Efort Open Reviews最新文献_第5页

Evidence-based guidelines on orthobiologics. 骨科循证指南。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0069

Tobias Winkler, Stephan Oehme, Alexander Hildebrandt, Azzurra Paolucci, Lorenz Pichler

{"title":"Evidence-based guidelines on orthobiologics.","authors":"Tobias Winkler, Stephan Oehme, Alexander Hildebrandt, Azzurra Paolucci, Lorenz Pichler","doi":"10.1530/EOR-2025-0069","DOIUrl":"10.1530/EOR-2025-0069","url":null,"abstract":"Orthobiologics (OBs) have seen a constant increase in the number of available therapies and their clinical applications. Existing therapies can be categorized into blood-based (e.g., platelet-rich plasma (PRP)) and tissue/cell-based (e.g. mesenchymal stromal cells) approaches. While the popularity of OBs continues to grow, their diverse natures create unique challenges for the establishment of evidence-based guidelines. PRP has been reported by meta-analyses to increase patient-reported outcomes for conditions such as knee osteoarthritis (KOA), lateral epicondylitis and plantar fasciitis. However, the randomized controlled trials (RCTs) included often exhibit a high risk of bias due to the heterogeneity in the PRP preparation protocols and accompanying measures as well as inconsistent trial quality. The development pipeline of cell/tissue-based therapies is typically longer and more cost-intensive than that of blood-based therapies. Nevertheless, several products have demonstrated clinical safety. While some RCTs and meta-analyses on the outcome of cell/tissue-based therapies exist, their number is considerably lower than that of blood-based therapies and they focus mainly on KOA, with limited evidence on other orthopedic indications. Orthopedic societies such as ESSKA and AAOS have taken on the challenge of developing guidelines for OBs by combining high-level synthesized evidence with expert consensus. Patient stratification strategies represent a promising key to unlocking the full potential of OBs and are currently being investigated in ongoing studies. Further efforts to establish guidelines for the use of OBs should focus on developing frameworks for clinical trials and their reporting, alongside standardized protocols for the preparation, application and accompanying measures of OB therapies.","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"10 6","pages":"345-351"},"PeriodicalIF":4.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posterolateral tibia plateau fractures: pros and cons of different surgical approaches. 胫骨平台后外侧骨折：不同手术入路的利弊。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0037

Mattia Alessio-Mazzola, Giacomo Placella, Marco Conca, Vincenzo Salini

引用次数: 0

Patellar instability: current approach. 髌骨不稳：当前入路。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0051

David H Dejour, David Mazy, Tomas Pineda, Nicolas Cance, Michael J Dan, Edoardo Giovannetti de Sanctis

引用次数: 0

Crush injury and crush syndrome: a comprehensive review. 挤压损伤和挤压综合征：综合综述。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0055

Vasileios S Akrivos, Antonios Koutalos, Nikolaos Stefanou, Alexandros Koskiniotis, Christina Arnaoutoglou

引用次数: 0

Management of failed carpal tunnel decompression. 腕管减压失败的处理。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0058

Arne Decramer, Carlos Heras-Palou, Maarten Van Nuffel, Tom Lattré, Ilse Degreef

引用次数: 0

Psychological and social aspects in orthopaedics and trauma surgery, challenges and solutions in trauma: a didactic overview. 骨科和创伤外科的心理和社会方面，创伤的挑战和解决方案：教学概述。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0054

Josef Grab

引用次数: 0

Degenerative cervical myelopathy: timing of surgery. 退行性颈椎病：手术时机。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0070

Maria Rossella Fasinella, Alberto Benato, Donato Creatura, Alexis Morgado, Cédric Yves Barrey

{"title":"Degenerative cervical myelopathy: timing of surgery.","authors":"Maria Rossella Fasinella, Alberto Benato, Donato Creatura, Alexis Morgado, Cédric Yves Barrey","doi":"10.1530/EOR-2025-0070","DOIUrl":"10.1530/EOR-2025-0070","url":null,"abstract":"Background: Despite the growing burden of degenerative cervical myelopathy (DCM), consensus on the optimal timing of surgical intervention remains lacking, especially for patients with mild symptoms or asymptomatic cord compression or in the context of recent trauma. Different scores, such as the mJOA, Nurick scale and NDI are commonly used to classify disease severity, but guidelines for managing these patients do not provide a clear framework for intervention timing.Materials and methods: We conducted a narrative review of the literature on the optimal timing of surgical intervention for DCM, using PubMed to identify relevant studies. The search was focused on surgical and non-operative management, clinical and radiological assessments, biomarkers and emerging technologies. The selected papers were reviewed for relevance and quality, with guidance from a senior author.Results: The initial search identified 6,705 articles, which were narrowed down to 136 relevant studies after applying filters for study type and clinical focus. A final selection of 87 papers was categorized by topics and the findings were synthesized to highlight trends, challenges and knowledge gaps in surgical timing for DCM.Focus of the study: This review article examines strategies for determining the optimal timing for surgery in DCM. It explores how radiological signs, clinical indicators and other markers may help identify patients at risk of rapid neurological deterioration, particularly in the 'grey-zone' population (mild symptoms or asymptomatic disease), enabling clinicians to assess correctly different clinical scenarios and to indicate timely surgical intervention.","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"10 6","pages":"403-415"},"PeriodicalIF":4.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cementing technique of the femur in primary THA: the French paradox. 原发性髋关节置换术中股骨骨水泥技术：法国悖论。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0053

