Children-Basel最新文献

{"title":"Diagnostic Value of Umbilical Cord Blood Interleukin-6 Level in Premature Infants with Early-Onset Sepsis.","authors":"Jinfang Yuan, Yufeng Wu, Yahui Zhang, Lin Zeng, Jiansuo Zhou, Meihua Piao, Xiaomei Tong, Yuan Wei, Liyan Cui, Tongyan Han","doi":"10.3390/children12030301","DOIUrl":"10.3390/children12030301","url":null,"abstract":"<p><strong>Objective: </strong>Early-onset sepsis (EOS) is a serious, grave, and frequently fatal condition in premature infants. This study aimed to assess the diagnostic value of interleukin-6 (IL-6) levels in umbilical cord blood for identifying EOS in preterm infants.</p><p><strong>Methods: </strong>This prospective cohort study was conducted on preterm infants between May 2019 and April 2021. Based on the diagnostic criteria for EOS, the participants were divided into EOS and non-EOS groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of cord blood IL-6 levels for EOS.</p><p><strong>Results: </strong>The levels of IL-6 were significantly higher in the EOS group (<i>n</i> = 10) compared to the non-EOS group (<i>n</i> = 178) [617.5 pg/mL (323.3, 1579.8) vs. 49.7 pg/mL (15.8, 142.8), respectively; <i>p</i> = 0.000]. ROC curve analysis demonstrated that a cutoff value of 250.5 pg/mL for cord blood IL-6 yielded a sensitivity of 90%, specificity of 82%, and area under the curve of 0.876, with a confidence interval of 0.753-0.999, indicating its high accuracy as a diagnostic marker for EOS among preterm infants (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The detection of IL-6 in the umbilical cord blood offers convenience and exhibits significant diagnostic potential for EOS in preterm infants, thereby providing valuable support for clinical decision-making.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foundations of Pediatric Lifestyle Medicine.","authors":"Marina Gaínza-Lein","doi":"10.3390/children12030304","DOIUrl":"10.3390/children12030304","url":null,"abstract":"<p><p><b>Background:</b> Lifestyle medicine utilizes therapeutic interventions to prevent, treat, and reverse chronic diseases by promoting healthy habits. While extensively studied in adults, its application in pediatrics remains underexplored. Given that many chronic diseases originate in early life, establishing the foundations of Pediatric Lifestyle Medicine is essential. <b>Methods</b>: This paper presents a comprehensive literature review and clinical insights to assess the evidence supporting Pediatric Lifestyle Medicine and provide age-appropriate, evidence-based guidelines for children and adolescents. <b>Results</b>: Pediatric Lifestyle Medicine is an evidence-based healthcare discipline focused on promoting and maintaining children's health by encouraging healthy habits from an early age. This approach prevents chronic diseases, supports physical and emotional well-being, and fosters long-term quality of life. Findings show that applying its principles in childhood can prevent obesity, improve mental health, and aid in disease management, while also reducing the risk of adult-onset conditions and benefiting planetary health. Pediatric Lifestyle Medicine is based on six pillars: preventive nutrition, physical activity, sleep, stress management, positive social connections, and risk prevention, the last of which includes toxin avoidance and other childhood-specific risks, such as accident prevention and screen overuse. <b>Conclusions</b>: Pediatric Lifestyle Medicine provides a cost-effective, evidence-based framework for improving childhood health and preventing chronic conditions. Integrating these principles into pediatric care can foster lifelong health benefits, emphasizing the need for further research and implementation in medical education.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pictorial Review of MRI Findings of Glycogen Storage Disease from Children to Young Adults.","authors":"Yasuo Amano, Mika Ishige, Maki Amano, Naoki Shinoda, Chisato Ando, Ryo Takagi","doi":"10.3390/children12030295","DOIUrl":"10.3390/children12030295","url":null,"abstract":"<p><p>Glycogen storage diseases (GSDs) are rare, inherited disorders of glycogen metabolism caused by a deficiency of enzymes or transporters. GSDs involve the liver, kidneys, skeletal muscles, and heart of children and young adults. The complications involving these organs affect the prognosis of patients with GSDs. Magnetic resonance imaging (MRI) is useful for identifying the complications of GSDs and monitoring the response to treatments owing to its ability of tissue characterization and the lack of a need for ionizing radiation. This pictorial review describes the MRI sequences used for GSDs, presents clinical examples, and emphasizes the pivotal role of MRI as an imaging tool in diagnosing complications associated with GSDs. MRI should be performed at least every year in patients with GSDs and hepatic tumors or myocardial scarring. Further MRI sequences that can be used to quantify the severity of GSDs are discussed.