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Impact of a Strength Training Program on Physical Performance in U10 Soccer Players: A Quasi-Experimental Trial. 力量训练计划对U10足球运动员体能表现的影响:一项准实验试验。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-08 DOI: 10.3390/children12091200
Adrián Torregrosa-Domínguez, Iván Moreno-Camacho, Eduardo José Fernández-Ozcorta, Rafael Ramos-Véliz
{"title":"Impact of a Strength Training Program on Physical Performance in U10 Soccer Players: A Quasi-Experimental Trial.","authors":"Adrián Torregrosa-Domínguez, Iván Moreno-Camacho, Eduardo José Fernández-Ozcorta, Rafael Ramos-Véliz","doi":"10.3390/children12091200","DOIUrl":"10.3390/children12091200","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The integration of strength training in grassroots youth soccer remains limited, often due to persistent myths regarding its safety and utility. This study evaluated the effectiveness of a tailored, playful strength training program in young players and analyzed the influence of the Relative Age Effect (RAE) on physical development and training response. <b>Methods:</b> A 14-week quasi-experimental pretest-posttest design was conducted with 27 federated male soccer players aged 9-10 years (experimental: <i>n</i> = 15; control: <i>n</i> = 12). The intervention consisted of twice-weekly, game-based strength training sessions integrated into the regular team routine. Outcomes included validated anthropometric (BMI) and functional (handgrip strength, standing long jump, Illinois agility test) indicators. RAE was analyzed according to birth quartile. Non-parametric statistical analyses and effect size (r) calculations were used. <b>Results:</b> The experimental group achieved significantly greater pre-post gains in handgrip strength than controls (right and left). Agility and standing long jump improved within the experimental group, but between-group differences were not significant. BMI decreased within the experimental group, yet the net between-group difference in BMI change was not significant in the context of a higher baseline BMI (<i>p</i> = 0.047). Although the Relative Age Effect (RAE) influenced baseline BMI, no moderating effect was detected on performance variables or training-induced changes in this sample. <b>Conclusions:</b> In U10 soccer players, a playful, context-integrated strength program produced superior gains in handgrip strength compared with usual practice. Improvements in agility and standing long jump were observed within the intervention group, but did not exceed those of the controls. BMI changes were not different between the groups and must be interpreted with caution, given baseline imbalances. In this sample, RAE did not moderate training response.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The "Bergamo Approach" for Pediatric and Adolescent Polytrauma-A One-Center Experience. 儿童和青少年多发创伤的“贝加莫方法”——一个中心体验。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-08 DOI: 10.3390/children12091194
Nicola Guindani, Maurizio Cheli, Daniela Ferrari, Giovanna Colombo, Ezio Bonanomi, Federico Chiodini, Maurizio De Pellegrin
{"title":"The \"Bergamo Approach\" for Pediatric and Adolescent Polytrauma-A One-Center Experience.","authors":"Nicola Guindani, Maurizio Cheli, Daniela Ferrari, Giovanna Colombo, Ezio Bonanomi, Federico Chiodini, Maurizio De Pellegrin","doi":"10.3390/children12091194","DOIUrl":"10.3390/children12091194","url":null,"abstract":"<p><p><b>Introduction.</b> Pediatric polytrauma (PPT) and major trauma in pediatric patients (PMT) present unique challenges compared to adult trauma care due to distinct anatomical and physiological differences. PPT/PMT remains the leading cause of death in children, responsible for over 50% of pediatric deaths and 15% of pediatric hospital admissions due to its long-term effects. This single-institution study focuses on the initial management of PPT/PMT from an orthopedics and traumatology point of view. <b>Material and Methods.</b> In the present study, data of PPT/PMT managed in one single institution, an academic level I pediatric trauma center, in patients <18 years of age, were analyzed over different periods. Over a 10-year period, diaphyseal femur fractures were analyzed as indicators of damage control (DCO) versus definitive treatment. Over a 4-year period (2021-2024), the associated lesions of PPT (head injuries, thoracic and abdominal lesions, spine lesions, major blood vessel lesions, and major musculoskeletal injury) were analyzed. Over a 1-year period (2019), the overall in-hospital mortality and admission rates in the pediatric intensive care unit were analyzed. <b>Results.