Children-Basel最新文献

{"title":"Disabilities and Handicaps of Patients with Laron Syndrome.","authors":"Zvi Laron","doi":"10.3390/children12091271","DOIUrl":"10.3390/children12091271","url":null,"abstract":"<p><p><b>Background</b>: Laron Syndrome (LS) is a rare hereditary form of dwarfism occurring, with few exceptions, in Jewish, Muslim, and Asian populations or their descendants spread over all continents. It is caused by deletions or mutations in the GH-Receptor gene, resulting in high serum levels of a structurally and biologically normal, but inactive GH and low-to-undetectable IGF-I. <b>Aim</b>: To summarize the disabilities and handicaps observed in patients with LS, from infancy through adult age. <b>Results</b>: Diagnosing, treating and following a cohort of 76 patients with LS (in many cases from infancy into adult age) enabled our department to study not only their growth and social achievements, but also the difficulties these patients encounter in life. The longstanding IGF-I deficiency caused somatic and biochemical changes which led to disabilities starting in infancy and becoming more severe with advancing age. The most serious symptoms LS patients have are dwarfism, progressive obesity, diabetes, fatty liver, cardiovascular disease, and neurological and orthopedic problems, leading to difficulties in vocational training, occupation, and social life, all lowering the Quality of Life (QoL) of these patients. <b>Conclusions</b>: Early initiation of IGF-I replacement treatment in patients with Laron Syndrome prevents and reverses some of the symptoms associated with longstanding IGF-I deficiency.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Longitudinal Transdisciplinary Approach for Autism Spectrum Disorder.","authors":"Aline Kabarite, Glória Maria Marques Ferreira, José Carlos Pitangueira, Rayana de Souza Arimatéa, Renata da Costa Rebello de Mendonça, Roberta Sousa Marcello, Thais Giudice Schulz, Rudimar Dos Santos Riesgo, Kamila Castro","doi":"10.3390/children12091272","DOIUrl":"10.3390/children12091272","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Autism Spectrum Disorder (ASD) presents complex developmental challenges that require coordinated, individualized interventions. This study aimed to evaluate the effectiveness of a transdisciplinary, family-centered approach in improving clinical and functional outcomes in children and adolescents with ASD. <b>Methods</b>: A longitudinal study was conducted with 53 participants aged 2 to 16 years, all with confirmed ASD diagnoses. Assessments were performed at baseline, 6 months, and 12 months. Participants received personalized, evidence-based interventions provided by a multidisciplinary team working within a transdisciplinary model. Therapies were delivered individually and in groups, with flexible intervention phases tailored to each participant's evolving needs. Outcomes were measured using the Clinical Global Impression (CGI), Global Assessment of Functioning (GAF), and the Aberrant Behavior Checklist (ABC). <b>Results</b>: Clinical and functional improvements were observed over the 12-month period. Most participants reached high functional levels by the end of the study. Caregivers reported notable reductions in support needs, while therapist ratings confirmed more moderate improvements. Decreases in behavioral challenges, sensory difficulties, and sleep disturbances were observed, alongside gains in adaptability and functional play. Greater family involvement was associated with more favorable outcomes. <b>Conclusions</b>: A transdisciplinary, family-centered intervention model was beneficial in supporting developmental progress in children and adolescents with ASD. The findings highlight the importance of flexible, team-based care and emphasize the critical role of family engagement in achieving positive long-term outcomes.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Pediatricians' Practice, Knowledge, and Barriers in Diagnosing Cerebral Palsy.","authors":"Vivian Wong, Stacey D Miller, Olivia Scoten, Mor Cohen-Eilig, Stephanie Glegg, Angie Ip, Chetna Jetha, Kishore Mulpuri, Maureen O'Donnell, Ram Mishaal","doi":"10.3390/children12091274","DOIUrl":"10.3390/children12091274","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Data from the Canadian Cerebral Palsy (CP) Registry suggests that children in British Columbia (BC) are diagnosed, on average, at 25 months of age. This is much later than currently recommended. This study aimed to examine current practices and beliefs of pediatricians in the province related to CP and CP diagnosis. <b>Methods:</b> All pediatricians and subspecialty pediatricians in the province were invited to participate in two consecutive online surveys. The initial survey aimed to assess current practice, knowledge of CP, and beliefs about diagnosis. The second survey, which was distributed to the same group of pediatricians, as well as pediatric neurologists and geneticists, aimed to re-assess current practice and identify specific barriers and facilitators to CP diagnosis. <b>Results:</b> The two surveys were completed by 76 and 59 respondents, respectively. Less than 60% of general pediatricians, in both surveys, reported diagnosing children with CP. In survey 