Translational Behavioral Medicine最新文献

{"title":"mHealth to support resistance training using outdoor gyms: the ecofit hybrid type 3 implementation-effectiveness trial.","authors":"Ronald C Plotnikoff, Anna K Jansson, Mitch J Duncan, Sam Beacroft, Adrian Bauman, John Attia, Emily R Cox, Jordan J Smith, Sara L Robards, Mark Babic, David R Lubans","doi":"10.1093/tbm/ibag024","DOIUrl":"10.1093/tbm/ibag024","url":null,"abstract":"<p><strong>Background: </strong>There is a need to scale up effective physical activity interventions among the general population, particularly those incorporating resistance training. Ecofit is a community-based, multicomponent intervention promoting resistance and aerobic physical activity through smartphone technology, the outdoor built environment, and social support. This study aimed to scale up ecofit by comparing Low versus Moderate implementation support on the reach (outdoor gym use) of ecofit within two large regional municipalities.</p><p><strong>Methods: </strong>A hybrid type 3 implementation-effectiveness trial was conducted across two large municipalities in eastern Australia. Outdoor gyms (n = 18) were randomized to Low (ecofit app only) or Moderate [ecofit app, QR (quick response) codes on equipment, face-to-face workout sessions] implementation support. The primary outcome of \"reach\" was defined as the baseline-adjusted difference in the number of outdoor gym users (i.e. adults using outdoor gym equipment for resistance training) between groups. Reach was measured at baseline and 3-month follow-up using a modified System for Observing Play and Recreation in Communities tool, with blinded assessors observing community members perceived to be ≥18 years [categorized as Adults (aged 18-59) or Seniors (aged ≥60)]. Secondary outcomes included app uptake, dose received, implementation fidelity, and acceptability, feasibility, and dose-satisfaction regarding the app and guided sessions.</p><p><strong>Results: </strong>There was no significant difference in people using outdoor gym equipment for resistance training between Low and Moderate support groups at 3-month follow-up [incidence rate ratio (IRR) = 1.68, 95% CI: 0.96-2.94]. Among adults (aged 18-59), the Moderate support group showed significantly higher outdoor gym use at follow-up (IRR = 1.83, 95% CI: 1.01-3.31) compared to the Low support group. Over 6 months, 1273 users registered for the app, completing 503 workouts, 62% of which occurred indoors.</p><p><strong>Conclusions: </strong>Ecofit shows promise for promoting resistance training, particularly among adults. Broader marketing and enhanced engagement strategies may be required to increase outdoor gym use and sustain participation over time.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community engagement in research: practical strategies and tools for successful implementation.","authors":"Sandhya Seshadri, Benzi M Kluger, Sandra Monacelli, Maureen Simmons, Claire Pensyl, Tabby Anvari, Carrie Baker, Amanda Laprime, Suzannah Iadarola","doi":"10.1093/tbm/ibag061","DOIUrl":"10.1093/tbm/ibag061","url":null,"abstract":"<p><strong>Background: </strong>Despite recognition for the value of community partnership in research, practical strategies for supporting authentic engagement can be unclear. Thompson et al. (Strategies of community engagement in research: definitions and classifications. Transl Behav Med 2021;11:441-51) present a continuum of community-engaged research interactions to create shared understanding for researchers and community members, along with specific engagement strategies along a continuum of community partnership.</p><p><strong>Purpose: </strong>This study (i) describes collaboration and partnership approaches and the concrete strategies utilized in two different research communities in the form of two case studies and (ii) addresses benefits, challenges, and outcomes associated with these approaches.</p><p><strong>Methods: </strong>Engagement strategies were selected from across two research studies with diverse populations: carers of people with Parkinson's disease and Lewy-body dementia and nurses caring for people with intellectual and developmental disabilities on inpatient hospital units. Contextualized within a community engagement framework, we describe the research studies, the engagement strategies used, challenges, accommodations, and adaptations.</p><p><strong>Results: </strong>Engagement strategies ranged from consultation to full partnership. Common strategies between studies included adaptations and accommodations, structured methods for soliciting feedback, integration of partner feedback into study design, co-design of intervention, respecting lived experience, creating space for vulnerability, and compensation. Challenges included supporting collaboration through virtual meetings, addressing distress-including feelings of hurt and loss and balancing research and grant requirements with community partner input.