Children-Basel最新文献

{"title":"Navigating a New Normal: A Mixed-Methods Study of the Pediatric Tracheostomy Parent-Caregiver Experience.","authors":"Laine DiNoto, Adrianne Frankel, Taylor Wheaton, Desirae Smith, Kimberly Buholtz, Rita Dadiz, Kathryn Palumbo","doi":"10.3390/children12070956","DOIUrl":"10.3390/children12070956","url":null,"abstract":"<p><strong>Objective: </strong>To explore the experiences and self-efficacy of parent-caregivers providing care for a child with a tracheostomy tube.</p><p><strong>Study design: </strong>Parent-caregivers completed surveys and participated in semi-structured interviews about their experiences learning to care for their child with a tracheostomy tube. Survey data were analyzed using descriptive statistics. Interviews were transcribed verbatim and analyzed thematically through coding.</p><p><strong>Results: </strong>Fifteen parent-caregivers participated in the survey, 13 of whom completed an interview. After receiving a tracheostomy, children were hospitalized a median of 6 months prior to discharge home. At the time of our study, children had been home for a median of 3.5 years. Parent-caregivers felt more prepared to perform routine daily care compared to triaging a change in medical status. Parent-caregiver self-efficacy in performing tracheostomy care skills improved with experience at home. Four themes were identified from interviews: new identity formation, enduring education, child and family biopsychosocial support, and establishing normalcy. Parent-caregivers shared that education was more than just acquiring skills; it also involved discovering diverse ways of learning and building confidence in one's own abilities to fulfill the many types of roles they serve to successfully care for and keep their child safe while supporting their social and emotional needs as parent-caregivers.</p><p><strong>Conclusions: </strong>Parent-caregivers' reflections on their experiences provide critical insight into their psychosocial needs and challenges in providing care to children with tracheostomies. Further investigation of lived experiences is vital to shaping a community that can support families of medically complex children.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeling the World Differently: Sensory and Emotional Profiles in Preschool Neurodevelopmental Disorders.","authors":"Federica Gigliotti, Maria Eugenia Martelli, Federica Giovannone, Carla Sogos","doi":"10.3390/children12070958","DOIUrl":"10.3390/children12070958","url":null,"abstract":"<p><strong>Background/objectives: </strong>Atypical sensory processing is increasingly recognized as a transdiagnostic dimension of neurodevelopmental disorders (NDDs), with critical implications for emotional and behavioral regulation. This study aimed to identify distinct sensory profiles in preschool children with NDDs and to examine their associations with emotional-behavioral and cognitive/developmental functioning.</p><p><strong>Methods: </strong>A total of 263 children (aged 21-71 months) diagnosed with autism spectrum disorder (ASD), language disorder (LD), or other NDDs (ONDD) were recruited. Sensory processing was assessed using the SPM-P, emotional-behavioral functioning was assessed via the CBCL 1½-5, and cognitive/developmental levels were assessed through standardized instruments. Latent profile analysis (LPA) was conducted to identify sensory subtypes. Group comparisons and multinomial logistic regression were used to examine profile characteristics and predictors of profile membership.</p><p><strong>Results: </strong>Three sensory profiles emerged: (1) Multisystemic Sensory Dysfunction (20.1%), characterized by pervasive sensory and emotional difficulties, primarily observed in ASD; (2) Typical Sensory Processing (44.9%), showing normative sensory and emotional functioning, predominantly LD; and (3) Mixed Subclinical Sensory Processing (35%), with subclinical-range scores across multiple sensory and emotional domains, spanning all diagnoses. Higher cognitive functioning and fewer internalizing symptoms significantly predicted membership in the typical profile. A gradient of symptom severity was observed across profiles, with the Multisystemic group showing the most pronounced emotional-behavioral impairments.</p><p><strong>Conclusions: </strong>Distinct sensory-emotional phenotypes were identified across diagnostic categories, supporting a dimensional model of neurodevelopment. Sensory profiles were strongly associated with emotional functioning, independently of diagnostic status. Early sensory assessment may therefore offer clinically meaningful insights into emotional vulnerability and inform targeted interventions in preschool populations with NDDs.