2, only 50% of respondents felt that pediatricians should provide a diagnosis of CP. Most general pediatricians (93%) identified that pediatricians, with support from a developmental pediatrician or neurologist, should provide a diagnosis. Common barriers to an early CP diagnosis included uncertainty about other potential diagnoses and uncertainty over diagnosing at a young age. Lack of access to education and therapists to help inform the diagnosis were also frequently identified barriers. <b>Conclusions:</b> While general pediatricians are knowledgeable about CP, a significant proportion in those surveyed were not diagnosing CP, despite believing that early diagnosis is important. Findings from these surveys have identified that general pediatricians have gaps in knowledge, skills, and confidence in diagnosing CP. Support from a developmental pediatrician or neurology colleague was identified as a potential strategy to support earlier diagnosis.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Infantile Malignant Solid Tumors: A Single-Center Experience.","authors":"Burcu Tufan Taş, Nurşah Eker","doi":"10.3390/children12091276","DOIUrl":"10.3390/children12091276","url":null,"abstract":"<p><p><b>Background:</b> Malignant solid tumors diagnosed during the first year of life represent a rare but clinically significant subgroup of pediatric cancers. Their biological behavior, treatment responses, and prognosis differ substantially from tumors diagnosed in older children due to developmental immaturity and age-related therapeutic limitations. <b>Methods:</b> We retrospectively analyzed 88 infants diagnosed with malignant solid tumors before 12 months of age at a single tertiary center between March 2011 and March 2023. Demographic, clinical, pathological, and treatment data were collected. Overall survival (OS) was estimated by Kaplan-Meier analysis, and prognostic factors were evaluated using univariate and multivariate Cox regression models. <b>Results:</b> Of the 98 initially screened patients, 88 were eligible for analysis. The median age at diagnosis was 7 months, with a median follow-up of 42 months. The most common tumor locations were intra-abdominal (64.7%), brain (20.5%), and bone/soft tissue (12.5%). Neuroblastoma was the leading diagnosis (30.7%), with spontaneous regression observed in 29.6% of cases. Atypical teratoid rhabdoid tumor (ATRT) was the most frequent brain tumor (9.1%). The 5-year OS for the entire cohort was 78.3%. Brain tumors were associated with significantly higher mortality (HR 4.32, <i>p</i> = 0.01), while intra-abdominal tumors predicted improved survival (HR 0.31, <i>p</i> = 0.02). <b>Conclusions:</b> Infantile malignant solid tumors display heterogeneous clinical behavior and outcomes. While favorable results can be achieved in neuroblastoma and soft tissue sarcomas, brain tumors, particularly ATRT, remain a therapeutic challenge. Age-specific, risk-adapted treatment strategies and earlier detection are critical to improving survival and reducing long-term sequelae in this vulnerable population.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mother-Preterm Infant Contingent Interactions During Supported Infant-Directed Singing in the NICU-A Feasibility Study.","authors":"Shulamit Epstein, Shmuel Arnon, Gabriela Markova, Trinh Nguyen, Stefanie Hoehl, Liat Eitan, Sofia Bauer-Rusek, Dana Yakobson, Christian Gold","doi":"10.3390/children12091273","DOIUrl":"10.3390/children12091273","url":null,"abstract":"<p><strong>Background: </strong>Supported infant-directed singing (IDS) for parents and their preterm infants has proven beneficial for parents and preterm infants' health and relationship building. Studying parent-infant contingent interactions through behavioral observations is an established method for assessing the quality of interactions. Very few studies have measured contingency between parent and preterm infants in the neonatal period during supported IDS.</p><p><strong>Methods: </strong>We conducted a feasibility study to assess the possibility of analyzing parent-very preterm infant dyads' contingency during supported IDS in the NICU. We recruited four mother-infant dyads and video-recorded a single music therapy (MT) session before their discharge from the hospital. Two independent researchers coded three selected segments (beginning, middle, and end) from each video, according to adapted behavioral scales with inter-rater agreement analysis. Contingency between infant and maternal behaviors was analyzed.</p><p><strong>Results: </strong>Twelve video segments were coded. High inter-rater agreements (Cohen's kappa) were found for infant eye-opening (0.93), hand positions (0.79), and head orientation (0.94), as well as maternal head orientation (0.95) and vocalizations (0.95). During supported IDS, increased infant head orientation toward the mother, eyes closed, as well as maternal head orientation toward the infant (all <i>p</i> < 0.001), were recorded compared to no IDS. Direction of the maternal head toward her infant was contingent on the infant's closed eyes, extended hands, and head not toward mother.