Pierre Laboudie, Moussa Hamadouche

引用次数: 0

Considerations in modern regenerative medicine for osteoarthritis. 现代再生医学治疗骨关节炎的考虑。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-06-02 DOI: 10.1530/EOR-2025-0050

Gun-Il Im

{"title":"Considerations in modern regenerative medicine for osteoarthritis.","authors":"Gun-Il Im","doi":"10.1530/EOR-2025-0050","DOIUrl":"10.1530/EOR-2025-0050","url":null,"abstract":"Current non-surgical managements of osteoarthritis (OA) do not change the clinical course or arrest the progression of the disease, while joint replacement is indicated for end-stage disease. Given these limitations, there is an unmet clinical demand for new treatment modalities that can improve the pain and quality of life of patients suffering from OA without surgery. The recent surge of interest in regenerative medicine (RM) for OA is based on these circumstances. Unlike traditional medicine, RM products may be accompanied by many uncertainties and long-term consequences. Considering that OA directly affects quality of life rather than life and death, the 'first do no harm' principle is more important when applying RM technology to the disease. Presently, culture-expanded mesenchymal stromal cells (MSCs) and orthobiologics, including bone marrow aspirate concentrate, stromal vascular fraction from adipose tissue and platelet-rich plasma have been applied to patients in clinical trials. Results of randomized clinical trials using MSCs have demonstrated that structural improvement and reversal of the pathologic process in OA are not definitely shown, while symptomatic relief is apparent. Orthobiologics seem to have efficiency comparable to those of culture-expanded MSCs. With the advantage of avoiding the approval process from regulation agencies, orthobiologics might provide a less expensive and handier option to culture-expanded MSCs. High-quality data from a large number of patients and head-to-head comparisons of several RM products will be necessary to define the place of culture-expanded MSCs or orthobiologics for OA treatment and resolve the reimbursement issue.","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"10 6","pages":"336-344"},"PeriodicalIF":4.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reinforcements and augmentations with the long head of the biceps tendon in shoulder surgery: a narrative review. 肩部手术中肱二头肌肌腱长头的增强和增强：叙述回顾。

IF 4.3 2区医学

Efort Open Reviews Pub Date : 2025-05-05 DOI: 10.1530/EOR-2024-0122

Alberto Guevara-Alvarez, Edwin Valencia-Ramón, Alejandro Lopez-Villers, Luis Fernando Navarro-Pérez, Israel Gonzalez-Rizo, Gonzalo Eduardo Gomez, Alexandre Laedermann

{"title":"Reinforcements and augmentations with the long head of the biceps tendon in shoulder surgery: a narrative review.","authors":"Alberto Guevara-Alvarez, Edwin Valencia-Ramón, Alejandro Lopez-Villers, Luis Fernando Navarro-Pérez, Israel Gonzalez-Rizo, Gonzalo Eduardo Gomez, Alexandre Laedermann","doi":"10.1530/EOR-2024-0122","DOIUrl":"https://doi.org/10.1530/EOR-2024-0122","url":null,"abstract":"The long head of the biceps tendon (LHBT) has recently emerged as a therapeutic option for various shoulder pathologies. Synthetic materials and allografts have not shown sufficient resistance or favorable outcomes to restore rotator cuff native tissue properties, leading to consideration of using LHBT as biological augmentation. LHBT mimics adjacent structures, such as the rotator cuff, is easily accessible during surgery, and is a good source of live autologous cells for regenerative augmentation in rotator cuff repair, as a superior capsular reconstruction in irreparable cuff tears, in subscapularis augmentation in shoulder replacement and as a stabilizer in anterior shoulder instability. This narrative review aims to collect, synthesize and critically evaluate the literature on the use of the LHBT and its current applications in the field of shoulder surgery, improving the understanding of the terminology and consolidating the concepts related to the various procedures in shoulder surgery.","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"10 5","pages":"297-308"},"PeriodicalIF":4.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0