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Values for Respiratory Impedance in Bulgarian Children Aged 2-8 Years Using the Forced Oscillation Technique (FOT).","authors":"Plamena Stoimenova, Stoilka Mandadzhieva, Blagoi Marinov","doi":"10.3390/children12070957","DOIUrl":"10.3390/children12070957","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The forced oscillation technique (FOT) is a non-invasive, effort-independent method for assessing respiratory mechanics and is particularly suited for young children who cannot reliably perform spirometry. This study aimed to evaluate the main anthropometric determinants of respiratory impedance parameters-resistance (Rrs) and reactance (Xrs)-in healthy Bulgarian children aged 2 to 8 years. <b>Methods</b>: A total of 100 healthy children were evaluated using a commercially available device at oscillation frequencies of 5, 11, and 19 Hz. Anthropometric data were collected, and FOT measurements were conducted following ATS/ERS guidelines. Stepwise multiple linear regression was applied to identify predictors of Rrs and Xrs. <b>Results</b>: Height (mean height of the children: 113.89 ± 8.46 cm) emerged as the most significant determinant of both Rrs and Xrs across all frequencies with a moderate inverse correlation observed between Rrs at 5 Hz and height (r = -0.446; <i>p</i> < 0.001). Weight additionally influenced reactance at 5 Hz. The mean R5-19 was 0.55, but no significant associations with height or weight were found. Stepwise regression confirmed height as the sole consistent predictor, while sex and age had no significant effect. <b>Conclusions</b>: This study is the first to present the determinants of key FOT parameters in a population of Bulgarian children. Height was identified as the strongest predictor of respiratory impedance and should be prioritized in the development of reference values for children under 8 years old. These findings reinforce the clinical utility of FOT in early childhood.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Carbohydrate Quality Index During Pregnancy and Risk for Large-for-Gestational-Age Neonates: Results from the BORN 2020 Study.","authors":"Antigoni Tranidou, Antonios Siargkas, Ioannis Tsakiridis, Emmanouela Magriplis, Aikaterini Apostolopoulou, Michail Chourdakis, Themistoklis Dagklis","doi":"10.3390/children12070955","DOIUrl":"10.3390/children12070955","url":null,"abstract":"<p><p><b>Background/Objectives</b>: To assess the association between early pregnancy carbohydrate quality, as measured by the Carbohydrate Quality Index (CQI), and the risk of delivering a large-for-gestational-age (LGA) infant in a Mediterranean pregnant cohort of northern Greece. <b>Methods</b>: We analyzed singleton pregnancies from the BORN 2020 prospective cohort in Greece. Dietary intake was assessed via a validated food frequency questionnaire, and CQI was computed from glycemic index, fiber density, whole-to-refined grain ratio, and solid-to-liquid carbohydrate ratio. Multivariable logistic regression was used to estimate the association between CQI (in tertiles) and LGA risk, defined as birthweight >90th percentile. <b>Results</b>: Among the 797 participants, 152 (19.1%) delivered LGA infants, and 117 (14.7%) were diagnosed with GDM. Of those with GDM, 23 (19.7%) delivered LGA infants. In the total population, higher maternal weight (<i>p</i> < 0.001), height (<i>p</i> = 0.006), and pre-pregnancy BMI (<i>p</i> = 0.004) were significantly associated with LGA. A greater proportion of women with LGA had a BMI > 25 (<i>p</i> = 0.007). In the GDM subgroup, maternal height remained significantly higher in those who delivered LGA infants (<i>p</i> = 0.017). In multivariable models, moderate CQI was consistently associated with increased odds of LGA across all models (Model 1: aOR = 1.60 (95% CI: 1.03-2.50), <i>p</i> = 0.037, Model 2: aOR = 1.57 (95% CI: 1.01-2.46), <i>p</i> = 0.046, Model 3: aOR = 1.58 (95% CI: 1.01-2.47), <i>p</i> = 0.044, Model 4 aOR: 1.70; 95% CI: 1.08-2.72; <i>p</i> = 0.023), whereas high CQI was not. In the GDM subgroup, a significant association between high CQI and increased LGA risk was observed in less adjusted models (Model 1 aOR: 6.74; 95% CI: 1.32-56.66; <i>p</i> = 0.039, Model 2 aOR: 6.64; 95% CI: 1.27-57.48; <i>p</i> = 0.044), but this was attenuated and became non-significant in the fully adjusted model (aOR: 3.05; 95% CI: 0.47-30.22; <i>p</i> = 0.28). When examining CQI components