Journal of Evidence-Based Dental Practice最新文献

{"title":"THE ROLE OF OZONE THERAPY IN THE TREATMENT OF TEMPOROMANDIBULAR DISORDERS: A SYSTEMATIC REVIEW","authors":"Tássia T. Machado ,&nbsp;Ana Carolina S. Machado ,&nbsp;Rodrigo L. Poluha ,&nbsp;Leilane S. Proença ,&nbsp;Nikolaos Christidis ,&nbsp;Carlos A. Parada ,&nbsp;Giancarlo De la Torre Canales ,&nbsp;Cláudia H. Tambeli","doi":"10.1016/j.jebdp.2025.102127","DOIUrl":"10.1016/j.jebdp.2025.102127","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular disorders (TMD) refer to a range of conditions affecting the temporomandibular joints (TMJ), masticatory muscles, and related structures, bothering around 12% of the population. This systematic review aims to answer whether ozone therapy effectively reduces TMD-related symptoms.</div></div><div><h3>Methods</h3><div>A systematic electronic search of 6 databases was conducted on July 15th, 2021, and updated on November 17th, 2023. Only clinical trials published in Portuguese, English, or Spanish were selected, with no restriction to the year of publication. Animal studies, retrospective studies, case reports, review papers, meta-analysis, and ozone therapy applications outside the orofacial region were excluded. The risk of bias analysis was performed following the Cochrane Collaboration tool, RoB 2.</div></div><div><h3>Results</h3><div>Of the 315 articles identified in the search, only 7 studies were included in this review. Two studies were considered low risk of bias, 2 with some concerns, and 3 as high risk of bias. Ozone therapy, applied to both articular and muscular TMDs, has been shown to reduce pain intensity and palpatory pain, and improve pressure pain thresholds and mandibular range of motion.</div></div><div><h3>Conclusion</h3><div>Ozone therapy emerges as a potential therapy for reducing TMD-related symptoms. However, the current evidence lacks robustness, and further high-quality randomized controlled trials are necessary to enhance the existing evidence base.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102127"},"PeriodicalIF":4.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF STEM CELLS IN ENDODONTIC REGENERATION: A SYSTEMATIC REVIEW","authors":"NAUSHEEN AGA MClinDent ,&nbsp;SCOTT McGregor MSc ,&nbsp;SARAH JONES PhD ,&nbsp;IAN ELLIS ,&nbsp;MARCO TATULLO PhD ,&nbsp;MUNA EISA MOHAMED HASSAN PhD ,&nbsp;MOHAMMAD ISLAM PhD","doi":"10.1016/j.jebdp.2025.102125","DOIUrl":"10.1016/j.jebdp.2025.102125","url":null,"abstract":"<div><h3>Introduction</h3><div>Regenerative endodontic procedures (REPs) aim to regenerate structural and functional integrity of necrosed or infected dental pulp, while promoting root development and closure. Conventional treatment methods often fail to regenerate dental pulp tissues effectively. This systematic review investigates the efficacy of stem cell therapy in REPs.</div></div><div><h3>Methodology</h3><div>An electronic search was conducted on the following research databases and registers: PubMed (includes MEDLINE and PubMed Central), Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and ClinicalTrials.gov. The study was registered in PROSPERO and PRISMA guidelines were followed to report the review. 19 original studies comprising 1 randomized clinical trial and 18 animal studies were included after applying inclusion and exclusion criteria. The studies evaluated different types of endodontic procedures, including pulp capping, pulpotomy, pulpectomy, and furcation repair, using various types of mesenchymal stem cells, such as dental pulp stem cells, bone marrow-derived stem cells and umbilical cord mesenchymal stem cells (UCMSCs). The outcomes assessed in the studies included pulpal regeneration, resolution of periapical radiolucency, and restoration of tooth vitality. The Systematic Review Center for Laboratory and Animal Experimentation (SYRCLE) and Risk of Bias 2.0 was used for assessing the risk of bias in animal studies and randomized trials, respectively.