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Automated Measurements of Long Leg Radiographs in Pediatric Patients: A Pilot Study to Evaluate an Artificial Intelligence-Based Algorithm. 自动测量儿科患者的长腿X光片:评估基于人工智能算法的试点研究。
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-27 DOI: 10.3390/children11101182
Thies J N van der Lelij, Willem Grootjans, Kevin J Braamhaar, Pieter Bas de Witte
{"title":"Automated Measurements of Long Leg Radiographs in Pediatric Patients: A Pilot Study to Evaluate an Artificial Intelligence-Based Algorithm.","authors":"Thies J N van der Lelij, Willem Grootjans, Kevin J Braamhaar, Pieter Bas de Witte","doi":"10.3390/children11101182","DOIUrl":"10.3390/children11101182","url":null,"abstract":"<p><strong>Background: </strong>Assessment of long leg radiographs (LLRs) in pediatric orthopedic patients is an important but time-consuming routine task for clinicians. The goal of this study was to evaluate the performance of artificial intelligence (AI)-based leg angle measurement assistant software (LAMA) in measuring LLRs in pediatric patients, compared to traditional manual measurements.</p><p><strong>Methods: </strong>Eligible patients, aged 11 to 18 years old, referred for LLR between January and March 2022 were included. The study comprised 29 patients (58 legs, 377 measurements). The femur length, tibia length, full leg length (FLL), leg length discrepancy (LLD), hip-knee-ankle angle (HKA), mechanical lateral distal femoral angle (mLDFA), and mechanical medial proximal tibial angle (mMPTA) were measured automatically using LAMA and compared to manual measurements of a senior pediatric orthopedic surgeon and an advanced practitioner in radiography.</p><p><strong>Results: </strong>Correct landmark placement with AI was achieved in 76% of the cases for LLD measurements, 88% for FLL and femur length, 91% for mLDFA, 97% for HKA, 98% for mMPTA, and 100% for tibia length. Intraclass correlation coefficients (ICCs) indicated moderate to excellent agreement between AI and manual measurements, ranging from 0.73 (95% confidence interval (CI): 0.54 to 0.84) to 1.00 (95%CI: 1.00 to 1.00).</p><p><strong>Conclusion: </strong>In cases of correct landmark placement, AI-based algorithm measurements on LLRs of pediatric patients showed high agreement with manual measurements.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Effectiveness of Biological Immunomodulators in SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children: A Systematic Review. 生物免疫调节剂对儿童 SARS-CoV-2 相关多系统炎症综合征的临床疗效:系统回顾
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-27 DOI: 10.3390/children11101180
Ji Young Lee, Jimin Kim, Soo-Han Choi, Dong Hyun Kim, Ki Wook Yun, Yae-Jean Kim, Giang Pham Ha Cao, Miyoung Choi, Jong Gyun Ahn
{"title":"Clinical Effectiveness of Biological Immunomodulators in SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children: A Systematic Review.","authors":"Ji Young Lee, Jimin Kim, Soo-Han Choi, Dong Hyun Kim, Ki Wook Yun, Yae-Jean Kim, Giang Pham Ha Cao, Miyoung Choi, Jong Gyun Ahn","doi":"10.3390/children11101180","DOIUrl":"10.3390/children11101180","url":null,"abstract":"<p><strong>Background: </strong>Although there is consensus to use immunoglobulins and corticosteroids as first-line treatments for multisystem inflammatory syndrome in children (MIS-C), the effectiveness of biological immunomodulators in patients refractory to standard therapy remains unclear. We aimed to outline real-world data on biological immunomodulators.</p><p><strong>Method: </strong>A literature search using Ovid-Medline, EMBASE, Cochrane CDSR, and KMBASE was conducted from September 2021 to August 2022; certainty of evidence was assessed via GRADE.</p><p><strong>Results: </strong>Among 258 studies, 10 were selected for analysis, of which 2 were observational studies (with control groups receiving standard therapy of either intravenous immunoglobulins and/or glucocorticoids) and 8 were single-arm studies. In all, 145 patients were treated with biological immunomodulators (anakinra (72; 49%) or infliximab (65; 44%)). In the first observational study, patients in the anakinra group initially exhibited a lower left ventricular ejection fraction than those in the control group. In the second study, patients in the infliximab group required less additional therapy and showed lower newly developed left ventricular dysfunction rate and reduced C-reactive protein levels. The clinical outcomes associated with each biological agent in single-arm studies were not reported individually.</p><p><strong>Conclusions: </strong>Biological immunomodulators are feasible therapeutic options for refractory MIS-C. Nevertheless, further research is warranted to demonstrate clinical efficacy.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors and Outcomes Associated with Pneumothorax in Very Preterm Infants. 早产儿气胸的相关风险因素和结果
