Children-Basel最新文献

{"title":"No-Risk, At-Risk, and High-Risk Middle School and High School Students: Contributions of the Quadripartite Model for Psychological Distress Prevention Programs.","authors":"Marina Carvalho, Cátia Branquinho, Catarina Noronha, Nuno Neto Rodrigues, Tânia Gaspar, Margarida Gaspar de Matos","doi":"10.3390/children12091188","DOIUrl":"10.3390/children12091188","url":null,"abstract":"<p><strong>Background/objectives: </strong>Students' psychological health problems have been widely studied for a long time. However, with the COVID-19 pandemic and due to the additional challenges related to the need for individual and contextual adjustment, a more comprehensive approach to psychological health and well-being is needed. The main goal of the present study was to identify the individual and contextual factors that could discriminate middle school and high school students based on well-being and psychological symptoms.</p><p><strong>Methods: </strong>In this study, carried out within the scope of the second wave of the study \"Psychological Health and Wellbeing | School Observatory\", promoted by the Ministry of Education, 3037 students from different regions and levels of public education in Portugal, 49.5% female, aged between 9 and 18 years, participated by completing a research protocol after informed consent was given.</p><p><strong>Results: </strong>Cluster analysis allowed the identification of four groups based on the scores of well-being and psychological symptoms: complete psychological health, incomplete psychological distress, incomplete psychological health and complete psychological distress. The analysis of discriminant variables additionally showed relevant differences between the two extreme groups: complete psychological health students reported higher socio-emotional skills, whereas complete psychological distress students reported higher stress and anxiety scores and low life satisfaction.</p><p><strong>Conclusions: </strong>The obtained results highlight the need for early identification of psychological distress using effective measures to prevent psychological symptoms and to promote socio-emotional skills in the school context.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of DISE-Directed Surgery for Obstructive Sleep Apnoea in Children.","authors":"Rachel Blokland, Yael Friedland, Aryan Kalra, Adelaide Withers, Shyan Vijayasekaran","doi":"10.3390/children12091185","DOIUrl":"10.3390/children12091185","url":null,"abstract":"<p><p><b>Background:</b> Obstructive sleep apnoea (OSA) affects 1-4% of children and may cause significant health issues if left untreated. While adenotonsillectomy is the primary intervention, up to 33% of children experience residual OSA. Drug-induced sleep endoscopy (DISE) enables identification of the site of anatomical obstruction, thus facilitating targeted surgical interventions. The approach of the institution at which this research was conducted is to only perform DISE in selected patients including those who fail adenotonsillectomy or when adenotonsillectomy is not expected to be successful. <b>Methods</b>: This retrospective case series reviewed 19 children who underwent DISE and DISE-directed surgeries for OSA at Perth Children's Hospital between 2018 and 2021. Polysomnography (PSG) parameters pre- and post-surgery were compared. <b>Results</b>: Overall, there were no significant improvements in PSG parameters in the group post-surgery. However, improvements were found with sub-group analyses in younger children, those with severe pre-operative OSA and non-obese children. No significant improvement was observed in children with Trisomy 21. Revision adenoidectomy was the most frequently performed surgery and tongue-base reduction achieved the highest rate of improvement (80%) based on PSG parameters. <b>Conclusions</b>: DISE-directed surgery offers a promising approach for managing residual paediatric OSA. Outcomes may be favourable in younger patients, those with severe OSA, and non-obese patients. Further research with larger cohorts is warranted to refine surgical strategies.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evolutionary Preamble Towards a Multilevel Framework to Understand Adolescent Mental Health: An International Delphi Study.","authors":"Federica Sancassiani, Vanessa Barrui, Fabrizio Bert, Sara Carucci, Fatma Charfi, Giulia Cossu, Arne Holte, Jutta Lindert, Simone Marchini, Alessandra Perra, Samantha Pinna, Antonio Egidio Nardi, Alessandra Scano, Cesar A Soutullo, Massimo Tusconi, Diego Primavera","doi":"10.3390/children12091189","DOIUrl":"10.3390/children12091189","url":null,"abstract":"<p><strong>Background/objectives: </strong>Adolescence is a sensitive developmental window shaped by both vulnerabilities and adaptive potential. From an evolutionary standpoint, mental health difficulties in this period may represent functional responses to environmental stressors rather than mere dysfunctions. Despite increasing interest, integrative models capturing the dynamic interplay of risk and protective factors in adolescent mental health remain limited. This study presents a holistic, multi-level framework grounded in ecological and evolutionary theories to improve understanding and intervention strategies.