</div></div><div><h3>Results</h3><div>The findings indicate that stem cell therapy holds promise for inducing dental pulp regeneration. However, synthesizing the overall efficacy of stem cell therapy compared to conventional methods remains challenging due to variations in methodologies and outcome measures used in animal studies. Despite these inconsistencies, most animal studies reported positive results for pulpal regeneration, regardless of the stem cell type, scaffold type or animal model used. Notably, a clinical trial utilizing umbilical cord mesenchymal stem cells (UCMSCs) combined with platelet-poor plasma demonstrated favorable outcomes in dental pulp revascularization and reperfusion.</div></div><div><h3>Conclusion</h3><div>The long-term safety and clinical efficacy of stem cell therapy in regenerative endodontic procedures (REPs) require validation through randomized clinical trials before widespread clinical adoption.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102125"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF LOW-LEVEL LIGHT THERAPY ON PAIN AND RELATED LESIONS IN PATIENTS WITH ORAL LICHEN PLANUS: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"CHENGHUI LU M.Med ,&nbsp;LANQING MO M.B.B.S ,&nbsp;XIN LI M.Sc ,&nbsp;GUANHUAN DU Ph.D ,&nbsp;ZHENGQUAN CHEN M.Sc ,&nbsp;FAN WU B.M ,&nbsp;LILI CAI B.M ,&nbsp;QING DU Ph.D ,&nbsp;GUOYAO TANG Ph.D","doi":"10.1016/j.jebdp.2025.102126","DOIUrl":"10.1016/j.jebdp.2025.102126","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>Oral lichen planus (OLP) is a relatively common immunological mucocutaneous disease that causes pain, burning sensations and poor quality of life. The use of low-level light therapy (LLLT) to treat OLP is still debated. This systematic review and meta-analysis aimed to systematically and quantitatively assess the efficacy of LLLT in the treatment of OLP.</div></div><div><h3>METHODS</h3><div>The PubMed, Embase, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Cochrane Library, and Web of Science electronic databases were searched up to February 28, 2023, to identify randomized controlled trials (RCTs) examining the use of LLLT in OLP patients reporting pain or other outcomes. The mean difference (MD) or <em>log</em> risk ratio (<em>log</em> RR) with 95% confidence intervals (<em>CI</em>s) were estimated separately for each outcome to determine the effect sizes. Subgroup analysis was used to detect the sources of heterogeneity. Sensitivity analysis was used to test the robustness of the pooled results. Funnel plots, Egger's test, and Begg's test were used to test publication bias. All the statistical analyses were performed using Stata 16.0 software. A graph of risk of bias was drawn using RevMan 5.4.1 software for the assessment of bias.</div></div><div><h3>RESULTS</h3><div>A total of twelve RCTs were included in this systematic review, 7 of which were also included in the meta-analysis. Among the included studies, 1 had a low risk of bias, whereas 7 had an unclear risk of bias. The meta-analysis results indicated that LLLT significantly improved long-term analgesic efficacy (over 12 weeks posttreatment, measured by the visual analogue scale; MD = -1.20, 95% <em>CI</em> -2.01 to -0.38, <em>P</em> &lt; .001), whereas no significant changes were observed in either the short term (MD = -0.68, 95% <em>CI</em> -1.38 to 0.01, <em>P</em> = .05) or the medium term (MD = -0.89, 95% <em>CI</em> -1.96 to 0.17, <em>P</em> = .10). Furthermore, LLLT improved the clinical severity of lesions (as assessed by the biopsy sign scores or reticular atrophic erosive scores; MD = -1.13, 95% <em>CI</em> -1.62 to -0.63, <em>P</em> &lt; .001) and reduced the recurrence rate (<em>log</em> RR = -1.34, 95% <em>CI</em> -2.30 to -0.37, <em>P</em> = .01). Additionally, there were no statistically significant differences in the clinical response rate (measured by efficacy indices; <em>log</em> RR = -0.12, 95% <em>CI</em> -0.37 to 0.13, <em>P</em> = .35). No adverse events related to LLLT were reported.</div></div><div><h3>CONCLUSION</h3><div>LLLT appears to alleviate pain, enhance the clinical outcomes of OLP lesions, and lower the likelihood of relapse in OLP patients. Future research should focus on longer intervention courses, larger sample sizes, and multidisciplinary intervention designs.</div></div><div><h3>SYSTEMATIC REVIEW REGISTRATION</h3><div>This meta-analysis was registered on PROSPERO (CRD42023384852).</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102126"},"PeriodicalIF":4.