individually, no consistent associations were observed. Notably, a higher intake of low-quality carbohydrates (≥50% of energy intake) was significantly associated with increased LGA risk in the total population (aOR: 4.25; 95% CI: 1.53-11.67; <i>p</i> = 0.005). <b>Conclusions</b>: Higher early pregnancy intake of low-quality carbohydrates was associated with an elevated risk of LGA in the general population. However, CQI itself showed a non-linear and inconsistent relationship with LGA, with moderate, but not high, CQI linked to increased risk, particularly in GDM pregnancies, where associations were lost after adjustment. Both carbohydrate quality and quantity evaluations are essential, particularly in high-risk groups, to inform dietary guidance in pregnancy.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Skipping Breakfast and Anxiety and Depression in Adolescents-A Scoping Review.","authors":"Tatiana Naumoska, Kristina Zafirovski, Fahad Hanna","doi":"10.3390/children12070953","DOIUrl":"10.3390/children12070953","url":null,"abstract":"<p><p><b>Background:</b> Anxiety and depression are among the most common mental health disorders affecting adolescents worldwide. Skipping breakfast is a prevalent dietary behaviour linked to inadequate nutrient intake, which may contribute to the development or exacerbation of mental health issues in this age group. Despite growing interest, a comprehensive synthesis of evidence on the association between breakfast omission and adolescent anxiety or depression remains limited. <b>Objectives:</b> This scoping review aimed to synthesise existing research on the association between skipping breakfast and the risk of anxiety and/or depression in adolescents. <b>Methods:</b> A systematic scoping review was conducted using the Joanna Briggs Institute (JBI) methodological framework. A comprehensive search of PubMed, ProQuest, and EBSCOhost databases was performed, focusing on studies published in English between 2014 and 2024. Keywords included \"skipping breakfast,\" \"risk,\" \"anxiety,\" \"depression,\" and \"adolescen*.\" Studies were screened and selected based on predefined inclusion and exclusion criteria. <b>Results</b>: Out of 1671 initially identified studies, 12 met the inclusion criteria. The majority were cross-sectional (n = 9), with one prospective cohort study, one secondary data analysis, and one systematic review with meta-analysis. Most studies reported a significant association between breakfast skipping and increased risk of anxiety and depression in adolescents. Only one study reported no significant relationship between the two variables. <b>Conclusions</b>: This review underscores a consistent association between skipping breakfast and elevated risk of anxiety and depression among adolescents. While causality remains to be established, breakfast omission emerges as a modifiable lifestyle factor with potential public health implications. These findings highlight the need for prospective research, as well as the importance of community- and school-based health promotion strategies that advocate for regular and nutritious breakfast consumption as part of broader mental health support efforts.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences of Sex Development: A Study of 420 Patients from a Single Tertiary Pediatric Endocrinology Center.","authors":"Silvia Ventresca, Laura Chioma, Rosario Ruta, Mafalda Mucciolo, Pasquale Parisi, Agnese Suppiej, Sandro Loche, Marco Cappa, Carla Bizzarri","doi":"10.3390/children12070954","DOIUrl":"10.3390/children12070954","url":null,"abstract":"<p><p><i>Background</i>: Differences of sex development (DSD) are a group of congenital conditions characterized by atypical development of genital structures. The diagnosis is complex and involves clinical, hormonal, and genetic evaluations. <i>Objective</i>: To describe the clinical profile, diagnosis, and management of patients with DSD, with particular attention to genetic diagnosis. <i>Study design</i>: Retrospective study from a tertiary care pediatric hospital in Italy. <i>Methods</i>: 420 patients with DSD referred to the Endocrine Unit of Bambino Gesù Children's Hospital in Rome, Italy, between 2016 and 2023 were included. <i>Results</i>: 75 patients had a 46,XY karyotype, 135 had a 46,XX karyotype, and 210 had chromosomal mosaicism. In our group of pediatric DSD patients, 21/420 patients were born from pregnancies induced with assisted reproduction techniques (ICSI/FIVET). Of these 21 patients, 5 had sex chromosome mosaicism. Using next-generation sequencing (NGS), we identified three new genetic variants: one in the <i>AR</i> gene, one in the <i>NR5A1</i> gene, and one in the <i>SRY</i> gene. The use of NGS significantly improved the diagnostic yield, and a definitive diagnosis was reached in 84.76% of the entire cohort. <i>Conclusions:</i> This study highlights the challenges in the management of patients with DSD from early recognition to treatment and follow-up. A multidisciplinary approach is essential for a comprehensive evaluation of these conditions and to understand the role and clinical significance of the genetic variants.