PATRICIA PEREIRA-LORES , VÍCTOR ALONSO DE LA PEÑA , TANIA GANCEDO-GANCEDO , CAROLINA VILLASENÍN-SÁNCHEZ , ALBA BELLO-CASTRO , BENJAMÍN MARTÍN-BIEDMA , PABLO CASTELO-BAZ
{"title":"A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL COMPARING THE EFFICACY OF A DESENSITIZING AGENT USED WITH AN AT-HOME BLEACHING TECHNIQUE","authors":"PATRICIA PEREIRA-LORES , VÍCTOR ALONSO DE LA PEÑA , TANIA GANCEDO-GANCEDO , CAROLINA VILLASENÍN-SÁNCHEZ , ALBA BELLO-CASTRO , BENJAMÍN MARTÍN-BIEDMA , PABLO CASTELO-BAZ","doi":"10.1016/j.jebdp.2024.102079","DOIUrl":"10.1016/j.jebdp.2024.102079","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of this study was to determine whether a sustained-release desensitizing gel containing 3% potassium nitrate and 0.11% fluoride ion reduces the risk of tooth sensitivity without compromising the effectiveness of bleaching treatment.</div></div><div><h3>Methods</h3><div>Thirty-two patients were randomly assigned to 2 experimental groups: desensitizing gel and placebo. The desensitizing gel or placebo was applied for 30 minutes prior to the at-home vital bleaching gel application. A nightguard dental bleaching treatment (NGVB) using a 16% carbamide peroxide gel was performed for 6 hours over a 3-week period. Patients recorded their tooth sensitivity daily using a 5-point Numeric Rating Scale (NRS). Whiteness index measurements were obtained using a dental spectrophotometer on the upper canines (right and left).</div></div><div><h3>Results</h3><div>The overall risk of sensitivity was 37.5% in the desensitizing gel group compared to 87.5% in the placebo group, yielding a relative risk of 0.42 (95% CI 0.22-0.82), showing a statistically significant difference between the groups (<em>P</em> < .05). During the first week, patients in the placebo group exhibited a higher risk of experiencing mild sensitivity. However, no statistically significant differences in sensitivity intensity were observed overall or during the second and third weeks (<em>P</em> > .05). Regarding color change, the mean difference between groups in the first week was 5.25 (-0.22 to 10.71), in the second week 4.25 (-2.56 to 11.02), and in the third week 2.55(-4.11 to 9.22). No statistically significant differences were found between the groups at any time point (<em>P</em> > .05).</div></div><div><h3>Conclusions</h3><div>The use of a sustained-release desensitizing gel containing 3% potassium nitrate and 0.11% fluoride ion for 30 minutes prior to the bleaching agent effectively reduced sensitivity during at-home bleaching procedures. Furthermore, the desensitizing gel did not impact the effectiveness of the at-home bleaching treatment.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102079"},"PeriodicalIF":4.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GISELA CRISTINA VIANNA CAMOLESI , AHMED SAMIR EL KATTAN , JOSÉ LOPEZ-LOPEZ , ANDRÉS BLANCO-CARRIÓN , ABEL GARCÍA-GARCÍA , PILAR GÁNDARA-VILA , MARIO PÉREZ-SAYÁNS
{"title":"PAIN, OEDEMA AND TRISMUS RESPONSES FOLLOWING PHOTOBIOMODULATION THERAPY IMMEDIATELY AFTER LOWER THIRD MOLAR EXTRACTION: RESULTS OF A RANDOMIZED, DOBLE-BLIND AND SPLIT MOUTH CLINICAL TRIAL","authors":"GISELA CRISTINA VIANNA CAMOLESI , AHMED SAMIR EL KATTAN , JOSÉ LOPEZ-LOPEZ , ANDRÉS BLANCO-CARRIÓN , ABEL GARCÍA-GARCÍA , PILAR GÁNDARA-VILA , MARIO PÉREZ-SAYÁNS","doi":"10.1016/j.jebdp.2024.102080","DOIUrl":"10.1016/j.jebdp.2024.102080","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the impact of photobiomodulation therapy in pain, facial oedema, and trismus mitigation in the postoperative period after lower third molar extractions.