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Nutritional Management for Pediatric Biliary Atresia Patients Preparing for Liver Transplantation.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030391
Uyory Choe
{"title":"Nutritional Management for Pediatric Biliary Atresia Patients Preparing for Liver Transplantation.","authors":"Uyory Choe","doi":"10.3390/children12030391","DOIUrl":"10.3390/children12030391","url":null,"abstract":"<p><p>Biliary atresia, a rare pediatric liver condition, results in blocked bile ducts, impeding bile secretion and causing significant nutritional challenges. This perspective emphasizes the critical role of nutrition in supporting children with biliary atresia awaiting liver transplantation. The liver's multifaceted functions in energy metabolism, vitamin storage, and waste excretion emphasize the importance of tailored dietary interventions. Medium-chain triglyceride (MCT) oil serves as a crucial energy source, addressing fat malabsorption, while specialized water-soluble formulations deliver essential fat-soluble vitamins. Additionally, weaning strategies and developmental food practices are discussed to ensure optimal growth and development despite dietary restrictions. Feeding assistance through nasogastric or gastrostomy tubes is explored as a means to combat malnutrition and support liver function. The collective efforts of caregivers and healthcare providers are pivotal in preparing these children for successful liver transplantation, aiming to secure their future health and quality of life.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Narrative Review of Multifactorial Determinants of Childhood Eating Behaviors: Insights and Interventions Using the Social Ecological Model.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030388
Qutaibah Oudat, Sarah E Messiah, Alia Dawlat Ghoneum, Anas Okour
{"title":"A Narrative Review of Multifactorial Determinants of Childhood Eating Behaviors: Insights and Interventions Using the Social Ecological Model.","authors":"Qutaibah Oudat, Sarah E Messiah, Alia Dawlat Ghoneum, Anas Okour","doi":"10.3390/children12030388","DOIUrl":"10.3390/children12030388","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Childhood eating behaviors result from a complex interplay of familial, social, and environmental factors, influenced by socioeconomic and cultural contexts. These behaviors impact dietary habits, nutritional status, and long-term health. Using the Social Ecological Model (SEM), this narrative review synthesizes evidence on key determinants of childhood eating behaviors and proposes a framework for multi-level interventions. <b>Methods</b>: A structured literature search was conducted across PubMed, PsycINFO, and CINAHL, focusing on studies published between January 2014 and September 2024. Keywords related to childhood eating behaviors, familial determinants, and social influences were used to identify relevant studies. Inclusion criteria centered on empirical research examining how social and familial factors impact childhood eating behaviors within the SEM framework. <b>Results</b>: The review highlights critical determinants, including parental feeding practices, home food environments, peer influences, screen time, school meal programs, and socioeconomic disparities. These factors interact across multiple levels, emphasizing the importance of holistic interventions that target both individual behaviors and broader systemic influences. <b>Conclusions</b>: Addressing childhood eating behaviors requires a multi-level approach that integrates caregiver education, peer-led interventions, improved food environments, and supportive policies. Healthcare providers and policymakers play a crucial role in implementing strategies that foster healthier dietary behaviors and mitigate childhood obesity risks.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Randomized Crossover Trial to Evaluate the Effect of Positioning on Obstructive Sleep Apnea in Infants with Robin Sequence.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030389
Cornelia Wiechers, Simon Goetz, Karen Kreutzer, Christina Weismann, Jessica LeClair, Glen McGee, Christian F Poets, Mirja Quante