</p><p><strong>Methods: </strong>A two-round Delphi method was used to develop and validate the framework. Twelve experts in adolescent mental health evaluated a preliminary draft derived from the literature. In Round 1, 12 items were rated across five criteria (YES/NO format), with feedback provided when consensus thresholds were not met. Revisions were made using consensus index scores. In Round 2, the revised draft was assessed across eight broader dimensions. A consensus threshold of 0.75 was used in both rounds.</p><p><strong>Results: </strong>Twelve out of thirteen experts (92%) agreed to join the panel. Round 1 item scores ranged from 0.72 to 0.85, with an average consensus index of 0.78. In Round 2, ratings improved significantly, ranging from 0.82 to 1.0, with an average of 0.95. The Steering Committee incorporated expert feedback by refining the structure, deepening content, updating sources, and clarifying key components.</p><p><strong>Conclusions: </strong>The final framework allows for the clustering of indicators across macro-, medium-, and micro-level domains. It offers a robust foundation for future research and the development of targeted, evolutionarily informed mental health interventions for adolescents.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Interventions in the Treatment of Self-Harming Behavior in Children and Adolescents with Autism Spectrum Disorder: A Review.","authors":"Pamela Labarca, Cristian Oyanadel, Melissa González-Loyola, Wenceslao Peñate","doi":"10.3390/children12091184","DOIUrl":"10.3390/children12091184","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Autism spectrum disorder (ASD) is frequently associated with self-injurious behaviors, posing significant risks to individuals and considerable challenges for families and professionals. While various interventions have been proposed, evidence regarding their relative effectiveness remains fragmented. The general aim of this study was to perform a narrative review to analyze effective non-pharmacological interventions targeting self-injurious behaviors (SIBs) in autistic children and adolescents, addressing the following research question: Which non-pharmacological interventions are effective in reducing self-injurious behaviors in autistic children and adolescents, and under what conditions? The review focused on identifying treatment types, contexts of implementation, and outcome efficacy. <b>Methods</b>: This review was conducted based on a search in WoS, SCOPUS and PubMed databases. According to the PICOS criteria, we included studies involving children and adolescents with ASD and interventions for self-injurious behaviors. We compared different types of interventions and evaluated outcomes in terms of reduction in SIBs. Eligible studies were those reporting quantitative or qualitative outcomes on SIB interventions, published within the past 10 years. <b>Results</b>: Thirteen studies met the inclusion criteria. The interventions included applied behavior analysis (ABA), cognitive behavioral therapy (CBT), sensory integration therapy, and pharmacology. The reported outcomes generally indicated reductions in the frequency and severity of self-injurious behaviors. However, many studies lacked long-term follow-up data, and few addressed the generalization of treatment effects. Methodological variability limited both the comparability across studies and the generalization of results. <b>Conclusions</b>: This review emphasized a multidisciplinary, individualized approach to treating self-injurious behaviors in autistic youth. ABA emerged as the most effective intervention, while CBT proved beneficial for higher-functioning adolescents, and sensory therapies addressed specific challenges. Combined treatments showed promise, and family involvement and long-term research remain essential.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Asthma in the Inland Empire: Environmental Burden, Gaps in Preventive Care, and Unmet Needs.","authors":"Catherine Kim, Christine Gharib, Hani Atamna","doi":"10.3390/children12091183","DOIUrl":"10.3390/children12091183","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Asthma is the most prevalent chronic illness in children worldwide, contributing to significant morbidity, health care utilization, and economic burden. In the United States, approximately five million children are affected by asthma. This review explores the environmental contexts and lifestyle determinants of pediatric asthma, with a focus on the Inland Empire (IE) region of Southern California. The IE's unique geographic landscape and importance as a major transportation hub highlights its critical role for understanding how both environmental and structural factors exacerbate asthma burden within the pediatric population. Variables such as household income, parental education levels, and lack of community-based asthma programs were explored. Despite significant burdens, the IE remains under-represented in asthma research, contributing to persistent disparity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A narrative literature review and regional data analysis were conducted via PubMed, Scopus, and Google Scholar (2000-2025), alongside data from the CDC, CDPH, and American Lung Association. Key words used included \"pediatric asthma, Inland Empire, air pollution, asthma disparity, emergency department utilization, socioeconomic status.