</div></div><div><h3>Methods</h3><div>We conducted a comparison between active photobiomodulation and simulated photobiomodulation after both lower third molars extraction in the same patients, within a double-center clinical trial. The role of photobiomodulation was evaluated based on pain, measured using the VAS scale. Oedema and trismus, assessed through millimetric measurements. Additionally, analgesic consumption was monitored during the 7-day's postoperative period. The study adhered to the CONSORT checklist and was registered on the ClinicalTrials (NCT05255731). The Levene test was used to assess precision (α=0.05), and statistical analysis was performed using Jamovi software. Paired t-tests or the Wilcoxon test were employed to analyze the primary and secondary outcomes.</div></div><div><h3>Results</h3><div>The study included 83 patients and 166 randomization units. The study group showed a significant reduction in pain at all evaluation times (<em>P < .</em>01), as well as reductions in facial oedema and trismus on postoperative days 2 and 7 (<em>P < .</em>01). A significant difference in analgesic use was observed on all days, except on the seventh postoperative day.</div></div><div><h3>Conclusion</h3><div>The photobiomodulation protocol, using an 808 nm, 100 mW Ga-Al-As diode laser, applied both intraorally and extraorally in a single 30 seconds (3 Joules/per point) postoperative session, significantly reduced pain, oedema, and trismus following mandibular third molar extraction, particularly on postoperative days 2 and 7.</div></div><div><h3>Clinical Significance</h3><div>Photobiomodulation can be an effective complementary therapy for reducing pain, facial oedema, and trismus in patients after lower third molar extraction.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102080"},"PeriodicalIF":4.1,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for Authors","authors":"","doi":"10.1016/S1532-3382(24)00115-5","DOIUrl":"10.1016/S1532-3382(24)00115-5","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"24 4","pages":"Article 102065"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Statement of Purpose/Levels of Evidence","authors":"","doi":"10.1016/S1532-3382(24)00113-1","DOIUrl":"10.1016/S1532-3382(24)00113-1","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"24 4","pages":"Article 102063"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RESIN INFILTRATION MAY HELP MASK ENAMEL WHITE SPOT LESIONS OR FLUOROSIS","authors":"LINDA L. CHENG (REVIEWER)","doi":"10.1016/j.jebdp.2022.101716","DOIUrl":"10.1016/j.jebdp.2022.101716","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div><span><span>Bourouni S, Dritsas K, Kloukos D, Wierichs RJ. Efficacy of resin infiltration to mask post-orthodontic or non-post-orthodontic white spot lesions or fluorosis - a </span>systematic review<span> and meta-analysis. Clin Oral Investig. 2021 Aug;25(8):4711-4719. doi:</span></span><span><span>10.1007/s00784-021-03931-7</span><svg><path></path></svg></span>. Epub 2021 Jun 9. PMID: 34106348.</div></div><div><h3>Source of Funding</h3><div>Open Access funding provided by Universit.±t Bern.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with meta-analysis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"24 4","pages":"Article 101716"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44889758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for Readers","authors":"","doi":"10.1016/S1532-3382(24)00114-3","DOIUrl":"10.1016/S1532-3382(24)00114-3","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"24 4","pages":"Article 102064"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FILIPE COLOMBO VITALI PhD , PAULA AKEMI ALBUQUERQUE KOMINAMI MS , ANA CRISTINA ANDRADA DMSc , ELIANA MITSUE TAKESHITA PhD , CARLA MASSIGNAN PhD