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiological Findings in Children and Adolescents Before and After Guanfacine Treatment for Attention Deficit and Hyperactivity Disorder.","authors":"Bekir Yükcü, Bedia Sultan Önal, Cansu Çobanoğlu Osmanlı, Gülsüm Yitik Tonkaz, Berkan Şahin","doi":"10.3390/children12030302","DOIUrl":"10.3390/children12030302","url":null,"abstract":"<p><p><b>Objective:</b> This study evaluates the short-term cardiovascular effects of guanfacine treatment in children and adolescents with attention deficit/hyperactivity disorder (ADHD). The treatment's impact on novel electrocardiographic parameters was also investigated. <b>Methods:</b> In a retrospective study conducted between January 2023 and June 2024, 37 patients aged 6-18 years with ADHD underwent baseline and follow-up cardiac evaluations including electrocardiography (ECG) and blood pressure measurements. Novel ECG markers (QRS-T angle, QT dispersion, QTc dispersion, Tp-e interval, Tp-e dispersion, Tp-e/QT ratio, and Tp-e/QTc ratio) were analyzed alongside standard parameters such as heart rate, QT, and corrected QT (QTc) intervals. Guanfacine was initiated at 1 mg and titrated weekly until an optimal clinical response was achieved. <b>Results:</b> Guanfacine treatment led to a significant reduction in heart rate (-12.3 bpm; <i>p</i> < 0.001) and P wave axis (-12.3°; <i>p</i> = 0.038) and an increase in QT interval (+16.8 ms; <i>p</i> = 0.014). However, no significant changes were observed in blood pressure, QTc duration, or the novel ECG parameters. Importantly, the absence of any changes in these advanced markers supports the cardiovascular safety of guanfacine. Two patients experienced side effects (bradycardia and hypotension), leading to treatment discontinuation. ANCOVA analysis indicated that the duration between ECG evaluations significantly influenced the QT interval changes, emphasizing the importance of timing when monitoring cardiovascular effects. <b>Conclusions:</b> Guanfacine demonstrated minor, statistically significant effects on the selected cardiac parameters without clinically meaningful changes to or adverse impacts on the novel ECG markers investigated. As extended-release guanfacine has only been available in Türkiye for the management of ADHD for approximately two years, studies evaluating its clinical efficacy and side effects are critical for clinicians working in this field.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Experience with Transdermal Preoperative Hormonal Treatment Before Severe Hypospadias Repair: Synergy Between Pediatric Surgeons and Endocrinologists.","authors":"Laura Lucaccioni, Filippo Ghidini, Paolo Repetto, Grazia Spampinato, Anna Insalaco, Sara Vandelli, Viola Trevisani, Lorenzo Iughetti, Pier Luca Ceccarelli","doi":"10.3390/children12030296","DOIUrl":"10.3390/children12030296","url":null,"abstract":"<p><p><b>Objectives:</b> The preoperative hormonal treatment (PHT) in eligible patients has the potential to become an asset for the treatment of severe hypospadias. The aim of the paper is to report the preliminary results on tolerability and efficacy of tailored transdermal PHT with testosterone before primary hypospadias repair, resulting by the joint activity between pediatric surgeons and endocrinologists. <b>Methods:</b> A retrospective study collected all the patients affected by severe hypospadias, with a glans width (GW) < 14 mm and/or a penile ventral curvature > 30°, treated with preoperative transdermal testosterone gel 2% at a standard dose of 2 mg/day after pediatric endocrinologist evaluation, from December 2020 to February 2024. Increases in GWs and penile lengths (PLs), together with adverse events and the rate of surgical complications, were reported. <b>Results:</b> During the period, ten patients were included and received transdermal PHT for 43 (±15) days on average. The treatment with PHT stopped 52 (±23) days before surgery. PL increased 0.76 (±0.27) cm (+37%) on average, and GW increased 0.42 (±0.26) cm (+40%). No adverse events were described. Three surgical complications were reported with an overall rate of 30%. <b>Conclusions:</b> Transdermal PHT was well-tolerated and showed a positive impact on the treatment of severe hypospadias. Future investigations might confirm these findings.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Presence of Associated Injuries in Pediatric Radial Neck Fractures: A Systematic Review of the Literature and Meta-Analysis of Pooled Individual Patient Data.","authors":"Lisette C Langenberg, Joyce L Benner, Nazira Bernal Bader, Christiaan J A van Bergen, Joost W Colaris","doi":"10.3390/children12030300","DOIUrl":"10.3390/children12030300","url":null,"abstract":"<p><p><b>Background:</b> Pediatric radial neck fractures (pRNFs) can occur in isolation or in association with concomitant injuries. It is unknown whether the presence of associated injuries should influence the choice of treatment. The aim of this study is to assess the incidence of associated injuries in pRNF and their correlation with fracture angulation (Judet grade) or the patient's age (under or over ten years of age). <b>Methods:</b> A systematic literature review was performed following PRISMA-IPD guidelines, including case series on pRNF with a minimum of five cases of children until 16 years of age. The quality assessment included a risk of bias analysis and evaluation using