</b> In the 10-year period, among 298 diaphyseal femur fractures, 46/298 (15%) were classified as PPT in which DCO was performed according to age as follows: in the age-group 15-17 years 23/23 (100%) with temporary external fixation (ExFix); in the age group 12-14 years, 9/14 (64%) with ExFix and 5/14 (26%) and elastic stable intramedullary nails (ESINs); in the age group 5-11 years, 1/5 (20%) with ExFix and 4 with ESIN; in the age group 0-4 years, 2/4 (50%) with ESIN and 2/4 (50%) with a cast. In the 4-year period, PPT/PMTs were associated with 60% head injury, 25% thoracic lesion(s), 18% abdominal lesion(s), 16% spine injury, 5% lesion of a major blood vessel, and 30% major musculoskeletal injuries. In 2019, there were 193 patients admitted to the emergency room as PPT/PMT: 115 were ≤12 years old and 78 were >12 years old. On admission, 46% were admitted to the pediatric intensive care unit, and 65% were admitted to the department of traumatology as inpatients. The in-hospital mortality rate was 7%. <b>Discussion and Conclusions.</b> In our institution, pediatric trauma is assessed using the Pediatric Trauma Score (PTS), and the workup follows the ATLS guidelines with a dedicated trauma team. The role of the orthopedic surgeon during the primary evaluation of PPT/PMT is to contribute to stopping bleeding and hemorrhagic shock. In PPT/PMT, DCO in adolescents is superimposable to adults, whilst in babies and children, DCO is still performed, but it is not a form of temporary external fixation.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight Status, Psychosocial Factors, and Health-Related Quality of Life Among Jordanian Adolescents: A Cross-Sectional Study Using Structural Equation Modeling. 约旦青少年体重状况、心理社会因素和健康相关生活质量:一项使用结构方程模型的横断面研究
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-08 DOI: 10.3390/children12091199
Randa AlQaisi, Walid Al-Qerem, Belal Al-Zu'bi, Basil Al-Tah, Moath H Daher, Mu'taz I Alfreahat, Nasser A Mousa, Seif D Jankhout, Ansam O Atrooz, Judith Eberhardt
{"title":"Weight Status, Psychosocial Factors, and Health-Related Quality of Life Among Jordanian Adolescents: A Cross-Sectional Study Using Structural Equation Modeling.","authors":"Randa AlQaisi, Walid Al-Qerem, Belal Al-Zu'bi, Basil Al-Tah, Moath H Daher, Mu'taz I Alfreahat, Nasser A Mousa, Seif D Jankhout, Ansam O Atrooz, Judith Eberhardt","doi":"10.3390/children12091199","DOIUrl":"10.3390/children12091199","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Childhood and adolescent obesity is a growing public health concern in Jordan, with implications for both physical and psychological well-being. While obesity's physical effects are well-documented, less is known about its broader association with adolescents' quality of life (QoL), particularly in Middle Eastern contexts. This study aimed to investigate the associations between weight status, psychosocial factors, and health-related quality of life (HRQOL) among Jordanian adolescents. This study aimed to investigate the associations between weight status, psychosocial factors, and HRQoL among Jordanian adolescents. <b>Methods:</b> A cross-sectional study was conducted with 719 adolescents (63.3% female) aged 11-18, recruited from public schools and pediatric clinics in three regions of Jordan. Data were collected using validated questionnaires assessing demographics, health behaviors, mental health (PHQ-9, GAD-7, SMFQ), and HRQoL (PedsQL 4.0). Structural equation modeling (SEM) was used to examine direct and indirect pathways predicting physical and psychological QoL. <b>Results:</b> Bullying emerged as a key mediator between weight status and QoL, particularly for physical well-being. Depression and anxiety were significant predictors of poorer psychological QoL. Positive school experience, academic performance, physical activity, and paternal education were positively associated with QoL. Nutritional habits were inversely associated with anxiety levels. Model fit indices supported the adequacy of both the physical and psychological QoL models. <b>Conclusions:</b> The findings highlight the interconnected relationship of weight-related stigma, school environment, and lifestyle behaviors on adolescent well-being. Multi-component, school-based interventions targeting bullying, physical activity, and mental health literacy may be effective in improving QoL in this population.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Childhood Diabetes. 儿童糖尿病研究进展。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-08 DOI: 10.3390/children12091195
Zvi Laron