{"title":"IMPACT OF PULPECTOMY VERSUS EXTRACTION OF PRIMARY TEETH ON PATIENT-CENTERED OUTCOMES: A SYSTEMATIC REVIEW OF CLINICAL STUDIES","authors":"FILIPE COLOMBO VITALI PhD , PAULA AKEMI ALBUQUERQUE KOMINAMI MS , ANA CRISTINA ANDRADA DMSc , ELIANA MITSUE TAKESHITA PhD , CARLA MASSIGNAN PhD","doi":"10.1016/j.jebdp.2024.102072","DOIUrl":"10.1016/j.jebdp.2024.102072","url":null,"abstract":"<div><h3>Objectives</h3><div>Although pulpectomy is recommended as the choice treatment for primary teeth with pulpal involvement, some clinicians and parents consider tooth extraction a viable option. This systematic review aimed to assess the impact of pulpectomy versus extraction of primary teeth on patient-centered outcomes.</div></div><div><h3>Methods</h3><div>Seven electronic databases and grey literature were searched on April 05, 2024. Two independent reviewers selected clinical trials comparing the impact of pulpectomy versus extraction of primary teeth on patient-centered outcomes. Studies not directly comparing pulpectomy versus tooth extraction were excluded. Critical data were summarized following the Synthesis Without Meta-analysis guideline. The risk of bias was assessed using the Version 2 Cochrane risk-of-bias tool for randomized clinical trials and the Risk Of Bias In Nonrandomized Studies of Interventions tool for nonrandomized clinical trials. The certainty of evidence was assessed using the GRADE approach.</div></div><div><h3>Results</h3><div>A total of 1228 studies were retrieved in the search. After the screening process, two studies were included. The outcomes evaluated were oral health-related quality of life (OHRQoL), dental anxiety, postoperative pain, and behavior. Qualitative synthesis indicated that children treated with pulpectomy exhibited improved OHRQoL and lower dental anxiety than those treated with tooth extraction. The treatment modality did not influence behavior and postoperative pain. Included studies present potential bias in specific domains. The certainty of evidence was low.</div></div><div><h3>Conclusion</h3><div>Pulpectomy demonstrated superior patient-centered outcomes, suggesting that it is a more favorable choice for treating primary teeth than tooth extraction.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102072"},"PeriodicalIF":4.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"OXIDATIVE STRESS AND ANTIOXIDANT MARKERS IN ORAL SUBMUCOUS FIBROSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CASE-CONTROL STUDIES","authors":"JINCAI GUO MD , HUI XIE PhD , XUERU CHEN MD","doi":"10.1016/j.jebdp.2024.102073","DOIUrl":"10.1016/j.jebdp.2024.102073","url":null,"abstract":"<div><h3>Objective</h3><div>This meta-analysis systematically investigates the markers of oxidative stress (OS) and antioxidant systems in the saliva and serum of patients with oral submucous fibrosis (OSF) and healthy controls.</div></div><div><h3>Methods</h3><div>Using a comprehensive search of databases from their inception period to December 31, 2023, articles related to OS or antioxidant markers in patients with OSF and healthy controls were retrieved. Literature screening and data extraction were performed by two reviewers according to the set criteria, and a third evaluator was involved in case of disagreements. The included studies were assessed with the Newcastle–Ottawa Scale, and the results were analyzed using Review Manager 5.4 software.</div></div><div><h3>Results</h3><div>A total of 14 studies were included. Patients with OSF exhibited significantly higher levels of malondialdehyde (serum: SMD: 7.65, 95% confidence interval [CI]: 5.14–10.17, <em>P</em> < .00001, saliva: SMD: 3.07, 95% CI: 0.6–5.54, <em>P</em> < .00001) and 8-hydroxy-deoxyguanosine (saliva: SMD: 4.84, 95% CI: 3.49–6.18, <em>P</em> < .00001) than healthy controls. Levels of vitamin C (serum: SMD: −3.54, 95% CI: −4.10 to −2.99, <em>P</em> < .00001, saliva: SMD: −1.10, 95% CI: −1.39 to −0.80, <em>P</em> < .00001), vitamin E (saliva: SMD: −1.78, 95% CI: −2.1 to −1.45, <em>P</em> < .00001), and superoxide dismutase (serum: SMD: −9.77, 95% CI: −13.79 to −5.74, <em>P</em> < .00001) were significantly lower in patients with OSF than in healthy controls.</div></div><div><h3>Conclusions</h3><div>The results showed increased levels of OS markers and decreased levels of antioxidant markers in patients with OSF, providing valuable indicators that may aid in clinical diagnosis and management.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102073"},"PeriodicalIF":4.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}