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIPLAQUE AND ANTIGINGIVITIS EFFECTS OF A NOVEL ORAL CARE REGIMEN FEATURING STANNOUS FLUORIDE TOOTHPASTE, A UNIQUE TOOTHBRUSH, AND CETYLPYRIDINIUM CHLORIDE MOUTHWASH: A RANDOMIZED CLINICAL TRIAL","authors":"FARID AYAD ,&nbsp;MAHA HETATA ,&nbsp;RABAB AHMED ,&nbsp;TAKAHIDE OKAI ,&nbsp;GOKUL GOVINDARAJU ,&nbsp;LUIS R. MATEO ,&nbsp;MARIA RYAN ,&nbsp;BAYARDO GARCÍA-GODOY","doi":"10.1016/j.jebdp.2025.102123","DOIUrl":"10.1016/j.jebdp.2025.102123","url":null,"abstract":"<div><h3>Background</h3><div>Antibacterial ingredients for oral care products are typically measured through single product forms. This study assessed the overall health outcome of using multiple forms: a stabilized stannous fluoride toothpaste, an enhanced cetylpyridinium chloride mouthwash and a unique toothbrush to deliver antibacterial performance.</div></div><div><h3>Methods</h3><div>A 12-week, single-center, phase III, masked, 2-arm, parallel-group, randomized controlled trial was conducted to assess the reduction of established dental plaque and gingivitis with a novel antibacterial oral regimen comprised of 0.454% stannous fluoride toothpaste stabilized with nitrate and phosphates, 0.075% cetylpyridinium chloride and 0.28% zinc lactate mouthwash, and rapid foaming manual toothbrush compared to a nonantibacterial commercially available regimen of toothpaste containing 0.76% sodium monofluorophosphate, no mouthwash, and commercially available manual toothbrush to represent standard toothbrushing practices.</div></div><div><h3>Results</h3><div>Adherence to this novel oral care regimen provided significant reduction in plaque and gingivitis compared to the control starting at 1 week (<em>P</em> &lt; .01) and continuing over 12 weeks (<em>P</em> &lt; .001) across all plaque and gingival score indices. At week 1, participants in the Antibacterial Regimen Group showed 15 times more plaque reduction than control (<em>P</em> &lt; .001). After 3 weeks of regimen adherence, 100% of Antibacterial Regimen participants had improved gingival index scores compared to baseline.</div></div><div><h3>Conclusions</h3><div>Within the limitations of the study, the results showed statistically significantly reduced gingival inflammation and improved plaque control from 1 week continuing through 12 weeks of adherence to this novel oral care regimen compared to standard toothbrushing practices.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102123"},"PeriodicalIF":4.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THREE YEARS CLINICAL ASSESSMENT OF LOW CONCENTRATION DIMETHYL SULFOXIDE PRIMER IN NON CARIOUS CERVICAL LESIONS: A RANDOMIZED CONTROLLED TRIAL","authors":"OMAR ABDELAZIZ ISMAIL DDS, MSc ,&nbsp;OLFAT ELSAYED HASSANEIN DDS, Ph.D. ,&nbsp;RANDA HAFEZ DDS, Ph.D. ,&nbsp;MAI MAMDOUH DDS, Ph.D. ,&nbsp;OMAR SHAALAN DDS, Ph.D. ,&nbsp;ARZU TEZVERGIL-MUTLUAY DDS, Ph.D. FADM","doi":"10.1016/j.jebdp.2025.102124","DOIUrl":"10.1016/j.jebdp.2025.102124","url":null,"abstract":"<div><h3>Objectives</h3><div>to evaluate the clinical effectiveness of 1% dimethyl-sulfoxide (DMSO/H₂O) dentin pretreatment on the clinical performance of 2-step etch-rinse adhesive after 36-months of a follow-up.</div></div><div><h3>Methods</h3><div>Twenty-nine patients with 82 non carious-cervical lesions NCCLs were eligible for the study. NCCLs were randomly distributed into 2 equal groups. Both groups were acid etched then bonded with (Single-bond2, 3M-ESPE) and restored with a nanohybrid composite (Z350XT, 3M-ESPE) under rubber-dam isolation. Only for the intervention group 1% DMSO/H₂O was applied for 60s then blot dried after etching and before bonding. The restorations were evaluated at baseline, 12-, 24-, and 36-months using FDI criteria for evaluation of the restoration. For the statistical analysis, intergroup comparison between interventions was performed using Chi-Square-test (<em>P</em> ≤ .05), intragroup comparison within each intervention was performed using the Cochran's Q-test (<em>P</em> ≤ .0083).