</p><p><strong>Conclusions: </strong>Both projects represented successes in engagement process and study outcomes, regardless of where they fell on the community engagement continuum. Having practical steps to guide community engagement in research can be valuable to both researchers and community partners.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying effective behavior change techniques in interventions for enhancing the implementation of school-based policies and/or practices to prevent chronic disease in students: a secondary analysis of a systematic review.","authors":"Daniel C W Lee, Kate M O'Brien, Justin Presseau, Serene Yoong, Sam McCrabb, Katrina McDiarmid, Christophe Lecathelinais, Luke Wolfenden, Rebecca K Hodder","doi":"10.1093/tbm/ibaf087","DOIUrl":"10.1093/tbm/ibaf087","url":null,"abstract":"<p><strong>Background: </strong>School-based interventions improve healthy eating, physical activity, and reduce tobacco, and/or alcohol use in students. While strategies supporting their implementation have been found effective, a comprehensive understanding of the active ingredients [e.g. behavior change techniques (BCTs)] remains unclear.</p><p><strong>Purpose: </strong>To describe and examine which BCTs within implementation strategies are associated with increased implementation of school-based interventions targeting healthy eating, physical activity, tobacco, and/or alcohol use in students aged 5-18.</p><p><strong>Methods: </strong>A secondary analysis was conducted on 39 randomized controlled trials (RCTs) from a 2024 Cochrane review. Individual BCTs within implementation strategies were coded using the BCT taxonomy v1 and mapped to the Behavior Change Technique Ontology (BCTO). Mode of delivery, setting, and source were coded. Meta-regressions using random-effect models assessed the associations between identified BCTs (at the highest level of aggregation of the BCTO) and effective implementation of policies and/or practice (e.g. number of curriculum lessons taught).</p><p><strong>Results: </strong>Eighty-four independent BCTs were identified and meta-regression analysis revealed that out of 14 highest level of aggregation BCTs, \"Associative learning\" (e.g. Prompt intended action) had a statistically significant association with increased implementation (standard mean difference 0.90, 95% confidence interval 0.08, 1.72; 30 trials), which were primarily delivered face to face and by teachers or researchers.</p><p><strong>Conclusions: </strong>Our findings suggest that \"Associative learning BCTs\" should be prioritized in future school-based interventions to address implementation barriers and increase implementation of policies and/or practices. Opportunities remain to operationalize and evaluate underrepresented BCTs amenable to school settings in future implementation studies.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12794013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring sociodemographic disparities in AI use for health: findings from a nationally representative study in Mainland China.","authors":"Tianen Chen, Mulin Jiang, Fengbin Hu, Fei Shen","doi":"10.1093/tbm/ibag068","DOIUrl":"https://doi.org/10.1093/tbm/ibag068","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) technologies are increasingly integrated into health contexts and may facilitate health management and healthcare support. However, not all populations may benefit equally from advances in AI health applications, especially those with disadvantaged social status.</p><p><strong>Purpose: </strong>This study examined sociodemographic disparities in AI use for health among adults in Mainland China and explored how social positions may intersect in shaping AI use for health.</p><p><strong>Methods: </strong>A nationally representative online sample of Chinese adults (N = 1200) completed questionnaire items assessing six forms of AI use for health and sociodemographic variables, including sex, age, income, education, and insurance coverage.</p><p><strong>Results: </strong>Participants reported low to moderate overall AI use for health. Higher income was associated with greater use of AI-powered wearable health reports, AI-assisted hospital care, and AI-based tools for mental health, but lower use of AI-based medical consultation chatbots. Having commercial health insurance was consistently positively associated with various AI health use, whereas having rural cooperative insurance was not associated with AI use behaviors. In addition, age significantly interacted with both income and insurance status in predicting overall AI use for health.</p><p><strong>Conclusions: </strong>Findings suggest that AI health use in Mainland China varies across sociodemographic groups and may reflect broader inequalities in healthcare access and resources.