EFFICACY OF HYALURONIC NANOGEL SPRAY FOR TREATING DRY MOUTH: A RANDOMIZED CROSSOVER STUDY

Abstract

Objectives

To evaluate the efficacy of Hy-N spray in dry mouth patients.

Materials and Methods

A randomized double-blind crossover study was conducted on patients with dry mouth. They were given 3 saliva substitute sprays: Hy-N, placebo, and Biotène. The unstimulated whole saliva flow rate (UWSFR), salivary pH, and xerostomia questionnaire (XQ) were evaluated at baseline and after 1 week of treatment with each spray. Patient satisfaction was evaluated after each treatment period.

Results

Twenty-nine patients completed the study. After using the Hy-N and Biotène sprays for 1 week, the UWSFR significantly increased from 0.12 ± 0.16 at baseline to 0.16 ± 0.18 mL/min postspray usage (P = .04, P ≤ .01) with moderate improvement. None of the sprays affected salivary pH (P = .72). The mean XQ score also significantly decreased from 34.2 ± 21.4 at baseline to 23.7 ± 17.4, 23.1 ± 15.2, and 26.5 ± 17.7 after using Hy-N, Biotène, and placebo spray, respectively (P = .001, P = .011, P = .009) with moderate improvement. Biotène was the most preferred saliva substitute spray, followed by Hy-N spray.

Conclusion

Using the Hy-N and Biotène for 1 week relieves subjective and objective dry mouth. They can be a useful product in the management of dry mouth without causing side-effects.