Journal of Evidence-Based Dental Practice最新文献

{"title":"HOW TO REPORT OUTCOMES IN CLINICAL DENTAL RESEARCH","authors":"Danchen Qin PhD ,&nbsp;Feiyang Guo PhD ,&nbsp;Fang Hua PhD","doi":"10.1016/j.jebdp.2024.102053","DOIUrl":"10.1016/j.jebdp.2024.102053","url":null,"abstract":"<div><div>Outcomes, also known as endpoints, are a critical component in clinical research evaluating the effects of healthcare interventions. The validity of a clinical study depends on the appropriate selection and usage of outcomes. Therefore, complete, accurate, and transparent reporting of outcomes is essential for the critical appraisal of a study's methods and findings. However, empirical research has shown that the reporting of outcomes is often incomplete and selective in clinical dental research, hindering evidence synthesis and evidence-based dental practice. To improve and standardize outcome reporting, reporting guidelines that provide specific guidance for all types of outcomes, namely the SPIRIT-Outcomes 2022 and CONSORT-Outcomes 2022, have been developed and released recently. In addition, reporting guidelines for certain types of outcomes have also been published, including harms, patient-reported outcomes (PROs), and surrogate outcomes. The present article describes common classifications of outcomes, current issues in outcome reporting, and using reporting guidelines to standardize and improve outcome reporting in clinical dental research. The role of core outcome sets in outcome reporting is also discussed. This article aims to provide guidance and suggestions to help improve the completeness and transparency of outcome reporting and reduce relevant research waste in clinical dental research.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102053"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERSONALIZED PROFILES OF ORAL HEALTH AND DISEASE: USING HIGH-DIMENSIONAL VECTOR MODELS FOR GUIDING PRECISION DENTAL CARE","authors":"CASEY D. WRIGHT ,&nbsp;MARCUS G. WILD ,&nbsp;REBECCA CUTLER ,&nbsp;KIMON DIVARIS","doi":"10.1016/j.jebdp.2024.102048","DOIUrl":"10.1016/j.jebdp.2024.102048","url":null,"abstract":"<div><div>Operationalizing the oral health experience is an ongoing effort with various clinical and patient-reported outcomes contributing to such conceptualizations. Computational technology has afforded advances in the ability to model complex interactions between various phenomena and provides an opportunity to reconsider the way oral health is conceptualized. High-dimensional vector space modeling is introduced and discussed as a theoretical way to incorporate all relative features associated with understanding oral health, including clinical, patient-reported, and demographic information. Specifically, a novel application of high-dimensional vector space models is proposed as a vehicle to operationalize the 3P model of oral health. Additionally, this paper outlines how this approach can 1) create more precise, person-level characterizations of oral health; 2) track oral health over time, offering greater opportunities for behavioral interventions to prevent, mitigate, or treat the negative impacts of dental, oral, and craniofacial diseases; and 3) offer comparisons to dynamically tuned comparison vectors which can define “good” oral health and quantify disparities and features on which to intervene to mitigate them.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102048"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ORAL HEALTH IMPACT OF DENTAL HYGIENE AND DENTAL THERAPY PATIENT POPULATIONS—AN EVIDENCE UPDATE IN 2024","authors":"APARNA INGLESHWAR ,&nbsp;MIKE T. JOHN ,&nbsp;PHONSUDA CHANTHAVISOUK ,&nbsp;NICOLE THEIS-MAHON ,&nbsp;DANNA R. PAULSON","doi":"10.1016/j.jebdp.2024.102083","DOIUrl":"10.1016/j.jebdp.2024.102083","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental patient-reported outcomes, especially the Oral Health-Related Quality of Life (OHRQoL) construct, are vital for evidence-based dentistry. This construct includes four dimensions (4D): Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact. This study updates previous work characterizing 4D OHRQoL impairment among patients in dental hygiene (DH) and dental therapy (DT) settings.</div></div><div><h3>Methods</h3><div>An expert panel revised previously determined DH and DT patient population groups to align them with current scopes of practice. An updated systematic review was then conducted to incorporate recent studies using the Oral Health Impact Profile (OHIP) to assess 4D OHRQoL in these populations. The search spanned 6 databases from January 1, 2023, to April 16, 2024.