{"title":"A Randomized Crossover Trial to Evaluate the Effect of Positioning on Obstructive Sleep Apnea in Infants with Robin Sequence.","authors":"Cornelia Wiechers, Simon Goetz, Karen Kreutzer, Christina Weismann, Jessica LeClair, Glen McGee, Christian F Poets, Mirja Quante","doi":"10.3390/children12030389","DOIUrl":"10.3390/children12030389","url":null,"abstract":"<p><strong>Background: </strong>The prone position is one of the most frequently used treatment options for infants with Robin sequence (RS), but its effect and its safety regarding the increased risk of sudden infant death syndrome are controversial.</p><p><strong>Methods: </strong>In a prospective randomized crossover study, we investigated the effects of the prone versus supine position on obstructive sleep apnea (OSA) using polygraphy. Infants with RS admitted to the University Hospital Tuebingen between 4/2021 and 5/2023 were analyzed for their obstructive apnea index (OAI), oxygen desaturation index < 80%, minimum and basal oxygen saturation, basal and highest transcutaneous carbon dioxide level, and respiratory and heart rate in both sleep positions.</p><p><strong>Results: </strong>A total of 29 children were analyzed. A total of 21/29 children were measured in both positions, while 6/29 children were only measured in the supine position and 2/29 only in the prone position. We found no significant difference in the OAI for the supine versus prone position in main effects analyses. In unadjusted linear model analysis, infants in the supine position had an OAI of 9.9 (95% CI, -2.4, 22.3) events/h higher than those in the prone position. A total of 13/21 infants benefitted from the prone position, whilst 8/21 had a worsening of their OSA. We found no evidence of a significant interaction between sleeping position and syndromic status.</p><p><strong>Conclusions: </strong>Prone positioning improves, but does not eliminate, OSA symptoms in infants with RS, and severe OSA may often persist. There are infants in whom a change to the prone position leads to a worsening of their OSA.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neglect of Children with Disabilities: A Scoping Review.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030386
Siwar Makhoul Khoury, Ayala Cohen, Matteo Angelo Fabris, Ayelet Gur
{"title":"Neglect of Children with Disabilities: A Scoping Review.","authors":"Siwar Makhoul Khoury, Ayala Cohen, Matteo Angelo Fabris, Ayelet Gur","doi":"10.3390/children12030386","DOIUrl":"10.3390/children12030386","url":null,"abstract":"<p><p><b>Background:</b> Children with disabilities face an increased risk of neglect and maltreatment due to their dependence on caregivers, social isolation, and challenges in seeking help. While extensive research has examined child abuse, neglect remains an underexplored yet pervasive issue affecting this vulnerable population. <b>Objective:</b> This scoping review synthesizes literature from the past decade to assess the prevalence, characteristics, and risk factors of neglect among children with disabilities, aiming to identify gaps in research and inform policy and intervention efforts. <b>Methods:</b> Following the PRISMA-ScR guidelines, a systematic search was conducted across multiple electronic databases, including PsycNET, Social Services Abstracts, ERIC, PubMed, and EBSCO. Studies were included if they focused on neglect among children with disabilities and were published in English within the last ten years. Thematic analysis was employed to extract and categorize findings. <b>Results:</b> Sixteen studies met the inclusion criteria, revealing a significantly higher prevalence of neglect among children with disabilities compared to their typically developing peers. The type and severity of disability influenced the likelihood and nature of neglect, with children with intellectual disabilities (ID), autism spectrum disorder (ASD), and sensory impairments facing particularly high risks. Key risk factors included parental stress, economic hardship, limited access to resources, and systemic failures in early identification and intervention. Despite the severity of neglect, evidence-based preventive strategies remain scarce, and existing child protection frameworks often fail to account for the unique needs of children with disabilities. <b>Conclusions:</b> The findings underscore the urgent need for targeted interventions, specialized training for professionals, and policy reforms to address the neglect of children with disabilities. Future research should focus on developing and evaluating culturally sensitive and disability-specific support systems to mitigate the long-term consequences of neglect.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vipera Snakebite in Children: A Focus on Europe.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030393
Greta Orlandi, Nadia Rossi, Francesco Chiarelli, Paola Di Filippo