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study.","authors":"Ivan S Samolygo, Marina A Manina, Ekaterina A Yablokova, Pavel A Stribul, Alexander V Novikov, Anton S Antishin, Albina S Pestova, Alexander S Tertychnyy, Daniel Munblit, Svetlana I Erdes","doi":"10.3390/children12070952","DOIUrl":"10.3390/children12070952","url":null,"abstract":"<p><p><b>Background:</b> Inflammatory bowel diseases with an early-onset form (EO-IBDs) make up a special disease group with certain clinical and phenotypic characteristics. This article discusses the features of such early onset in a group of children, based on five years of monitoring a registry of children with IBD from a specialized center. <b>Methods:</b> This retrospective single-center cohort study included pediatric patients diagnosed with EO-IBD between 2019 and 2024. Clinical, laboratory, and endoscopic data were collected from medical records, including fecal calprotectin, inflammatory markers, disease activity indices, and endoscopic severity scores. Localization was classified according to the Paris system, and histological activity was assessed using the IBD-DCA score. <b>Results:</b> There were 20 patients with ulcerative colitis (UC) and 17 with Crohn's disease (CD). Clinical activity was moderate or high (<i>p</i> = 0.179). UC was more characterized by diarrhea and rectal bleeding. CD was more often accompanied by abdominal pain, weight loss, and fever. In total, 82.4% of patients with CD had an inflammatory form. UC-like intestinal lesion was typical of both nosologies-L3 64.7% and E4 60% forms in CD and UC, respectively. Morphological activity was moderate for both nosologies (<i>p</i> = 0.54). IBD-U was present in 43.2% of patients. The median time after which it was possible to diagnose UC was 24 weeks (IQR 20-48) and 40 weeks (IQR 30-45.5) for CD (<i>p</i> = 0.56). <b>Conclusions:</b> Our study confirms the presence of characteristic signs of EO-IBD development, such as a frequent family history of IBD, high or moderate clinical activity during diagnosis verification, colon damage, and a high frequency of extraintestinal manifestations.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Carbapenem vs. Amikacin Antimicrobial Therapy for Pediatric Acute Pyelonephritis Caused by Extended-Spectrum Β-Lactamase-Positive Enterobacteriaceae.","authors":"Burcu Ceylan Cura Yayla, Tuğba Bedir Demirdağ, Anıl Tapısız, Yeşim Özdemir Atikel, Hasan Tezer, Elif Ayça Şahin, Kayhan Çağlar, Sevcan A Bakkaloğlu, Necla Buyan","doi":"10.3390/children12070945","DOIUrl":"10.3390/children12070945","url":null,"abstract":"<p><p><b>Objectives</b>: Acute pyelonephritis (APN) caused by extended-spectrum β-lactamase (ESBL)-positive Enterobacteriaceae poses a growing therapeutic challenge in children, as carbapenems remain the mainstay of treatment even when susceptibility to alternative agents such as amikacin is demonstrated. However, the widespread and inappropriate use of carbapenems can lead to carbapenem resistance. The aim of this study was to compare the clinical efficacy of amikacin and carbapenems in the management of pediatric acute pyelonephritis caused by ESBL-positive Enterobacteriaceae. <b>Methods</b>: We analyzed cases of pediatric acute pyelonephritis caused by ESBL-positive Enterobacteriaceae that were treated with either carbapenems or amikacin over a two-year period. This study compared microbiological cure, clinical improvement, and recurrence rates across the amikacin and carbapenem treatment groups. <b>Results</b>: Fifty-five patients were evaluated. The median age of the patients was 3 years (range, 0.1-13 years). The causative agents were <i>E. coli</i> in 43 cases (78.2%) and <i>Klebsiella</i> spp. in 12 cases (21.8%). All were susceptible to both carbapenem and amikacin in vitro. Twenty patients (36.3%) received a carbapenem and thirty-five (63.7%) received amikacin. Twenty-four (43.6%) had an underlying urological disease. No difference was observed between the groups in terms of microbiological cure, clinical improvement, or recurrence rates. <b>Conclusions</b>: Amikacin may be a potential alternative to carbapenems for treating pediatric ESBL-positive APN when in vitro susceptibility is confirmed.