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-27 DOI: 10.3390/children11101179
Cristina Nogueroles Blanco, Ana Herranz-Barbero, Mar Velilla-Aparicio, Carla Balcells-Esponera, Marta Teresa-Palacio, Miguel Alsina Casanova, Cristina Carrasco Carrasco, Cristina Borràs-Novell, José Manuel Rodríguez-Miguélez, Ma Dolors Salvia-Roigés, Victoria Aldecoa-Bilbao
{"title":"Risk Factors and Outcomes Associated with Pneumothorax in Very Preterm Infants.","authors":"Cristina Nogueroles Blanco, Ana Herranz-Barbero, Mar Velilla-Aparicio, Carla Balcells-Esponera, Marta Teresa-Palacio, Miguel Alsina Casanova, Cristina Carrasco Carrasco, Cristina Borràs-Novell, José Manuel Rodríguez-Miguélez, Ma Dolors Salvia-Roigés, Victoria Aldecoa-Bilbao","doi":"10.3390/children11101179","DOIUrl":"10.3390/children11101179","url":null,"abstract":"<p><strong>Background/objectives: </strong>Pneumothorax can be a major complication of neonatal lung diseases. We aim to delineate trends and describe the main outcomes related to pneumothorax in very preterm infants (VPI).</p><p><strong>Methods: </strong>Preterm infants < 32 weeks of gestation admitted in two-level III neonatal intensive care units (1995-2019) were included. Risk factors and outcomes were assessed by logistic regression and adjusted for gestational age (GA).</p><p><strong>Results: </strong>In total, 4271 VPI with a mean GA of 28.7 ± 2.3 weeks were evaluated. Pneumothorax was diagnosed in 174 patients (4.1%, 95% Confidence Interval (CI) 3.5-4.7) with its incidence inversely proportional to GA: 9.9% in 23-25 w and 2.1% in 30-31 w (<i>p</i> < 0.001), but stable over the years 1995-1999 (5.2%) and 2015-2019 (4.2%) (<i>p</i> = 0.309). Patients with pneumothorax exhibited higher rates of severe intraventricular hemorrhage (IVH) (Odds Ratio (OR) = 2.0 (95%CI 1.3-3.1), <i>p</i> = 0.003), bronchopulmonary dysplasia (OR = 2.7 (95%CI 1.7-4.4), <i>p</i> < 0.001), and death (OR = 8.5 (95%CI 6.2-11.6), <i>p</i> < 0.001). Independent risk factors for pneumothorax were GA, prolonged premature rupture of membranes, and intubation in the delivery room. The composite outcome of death or severe IVH was higher in patients with pneumothorax with an adjusted OR = 6.7 (95%CI 4.7-9.6), <i>p</i> < 0.001. Although VPI mortality has significantly decreased over the years (20.3% 1995-1999 and 11.7% 2015-2019, <i>p</i> < 0.001), we found no significant difference in pneumothorax-related deaths.</p><p><strong>Conclusion: </strong>Pneumothorax remains a serious threat to VPI, leading to a higher incidence of morbidity, and mortality attributable to this complication has not decreased. Preventive strategies and early recognition are essential for improving disability-free survival in VPI.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Narrative Review of the Theoretical-Methodological Foundations of the TREINI Program. 对 TREINI 计划的理论和方法论基础的叙述性回顾。
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-27 DOI: 10.3390/children11101181
Renato Guimarães Loffi, Deisiane Oliveira Souto, Thalita Karla Flores Cruz, Arthur Felipe Barroso de Lima, Fabiana Rachel Martins Costa Rocha, Simone Rosa Barreto, Patrícia Aparecida Neves Santana, Amanda Aparecida Alves Cunha Nascimento, Vitor Geraldi Haase
{"title":"Narrative Review of the Theoretical-Methodological Foundations of the TREINI Program.","authors":"Renato Guimarães Loffi, Deisiane Oliveira Souto, Thalita Karla Flores Cruz, Arthur Felipe Barroso de Lima, Fabiana Rachel Martins Costa Rocha, Simone Rosa Barreto, Patrícia Aparecida Neves Santana, Amanda Aparecida Alves Cunha Nascimento, Vitor Geraldi Haase","doi":"10.3390/children11101181","DOIUrl":"10.3390/children11101181","url":null,"abstract":"<p><p>Scientific knowledge has advanced in the implementation of safe and beneficial interventions for children and adolescents with cerebral palsy (CP). Although the importance of interdisciplinary interventions that integrate all components of the International Classification of Functioning, Disability and Health (ICF) into family-centered practices is widely recognized, this approach