{"title":"Advances in Childhood Diabetes.","authors":"Zvi Laron","doi":"10.3390/children12091195","DOIUrl":"10.3390/children12091195","url":null,"abstract":"<p><p>Despite great technological advances in Type 1 Diabetes (TID) [...].</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperferritinemia and Macrophage Activation Syndrome in Septic Shock: Recent Advances with a Pediatric Focus (2020-2025). 感染性休克中的高铁蛋白血症和巨噬细胞激活综合征:以儿科为重点的最新进展(2020-2025)。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-08 DOI: 10.3390/children12091193
Efrossini Briassouli, Natalia Syrimi, Stavroula Ilia
{"title":"Hyperferritinemia and Macrophage Activation Syndrome in Septic Shock: Recent Advances with a Pediatric Focus (2020-2025).","authors":"Efrossini Briassouli, Natalia Syrimi, Stavroula Ilia","doi":"10.3390/children12091193","DOIUrl":"10.3390/children12091193","url":null,"abstract":"<p><p>Macrophage activation syndrome (MAS), a hyperinflammatory condition driven by uncontrolled immune activation, is widely recognized as a critical complication in pediatric septic shock. This syndrome shares pathophysiological features with hemophagocytic lymphohistiocytosis (HLH) and other cytokine storm syndromes, and it contributes to significant morbidity and mortality in pediatric and adult patients. Hyperferritinemia-a hallmark of MAS-is not only a diagnostic clue but also a prognostic marker for poor outcomes in sepsis. High ferritin levels are strongly suggestive of MAS, yet even moderate elevations in combination with the trend of ferritin levels can be indicative of heightened mortality risk. Distinguishing MAS from severe sepsis or other hyperinflammatory syndromes in children (such as multisystem inflammatory syndrome in children (MIS-C)) can be challenging, as clinical features often overlap. However, early recognition and timely immunomodulatory therapy, particularly corticosteroids and targeted biologic agents, can be life-saving. Recent advances emphasize a syndromic approach to diagnosing MAS within the spectrum of hyperferritinemic sepsis, using scoring tools or MAS-specific criteria adapted to sepsis or MIS-C contexts. Ongoing studies aim to refine biomarker-based stratification and therapeutic algorithms. This review synthesizes current knowledge on MAS as a complication of sepsis, including the diagnostic importance of ferritin levels, differential diagnosis with other cytokine storm syndromes, and the latest therapeutic approaches. It underscores the importance of early suspicion and intervention to reverse immune dysregulation and improve outcomes in critically ill pediatric patients.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal Renal Ultrasound Reference Values in Romanian Term Newborns: Correlations with Anthropometric Characteristics. 罗马尼亚足月新生儿肾脏超声参考值:与人体测量特征的相关性。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-08 DOI: 10.3390/children12091191
Leonard Năstase, Adrian-Ioan Toma, Alexandru Dinulescu, Adelina Androne
{"title":"Neonatal Renal Ultrasound Reference Values in Romanian Term Newborns: Correlations with Anthropometric Characteristics.","authors":"Leonard Năstase, Adrian-Ioan Toma, Alexandru Dinulescu, Adelina Androne","doi":"10.3390/children12091191","DOIUrl":"10.3390/children12091191","url":null,"abstract":"<p><strong>Background: </strong>The establishment of population-specific reference values for neonatal renal dimensions is essential for accurate assessment of kidney development. Currently, standardized reference data for renal volume in Romanian newborns are lacking. This study aims to establish normal renal dimensions and volumes in Romanian term newborns and evaluate their correlations with anthropometric characteristics.</p><p><strong>Methods: </strong>A prospective study was conducted at Polizu Maternity, Bucharest, Romania, involving a cohort of 100 term newborns with a gestational age (GA) between 37 and 42 weeks, all delivered at the INSMC \"Alessandrescu-Rusescu\" Polizu Maternity Hospital. Routine renal ultrasound was performed for all term newborns within the first 72 h of life. Renal dimensions were measured in the longitudinal and axial sections, and the volume was calculated.</p><p><strong>Results: </strong>The average kidney dimensions were as follows: length 42.0 ± 3.4 mm, width 22.6 ± 2.6 mm, and thickness 19.9 ± 2.5 mm. Renal volume ranged from 5.1 to 18.9 mL, with an average of 10.2 ± 2.5 mL. The kidney volume was significantly correlated with gestational age (r = 0.195; <i>p</i> = 0.05) and birth length (r = 0.267; <i>p</i> = 0.008), and most strongly with birth weight (r = 0.306; <i>p</i> = 0.002).</p><p><strong>Conclusions: </strong>This study provides the first reference values for renal dimensions in Romanian term newborns. Renal volume shows modest correlations with anthropometric characteristics, particularly birth weight. These reference values may serve as baseline measurements for future longitudinal studies investigating renal development and disease risk.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Gross Motor Skills Performance in Italian Children with and Without Visual Impairment. 意大利有视力障碍和无视力障碍儿童大肌肉运动技能表现的评估。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-08 DOI: 10.3390/children12091197