</p><p><strong>Conclusions: </strong>This feasibility study demonstrates contingency between mothers and their preterm infants' specific behaviors during IDS. These interactions can be analyzed through video segments with high inter-rater agreement. The method described might help in evaluating other modalities that might be related to contingency. Recent advances in AI can make this tool easier to accomplish, with further studies to evaluate the importance of contingency for child development. The findings suggest that supported IDS influences infant attention and regulation.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting Pediatric Emergency Services for Children with Autism Spectrum Disorder: A Phenomenological Approach.","authors":"Saray Betancort-Avero, María-Ángeles Ferrera-Fernández, Héctor González-de la Torre, Javier Auyanet-Franchy, Claudio-Alberto Rodríguez-Suárez","doi":"10.3390/children12091275","DOIUrl":"10.3390/children12091275","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Children with Autism Spectrum Disorder (ASD) who attend pediatric emergency services face challenges related to their sensory, cognitive, and behavioral characteristics. This study explored the perceptions of healthcare professionals and parents regarding the need to implement adaptations, particularly a sensory-adapted room, for children with ASD in pediatric emergency departments. <b>Methods</b>: A phenomenological qualitative study was conducted through semi-structured interviews (October-December 2024) until data saturation. Participants included healthcare professionals and parents of children diagnosed with ASD. Intentional coding and co-occurrence analysis were performed using Atlas.ti (version 25.0.1). The study was approved by the Research Ethics Committee (code: 204-458-1). <b>Results</b>: Eighteen informants participated (10 professionals and 8 parents). Professionals' interviews revealed three themes and eight subthemes: Professional Training (approach strategies; training received; perceived needs), Hospital Environment (resource allocation; infrastructure; perceived needs during the emergency visit), and Emotional Aspects (emotional experience related to patient care; professionals' personal perceptions). Parents' interviews yielded four themes and ten subthemes: Professional Training (perceptions of staff training; demonstrated emotional competencies; socioemotional relationships during care), Hospital Environment (infrastructure; perceived needs during emergency visits), Emotional Aspects (families' experiences; emotions during care), and ASD (diagnostic characteristics; children's needs; sensory regulation). <b>Conclusions</b>: Pediatric emergency services should be adapted to better meet the needs of children with ASD. Both healthcare professionals and parents recognize the importance of such adaptations, particularly sensory-adapted spaces. The main barriers identified were a lack of professional training, inadequate hospital environments, and stress affecting both patients and provider. Priority measures include continuous ASD-specific training programs, improvements in sensory infrastructure, and more flexible clinical protocols, advancing toward a more inclusive and comprehensive model of care.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping Review of the Psychological Effects of Gender-Based Violence on Children.","authors":"Maria Rodriguez Rodriguez, Diego Gomez-Baya","doi":"10.3390/children12091277","DOIUrl":"10.3390/children12091277","url":null,"abstract":"<p><p>The lack of acknowledgment of children as victims of gender-based violence hinders the support they receive. This study aimed to identify the psychological consequences of children's exposure to gender-based violence and gaps in knowledge. This work used a scoping review approach, based on the PRISMA quality criteria. The search was conducted in the 14 databases included in the Web of Science platform. A total of 13 open-access articles published in English between 2015 and 2025 that focus on gender-based violence psychological consequences in children met the inclusion criteria. The results of the review indicate that gender violence has significant negative psychological, emotional, and social effects on children exposed to it. Thus, symptoms of internalizing, externalizing, and post-traumatic stress disorder may appear. Additionally, there is a high probability of experiencing difficulties in school, interpersonal relationships, and identity development. These effects may have long-term consequences affecting well-being and development later in life. It is crucial to recognize children as direct and significant victims of gender-based violence and promote their protection through psychological, educational, and social support.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemiology of Nontuberculous Mycobacteria in Cystic Fibrosis.","authors":"Aikaterini Sotiropoulou, Ioanna Loukou, Christiana Vliora, Konstantinos Douros, Maria Moustaki","doi":"10.3390/children12091270","DOIUrl":"10.3390/children12091270","url":null,"abstract":"<p><strong>Background: </strong>Nontuberculous mycobacteria (NTM) are opportunistic pathogens responsible for chronic pulmonary infections, primarily affecting individuals with underlying conditions such as cystic fibrosis (CF). The aim of this review is to present the epidemiological profile of NTM in CF patients, with a focus on incidence, prevalence, predominant species, and geographic distribution.