is not yet widely adopted. Instead, many programs remain focused on isolated domains. This study presents the theoretical and methodological foundation of TREINI, an interdisciplinary and family-centered program developed for children and youth with CP and other neurodevelopmental disorders. TREINI incorporates intervention strategies that address all ICF domains. It is grounded in the biopsychosocial model of health and utilizes principles based on the best evidence in pediatric rehabilitation, including intensive training, task-oriented training, and a naturalistic learning environment. Unlike traditional rehabilitation approaches, the care provided by the TREINI program is delivered through an intensive and interdisciplinary approach, by a team working collaboratively in a single location. In addition to including evidence-based interventions, the TREINI program features two innovative components: the \"City of Tomorrow\", a naturalistic learning environment, and the \"TREINI Exoflex\" therapeutic suit, specifically designed to address deficiencies in the body functions and structures of children with CP and other neurodevelopmental disorders. This program has been carefully designed to support the process of neurological re-education and rehabilitation for children and adolescents with neuropsychomotor developmental delays.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Unperceived Victimization on Adolescent Well-Being. 未意识到的受害对青少年幸福感的影响。
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-27 DOI: 10.3390/children11101183
Elisa Larrañaga, Maria Carmen Cabrera, Santiago Yubero
{"title":"Influence of Unperceived Victimization on Adolescent Well-Being.","authors":"Elisa Larrañaga, Maria Carmen Cabrera, Santiago Yubero","doi":"10.3390/children11101183","DOIUrl":"10.3390/children11101183","url":null,"abstract":"<p><p><b>Background:</b> Bullying has been shown to have negative consequences on the health and well-being of adolescents. Some students may experience various bullying behaviors and not consider themselves victims, finding themselves in a situation of unperceived mistreatment. Few studies have focused on the relationship between self-reported victimization behaviors and self-identification as a victim. Our objective is to determine the prevalence of unperceived victimization and analyze its relationship with adolescent distress. <b>Methods:</b> A total of 964 adolescents aged between 12 and 19 years participated. Standardized instruments were used to assess psychological distress, bullying in the last month and previous years, perception of victimization, and resilience. <b>Results:</b> More than 20% of adolescents are in a situation of unperceived victimization, not recognizing themselves as victims despite reporting bullying behaviors. Among girls and middle adolescence, perceiving oneself as a victim increases the likelihood of feeling distress. The likelihood of experiencing distress increases with previous victimization and decreases with high resilience. <b>Conclusions:</b> Mental health professionals should consider bullying as a factor of distress in adolescence. It is essential to refer adolescent victims of bullying to specialized mental health resources to adequately address their well-being and increase resilience as a protective factor.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Free-Weight Resistance Training Enhances Core Muscle Strength but Does Not Translate to Improved Athletic Performance in Adolescent Canoe/Kayak Athletes. 自由重量阻力训练能增强青少年皮划艇/皮划艇运动员的核心肌力,但并不能转化为运动成绩的提高。
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-27 DOI: 10.3390/children11101177
Ting-Ting Lee, Bo-Jen Ko, Chu-Han Chang, I-Shiung Cheng
{"title":"Free-Weight Resistance Training Enhances Core Muscle Strength but Does Not Translate to Improved Athletic Performance in Adolescent Canoe/Kayak Athletes.","authors":"Ting-Ting Lee, Bo-Jen Ko, Chu-Han Chang, I-Shiung Cheng","doi":"10.3390/children11101177","DOIUrl":"10.3390/children11101177","url":null,"abstract":"<p><strong>Background/objectives: </strong>While previous evidence has shown that using free weights for resistance training is a more practical approach to enhancing strength, there is a relatively low prevalence of free-weight resistance training among adolescent kayak/canoe athletes. Therefore, this study aims to assess the impact of free-weight resistance training on body composition and various performance factors among adolescent canoe/kayak athletes.