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet and Fibrinogen Contribution to Clot Strength in Premature Neonates with Sepsis.","authors":"Dimitra Gialamprinou, Christos-Georgios Kontovazainitis, Abraham Pouliakis, Alexandra Fleva, Anastasia Giannakou, Elisavet Diamanti, Panagiotis Kratimenos, Georgios Mitsiakos","doi":"10.3390/children12070948","DOIUrl":"10.3390/children12070948","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Platelet transfusions are administered to preterm neonates with thrombocytopenia prophylactically to decrease their bleeding risk. The amplitude difference between the extrinsic rotational thromboelastometry (EXTEM) and the fibrinogen rotational thromboelastometry (FIBTEM) assays is considered an index of platelet contribution to clot strength, guiding transfusion management. The difference in maximum clot elasticity (MCE) (namely the platelet contribution to clot elasticity-MCEplatelet) is considered highly accurate. Limited data exist to specify the contribution of platelets and fibrinogen in clot formation during sepsis in neonates with thrombocytopenia. We investigated the potential of MCFplatelet (platelet contribution to clot firmness) and MCEplatelet in reflecting platelet count and function in septic preterm neonates. We simultaneously assessed the contribution of both platelets and fibrinogen to clot strength during sepsis. <b>Methods</b>: We compared 28 preterm neonates with sepsis born (gestational age 24⁺¹-34⁺³) with 30 healthy counterparts by using rotational thromboelastometry (ROTEM) and platelet flow cytometry. <b>Results</b>: MCEplatelet showed a higher association with platelet count in the sepsis group than MCFplatelet (R² = 47.66% vs. R² = 18.79%). MCEplatelet (AUC = 0.81) had better discrimination capability than MCFplatelet (AUC = 0.78) in platelet count <100 × 10³/L. MCEplatelet was poorly associated with platelet function. The contribution of platelets was significantly lower (MCEplatelet = 84.03 vs. 89.21; <i>p</i> < 0.001) compared with fibrinogen (36.9 vs. 25.92; <i>p</i> < 0.001) in the sepsis group. <b>Conclusions</b>: MCEplatelet has a better predictive value than MCFplatelet. In clinical practice, the elasticity difference between EXTEM and FIBTEM may replace the amplitude difference. The higher contribution of fibrinogen in clot strength during neonatal sepsis results in higher MCF, even in neonates with thrombocytopenia.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Parental Needs in General Pediatric Inpatient Units: A Comparative Study Between Nurses and Parents in Saudi Arabia.","authors":"Hawa Alabdulaziz, Malak Alharthi, Sara Alhazmi, Alyaa Hawsawi, Shahad Almuhyawi, Zahra Almalki","doi":"10.3390/children12070947","DOIUrl":"10.3390/children12070947","url":null,"abstract":"<p><p><b>Introduction</b>: Hospitalization of children creates significant emotional and psychological stress for parents, highlighting the importance of addressing their needs in pediatric care settings. <b>Aims</b>: This study examines the perceptions of both parents and pediatric nurses regarding the needs of hospitalized children. <b>Method</b>: A cross-sectional survey using the validated Needs of Parents of Hospitalized Children (NPQ) was administered to 218 parents and 218 pediatric nurses in four hospitals in Jeddah, Saudi Arabia. Key domains assessed included trust, information, and support. Group differences were evaluated using non-parametric statistical analyses. <b>Results</b>: Trust was prioritized more by parents (83.9%) than nurses (72.4%) (<i>p</i> < 0.05). Both groups deemed information important, but parents (87.2%) rated it as more necessary than nurses (74.1%) (<i>p</i> = 0.02). Parents (79.8%) expressed a greater need for support compared to nurses (67.3%) (<i>p</i> = 0.03). <b>Conclusions</b>: This study identified perceptual differences between parents and nurses regarding trust, communication, and support. Some differences were statistically significant at the <i>p</i> < 0.01 level, while others were suggestive (<i>p</i>-value between 0.01 and 0.05) and require further investigation. These disparities suggest a need to foster mutual understanding and improve communication practices to better align healthcare delivery with family expectations and strengthen family-centered care.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12293146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}