{"title":"Vipera Snakebite in Children: A Focus on Europe.","authors":"Greta Orlandi, Nadia Rossi, Francesco Chiarelli, Paola Di Filippo","doi":"10.3390/children12030393","DOIUrl":"10.3390/children12030393","url":null,"abstract":"<p><p>Although there are over 5 million cases of snakebites each year, up-to-date data on epidemiology and management in European children are lacking in literature. Snakebite envenoming is a rare but potentially life-threatening event, and children are more susceptible due to their lower weight-to-venom ratio. Symptoms of viper envenomation in children are mainly local, but the lymphatic and blood diffusion of the venom may cause systemic symptoms, mainly hemotoxic and cytotoxic symptoms. Immunotherapy with anti-viper serums is the cornerstone of treatment for viper bites, while the use of antibiotics, steroids and analgesics is still unclear and unstandardized. Recently, efforts have been made to improve the pediatric approach to viper envenomation in European children. Several pediatric case reports in children were reported in literature, and a pediatric grading severity score and electronic clinical tool (VipGrade<sup>®</sup>) were created to better manage this issue. However, larger studies are needed to validate these pediatric tools. This narrative review focuses on the clinical characteristics and management of European snake envenomation in children.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Status, Social Determinants of Health and Clinical Outcomes in Critically Ill Children.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030390
Yash Desai, Andrea Marroquín, Paola Hong-Zhu, Nicole Knebusch, Stephanie Vazquez, Marwa Mansour, Thomas P Fogarty, M Hossein Tcharmtchi, Fernando Stein, Jorge A Coss-Bu
{"title":"Nutritional Status, Social Determinants of Health and Clinical Outcomes in Critically Ill Children.","authors":"Yash Desai, Andrea Marroquín, Paola Hong-Zhu, Nicole Knebusch, Stephanie Vazquez, Marwa Mansour, Thomas P Fogarty, M Hossein Tcharmtchi, Fernando Stein, Jorge A Coss-Bu","doi":"10.3390/children12030390","DOIUrl":"10.3390/children12030390","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood malnutrition remains a risk factor for morbidity and mortality. Children admitted to the Pediatric Intensive Care Unit (PICU) are at a higher risk of worsening nutritional status with adverse clinical outcomes. The burden of malnutrition is strongly linked to various well-defined social determinants of health, including race, socioeconomic status, and geography, as these factors influence household food insecurity. This study aimed to analyze the interrelationships of nutritional status, social determinants of health, and health outcomes in critically ill children.</p><p><strong>Methods: </strong>Retrospective cohort study of 6418 critically ill children admitted to PICU from January 2014 to December 2017. Demographic and anthropometric measurements were collected upon admission and outcomes. Based on the patient's zip code, and median household income, we estimated the percentage of the population living in poverty, and the percentage of the population experiencing food insecurity for 5912 children.</p><p><strong>Results: </strong>The prevalence of underweight, chronic, and acute malnutrition was 13.2%, 17.9%, and 5.6%, respectively. Malnourished children had longer duration of mechanical ventilation and longer PICU and hospital lengths of stay (LOS) compared to nourished children. Underweight and chronic malnutrition were associated with higher mortality. Hispanic children had the highest prevalence of poverty level, while non-Hispanic Black children had the highest food insecurity level and lowest median income. Ethnicity was not associated with mortality.</p><p><strong>Conclusions: </strong>Malnourished critically ill children who were disproportionately non-Hispanic Black, Hispanic, and Asian had worse hospital outcomes, including prolonged hospital and PICU length of stay, increased time on mechanical ventilation, and a higher risk of mortality.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D: What We Know and What We Still Do Not Know About Vitamin D in Preterm Infants-A Literature Review.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030392
Ioana Andrada Radu, Maria Livia Ognean, Laura Ștef, Doina Ileana Giurgiu, Manuela Cucerea, Cristian Gheonea
{"title":"Vitamin D: What We Know and What We Still Do Not Know About Vitamin D in Preterm Infants-A Literature Review.","authors":"Ioana Andrada Radu, Maria Livia Ognean, Laura Ștef, Doina Ileana Giurgiu, Manuela Cucerea, Cristian Gheonea","doi":"10.3390/children12030392","DOIUrl":"10.3390/children12030392","url":null,"abstract":"<p><strong>Background/objectives: </strong>Preterm infants represent a population group at increased risk for vitamin D deficiency (VDD) and for its negative impact on various outcomes like metabolic bone disease or rickets, respiratory complications like respiratory distress syndrome and the development of bronchopulmonary dysplasia, necrotizing enterocolitis, or retinopathy of prematurity.</p><p><strong>Methods: </strong>Despite the growing interest in vitamin D research, there is still uncertainty regarding clear recommendations for each high-risk category of premature infants concerning the optimal dosage, optimal product, and timing for initiating vitamin D supplementation to prevent VDD.