Giulia Chiara Castiglioni, Giulia Hirn, Marco Lippolis, Matteo Porro
{"title":"Assessment of Gross Motor Skills Performance in Italian Children with and Without Visual Impairment.","authors":"Giulia Chiara Castiglioni, Giulia Hirn, Marco Lippolis, Matteo Porro","doi":"10.3390/children12091197","DOIUrl":"10.3390/children12091197","url":null,"abstract":"<p><strong>Background/objectives: </strong>Vision plays a key role in acquiring and automating fundamental movement skills. Evidence from Italy is scarce. This study compared Test of Gross Motor Development-2 (TGMD-2) performance between Italian children with visual impairment (VI) and sighted peers and explored differences by degree of VI (severe VI vs. blindness).</p><p><strong>Methods: </strong>This was a cross-sectional study including 38 children (VI: <i>n</i> = 19, 5-12 y; sighted: <i>n</i> = 19, 5-11 y). VI was classified per the WHO criteria. TGMD-2 was administered with adaptations suitable for VI (e.g., high-contrast cones, auditory balls, verbal cueing). Group differences (VI vs. sighted; blindness vs. severe VI; severe VI vs. sighted) were analyzed with Mann-Whitney U (α = 0.05). For participants > 10 y, raw scores were analyzed and age-equivalent scores were summarized to calculate developmental gaps.</p><p><strong>Results: </strong>Children with VI scored lower than sighted peers on locomotor, object control, and total TGMD-2 scores (all <i>p</i> < 0.001). Within VI, blindness was associated with lower locomotor, object control, and total scores than severe VI (<i>p</i> = 0.013; <i>p</i> = 0.043; <i>p</i> = 0.013). Children with severe VI also scored lower than sighted peers across outcomes (all <i>p</i> < 0.001). Based on age-equivalent estimates, average gross motor performance in VI was ~4-5 years below chronological age; values < 3 years were set to 3 years for calculation (the floor effect).</p><p><strong>Conclusions: </strong>Italian children with VI show reduced gross motor competence compared with sighted peers, with a substantial developmental lag. Findings support early adapted physical education and structured movement opportunities to promote participation and inclusion. Future studies should examine long-term outcomes and contextual factors shaping motor competence in youth with VI.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tips and Tricks for Installation of the SLIM Nail in Osteogenesis Imperfecta with Narrow Medullary Canals: A Surgical Guide with Case Insights. 在髓管狭窄的成骨不全症中安装细钉的技巧和技巧:一份手术指南和案例分析。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-07 DOI: 10.3390/children12091190
Peter Joseph Mounsef, Jack Legler, Reggie Hamdy
{"title":"Tips and Tricks for Installation of the SLIM Nail in Osteogenesis Imperfecta with Narrow Medullary Canals: A Surgical Guide with Case Insights.","authors":"Peter Joseph Mounsef, Jack Legler, Reggie Hamdy","doi":"10.3390/children12091190","DOIUrl":"10.3390/children12091190","url":null,"abstract":"<p><strong>Introduction: </strong>Osteogenesis imperfecta (OI) presents significant surgical challenges due to bone fragility, narrow medullary canals, and complex deformities. While telescoping rods like the Fassier-Duval (FD) system are commonly used in growing patients, they are unsuitable when the canal diameter is too small or when patients approach skeletal maturity. The Simple Locking Intramedullary (SLIM) nail offers a solid, non-telescoping alternative in these cases.</p><p><strong>Methods: </strong>We describe the surgical technique for SLIM nail implantation and highlight key technical pearls developed through institutional experience, focusing on preoperative planning, intraoperative strategies, and the management of unique anatomical challenges in OI patients.</p><p><strong>Results: </strong>Three cases illustrate the application of these techniques: the first case demonstrates SLIM nail insertion in a 3-year-old child with a narrow IM canal to correct significant bowing; reaming was performed retrograde from the osteotomy site for the proximal segment and antegrade for the distal segment. The second case is a 15-year-old OI patient with a disengaged FD rod and narrow IM canal showing insertion of SLIM rod, and the third case is a 16-year-old patient with femoral deformity and telescoping rod who needed revision with SLIM nail and supplemental plate fixation.</p><p><strong>Conclusions: </strong>The SLIM nail is a viable option for select OI patients.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choosing the "Ideal" Oral Dosage Form for Pediatric Patients: Parents' Perspectives on Children's Preferences with a Focus on Orodispersible Tablets. 为儿科患者选择“理想”的口服剂型:家长对儿童偏好的看法,以口服分散片为重点。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-05 DOI: 10.3390/children12091187