</div></div><div><h3>Results</h3><div>In the current study, intergroup comparison between both groups at baseline and after 12, 24 and 36 months showed no statistically significant differences for all tested outcomes (<em>P</em> &gt; .05), except for marginal discoloration at 36 months, where there was statistically significant difference (<em>P</em> &lt; .05) favoring DSMO. Intragroup comparison within control revealed statistically significant deterioration through time (<em>P</em> &lt; .001) for all tested parameters, also within DSMO there was statistically significant change through time (<em>P</em> &lt; .0083).</div></div><div><h3>Conclusion</h3><div>The clinical performance of a 2-step etch-rinse adhesive in combination with 1% DMSO pretreatment was better than the control without pretreatment. Longer follow-up and higher concentrations of DMSO pretreatment should be evaluated in the future.</div></div><div><h3>Clinical Significance</h3><div>Several laboratory studies showed that DMSO pretreatment improves the hybrid layer quality and integrity. However, this clinical trial gave the proof of the clinical effectiveness of this protocol after 36-months follow-up.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102124"},"PeriodicalIF":4.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S1532-3382(25)00029-6","DOIUrl":"10.1016/S1532-3382(25)00029-6","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102114"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Purpose/Levels of Evidence","authors":"","doi":"10.1016/S1532-3382(25)00028-4","DOIUrl":"10.1016/S1532-3382(25)00028-4","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102113"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Authors","authors":"","doi":"10.1016/S1532-3382(25)00030-2","DOIUrl":"10.1016/S1532-3382(25)00030-2","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102115"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of Evidence—Grading System","authors":"","doi":"10.1016/S1532-3382(25)00031-4","DOIUrl":"10.1016/S1532-3382(25)00031-4","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102116"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE MANAGEMENT OF TEETH IN ODONTOGENIC KERATOCYST AND AMELOBLASTOMA AND ITS PROGNOSTIC ROLE IN RECURRENCE: A SYSTEMATIC REVIEW AND META-ANALYSIS WITH TRIAL SEQUENTIAL ANALYSIS","authors":"PIERLUIGI MARIANI DDS ,&nbsp;DIANA RUSSO DDS, PhD ,&nbsp;MARCO CICCIÙ DDS, PhD ,&nbsp;LUIGI LAINO DDS, PhD","doi":"10.1016/j.jebdp.2025.102121","DOIUrl":"10.1016/j.jebdp.2025.102121","url":null,"abstract":"<div><h3>Introduction</h3><div>Odontogenic Keratocystic (OKC) and Ameloblastoma (AB) are pathological entities characterized by aggressive behavior, slow growth, local invasiveness, and high recurrence rates. The aim of this systematic review with meta-analysis and trial sequential analysis (TSA) is to assess the prognostic role of extracting involved teeth during the surgical enucleation of OKCs and ABs in terms of recurrence risk.</div></div><div><h3>Materials and Methods</h3><div>A search was conducted in PubMed/Medline, Scopus, and Web of Science databases for studies reporting data on teeth extraction and recurrence rates. This systematic review was performed according to guidelines in the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Meta-analysis was performed using the Mantel-Haenszel method with a random-effects model due to heterogeneity. The TSA was conducted to control and reduce for type I and II errors of statistical analysis.</div></div><div><h3>Results</h3><div>Six studies were identified and analyzed qualitatively and quantitatively. A total of 737 lesions (674 OKCs and 64 ABs) were included, of which 508 had involved teeth. The meta-analysis included 451 OKCs; 367 lesions were treated with teeth extraction, and in 141 cases, the teeth were preserved. The overall Risk Ratio was 0.17 (95% CI: [0.04, 0.74]; <em>P</em> &lt; .0001) for OKCs. Quantitative analysis could not be performed for ABs.</div></div><div><h3>Conclusion</h3><div>The analysis revealed that tooth extraction contextually to the enucleation of the lesion reduces the risk of recurrence by approximately 83% in the OKCs; this appears to have the same trend for ABs, but more evidence is needed.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102121"},"PeriodicalIF":4.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}