一项三盲随机临床试验，比较脱敏剂与家庭漂白技术的效果

IF 4 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2024-12-09 DOI:10.1016/j.jebdp.2024.102079

PATRICIA PEREIRA-LORES , VÍCTOR ALONSO DE LA PEÑA , TANIA GANCEDO-GANCEDO , CAROLINA VILLASENÍN-SÁNCHEZ , ALBA BELLO-CASTRO , BENJAMÍN MARTÍN-BIEDMA , PABLO CASTELO-BAZ

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引用次数: 0

摘要

本研究的目的是确定含有3%硝酸钾和0.11%氟离子的缓释脱敏凝胶是否能在不影响牙齿漂白治疗效果的情况下降低牙齿敏感的风险。方法32例患者随机分为2个实验组：脱敏凝胶组和安慰剂组。脱敏凝胶或安慰剂在家用重要漂白凝胶应用前应用30分钟。使用16%过氧化脲凝胶进行夜间牙齿漂白治疗（NGVB），为期3周，持续6小时。患者每天使用5分数字评定量表（NRS）记录他们的牙齿敏感性。白度指数测量使用牙分光光度计在上犬（右和左）。结果脱敏凝胶组的总体敏感性风险为37.5%，安慰剂组为87.5%，相对风险为0.42 (95% CI 0.22-0.82)，两组间差异有统计学意义(P <；. 05)。在第一周，安慰剂组的患者表现出更高的轻度敏感风险。然而，总体或第二周和第三周的敏感性强度没有统计学上的显著差异(P >；. 05)。在颜色变化方面，第一周组间平均差异为5.25(-0.22 ~ 10.71)，第二周组间平均差异为4.25(-2.56 ~ 11.02)，第三周组间平均差异为2.55（-4.11 ~ 9.22）。两组在任何时间点均无统计学差异(P >；. 05)。结论在使用漂白剂前使用含有3%硝酸钾和0.11%氟离子的缓释脱敏凝胶30分钟，可有效降低居家漂白过程中的敏感性。此外，脱敏凝胶不影响在家漂白治疗的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL COMPARING THE EFFICACY OF A DESENSITIZING AGENT USED WITH AN AT-HOME BLEACHING TECHNIQUE

Purpose

The aim of this study was to determine whether a sustained-release desensitizing gel containing 3% potassium nitrate and 0.11% fluoride ion reduces the risk of tooth sensitivity without compromising the effectiveness of bleaching treatment.

Methods

Thirty-two patients were randomly assigned to 2 experimental groups: desensitizing gel and placebo. The desensitizing gel or placebo was applied for 30 minutes prior to the at-home vital bleaching gel application. A nightguard dental bleaching treatment (NGVB) using a 16% carbamide peroxide gel was performed for 6 hours over a 3-week period. Patients recorded their tooth sensitivity daily using a 5-point Numeric Rating Scale (NRS). Whiteness index measurements were obtained using a dental spectrophotometer on the upper canines (right and left).

Results

The overall risk of sensitivity was 37.5% in the desensitizing gel group compared to 87.5% in the placebo group, yielding a relative risk of 0.42 (95% CI 0.22-0.82), showing a statistically significant difference between the groups (P < .05). During the first week, patients in the placebo group exhibited a higher risk of experiencing mild sensitivity. However, no statistically significant differences in sensitivity intensity were observed overall or during the second and third weeks (P > .05). Regarding color change, the mean difference between groups in the first week was 5.25 (-0.22 to 10.71), in the second week 4.25 (-2.56 to 11.02), and in the third week 2.55(-4.11 to 9.22). No statistically significant differences were found between the groups at any time point (P > .05).

Conclusions

The use of a sustained-release desensitizing gel containing 3% potassium nitrate and 0.11% fluoride ion for 30 minutes prior to the bleaching agent effectively reduced sensitivity during at-home bleaching procedures. Furthermore, the desensitizing gel did not impact the effectiveness of the at-home bleaching treatment.

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来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.