Bioimpacts最新文献

{"title":"Exaggerating the risks of vaccination is a dangerous health threat.","authors":"Robert C Speth","doi":"10.34172/bi.33132","DOIUrl":"10.34172/bi.33132","url":null,"abstract":"<p><p>Vaccine hesitancy and opposition lacking empirical support represent significant threats to public health, particularly when amplified by public health officials. This commentary provides evidence-based refutation of such anti-vaccine arguments, including (i) the robust epidemiological data demonstrating vaccine efficacy in reducing disease incidence, mortality, and transmission; (ii) the comprehensive safety surveillance systems (VAERS, VSD, CISA) that monitor adverse events and consistently demonstrate favorable risk-benefit profiles; (iii) the biological mechanisms underlying both vaccine-induced immunity and rare adverse events; and (iv) the distinction between temporal association and causation in adverse event reporting. Thus it can be deduced that flawed logic and falsifications have been used to misrepresent the risks of vaccination. This endangers the lives and well-being of people who are susceptible to the diseases that vaccines can effectively prevent.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33132"},"PeriodicalIF":2.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between non-coding RNAs and Wnt signaling pathway in leukemia: A narrative review.","authors":"Reza Biglari, Majid Farshdousti Hagh, Khadijeh Abbasi, Maghsood Shaaker, Amir Mehdizadeh","doi":"10.34172/bi.32564","DOIUrl":"10.34172/bi.32564","url":null,"abstract":"<p><p>Leukemias are heterogeneous hematologic malignancies that involve dysregulated proliferation and impaired differentiation of hematopoietic cells. The Wnt signaling pathway, which regulates hematopoietic stem cell self-renewal and lineage commitment, is dysregulated across leukemia subtypes. Non-coding RNAs (ncRNAs), which include microRNAs, long non-coding RNAs (lncRNAs), and circular RNAs, have been identified as important post-transcriptional and epigenetic regulators of oncogenic signaling networks. There is growing evidence for a complex, bidirectional relationship between ncRNAs and the Wnt/β-catenin pathway, but this has not yet been summarized or integrated into the context of leukemia. This study examines how ncRNA manipulation of core Wnt components - β-catenin, Frizzled receptors, and Dvl (dishevelled) proteins - affect leukemic cell survival, proliferation, stemness, and treatment resistance. Furthermore, we discuss reciprocal regulation, in which Wnt stimulation affects ncRNA production, forming feed-forward loops that promote leukemogenesis. By synthesizing disparate findings from studies investigating ncRNA and Wnt signaling mechanisms across leukemia subtypes, we identify critical mechanistic gaps in the literature, as well as opportunities and controversies that could be that could be leveraged in evaluating ncRNA-Wnt interactions as diagnostic and therapeutic targets. This review presents a comprehensive study integrating ncRNA biology and Wnt-driven leukemic development in order to identify crucial insights into disease vulnerabilities and future research initiatives.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"32564"},"PeriodicalIF":2.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes: Redefining intercellular communication and the future of translational medicine.","authors":"Khosro Adibkia, Adel Mahmoudi Gharehbaba","doi":"10.34172/bi.33099","DOIUrl":"10.34172/bi.33099","url":null,"abstract":"<p><p>Exosomes are promising extracellular vesicles for diagnostics, drug delivery, and regenerative medicine. While we have made significant strides in understanding exosomes biogenesis and cargo variability, the translation of exosome-based methods into clinical applications remains limited by challenges in manufacturing, standardization, and regulatory requirements. This editorial attempts to summarize the diverse field of exosome research including advances in isolation technologies and methodologies, omics characterization, and emerging bioengineering strategies that are elevating profile of exosomes as biomaterials for biomedical applications. We propose that exosomes are not just by-products of biological processes, but active information carriers with exceptional therapeutic potential. Therefore, the advancement of exosome methodologies in practice will ultimately alter the ways clinicians will evaluate diagnostic and therapeutic measures. We anticipate that the coming decades will establish a new, integrated framework for exosome science, one that harmonizes innovation, ethics, and cross-disciplinary collaboration to translate the promise of exosomes into tangible clinical reality.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"33099"},"PeriodicalIF":2.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emergence of advanced technologies in the pharmacy profession and the need for education: The case of point-of-care sensing systems and 3D printing of pharmaceuticals.","authors":"Jaleh Barar, Matthew Seamon, Yadollah Omidi","doi":"10.34172/bi.31081","DOIUrl":"10.34172/bi.31081","url":null,"abstract":"<p><strong>Introduction: </strong>The pharmacy profession is undergoing significant transformation through the adoption of point-of-care testing (POCT) and three-dimensional (3D) printing of pharmaceuticals. These technologies offer enhanced diagnostic accuracy, faster therapeutic interventions, and the potential for personalized medication regimens. Accordingly, there lies a great need for proper education.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted to explore the impacts and current educational integration of POCT and 3D printing of pharmaceuticals in the pharmacy profession, and a qualitative analysis was performed.