for the determination of lacunar shape, orientation, density, and volume. Deviations between 2D-based and 3D-based lacunar volume estimations are often not sufficiently addressed and may give rise to contradictory findings. Thus, the systematic error arising from 2D-based estimations of lacunar volume will be discussed, and an alternative calculation proposed. Further, standardized morphological parameters and best practices for sampling and segmentation are suggested.Recent findings: We quantified the errors in reported estimation methods of lacunar volume based on 2D cross-sections, which increase with variations in lacunar orientation and histological cutting plane. The estimations of lacunar volume based on common practice in 2D imaging methods resulted in an underestimation of lacunar volume of up to 85% compared to actual lacunar volume in an artificial dataset. For a representative estimation of lacunar size and morphology based on 2D images, at least 400 lacunae should be assessed per sample.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging. 骨髓微环境中骨骼细胞和造血细胞在平衡和衰老过程中的相互作用

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-08-01 Epub Date: 2024-05-23 DOI: 10.1007/s11914-024-00874-2

Emily R Quarato, Noah A Salama, Laura M Calvi

引用次数: 0

Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints. 用于骨骼和关节微结构成像的光子计数计算机断层扫描。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-08-01 Epub Date: 2024-06-04 DOI: 10.1007/s11914-024-00876-0

Jilmen Quintiens, G Harry van Lenthe

{"title":"Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints.","authors":"Jilmen Quintiens, G Harry van Lenthe","doi":"10.1007/s11914-024-00876-0","DOIUrl":"10.1007/s11914-024-00876-0","url":null,"abstract":"Purpose of review: Recently, photon-counting computed tomography (PCCT) has been introduced in clinical research and diagnostics. This review describes the technological advances and provides an overview of recent applications with a focus on imaging of bone.Recent findings: PCCT is a full-body scanner with short scanning times that provides better spatial and spectral resolution than conventional energy-integrating-detector CT (EID-CT), along with an up to 50% reduced radiation dose. It can be used to quantify bone mineral density, to perform bone microstructural analyses and to assess cartilage quality with adequate precision and accuracy. Using a virtual monoenergetic image reconstruction, metal artefacts can be greatly reduced when imaging bone-implant interfaces. Current PCCT systems do not allow spectral imaging in ultra-high-resolution (UHR) mode. Given its improved resolution, reduced noise and spectral imaging capabilities PCCT has diagnostic capacities in both qualitative and quantitative imaging that outperform those of conventional CT. Clinical use in monitoring bone health has already been demonstrated. The full potential of PCCT systems will be unlocked when UHR spectral imaging becomes available.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development. 骨髓脂肪组织与恶性造血相互作用的分子解构：开发新疗法的潜力。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-08-01 Epub Date: 2024-06-26 DOI: 10.1007/s11914-024-00879-x

Drenka Trivanović, Marko Vujačić, Rossella Labella, Ivana Okić Djordjević, Marija Ćazić, Brian Chernak, Aleksandra Jauković

{"title":"Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development.","authors":"Drenka Trivanović, Marko Vujačić, Rossella Labella, Ivana Okić Djordjević, Marija Ćazić, Brian Chernak, Aleksandra Jauković","doi":"10.1007/s11914-024-00879-x","DOIUrl":"10.1007/s11914-024-00879-x","url":null,"abstract":"Purpose of review: Along with a strong impact on skeletal integrity, bone marrow adipose tissue (BMAT) is an important modulator of the adult hematopoietic system. This review will summarize the current knowledge on the causal relationship between bone marrow (BM) adipogenesis and the development and progression of hematologic malignancies.Recent findings: BM adipocytes (BMAds) support a number of processes promoting oncogenesis, including the evolution of clonal hematopoiesis, malignant cell survival, proliferation, angiogenesis, and chemoresistance. In addition, leukemic cells manipulate surrounding BMAds by promoting lipolysis and release of free fatty acids, which are then utilized by leukemic cells via β-oxidation. Therefore, limiting BM adipogenesis, blocking BMAd-derived adipokines, or lipid metabolism obstruction have been considered as potential treatment options for hematological malignancies. Leukemic stem cells rely heavily on BMAds within the structural BM microenvironment for necessary signals which foster disease progression. Further development of 3D constructs resembling BMAT at different skeletal regions are critical to better understand these relationships in geometric space and may provide essential insight into the development of hematologic malignancies within the BM niche. In turn, these mechanisms provide promising potential as novel approaches to targeting the microenvironment with new therapeutic strategies.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models. 洞察颅面发育和异常：探索斑马鱼模型中的 Fgf 信号传导。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-06-01 Epub Date: 2024-05-13 DOI: 10.1007/s11914-024-00873-3

Rachel Pereur, Emilie Dambroise

{"title":"Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models.","authors":"Rachel Pereur, Emilie Dambroise","doi":"10.1007/s11914-024-00873-3","DOIUrl":"10.1007/s11914-024-00873-3","url":null,"abstract":"Purpose of review: To illustrate the value of using zebrafish to understand the role of the Fgf signaling pathway during craniofacial skeletal development under normal and pathological conditions.Recent findings: Recent data obtained from studies on zebrafish have demonstrated the genetic redundancy of Fgf signaling pathway and have identified new molecular partners of this signaling during the early stages of craniofacial skeletal development. Studies on zebrafish models demonstrate the involvement of the Fgf signaling pathway at every stage of craniofacial development. They particularly emphasize the central role of Fgf signaling pathway during the early stages of the development, which significantly impacts the formation of the various structures making up the craniofacial skeleton. This partly explains the craniofacial abnormalities observed in disorders associated with FGF signaling. Future research efforts should focus on investigating zebrafish Fgf signaling during more advanced stages, notably by establishing zebrafish models expressing mutations responsible for diseases such as craniosynostoses.","PeriodicalId":48750,"journal":{"name":"Current Osteoporosis Reports","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential. 骨质疏松症治疗中的槲皮素：槲皮素在骨质疏松症治疗中的作用：对其机制和治疗潜力的全面回顾。

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-04-23 DOI: 10.1007/s11914-024-00868-0

Yanchen Feng, Xue Dang, Pan Zheng, Yali Liu, Diyan Liu, Zhiying Che, Jianping Yao, Zixuan Lin, Ziyun Liao, Xingyuan Nie, Feixiang Liu, Yunke Zhang

引用次数: 0