</p><p><strong>Methods: </strong>Twenty-seven young sprint kayakers and canoeists (14 ± 1 years; 164 ± 7 cm; 56 ± 8 kg) completed this study. Following baseline assessments, athletes were randomly divided into two training groups: the free-weight resistance training group (FW) or the control group (C). The FW group underwent free-weight resistance training sessions twice weekly for 24 weeks. The C group maintained their regular bodyweight training sessions during the same timeframe. All participants performed both the pre- and post-training assessments for the following dependent variables: body composition, upper-body power, upper-body isometric muscle strength, isometric mid-thigh pull, core strength, countermovement jump, balance, anaerobic ability, and aerobic performance.</p><p><strong>Results: </strong>After 24 weeks of training, the free-weight resistance training group exhibited a significant increase in body weight (from 56 ± 5 kg to 58 ± 4 kg, <i>p</i> < 0.05) and improvements in the number of straight leg raise repetitions (from 23 ± 6 to 26 ± 4, <i>p</i> < 0.05) compared to the control group. However, the two groups observed no significant differences between upper-body isometric muscle strength, power, balance, and anaerobic/aerobic performance.</p><p><strong>Conclusions: </strong>A 24-week training duration might be insufficient for novice participants in resistance training. Future research should consider incorporating an adaptation period or a learning phase for movements before training, thereby enhancing the efficacy of free-weight resistance training in increasing strength.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Microbiota in Children and Adolescents with Asthma. 儿童和青少年哮喘患者的微生物群。
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-27 DOI: 10.3390/children11101175
Lucio Casali, Giulia Maria Stella
{"title":"The Microbiota in Children and Adolescents with Asthma.","authors":"Lucio Casali, Giulia Maria Stella","doi":"10.3390/children11101175","DOIUrl":"10.3390/children11101175","url":null,"abstract":"<p><p>The role of the respiratory microbiome has been deeply explored for at least two decades. Its characterization using modern methods is now well-defined, and the impacts of many microorganisms on health and diseases have been elucidated. Moreover, the acquired knowledge in related fields enables patient stratification based on their risk for disease onset, and the microbiome can play a role in defining possible phenotypes. The interplay between the lung and gut microbiomes is crucial in determining the microbial composition and immuno-inflammatory reaction. Asthma is still not a well-defined condition, where hyperreactivity and the immune system play important roles. In this disease, the microbiome is mostly represented by <i>Proteobacteria</i>, <i>Streptococcus</i>, and <i>Veillonella</i>, while <i>Cytomegalovirus</i> and <i>Epstein-Barr</i> viruses are the most prevalent viruses. A mycobiome may also be present. The passage from infancy to adolescence is examined by evaluating both the clinical picture and its relationship with possible variations of the microbiome and its effects on asthma. Otherwise, asthma is considered a heterogeneous disease that often starts in childhood and follows a particular personalized track, where adolescence plays a pivotal role in future prognosis. Under this point of view, the microbiota, with its possible variations due to many factors, both internal and external, can modify its composition; consequently, its inflammatory action and role in the immunological response has obvious consequences on the clinical conditions.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of an 8-Week Active Play Intervention on Body Composition and Fundamental Motor Skills in Preschool Children. 为期 8 周的积极游戏干预对学龄前儿童身体成分和基本运动技能的影响
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-26 DOI: 10.3390/children11101173
Katherine E Spring, Danielle Lang, Melissa M Pangelinan, Danielle D Wadsworth