</div></div><div><h3>Results</h3><div>The panel identified 20 patient populations, representing the scope of DH and DT practice. The systematic review contained 19 studies (17 from the previous review and 2 new ones). Studies’ OHRQoL data covered only 30 % of dental hygiene and dental therapy patient populations identified by the panel. The most frequently studied group was “therapeutic periodontal treatment–patients with periodontitis” (<em>n</em> = 17, 89 %), followed by “oral hygiene instructions–all patients” (<em>n</em> = 13, 68 %). Only four studies provided 4D OHRQoL data, showing the greatest impacts in Orofacial Pain (baseline OHIP: 3.10-4.20; follow-up: 1.52-3.60) and Orofacial Appearance (baseline OHIP: 0.44-2.50; follow-up: 0.91-2.25). Among studies reporting summary OHIP scores only (<em>n</em> = 15), overall OHRQoL impairment ranged from 1.40 to 42.35 at baseline and 1.50-40.56 at follow-up. All studies demonstrated a general trend of reduced OHRQoL impairment over time with treatment. Risk of bias was low, with no evidence of publication bias.</div></div><div><h3>Conclusion</h3><div>Current evidence on OHRQoL impairment in DH and DT patient populations is limited, covering only a third of those treated by dental hygienists and therapists. Especially, scarce 4D OHRQoL data prompts the need for more research in this format. Despite these limitations, the findings show promising trends of reduced OHRQoL impairment over time for DH and DT patient populations.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102083"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USE OF DENTAL PATIENT-REPORTED OUTCOMES (dPROs) IN PREDICTION MODELING STUDIES IN ORAL HEALTH: A METHODOLOGICAL REVIEW","authors":"NAICHUAN SU ,&nbsp;MICHIEL VAN DER LINDEN ,&nbsp;CLOVIS MARIANO FAGGION JR ,&nbsp;NIELS VAN DER AA","doi":"10.1016/j.jebdp.2024.102057","DOIUrl":"10.1016/j.jebdp.2024.102057","url":null,"abstract":"<div><h3>Objective</h3><div>Dental patient-reported outcomes (dPROs) are critical indicators of shared decision-making in oral healthcare. This study aimed to assess the frequency of use of dPROs and dPRO-related factors being used as predictors or predicted outcomes in clinical prediction models (CPMs) in oral health, and to identify variables associated with the use of dPROs and/or dPRO-related factors in CPMs.</div></div><div><h3>Methods</h3><div>A PubMed search was conducted on 17th May, 2024, to identify eligible studies. The studies which aimed to develop CPMs in oral health using traditional statistical techniques (e.g. logistic or Cox regression) and were published from 2018 onwards were included. The dPROs and dPRO-related factors used as potential predictors, final predictors, and predicted outcomes in the CPMs were extracted and summarized. Logistic regression analyses were performed to assess the associations between various variables and the use of dPROs and dPRO-related factors.</div></div><div><h3>Results</h3><div>A total of 144 studies were included, of which 88.2% were retrospective studies and 73.6% were on oral oncology. dPROs and/or dPRO-related factors were used as potential predictors, final predictors, and predicted outcomes in 28 (19.4%), 21 (14.6%), and 7 (4.9%) studies, respectively. The most frequently used dPRO as both potential and final predictors was self-reported orofacial pain, while the most frequently used dPRO-related factor was self-reported toothbrushing. The most frequently used dPRO as a predicted outcome was self-reported xerostomia, while no studies used dPRO-related factors as outcomes. The study topic was statistically significantly associated with the use of dPROs and/or dPRO-related factors (Odds Ratio [OR]: 9.98; 95% confidence interval [CI]: 3.36 29.67; <em>P</em> &lt; .01).</div></div><div><h3>Conclusions</h3><div>dPROs and dPRO-related factors were infrequently used as predictors or predicted outcomes in prediction modeling studies in oral health. Studies in dental fields other than oral oncology, such as cariology and periodontology, were more likely to use dPROs and/or dPRO-related factors compared to those in oral oncology.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102057"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USAGE AND REPORTING OF DENTAL PATIENT-REPORTED OUTCOMES AMONG SYSTEMATIC REVIEWS IN ORTHODONTICS: A METHODOLOGICAL STUDY","authors":"QI WANG ,&nbsp;ZHENDONG TAO ,&nbsp;TINGTING ZHAO ,&nbsp;DANCHEN QIN ,&nbsp;HONG HE ,&nbsp;FANG HUA","doi":"10.1016/j.jebdp.2024.102049","DOIUrl":"10.1016/j.jebdp.2024.102049","url":null,"abstract":"<div><h3>Objective</h3><div>To summarize and analyze the usage and reporting of dental patient-reported outcomes (dPROs) within systematic reviews (SRs) published in 5 leading orthodontic journals between 2015 and 2023.