</p><p><strong>Methods: </strong>The search included cross-sectional, retrospective, and prospective observational studies published in English that reported epidemiological data concerning the isolation and/or infection of individuals with CF by NTM. NTM infection was defined as the isolation of any NTM species at least once per patient. Out of an initial 1120 references identified in PubMed, and following the application of exclusion criteria based on PRISMA guidelines, a total of 78 studies were included.</p><p><strong>Results: </strong>The reported prevalence of NTM in CF patients ranges globally from 0% to 40.9%. This wide variability is attributed to population heterogeneity, study period, and geographical region. Of the studies included, 30 were conducted in Europe and 25 in the U.S.A. <i>Mycobacterium abscessus</i> and the <i>Mycobacterium avium</i> complex (<i>MAC</i>) were the most commonly isolated species, with <i>MAC</i> being more prevalent in older individuals. The incidence of NTM pulmonary disease was high, with the majority of cases being associated with <i>M. abscessus</i>. Although emerging evidence suggests that CFTR modulator therapy may reduce the risk of NTM isolation and/or disease, current data remain limited.</p><p><strong>Conclusions: </strong>Nontuberculous mycobacteria are significant pathogens in patients with cystic fibrosis, with a negative impact on respiratory health.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents' Perceptions of What Health Means for Adolescents with Depression-A Qualitative Study.","authors":"Stina Persson, Emma Haglund, Rebecca Mortazavi, Håkan Jarbin, Ingrid Larsson","doi":"10.3390/children12091267","DOIUrl":"10.3390/children12091267","url":null,"abstract":"<p><strong>Background: </strong>Adolescent depression is a growing public health concern. Health promotion for this group requires an understanding of what health means in the context of depression. Given that parents play a central role in adolescents' everyday lives, their perspectives on health for adolescents are important. The aim of this study was to describe parents' perceptions of what health means for adolescents with depression.</p><p><strong>Methods: </strong>This qualitative study employed a phenomenographic approach. In-depth interviews were conducted with 28 parents of adolescents with depression. The analysis resulted in four categories, each comprising two sub-categories, reflecting variations in how health was perceived.</p><p><strong>Results: </strong>Parents described health for adolescents with depression in terms of taking initiative in everyday life and creating a daily structure through routines (navigating daily life with depression); experiencing belonging in supportive relationships and understanding one's own value (building trust in self and others); having a positive outlook while facing struggles and finding pleasure in daily activities (experiencing joy despite depression); and balancing body and mind and maintaining healthy habits (supporting well-being despite depression).</p><p><strong>Conclusions: </strong>The findings provide new insights into how parents understand health for adolescents with depression. These perceptions may inform the development of supportive and health-promoting strategies tailored to adolescents' and their families' everyday challenges.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Technique for Revision of the Distally Migrated Fassier-Duval Femoral Rod in Osteogenesis Imperfecta: A Case Report.","authors":"Peter Staunton, Pasin Tangadulrat, Reggie Charles Hamdy","doi":"10.3390/children12091269","DOIUrl":"10.3390/children12091269","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Managing long bone fractures and deformities in osteogenesis imperfecta (OI) with telescoping rods is a common but challenging procedure. A rare complication is the distal migration of the rod's proximal female component, which complicates standard revision surgery. This article aims to describe a surgical technique for the revision of a distally migrated Fassier-Duval (FD) femoral rod. <b>Methods</b>: We present the case of an 8-year-old girl with OI type IV who experienced distal migration of her right femoral FD rod-the surgical technique involved extracting the rod retrogradely through the fracture/osteotomy site. We used a trephine to remove surrounding bone within the canal, thereby preserving the critical bone stock in the greater trochanter needed for secure fixation of the revision implant. <b>Results</b>: The distally migrated female component was successfully removed through the trephined canal with a combination of axial traction and rotational force. The proximal bone stock was preserved, allowing for the stable placement of a revision FD rod. <b>Conclusions</b>: The retrograde trephine technique is a viable and effective strategy for revising a distally migrated telescoping rod in patients with OI. This approach prioritizes the preservation of proximal bone stock, which is crucial for the stability and longevity of the revision implant.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}