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the reach, adoption, implementation, and effectiveness of a single occupational physiotherapy advice session for employees with low back pain: an RE-AIM evaluation.","authors":"Takahiro Miki, Genta Asano, Yuta Hagiwara, Hiroshi Takasaki","doi":"10.1093/tbm/ibag029","DOIUrl":"10.1093/tbm/ibag029","url":null,"abstract":"<p><strong>Background: </strong>While biopsychosocial interventions are effective for low back pain (LBP), implementing them in workplace settings remains challenging due to resource constraints. We adapted a comprehensive biopsychosocial approach into a single, brief, individualized advice session to enhance real-world feasibility. This study aimed to evaluate the reach, adoption, implementation, and preliminary effectiveness of this program using the RE-AIM (Reach, Adoption, Implementation, Effectiveness, and Maintenance) framework.</p><p><strong>Methods: </strong>A prospective pre-post quasi-experimental study was conducted in a Japanese insurance company. Employees with LBP were invited to a single 30-min occupational physiotherapy advice session. Outcomes were assessed at baseline and 3 months. Effectiveness was evaluated using mean changes in pain (numerical rating scale) and disability (Roland-Morris Disability Questionnaire), supplemented by a responder analysis based on minimal important change (MIC).</p><p><strong>Results: </strong>Of 1201 eligible employees, 154 (12.8%) attended the session (Reach), and 68 (44.2%) provided completed the 3-month follow-up (Implementation). Regarding effectiveness, mean pain intensity showed no significant change (+0.12). However, the responder analysis revealed that 17.6% of participants achieved MIC in pain (≥2 points), and 35.3% were classified as meeting MIC in disability (≥2 points). Additionally, the proportion of participants perceiving LBP as the primary cause of productivity loss decreased from 58.8% to 16.2%. Between-group analyses showed no statistically significant differences.</p><p><strong>Conclusions: </strong>This quasi-experimental evaluation suggests that a single 30-min workplace physiotherapy advice session is feasible to implement. Effectiveness findings were exploratory: mean pain intensity changed little and between-group differences were not statistically significant, while some attendees who completed follow-up met the MIC threshold for disability.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incentivizing social support in the randomized mobile Lifestyle Intervention for Food and Exercise study: the impact of gamification on social support perceptions, provision, and receipt.","authors":"Gabrielle Turner-McGrievy, Courtney Monroe, Carolina Delgado-Diaz, Halide Zeynep Aydin, Kelli DuBois, Yesil Kim, Homayoun Valafar, Sara Wilcox","doi":"10.1093/tbm/ibaf086","DOIUrl":"10.1093/tbm/ibaf086","url":null,"abstract":"<p><strong>Background: </strong>Few weight loss interventions have isolated the use of gamification through points to incentivize the social support needed for successful weight loss during a mobile intervention.</p><p><strong>Purpose: </strong>To compare a group that receives points [mLife (mobile Lifestyle Intervention for Food and Exercise)+points] vs. a group that did not receive points (mLife) for completing social support activities. Differences in social support perceptions, provision, and receipt were examined as part of a 12-month weight loss intervention. The mediating role of these activities with weight loss was also examined.</p><p><strong>Methods: </strong>Participants with overweight/obesity (n = 243 enrolled) were recruited to participate in a 12-month randomized trial delivered via the mLife app. Perceived social support was measured via survey [Multidimensional Scale of Perceived Social Support (MSPSS)] and by ratings of support received in the app. Social support provision was assessed via the number of social support activities completed in the mLife app over 12 months, and social support receipt was assessed as the number of social support activities a participant received over 12 months.</p><p><strong>Results: </strong>At 12 months, mLife+points participants had greater perceived social support (difference between groups: total MSPSS 0.52 ± 0.16, P < .01; ratings of support via app: 0.17 ± 0.07, P = .02) and greater rate ratio (RR) of providing social support (RR = 2.23, P < .001) and receiving social support (RR = 2.4, P < .001) as compared to mLife participants. Both social support receipt and provision mediated the relationship between group and 12-month weight loss.</p><p><strong>Conclusions: </strong>Incentivizing social support provision during a weight loss intervention via points is a potential way to increase social support perceptions, provision, and receipt.</p><p><strong>Clinical trial information: </strong>The Clinical Trials Registration #NCT05176847.