</p><p><strong>Results: </strong>Through the integration of POCT into community and clinical settings, pharmacists can promptly identify health conditions and provide timely referrals or interventions, ultimately improving patient outcomes. Additionally, 3D printing allows for the creation of highly customized dosage forms, supporting targeted drug delivery and better patient adherence. These innovations necessitate adjustments in pharmacy education to equip future professionals with the requisite clinical and technical skills to provide value to the healthcare system. Pharmacy educators must be current in their knowledge. Curricula must emphasize hands-on experiences, such as simulations and laboratory training, to foster proficiency in using diagnostic devices, interpreting results, and designing bespoke drug formulations. Interprofessional collaboration, policy development, advocacy, and ongoing faculty training are also crucial for ensuring that pharmacists remain at the forefront of technological advancements. This context underscores the importance of weaving these modern tools into educational strategies.</p><p><strong>Conclusion: </strong>By preparing pharmacists for expanded and more technical roles in healthcare, including diagnostics and medication customization, schools and colleges of pharmacy can propel the profession forward and elevate the standard of patient care in rapidly evolving healthcare environments and improve patient outcomes, thereby providing critical cost savings to the system.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"16 ","pages":"31081"},"PeriodicalIF":2.5,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Time dependency of morphological remodeling of endothelial cells in response to substrate stiffness.","authors":"Zahra Goli-Malekabadi, Mohammad Tafazzoli-Shadpour, Ali Tamayol, Ehsan Seyedjafari","doi":"10.34172/bi.32671","DOIUrl":"https://doi.org/10.34172/bi.32671","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.15171/bi.2017.06.].</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"15 ","pages":"32671"},"PeriodicalIF":2.2,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-imprinted substrates as biomimetic platforms for osteoarthritis modeling with mesenchymal stem cells.","authors":"Hanieh Sadat Hashemi Motahar, Mojtaba Tajbakhsh, Mahboobeh Tavassoli, Shahin Bonakdar, Mohammad Reza Sadeghi","doi":"10.34172/bi.32628","DOIUrl":"10.34172/bi.32628","url":null,"abstract":"<p><p></p><p><strong>Introduction: </strong>The objective of this study is twofold: first, to investigate the relationship between chondrocyte morphology and their own gene and protein expression profiles in healthy and osteoarthritic (OA) cartilage; and second, to assess whether replicating the morphology of OA chondrocytes (OACs) can induce a hypertrophic expression pattern in MSCs.</p><p><strong>Methods: </strong>Polydimethylsiloxane (PDMS) substrates were fabricated to replicate the morphologies of human OACs and healthy chondrocytes (HCs). MSCs were cultured on these imprinted substrates, and differentiation was assessed using real-time PCR, immunocytochemistry, Alcian blue/Safranin O staining, and scanning electron microscopy (SEM).</p><p><strong>Results: </strong>SEM and optical microscopy revealed that OACs had a larger surface area than HCs. Real-time PCR analysis showed morphology-dependent variations in the expression of cartilage- and OA-related markers, with statistically significant differences observed only for <i>SOX9</i>. Immunofluorescence analysis of collagen types I and II supported these findings, though visual inspection of the staining did not indicate any significant changes.</p><p><strong>Conclusion: </strong>The results show that OACs-imprinted substrates can be effectively combined with other methods to improve in vitro models of OA. This offers a useful tool for exploring disease mechanisms and potential therapies.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"15 ","pages":"32628"},"PeriodicalIF":2.5,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted therapy for liver cancer: Current status and future directions.","authors":"Qian Wang","doi":"10.34172/bi.32630","DOIUrl":"10.34172/bi.32630","url":null,"abstract":"<p><p>Because of its intrinsic tumor heterogeneity, poor response to traditional chemotherapy, and lack of viable molecular targets, liver cancer mostly hepatocellular carcinoma (HCC) continues to be a major worldwide health concern. With a focus on molecular processes, resistance routes, and combination therapy approaches, this review provides a thorough analysis of the status and new advancements in targeted therapeutics for liver cancer. By blocking the mechanisms that lead to angiogenesis and tumor growth, first-line systemic treatments, such the multi-tyrosine kinase inhibitors (TKIs) lenvatinib and sorafenib, have shown moderate improvements in survival. However, their long-term efficacy is significantly reduced by intrinsic and acquired resistance, which is why second-line medications like regorafenib, cabozantinib, and ramucirumab are being studied. When combined with anti-VEGF treatments, parallel developments in immunotherapy, in particular immune checkpoint inhibitors (ICIs) such as atezolizumab and nivolumab, have shown promising outcomes. The review highlights the role of the tumor microenvironment, epigenetic regulators including EZH2 and HDACs, and key oncogenic drivers and aberrant signaling cascades in HCC, such as the Wnt/β-catenin, PI3K/AKT/mTOR, and RAS/RAF/MEK/ERK pathways. It also covers metabolic vulnerabilities, DNA damage response pathways, and new targets including FGFR4, AXL, and c-MET. To get around resistance mechanisms and improve therapeutic effectiveness, special attention is paid to logical combination treatments, which include combining targeted medicines with ICIs, irradiation, or synthetic lethality techniques. In the end, the review promotes the combination of dynamic molecular profiling and biomarker-driven precision medicine to enhance patient stratification, improve treatment decision-making, and provide long-lasting clinical effects. A strategic foundation for future advancements and individualized treatment of hepatocellular carcinoma is provided by this comprehensive synthesis.