Yana Gvozdeva, Radiana Staynova
{"title":"Choosing the \"Ideal\" Oral Dosage Form for Pediatric Patients: Parents' Perspectives on Children's Preferences with a Focus on Orodispersible Tablets.","authors":"Yana Gvozdeva, Radiana Staynova","doi":"10.3390/children12091187","DOIUrl":"10.3390/children12091187","url":null,"abstract":"<p><p><i>Background</i>: Developing suitable dosage forms presents multiple challenges, such as ensuring the medication can be easily swallowed by young children, mixed with a small amount of food or liquid, and effectively taste-masked. There is no standardized guidance on pediatric dosage forms, taste preferences, or acceptable excipients, often resulting in costly delays due to required toxicology studies. Additionally, regulatory considerations around bioequivalence may necessitate further discussions between industry and regulatory authorities. <i>Objective</i>: This research aimed to investigate and analyze Bulgarian parents' perspectives on their children's preferences regarding different oral dosage forms, with a particular emphasis on orodispersible tablets (ODTs). Additionally, challenges related to the development of age-appropriate formulations were comprehensively discussed. <i>Methods</i>: A cross-sectional, online questionnaire-based study was conducted among 303 parents in Plovdiv, the second-largest city in Bulgaria, between January and March 2021. <i>Results</i>: The majority of parents (78.2%) reported no difficulties in administering medication to their child. Liquids were identified as the most preferred oral dosage form (68.3%), followed by tablets (21.8%). With respect to the importance of taste, most parents indicated that it is a very important factor influencing their child's acceptance of medication. Although 249 parents stated that they were familiar with ODTs, only 11.2% reported that their child had previously taken ODTs. <i>Conclusions</i>: The results of our study show that the taste of the dosage form is a leading factor in child acceptability. The sweet fruit flavor was a favorite among children. Parental attitudes toward ODTs were strongly positive, with 91.1% indicating a preference for their child to receive ODTs rather than conventional tablets.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skeletal Maturity Assessment in Pediatric ACL-Reconstruction. 儿童acl重建中的骨骼成熟度评估。
IF 2.1 4区 医学
Children-Basel Pub Date : 2025-09-05 DOI: 10.3390/children12091186
Umile Giuseppe Longo, Mariajose Villa Corta, Federica Valente, Laura Ruzzini, Pieter D'hooghe, Kristian Samuelsson, Frank A Cordasco, Alexander S Nicholls
{"title":"Skeletal Maturity Assessment in Pediatric ACL-Reconstruction.","authors":"Umile Giuseppe Longo, Mariajose Villa Corta, Federica Valente, Laura Ruzzini, Pieter D'hooghe, Kristian Samuelsson, Frank A Cordasco, Alexander S Nicholls","doi":"10.3390/children12091186","DOIUrl":"10.3390/children12091186","url":null,"abstract":"<p><p>Anterior cruciate ligament (ACL) injuries in skeletally immature patients pose unique clinical and surgical challenges due to the presence of open physes and ongoing growth. In recent years, multiple surgical strategies have been developed to restore knee stability while minimizing the risk of growth disturbances. However, clinical decision-making remains complex due to the lack of consensus regarding the optimal timing, technique, and graft selection for this population. This narrative review outlines the current clinical and radiological tools used to assess skeletal maturity and explores how maturity status informs surgical approach, with particular emphasis on physeal-sparing, hybrid, and transphyseal techniques. We summarize postoperative complications-including growth disturbances and graft failure-while highlighting current guideline recommendations and ongoing controversies. Lastly, we propose a multimodal model for skeletal maturity assessment to support individualized treatment strategies and emphasize the need for standardized protocols and high-quality research to improve long-term outcomes in pediatric ACL reconstruction.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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