</p><p><strong>Results: </strong>An analysis of the literature suggests that early intervention for the optimal enteral supplementation of vitamin D is not only successful in achieving higher 25-hydroxi-vitamin D (25(OH)D) at one month but is also linked with improved outcomes.</p><p><strong>Conclusions: </strong>The traditional concepts and current recommendations for assessing vitamin D status and optimal supplementation need to be revised. Since parenteral nutrition, fortified mothers' own milk, and special formula for preterm infants cannot provide adequate vitamin D levels, initiating oral supplementation soon after birth is essential to correct VDD in preterm infants.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Radiomics in Predicting the Prognosis of Medulloblastoma in Children.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-20 DOI: 10.3390/children12030387
Jiashu Chen, Wei Yang, Zesheng Ying, Ping Yang, Yuting Liang, Chen Liang, Baojin Shang, Hong Zhang, Yingjie Cai, Xiaojiao Peng, Hailang Sun, Wenping Ma, Ming Ge
{"title":"Application of Radiomics in Predicting the Prognosis of Medulloblastoma in Children.","authors":"Jiashu Chen, Wei Yang, Zesheng Ying, Ping Yang, Yuting Liang, Chen Liang, Baojin Shang, Hong Zhang, Yingjie Cai, Xiaojiao Peng, Hailang Sun, Wenping Ma, Ming Ge","doi":"10.3390/children12030387","DOIUrl":"10.3390/children12030387","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and purpose: &lt;/strong&gt;Medulloblastoma (MB) represents the predominant intracranial neoplasm observed in pediatric populations, characterized by a five-year survival rate ranging from 60% to 80%. Anticipating the prognostic outcome of medulloblastoma in children prior to surgical intervention holds paramount significance for informing treatment modalities effectively. Radiomics has emerged as a pervasive tool in both prognostic anticipation and therapeutic management across diverse tumor spectra. This study aims to develop a radiomics-based prediction model for the prognosis of children with MB and to validate the contribution of radiomic features in predicting the prognosis of MB when combined with clinical features.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;Patients diagnosed with medulloblastoma at our hospital from December 2012 to March 2022 were randomly divided into a training cohort (&lt;i&gt;n&lt;/i&gt; = 40) and a test cohort (&lt;i&gt;n&lt;/i&gt; = 41). Regions of interest (ROIs) were manually drawn on T1-weighted images (T1WI) along the boundary of the tumor, and radiomic features were extracted. Radiomic features related to survival prognosis were selected and used to construct a radiomics model. The patients were classified into two different risk stratifications according to the Risk-score calculated from the radiomics model. The log-rank test was used to test the difference in survival between the two stratifications to verify the classification value of the radiomics model. Clinical features related to the prognosis were used to construct a clinical model or clinical-radiomics model together with the radiomic features. Then, the clinical model, radiomics model, and clinical-radiomics model were compared to validate the improvement of radiomics in predicting the prognosis of medulloblastoma. The performance of the three models was evaluated with the C-index and the time-dependent AUC. Overall survival (OS) was defined as the time from receiving the operation to death or last follow-up.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 81 children were included in this study. A total of five prognostic radiomic features were selected. The radiomics model could discriminate different risk hierarchies with good performance power in the training and testing datasets (training set &lt;i&gt;p&lt;/i&gt;= 0.0009; test set &lt;i&gt;p&lt;/i&gt; = 0.0286). Six clinical features associated with prognosis (duration of disease, risk hierarchy, dissemination, radiology, chemotherapy, and last postoperative white blood cell (WBC) level in CSF) were selected. The radiomic-clinical molecular features had better predictive value for OS (C-index = 0.860; Brier score: 0.087) than the radiomic features (C-index = 0.762; Brier score: 0.073) or clinical molecular characteristics (C-index = 0.806; Brier score: 0.092).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Radiomic features based on T1-weighted imaging have predictive value for pediatric medulloblastoma. Radiomics has incremental value i","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of a Rapid Host-Protein Score to Discriminate Bacterial from Viral Infections in Hospitalized Febrile Pediatric Patients. 验证用于区分住院发热儿科患者细菌和病毒感染的快速宿主蛋白评分法
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-19 DOI: 10.3390/children12030381