the MINORS criteria. Individual patient data on age, Judet classification and associated injuries were extracted from the included studies and pooled for the meta-analysis. The correlation between the presence of associated injury and the patient's age or Judet classification was depicted in two forest plots. <b>Results:</b> A total of 20 articles published sufficient individual patient data (n = 371) on associated injuries. All but one were retrospective case series. Fifteen articles had MINORS scores of 8 or higher. The incidence of associated injuries was 33% (123 of 371 cases). Almost half of the associated injuries included an olecranon fracture (61/123). There was no correlation between Judet classification (<i>p</i> = 0.243) and incidence nor between patient age and the incidence of associated injuries (<i>p</i> = 0.694). <b>Conclusions:</b> Surgeons should be aware of potential associated injuries in over a third of pRNF cases, regardless of the patient's age or fracture angulation. Deduction of the trauma mechanism may be a more useful tool for assessing the potential presence of associated injuries than the most frequently used fracture classification or the patient's age. More research is needed regarding the requirements for enhanced diagnostic imaging, specific treatment or follow-up adaptations in children with pRNFs and associated injuries.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Intraosseous Local Anesthesia (QuickSleeper 5) During Pulpotomy and Stainless Steel Crown Placement on Mandibular Primary Molars: A Crossover Randomized Controlled Clinical Trial.","authors":"Zeyad A AlRaddadi, Latifa A AlHowaish, Ayman M Sulimany","doi":"10.3390/children12030294","DOIUrl":"10.3390/children12030294","url":null,"abstract":"<p><strong>Background: </strong>Effective pain management during dental procedures is essential to ensure positive treatment outcomes, particularly for pediatric patients. Intraosseous anesthesia, administered via the QuickSleeper system, has shown promise as an alternative to traditional local anesthesia techniques.</p><p><strong>Methods: </strong>A single-blinded split-mouth randomized controlled clinical trial took place at the dental hospital at King Saud University with 33 healthy patients (aged 4-9 years), who required pulpotomies and stainless steel crown procedures on two mandibular primary molars, to evaluate the effectiveness of two local anesthetic techniques. Each tooth was randomly assigned to receive 4% articaine either delivered via the intraosseous route using QuickSleeper 5 or buccal infiltration. The effectiveness of the anesthesia was evaluated by the number of injections needed and at various stages using the Sounds, Eyes, and Motor (SEM) scale. Postoperative complications, including pain, swelling, and lip numbness, were assessed through follow-up phone calls with the patients' legal guardians.</p><p><strong>Results: </strong>The techniques demonstrated comparable effectiveness; there were no statistically significant differences in the number of injections and in the SEM scale scores. Minimal postoperative complications were reported: lip biting (two cases) and prolonged numbness (nine cases) were reported only when buccal infiltration was used, and swelling and pain were reported when both techniques were used.</p><p><strong>Conclusions: </strong>Intraosseous anesthesia via the QuickSleeper 5 system is comparable to traditional buccal infiltration anesthesia for pulpotomies and stainless steel crown procedures in pediatric mandibular molars. Intraosseous anesthesia offers the added benefit of reduced soft tissue numbness and associated complications.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Myringoplasty for Pediatric Tympanic Membrane Perforations: Is It Worth It?","authors":"Riccardo Nocini, Daniele Monzani, Valerio Arietti, Flavia Bonasera, Luca Bianconi, Luca Sacchetto","doi":"10.3390/children12030293","DOIUrl":"10.3390/children12030293","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The endoscopic repair of the tympanic membrane is an established method for addressing perforations in the tympanic membrane. However, there are limited studies in the literature examining the success rate of this procedure in the pediatric population. <b>Methods</b>: This study retrospectively analyzed data from the tertiary referral center at the University Hospital of Verona, Italy. This medical record contains data from 84 type 1 transcanal endoscopic tympanoplasties performed in pediatric patients between November 2014 and February 2022. Seventy-seven pediatric patients aged 4 to 16 years who underwent type 1 transcanal endoscopic tympanoplasty (seven of whom underwent bilateral surgery at different time points) were included in the study. Our study did not include more extensive procedures than type 1 endoscopic tympanoplasty. Only patients with tympanic membrane perforation due to simple chronic otitis media, trauma or when no apparent cause was found were included. Chronic otitis with cholesteatoma and other pathologies of the external or middle ear were exclusion criteria. Patients with a follow-up of less than 12 months were excluded from this study. The technique was