\" Inclusion criteria were: (1) studies or reports focusing on pediatric asthma (ages 0-17), (2) articles addressing environmental, socioeconomic, or health care-related risk factors, and (3) research with either national, state-level, or IE-specific data. Exclusion criteria were: (1) articles not in English, adult-only asthma studies, and (3) publications without original data or reference to pediatric asthma burden, management, or outcomes. Titles and abstracts were screened for relevance, and full texts were reviewed when abstracts met inclusion criteria. A total of 61 studies, reports, and data sources met this criterion and were included into this review.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The IE-comprised of San Bernardino (SB) and Riverside Counties- is home to four of the top five most polluted cities in North America. Vehicle emissions and industrial waste are concentrated in the region due to limited air circulation from surrounding mountains that entrap pollutants. Pediatric asthma ED visit rates in SB and Riverside were 60.5% and 59.3%, compared to California's average of 56.7%. Hospitalization rates for children aged 0-4 were also higher in SB (24.4%) compared to the state average (17.3%). The elevated rates among school-aged children underscore the crucial need for interventions aimed at improving air quality, enhancing asthma management, and increasing access to preventive health care.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Pediatric asthma in the IE reflects heightened environmental risks, socioeconomic barriers, and gaps in health care access. Addressing these disparities requires targeted interventions, policies, and region-specific research to enhance long-term management strategies ","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-Related Pharmacokinetic and Pharmacodynamic Effects of Intramuscular Epinephrine in Healthy Neonatal Piglets.","authors":"Marwa Ramsie, Po-Yin Cheung, Raza Hyderi, Shrieya Praveen, Tze-Fun Lee, Megan O'Reilly, Georg M Schmölzer","doi":"10.3390/children12091180","DOIUrl":"10.3390/children12091180","url":null,"abstract":"<p><strong>Background: </strong>Epinephrine is currently the only vasopressor recommended during neonatal cardiopulmonary resuscitation (CPR). Rapid vasopressor administration is critical during CPR; however, establishing vascular access can take several minutes and requires extensive skills and/or training. The intramuscular (IM) route provides rapid drug administration and does not require special skills, training, or equipment. We aimed to compare various doses of IM epinephrine to intravascular (IV) epinephrine in a healthy neonatal piglet model.</p><p><strong>Method: </strong>Fifteen newborn piglets (1-3 days of age) underwent anesthesia, intubation via a tracheostomy, and randomization to 0.02 mg/kg IM epinephrine, 0.1 mg/kg IM epinephrine, or 0.02 mg/kg IV epinephrine. Hemodynamic and cardiac function parameters were continuously recorded throughout the experiment. Blood was collected prior to drug administration and throughout the experiment for pharmacokinetic and pharmacodynamic analysis.</p><p><strong>Results: </strong>Dose-dependent changes in hemodynamic and cardiac function parameters were observed following IM epinephrine administration. Greater changes were observed with 0.1 mg/kg IM epinephrine, while there were little to no changes with 0.02 mg/kg IM epinephrine. Pharmacokinetic parameters were not different between 0.02 mg/kg IV epinephrine or 0.1 mg/kg IM epinephrine.</p><p><strong>Conclusions: </strong>IM epinephrine dose of 0.1 mg/kg was more effective in producing systemic hemodynamic and cardiac function changes compared to the lower IM dose 0.02 mg/kg.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Complexity in Rett Syndrome with a Focus on Respiratory Involvement: A Tertiary Center Experience.","authors":"Adele Corcione, Luigi Antonio Del Giudice, Simona Basilicata, Mariantonia Maglio, Salvatore Aiello, Raffaele Cerchione, Anna Annunziata, Alessandro Amaddeo, Melissa Borrelli","doi":"10.3390/children12091181","DOIUrl":"10.3390/children12091181","url":null,"abstract":"<p><strong>Background: </strong>Rett syndrome (RS) is a rare neurodevelopmental disorder primarily affecting females, characterized by severe neurological impairment and complex comorbidities, including epilepsy, scoliosis, and respiratory dysfunction. Respiratory complications, such as recurrent infections and sleep-disordered breathing (SDB), are increasingly recognized as significant contributors to morbidity. This study aimed to evaluate the prevalence, severity, and management of major comorbidities-including epilepsy, scoliosis, respiratory infections, and SDB-in a pediatric cohort with genetically confirmed RS.</p><p><strong>Methods: </strong>We conducted a retrospective review of medical records from 23 female patients under 18 years of age with MECP2 mutations, referred to our tertiary care center from 2021 to 2025. Data on epilepsy, scoliosis, respiratory infections, and nutritional status were collected. The presence of SDB was assessed through overnight home polygraphy (oPG) and transcutaneous carbon dioxide monitoring in selected cases.