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the Hispanic/Latino engagement gap in diabetes prevention: feasibility of a community co-designed, participate-to-lead program.","authors":"Maribel Cedillo, Jesell Zepeda, Chaorong Wu, Isabel Teresa Molina, Molly B Conroy","doi":"10.1093/tbm/ibag054","DOIUrl":"10.1093/tbm/ibag054","url":null,"abstract":"<p><strong>Background: </strong>Hispanic/Latino (H/L) adults show lower engagement and smaller weight-loss outcomes than non-Hispanic White (NHW) participants in the National Diabetes Prevention Program (NDPP), a gap driven by delivery rather than biological differences.</p><p><strong>Purpose: </strong>To evaluate the feasibility, engagement, and preliminary clinical outcomes of Paso a Paso, a community co-designed, culturally relevant diabetes prevention program for Spanish-speaking H/L adults, across two cohorts: instructor-trainees (Cohort 1) and community participants (Cohort 2).</p><p><strong>Methods: </strong>Single-arm feasibility pilot guided by RE-AIM, EPIS, and ERIC frameworks. Cohort 1 (n = 18 H/L community leaders) completed 16 weekly in-person sessions; Cohort 2 (n = 30 at two sites) completed 13-15 weekly sessions, both led by a registered dietitian. Participants were classified into three engagement tiers: high-dose (≥50% sessions), low-dose community-connected (<50% but retained at the final session), and discontinued. Body mass index (BMI), waist circumference, and HbA1c were assessed at baseline and 4 months.</p><p><strong>Results: </strong>Cohort 1 achieved 100% retention and a median attendance rate of 93.8% (range 31.2%-100.0%). Cohort 2 achieved 73% 4-month retention and a median attendance rate of 61.5% (range 0.0%-93.3%). Among 21 paired participants, mean % body weight change was -1.5% (SD, 2.3) and 81% achieved any weight reduction; participants with overweight and obesity, the primary target population, lost -1.7% (SD, 1.5) and -1.9% (SD, 2.6) respectively.</p><p><strong>Conclusions: </strong>Paso a Paso suggests feasibility, with engagement and retention exceeding NDPP benchmarks for H/L participants and preliminary, clinically meaningful weight reductions observed across the winter holiday season. These hypothesis-generating findings support advancement to a powered hybrid effectiveness-implementation trial.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a culturally adapted group-based lifestyle intervention in reducing cardiovascular risk factors in a high-risk Latin American population.","authors":"Rosario Suárez, Yoredy Sarmiento-Andrade, Karem Carrión, Martha Montalvan, Milenka Zhindón, Jorge Ramirez, Sebastián Chapela, Evelyn Frias-Toral","doi":"10.1093/tbm/ibag038","DOIUrl":"10.1093/tbm/ibag038","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes (T2D) is a global public health challenge globally. Effective prevention programs must be tailored to cultural and logistical contexts.</p><p><strong>Purpose: </strong>This study evaluated the comparative efficacy of a culturally adapted diabetes prevention program (DPP) intervention versus usual care in reducing T2D risk factors in Ecuadorian institutional settings.</p><p><strong>Methods: </strong>This quasi-experimental study included adults with high T2D risk (FINDRISC score ≥12). Participants voluntarily enrolled to an experimental group (EG, N = 192) receiving a 16-week, 10 session culturally adapted DPP, or a control group (CG, N = 91), receiving usual care. Primary comparative efficacy was assessed using analysis of covariance (ANCOVA), adjusting for key baseline imbalances.</p><p><strong>Results: </strong>Intragroup analysis showed that EG achieved significant reductions in weight (average loss of 1.06%), BMI, and body fat mass (P < .05). However, the primary outcome reduction in FINDRISC score (P = .013) did not retain significance after Holm-Bonferroni correction. The comparative ANCOVA analysis revealed no significant difference between EG and CG for the primary outcomes of weight (P = .330) or FINDRISC score (P = .291). The intervention showed a reduction in systolic blood pressure (SBP) that was statistically significant in the per-protocol analysis (adjusted Δ = -3.338 mmHg; F = 5.160, P = .024), although this effect was attenuated to a trend (P = .079) in a multiply imputed intention-to-treat sensitivity analysis.</p><p><strong>Conclusion: </strong>The short-term, culturally adapted DPP intervention failed to demonstrate superior comparative efficacy in achieving the primary goals of T2D risk reduction or weight loss compared to usual care. Nevertheless, the per-protocol analysis identified a promising reduction in SBP, whose robustness was supported by inverse probability of treatment weighting but attenuated under intention-to-treat multiple imputation. These findings suggest partial efficacy of the short-term adaptation on cardiovascular health and underscore the critical need for longer program duration and strategies to reduce attrition in similar institutional settings.