based on the endoscopic placement of an underlay graft of temporal fascia or tragal cartilage to repair a tympanic membrane perforation. Demographic, clinical, audiologic, and surgical data were collected from each patient. In the study, we considered the reduction of the air-bone gap (ABG) as a functional outcome and the integrity of the reconstruction as an anatomic outcome of success. <b>Results</b>: The primary surgery had a closure rate of 92.9% (78 of 84). All patients underwent audiological evaluation 4-6 months post-surgery, with 84 ears tested. The mean preoperative ABG was 17.13 dB HL, reduced to 9.16 dB HL postoperatively, showing a mean reduction of 7.97 dB HL. No significant complications occurred. <b>Conclusions</b>: Transcanal endoscopic type 1 tympanoplasty should be considered a safe procedure with a high success rate for the repair of tympanic membrane perforations, even in pediatric patients.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation and Implementation of the Global Scales for Early Development (GSED) Tool in Ethiopia.","authors":"Kalkidan Yibeltal, Atsede Teklehaimanot, Firehiwot Workneh, Nebiyou Fasil, Sarah K G Jensen, Theresa I Chin, Krysten North, Betelhem Haymanot, Alemayehu Worku, Anne Cc Lee, Yemane Berhane","doi":"10.3390/children12030299","DOIUrl":"10.3390/children12030299","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization (WHO) recently developed the Global Scales for Early Development (GSED) tool to address the lack of a population-level metric for early childhood development globally. This paper describes learning from the first experience with the translation, adaptation, and implementation of the GSED tool in Ethiopia.</p><p><strong>Methods: </strong>WHO guidelines were followed to translate and adapt the GSED tool to Amharic. Two Ethiopian child health experts were trained as GSED Master Trainers. The tool was forward translated by two independent translators with previous experience in child development assessment, consensus was obtained, and the back translation was reviewed/approved by the WHO. The GSED app was programmed in Amharic and piloted for 40 children aged 6-36 months, followed by its implementation by trained study nurses in a child development study in Bahir Dar.</p><p><strong>Results: </strong>Minor adaptations were made to terminologies and certain items were rephrased in the short and long forms. Modifications were made to physical objects used in the long form to make the items culturally appropriate and familiar. Local examples were used where necessary. The tool was administered to 364 children aged 6-36 months with an average administration time of 50-60 min. Quality control assessments by master trainers showed high agreement with assessments by trained study nurses throughout the study (average agreement: 91%). This study demonstrated the high acceptability and feasibility of the GSED tools.</p><p><strong>Conclusions: </strong>Local adaptations were required to contextualize the GSED tool for the Ethiopian setting. The preliminary experience with the GSED tool in Ethiopia is positive, with high-competency trained staff and ease of administration.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminatory Value and Validation of a Risk Prediction Model Based on Serum Cytokines in Pediatric Acute Appendicitis: A Single-Center Experience of 483 Cases.","authors":"Jiajia Zhou, Guobin Liu, Xiaofeng Song, Quan Kang","doi":"10.3390/children12030298","DOIUrl":"10.3390/children12030298","url":null,"abstract":"<p><p><b>Objectives</b>: Pediatric acute appendicitis (AA) is one of the most prevalent acute abdominal conditions in pediatric surgery. Children with complicated acute appendicitis (CA) may need timely surgical decisions and have a worse prognosis. In this study, we explored the risk factors and developed a predictive model for complicated AA in children. <b>Methods</b>: A retrospective analysis was conducted on patients data from those hospitalized for acute appendicitis, confirmed by post-surgery pathological results, at Children's Hospital of Chongqing Medical University between September 2022 and October 2023. Lasso regression was performed to identify risk factors, and multivariate logistic regression analysis was used for model establishment. <b>Results</b>: Serum levels of IFN-γ, IL-5, IL-6, IL-8, and IL-10 before surgery were useful in classifying acute appendicitis in children. IL-6, IL-8, and IL-10, on their own, had high predictive values for CA in children. Independent risk factors for CA were age, IL-10, and IFN-γ. A multifactorial logistic regression prediction model was established, demonstrating good predictive efficacy. Its predictive sensitivity was 70.0%, specificity 73.9%, with an AUC of 0.7949. Furthermore, the results of the external validation indicated that the model's accuracy was good, with an AUC of 0.8567. <b>Conclusions</b>: Early identification of CA is imperative for timely clinical decision-making. Prediction models based on age, IL-10, and IFN-γ may be reliable and accurate in predicting the incidence of CA, which may lead to better clinical outcomes for children with AA.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}