</div></div><div><h3>Methods</h3><div>A manual search was conducted to identify intervention (therapeutic or preventive) involved SRs published in selected journals between 2015 and 2023 from the official online archives. Two authors independently and in duplicate extracted the characteristics of each included SR, recording both the usage of dPROs in the Methods sections and the reporting of dPROs in the Results sections.</div></div><div><h3>Results</h3><div>A total of 244 SRs were found eligible and included, of which 81 (33.2%) included dPROs. Out of the 81 SRs, 19 (23.5%) described dPROs in the Methods sections, 6 (7.4%) reported dPROs exclusively in the Results sections, and 56 (69.1%) included dPROs in both sections. In the 75 SRs that stated dPROs in their Methods sections, 38 (50.7%) identified them as primary outcomes, while 37 (49.3%) considered them secondary outcomes. Among the 62 SRs that reported dPROs in the Results section, 17 (27.4%) performed quantitative synthesis, and the remaining 45 (72.6%) conducted only qualitative synthesis. A total of 26 dPROMs were identified, of which only 11 were included in meta-analyses.</div></div><div><h3>Conclusions</h3><div>Only about one-third of SRs published in leading orthodontic journals included dPROs. It is recommended that researchers consider the usage of dPROs and dPROMs during the design and registration stages of orthodontic SRs and ensure transparent reporting of the results, thus facilitating evidence-based practice and shared decision-making in clinical care.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102049"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT BY ORAL HEALTH PROFESSIONALS OF PATIENT-REPORTED OUTCOMES IN OBSTRUCTIVE SLEEP APNEA","authors":"NATHALIA CAROLINA FERNANDES Fagundes,&nbsp;CARLOS FLORES-MIR","doi":"10.1016/j.jebdp.2024.102045","DOIUrl":"10.1016/j.jebdp.2024.102045","url":null,"abstract":"<div><div>Oral health professionals, including general dentists and orthodontists, may participate in the provision of care to adults and children with obstructive sleep apnea (OSA) when referred by a sleep medicine specialist. The use of oral appliances (OA) has been presented as a possible management option for mild obstructive sleep apnea among adults. In children, although oral interventions are not supported as a first-line stand-alone management option for OSA, short-term studies have suggested an improvement in sleep signs and symptoms in milder cases. The monitoring of management outcomes from OA interventions is essential to monitor OSA conditions. Due to the chronic nature of OSA, the measure of dental patient-reported outcomes (dPROs) will likely help to understand interplaying factors that may influence the effectiveness of OA interventions among subjects with OSA. This narrative review discusses the current evidence regarding main dPROs in OSA, evaluation methods, and the contribution of oral health professionals in assessing it for both children and adults. The main dPROs assessed among OA users include quality of life, treatment adherence, and side effects. The use of validated tools to measure dPROs must be preferred when available. Overall, the clinical assessment of dPROs by oral health professionals is likely beneficial to monitoring OSA management outcomes and must be encouraged as part of an interdisciplinary approach led by the sleep physician.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102045"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DENTAL PATIENT-REPORTED OUTCOMES UPDATE 2024","authors":"FANG HUA","doi":"10.1016/j.jebdp.2025.102122","DOIUrl":"10.1016/j.jebdp.2025.102122","url":null,"abstract":"<div><div>As the medical field develops rapidly towards evidence-based, personalized and intelligent care, patient-reported outcomes (PRO) related research is becoming increasingly refined in terms of coverage, precision and practicability. In order to help improve the quality and quantity of patient-centered evidence in dentistry and to further promote the wide and standard use of dental patient-reported outcomes (dPROs) and dental patient-reported outcome measures (dPROMs), the <em>Journal of Evidence-Based Dental Practice</em> has put together this Special Issue, the fourth of a series entitled Dental Patient-Reported Outcomes Update.</div><div>A total of 7 solicited articles are included in this issue. To put them into a broader perspective, this review provides a concise summary of key, selected PRO and dPRO articles published during 2024. A brief introduction to those articles included in this Special Issue follows. Four main domains are covered in this Special Issue: (i) dPROs and general health, (ii) standardization of dPRO-related methodology, (iii) methodological considerations in dPRO-related research, and (iv) current usage of dPROs and dPROMs in published research.