Maria Noni, Eleni Kalogera, Athina Xydia, Georgios Paradeisis, Kalliopi Spyridopoulou, Levantia Zachariadou, Evanthia Botsa
{"title":"Validation of a Rapid Host-Protein Score to Discriminate Bacterial from Viral Infections in Hospitalized Febrile Pediatric Patients.","authors":"Maria Noni, Eleni Kalogera, Athina Xydia, Georgios Paradeisis, Kalliopi Spyridopoulou, Levantia Zachariadou, Evanthia Botsa","doi":"10.3390/children12030381","DOIUrl":"10.3390/children12030381","url":null,"abstract":"<p><p><b>Background:</b> The MeMed BV<sup>®</sup> BV score is a novel, promising host-protein score, differentiating bacterial from viral infections, that combines the expression levels of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein (CRP). The aim of our study was to determine its diagnostic accuracy in hospitalized febrile children. <b>Methods:</b> A prospective study was performed from December 2023 to April 2024 in two pediatric clinics at \"Aghia Sophia\" Children's Hospital, Athens, Greece. Patients > 3 months old, presenting with fever, clinical suspicion of acute infection, and symptoms onset up to 7 days prior were considered eligible. Patients with cancer, Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Tuberculosis (TB), and immunodeficiency were excluded. Two pediatricians reviewed the clinical, laboratory, microbiological, and radiological data and assigned the final diagnosis. The experts were blinded to the BV scores. <b>Results:</b> One hundred and thirty-five patients were enrolled. The predominant medical condition was respiratory tract infection (59.3% lower, 26.7% upper). Twenty-nine (21.5%) patients were diagnosed with bacterial infections. The BV score demonstrated a sensitivity of 96.2%, specificity of 88.7%, and negative predictive value (NPV) of 98.9% for bacterial infections. Equivocal BV scores were reported in 8.9% of cases and were excluded from calculations. The area under the curve was 0.96 (95% CI: 0.93-0.99). A ROC curve analysis was performed, and the optimal cut-off score was estimated at 60, providing a sensitivity of 93.1%, specificity of 88.7%, and NPV of 97.9%. <b>Conclusions:</b> In our study population, the BV score showed high sensitivity and NPV in bacterial infection diagnosis. Further studies are needed to assess the possibility of replacing the \"equivocal\" range with a narrower one or a specific cut-off value.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Childhood Experiences to Social Media Addiction: Unraveling the Impact on Adolescents.
IF 2 4区 医学
Children-Basel Pub Date : 2025-03-19 DOI: 10.3390/children12030385
Demet Aydın, Halide Bengü Göncü
{"title":"From Childhood Experiences to Social Media Addiction: Unraveling the Impact on Adolescents.","authors":"Demet Aydın, Halide Bengü Göncü","doi":"10.3390/children12030385","DOIUrl":"10.3390/children12030385","url":null,"abstract":"<p><p>Social media usage among adolescents has significantly increased in recent years, playing a crucial role in contemporary youth culture. The increasing adoption of the internet across all age groups has led to numerous benefits, but also concerns regarding its misuse, particularly among adolescents. However, alongside these benefits, problems related to internet misuse have also escalated. <b>Background/Objectives</b>: A review of the literature reveals a lack of studies examining the long-term effects of childhood experiences on later social media addiction. This study aims to investigate the impact of childhood experiences on social media addiction during adolescence. <b>Methods</b>: This study employs a relational survey model, a quantitative research method. Data were collected using the Childhood Experiences Scale and the Social Media Addiction Scale for Adolescents. This study's participants included 371 adolescents attending secondary education institutions under the Ministry of National Education of Türkiye during the 2024-2025 academic year. Participants were selected through simple random sampling. Relationship and impact tests were used to analyze the data. <b>Results</b>: This study found that adolescents with adverse school experiences exhibited social media addiction. A significant relationship was found between adverse school experiences and the time spent on social media. Furthermore, in terms of the gender variable, it was found that females scored significantly higher on the Social Media Addiction Scale for Adolescents compared to males. <b>Conclusions</b>: Based on the results of this study, it is observed that adverse experiences encountered in children's school life may influence social media addiction in their future lives. In future studies, researchers may identify different childhood experiences that impact social media addiction.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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