</p><p><strong>Results: </strong>Epilepsy affected 65% of patients, all with good seizure control. Scoliosis was present in 52%, with two patients requiring spinal surgery. At least one episode of lower respiratory tract infection (LRTI) was presented in 39% of our girls. LRTIs positively correlated with the number of hospitalization and antibiotic treatment. Among patients undergoing oPG, 67% presented obstructive sleep apnea, with its severity positively correlating with the frequency of lower respiratory infections. Severe nocturnal hypercapnia was documented in three patients, leading to non-invasive or invasive ventilation.</p><p><strong>Conclusions: </strong>Our findings highlight the high prevalence of sleep-related respiratory disorders and their association with respiratory infections in children with RS. Systematic respiratory assessment, including sleep studies, and early implementation of airway clearance techniques and ventilatory support are crucial to improving clinical outcomes in this vulnerable population.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity as a Key Factor in Elevated BMI Among Children with Developmental Coordination Disorder: A Cross-Sectional Analysis.","authors":"Pablo Lizoain, Diana Rodriguez-Romero, Carmen Gándara, Leyre Gambra, Apolinar Varela, Nerea Crespo-Eguilaz, Sara Magallón, Martín Martínez","doi":"10.3390/children12091178","DOIUrl":"10.3390/children12091178","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Developmental Coordination Disorder (DCD) affects approximately 5% of children globally and is characterized by motor difficulties that can negatively impact physical activity levels and increase the risk of obesity. Understanding the behavioral and physiological profiles of children with DCD is essential for early intervention. This cross-sectional study compared physical activity, dietary habits, and obesity indicators between children with DCD and their typically developing (TD) peers. <b>Methods</b>: A total of 243 children (134 boys, 109 girls) aged 6.65 to 11.65 years (M = 9.50, SD = 1.38) from two mainstream schools in the Chartered Community of Navarre, Spain, participated in the study. Children with conditions that could explain poor motor development were excluded based on DSM-5 Criterion D. Motor competence was evaluated using the FUNMOVES (n = 243) and MABC-2 tools (n = 49). Physical activity was assessed using the Physical Activity Questionnaire for Children (PAQ-C), dietary habits with the Krece Plus questionnaire, and obesity indicators through bioimpedance analysis (Body Mass Index and body fat percentage). Regression analyses were adjusted for age and sex. <b>Results</b>: Children classified with probable DCD (pDCD) using FUNMOVES showed significantly higher BMI (95% CI: 0.96 to 4.30 kg/m²) and body fat percentage (95% CI: 3.99 to 10.24%) than TD peers. Differences in physical activity were not statistically significant between DCD and TD (95% CI: -0.68 to 0.01. No significant differences were found in dietary quality. When assessing motor development with MABC-2, the results followed similar trends but lacked statistical significance. <b>Conclusions</b>: Children with DCD are at increased risk of overweight and obesity, primarily due to lower physical activity rather than dietary differences. Early identification and targeted interventions are essential to promote healthier lifestyles in this population.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Hoppe et al. Bilateral Symmetrical Brain MRI Findings in Acute Necrotising Encephalopathy Type 1. <i>Children</i> 2025, <i>12</i>, 974.","authors":"Memik Teke","doi":"10.3390/children12091182","DOIUrl":"10.3390/children12091182","url":null,"abstract":"<p><p>I read with great interest the recent case report by Alexander T. Hoppe et al. [...].</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Renal Failure After Maternal Motor Vehicle Accident.","authors":"Jasmine Y Massoumi, Caroline M Bebawy, Sheema Gaffar","doi":"10.3390/children12091179","DOIUrl":"10.3390/children12091179","url":null,"abstract":"<p><strong>Background: </strong>Motor vehicle accidents account for the majority of abdominal trauma in pregnancy and can result in fetal morbidity and mortality. With advancing gestation, the fetus becomes more vulnerable to injury.</p><p><strong>Case presentation: </strong>A preterm neonate is born at 32 weeks' gestation via cesarean section due to placental abruption after maternal motor vehicle accident. Initially, the infant presented with anemia, thrombocytopenia, and acute kidney injury in the setting of renal contusions.</p><p><strong>Results: </strong>Hyponatremia, acidosis, oliguria, and uremia progressed to frank anuric renal failure, requiring several months of hemodialysis before transition to peritoneal dialysis for chronic renal replacement therapy at home.</p><p><strong>Conclusions: </strong>Fetal renal injury resulting in postnatal renal failure is a rare but potentially devastating complication of blunt abdominal injury during pregnancy. Sonographic and laboratory evaluation of a neonate with suspected in utero injury after maternal motor vehicle accident is imperative, as is a high index of suspicion for neonatal renal injury.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}