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102122"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LOW-QUALITY EVIDENCE SUGGESTS SKELETAL ANCHORAGE MAY PROVIDE SHORT-TERM CORRECTION OF ANTERIOR OPEN BITE","authors":"ZORAN JEZDIC (Reviewers),&nbsp;MARKO LAZIC,&nbsp;ALEKSANDAR JAKOVLJEVIC","doi":"10.1016/j.jebdp.2025.102129","DOIUrl":"10.1016/j.jebdp.2025.102129","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Orthodontic correction of anterior open bite using skeletal anchorage: systematic review and meta-analysis. Kwon TG, Elnagar MH, Shirazi S, Goben AH, Miloro M, Han MD. Int J Oral Maxillofac Surg. 2024 May;53(5):393-404.</div></div><div><h3>Source of Funding</h3><div>The authors did not report funding for this investigation.</div></div><div><h3>Type of Study/Design</h3><div>Systematic Review with Meta-Analysis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102129"},"PeriodicalIF":4.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROPHYLACTIC ANTIBIOTIC USE IN LOWER THIRD MOLAR SURGERY MAY REDUCE DRY SOCKET AND INFECTIONS, BUT EVIDENCE REMAINS WEAK","authors":"OMER WALEED MAJID (Reviewer)","doi":"10.1016/j.jebdp.2025.102128","DOIUrl":"10.1016/j.jebdp.2025.102128","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Camps-Font O, Sábado-Bundó H, Toledano-Serrabona J, Valmaseda-de-la-Rosa N, Figueiredo R, Valmaseda-Castellón E. Antibiotic prophylaxis in the prevention of dry socket and surgical site infection after lower third molar extraction: a network meta-analysis. Int J Oral Maxillofac Surg. 2024;53(1):57-67.</div></div><div><h3>Source of Funding</h3><div>None declared.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with network meta-analysis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102128"},"PeriodicalIF":4.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF STEM CELLS IN ENDODONTIC REGENERATION: A SYSTEMATIC REVIEW","authors":"NAUSHEEN AGA MClinDent ,&nbsp;SCOTT McGregor MSc ,&nbsp;SARAH JONES PhD ,&nbsp;IAN ELLIS ,&nbsp;MARCO TATULLO PhD ,&nbsp;MUNA EISA MOHAMED HASSAN PhD ,&nbsp;MOHAMMAD ISLAM PhD","doi":"10.1016/j.jebdp.2025.102125","DOIUrl":"10.1016/j.jebdp.2025.102125","url":null,"abstract":"<div><h3>Introduction</h3><div>Regenerative endodontic procedures (REPs) aim to regenerate structural and functional integrity of necrosed or infected dental pulp, while promoting root development and closure. Conventional treatment methods often fail to regenerate dental pulp tissues effectively. This systematic review investigates the efficacy of stem cell therapy in REPs.</div></div><div><h3>Methodology</h3><div>An electronic search was conducted on the following research databases and registers: PubMed (includes MEDLINE and PubMed Central), Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and ClinicalTrials.gov. The study was registered in PROSPERO and PRISMA guidelines were followed to report the review. 19 original studies comprising 1 randomized clinical trial and 18 animal studies were included after applying inclusion and exclusion criteria. The studies evaluated different types of endodontic procedures, including pulp capping, pulpotomy, pulpectomy, and furcation repair, using various types of mesenchymal stem cells, such as dental pulp stem cells, bone marrow-derived stem cells and umbilical cord mesenchymal stem cells (UCMSCs). The outcomes assessed in the studies included pulpal regeneration, resolution of periapical radiolucency, and restoration of tooth vitality. The Systematic Review Center for Laboratory and Animal Experimentation (SYRCLE) and Risk of Bias 2.0 was used for assessing the risk of bias in animal studies and randomized trials, respectively.</div></div><div><h3>Results</h3><div>The findings indicate that stem cell therapy holds promise for inducing dental pulp regeneration. However, synthesizing the overall efficacy of stem cell therapy compared to conventional methods remains challenging due to variations in methodologies and outcome measures used in animal studies. Despite these inconsistencies, most animal studies reported positive results for pulpal regeneration, regardless of the stem cell type, scaffold type or animal model used. Notably, a clinical trial utilizing umbilical cord mesenchymal stem cells (UCMSCs) combined with platelet-poor plasma demonstrated favorable outcomes in dental pulp revascularization and reperfusion.</div></div><div><h3>Conclusion</h3><div>The long-term safety and clinical efficacy of stem cell therapy in regenerative endodontic procedures (REPs) require validation through randomized clinical trials before widespread clinical adoption.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102125"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}