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"15 ","pages":"32630"},"PeriodicalIF":2.5,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-modulatory biomimetic nanoparticles: Advances in design, mechanisms, and nanomedicine applications.","authors":"Somayeh Vandghanooni, Parniya Kehtari, Niloufar Ahdeno","doi":"10.34172/bi.33124","DOIUrl":"10.34172/bi.33124","url":null,"abstract":"<p><p>The development of biomimetic nanoparticles (NPs) represents an innovative approach to address the lacks of conventional drug delivery systems. This advancement demonstrates promising potential in immunotherapy. Biomimetic NPs imitate biological structures to improve the effectiveness of drug delivery and enhance interactions with cancer cells. Their beneficial features include biocompatibility, long circulation time, tissue specificity, enhanced drug absorption, and low toxicity. Recent advancements confirm the efficacy of biomimetic NPs especially cell-membrane coated biomimetic NPs in immune modulation in cancer and inflammatory diseases. Furthermore, their integration with innovative gene engineering techniques, such as mRNA therapeutics and CRISPR-Cas9, for immune system targeting represents a novel therapeutic approach. This editorial explains the potential of biomimetic NPs in tumor immunotherapy and precision medicine, as well as the challenges they face in clinical translation, including biodistribution, long-term biosafety, the risk of unexpected activation of the immune system and scalability. Future recommendations emphasize the use of advanced biosensing tracking systems and the standardization of production for medicinal translation. BioImpacts invites researchers and scholars involved in this interdisciplinary field to collaborate to advance innovation at the intersection of nanotechnology and immunology.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"15 ","pages":"33124"},"PeriodicalIF":2.5,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoid-engineered neurovascular units for drug discovery and neurodegeneration research.","authors":"Ailar Nakhlband","doi":"10.34172/bi.33140","DOIUrl":"10.34172/bi.33140","url":null,"abstract":"<p><p>The highly selective permeability of the human blood-brain barrier presents a major obstacle to neurological disease modeling. Established 2D cell cultures and animal models are unable to accurately reproduce the physiological and molecular features of the human blood-brain barrier, limiting the translation of bench to bedside. Recent advances in the use of human induced pluripotent stem cells and organoid engineering have enabled the development of more physiologically relevant <i>in vitro</i> brain models for studying blood-brain barrier function. Blood-brain barrier organoids, mimic key structural and functional features of the blood-brain barrier. Moreover, integration of blood brain barrier organoids with brain organoids or microphysiological systems allows the formation of functional neurovascular units that better represent <i>in vivo</i> conditions. The development of scalable, reproducible, and partially vascularized blood-brain barrier organoid models holds promise for high-throughput drug discovery platforms, and the development of personalized therapeutic strategies for central nervous system disorders.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"15 ","pages":"33140"},"PeriodicalIF":2.5,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of tubulin-associated unit protein as a biomarker for schizophrenia.","authors":"Ali Reza Shafiee-Kandjani, Ali Bazzaz Haghighat Talab, Sara Farhang, Dariush Shanehbandi, Milad Asadi, Ailar Nakhlband","doi":"10.34172/bi.30813","DOIUrl":"10.34172/bi.30813","url":null,"abstract":"<p><p></p><p><strong>Introduction: </strong>Schizophrenia is a chronic and debilitating psychiatric disease characterized by various causes and symptoms. The tau protein is recognized as a biomarker that plays a crucial role in neurocognitive and neurodegenerative diseases. Given the presence of cognitive symptoms in individuals with schizophrenia, the objective of this study was to measure to evaluate the diagnostic potential of measuring serum levels of total tau and phosphorylated tau in patients with schizophrenia.</p><p><strong>Methods: </strong>A total of 40 patients with schizophrenia who met the inclusion criteria were selected, along with 40 age- and sex-matched healthy individuals. Written consent was obtained from all participants, and blood samples were collected to measure the serum levels of total tau protein and phosphorylated tau. The obtained data were analyzed using appropriate statistical methods with SPSS 23 software.</p><p><strong>Results: </strong>There was no statistically significant disparity detected in the serum concentrations of total and phosphorylated tau protein when comparing individuals with schizophrenia to those without the disorder.</p><p><strong>Conclusion: </strong>Based on the results obtained, it can be concluded that total tau protein and phosphorylated tau cannot be considered as diagnostic biomarkers for schizophrenia. Furthermore, the findings of this study do not support the presence of neuroanalysis in schizophrenia.</p>","PeriodicalId":48614,"journal":{"name":"Bioimpacts","volume":"15 ","pages":"30813"},"PeriodicalIF":2.5,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}