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13387157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent fasting versus continuous calorie energy reduction in prostate cancer patients on active surveillance.","authors":"Karen H Kim Yeary, Han Yu, Ahmed A Hussein, Krista Varady, Elizabeth DiCarlo, Allison Escaldi, Li Tang","doi":"10.1093/tbm/ibag069","DOIUrl":"https://doi.org/10.1093/tbm/ibag069","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer (PCa) is the most common cancer in US men. Nearly half of those diagnosed with PCa present with low-risk disease based on clinical guidelines, for which active surveillance (AS) is increasingly recommended by clinicians to avoid invasive treatment. Obesity is a well-recognized risk factor for poor PCa prognosis. Yet weight loss interventions for PCa patients on AS are limited.</p><p><strong>Purpose: </strong>Using the NIH Stage Model for Behavioral Intervention Development as a guide, our Stage 1 study translated and assessed the feasibility, estimated preliminary efficacy signals, and conducted exploratory analyses of two evidence-based behavioral weight loss interventions for PCa patients on AS.</p><p><strong>Methods: </strong>We worked with patients to translate evidence-based continuous energy restriction (CER) and 5:2 (two 600 kcal fast days, eat normally 5 days) intermittent fasting (IF) interventions for PCa patients on AS. Feasibility, estimated preliminary efficacy signals, and exploratory analyses on outcomes from baseline to 3 and 6 months was assessed using a parallel arm randomized controlled trial.</p><p><strong>Results: </strong>The study met the pre-established benchmarks for feasibility. Twenty patients were randomized (10 CER, 10 IF). All were retained over 6-month follow-up. Participants were predominantly White (95%), with an average age of 65.9 (SD 8.45) years. Each arm produced clinically meaningful weight loss from baseline to 6 months (CER -5.79% [95% confidence interval, CI: -3.48, -8.09; P < .01); IF -7.50% (95% CI: -5.19, -9.80; P < .01). Within IF only, there were favorable exploratory changes in biomarkers related to lipid and glucose metabolism, inflammation and immune function, and signaling pathways critical for PCa progression.</p><p><strong>Conclusions: </strong>Our study provides evidence for our interventions' feasibility and preliminary efficacy signals for clinically meaningful weight loss in PCa patients on AS. Future studies examining weight loss' impact on PCa progression and related biomarkers are needed.</p><p><strong>Clinical trial information: </strong>The Clinical Trials Registration NCT05764330.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of a refined web-based adaptation tracking tool across three varied interventions to understand adaptations, their characteristics, and perceived impact on outcomes.","authors":"Heidi Sjoberg, Marina McCreight, Lauren McKown, Catherine Battaglia, Summer Huang, Brianne Morgan, Reed Hale, Joseph Frank, Christine D Jones, Russell Glasgow, Borsika Rabin","doi":"10.1093/tbm/ibag046","DOIUrl":"https://doi.org/10.1093/tbm/ibag046","url":null,"abstract":"<p><strong>Background: </strong>Adaptations are changes to interventions or implementation strategies to improve fit in the real-world. Adaptations can promote research translation and intervention sustainment.</p><p><strong>Purpose: </strong>The study adaptations team refined their tracking methods and analyzed adaptations' perceived impact across three interventions executed in Veterans Health Administration (VHA).</p><p><strong>Methods: </strong>From 2020 to 2025 the study team supported 15 VHA sites implementing one of three interventions intended to improve Veteran outcomes, clinician engagement, and care costs. Intervention and implementation strategy adaptations were tracked and analyzed in a web-based tool refined from previous projects, incorporating Framework for Reporting Modifications to Evidence-based Implementation Strategies and Practical, Robust, Implementation, and Sustainability Model components. Data were collected pragmatically via multi-methods. Proximal impact was analyzed close to real-time. The team used data validation, member checking, and data triangulation.</p><p><strong>Results: </strong>Across interventions, 224 unique adaptations were recognized from audit trails (n = 119), interviews (n = 55), process maps (n = 51), and team meetings (n = 17). Intervention 1 made 119 adaptations, Intervention 2 made 44, Intervention 3 made 23, and the study team made 38 to enhance implementation support (implementation strategy adaptations). Most adaptations occurred during implementation (n = 161) and targeted adoption and implementation. The study adaptations team assessed adaptations' perceived impact on outcomes and found 130 adaptations impacted multiple outcomes. Adoption (n = 153) was impacted the most.</p><p><strong>Conclusions: </strong>The refined tool was effective for tracking and analyzing adaptations' impact. Future research should refine strategies for adaptation impact assessment.</p>","PeriodicalId":48679,"journal":{"name":"Translational Behavioral Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}