{"title":"Effects of an 8-Week Active Play Intervention on Body Composition and Fundamental Motor Skills in Preschool Children.","authors":"Katherine E Spring, Danielle Lang, Melissa M Pangelinan, Danielle D Wadsworth","doi":"10.3390/children11101173","DOIUrl":"10.3390/children11101173","url":null,"abstract":"<p><p><b>Objective:</b> Examine the effect of an 8-week teacher-guided active play intervention on preschoolers' body composition and fundamental motor skills. <b>Methods:</b> Participants were from two local preschool centers randomly assigned to either the intervention (<i>n</i> = 25, 3.91 ± 0.53 years) or the control group (<i>n</i> = 25, 3.69 ± 0.81 years). All measures were assessed at baseline (week 0), post-intervention (weeks 9-11), and follow-up (weeks 30-33). Bioelectrical Impedance assessed body composition (fat mass (FM) and fat-free mass (FFM)). The Peabody Developmental Motor Scales, Second Edition (PDMS-2) assessed fundamental motor skills (gross motor quartile (GMQ)). <b>Results:</b> A significant Group × Time interaction for GMQ at post-intervention (<i>p</i> = 0.03), with the intervention group scoring significantly higher on GMQ. A significant main effect of Time (<i>p</i> < 0.001) indicated that GMQ increased in both groups across the 33-week period. For FM, a significant main effect of Time at both post-intervention (<i>p</i> < 0.05) and follow-up testing (<i>p</i> < 0.001) indicated that participants increased FM over the 33-week period. Lastly, there was a significant main effect of Time for FFM at post-intervention (<i>p</i> = 0.003) and follow-up (<i>p</i> < 0.001). Interestingly, there was a significant Group × Time interaction (<i>p</i> < 0.05) at follow-up testing showing that FFM increased over time but significantly more for the control group. <b>Conclusions:</b> Results indicate that active play interventions might be a successful pathway to improve gross motor skills in young children. Further research is needed to understand the effect that active play interventions have on body composition in preschoolers.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review. 与 COVID-19 有关的儿童多系统炎症综合征(MIS-C)的蛋白质组特征:叙述性综述。
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-26 DOI: 10.3390/children11101174
Maria-Myrto Dourdouna, Elizabeth-Barbara Tatsi, Vasiliki Syriopoulou, Athanasios Michos
{"title":"Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review.","authors":"Maria-Myrto Dourdouna, Elizabeth-Barbara Tatsi, Vasiliki Syriopoulou, Athanasios Michos","doi":"10.3390/children11101174","DOIUrl":"10.3390/children11101174","url":null,"abstract":"<p><strong>Background/objectives: </strong>Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious complication of COVID-19. MIS-C has overlapping features with other pediatric inflammatory disorders including Kawasaki Disease (KD), Macrophage Activation Syndrome (MAS), Toxic Shock Syndrome and sepsis. The exact mechanisms responsible for the clinical overlap between MIS-C and these conditions remain unclear, and biomarkers that could distinguish MIS-C from its clinical mimics are lacking. This study aimed to provide an overview of how proteomic methods, like Mass Spectrometry (MS) and affinity-based proteomics, can offer a detailed understanding of pathophysiology and aid in the diagnosis and prognosis of MIS-C.</p><p><strong>Methods: </strong>A narrative review of relevant studies published up to July 2024 was conducted.</p><p><strong>Results: </strong>We identified 15 studies and summarized their key proteomic findings. These studies investigated the serum or plasma proteome of MIS-C patients using MS, Proximity Extension, or Aptamer-based assays. The studies associated the proteomic profile of MIS-C with laboratory and clinical parameters and/or compared it with that of other diseases including acute COVID-19, KD, MAS, pediatric rheumatic diseases, sepsis and myocarditis or pericarditis following COVID-19 mRNA immunization. Depending on the method and the control group, different proteins were increased or decreased in the MIS-C group. The limitations and challenges in MIS-C proteomic research are also discussed, and future research recommendations are provided.</p><p><strong>Conclusions: </strong>Although proteomics appear to be a promising approach for understanding the pathogenesis and uncovering candidate biomarkers in MIS-C, proteomic studies are still needed to recognize and validate biomarkers that could accurately discriminate MIS-C from its clinical mimics.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Results of an Innovative Scalable Digital Treatment for Diabetes Distress in Families of School-Age Children with Type 1 Diabetes. 针对 1 型糖尿病学龄儿童家庭糖尿病困扰的创新型可扩展数字疗法的早期成果。
IF 2 4区 医学
Children-Basel Pub Date : 2024-09-26 DOI: 10.3390/children11101169
Susana R Patton, Jessica S Pierce, Nicole Kahhan, Matthew Benson, Mark A Clements, Larry A Fox
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