Children-Basel最新文献

{"title":"The Association of Vitamin D, Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell-Derived Neurotrophic Factor (GDNF) with Development in Children.","authors":"Mia Milanti Dewi, Akhmad Imron, Nelly Amalia Risan, Grace Mediana, Raden Tina Dewi Judistiani, Budi Setiabudiawan","doi":"10.3390/children12010060","DOIUrl":"10.3390/children12010060","url":null,"abstract":"<p><strong>Background: </strong>Short stature remains a global problem and is associated with vitamin D status. Vitamin D is also a neurosteroid with regard to neurotrophic factors but its role in development is unclear. Therefore, this study analyzed the relationships between vitamin D, NGF, GDNF, and BDNF and developmental status in children with a history of short stature (<2 years).</p><p><strong>Methods: </strong>This research is a prospective cross-sectional study conducted in March 2022. The vitamin D, NGF, GDNF, and BDNF levels were measured in stored biological materials from children aged 2-4 years, and their Ages and Stages Questionnaire (ASQ-3) scores were also assessed. The results were analyzed via the chi-square test, Fisher's exact test, Mann-Whitney test for NGF, unpaired <i>t</i>-test, and Spearman rank correlation.</p><p><strong>Results: </strong>Among the 85 study subjects, 41.2% were short in stature, with 37% having developmental deviation. Male sex (<i>p</i> = 0.038) and low maternal education (<i>p</i> = 0.024) were associated with short stature. The mean vitamin D level was lower (<i>p</i> = 0.041) in children with short stature (27.65 ng/dL). The risk factors associated with short stature were vitamin D levels ≤ 32.7 ng/dL, GDNF levels ≤ 12.99 ng/mL, male sex, and low maternal education. Children with short stature (<2 years old) also demonstrated impaired problem-solving as assessed by the ASQ-3 (<i>p</i> = 0.005). Vitamin D was also associated with gross motor skills (<i>p</i> = 0.035) and personal social development (<i>p</i> = 0.038).</p><p><strong>Conclusions: </strong>There was no association of vitamin D with NGF, GDNF, or BDNF levels. Vitamin D levels are associated with short stature and development in children, especially gross motor skills, personal social development, and problem solving.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Diaphragmatic Breathing as a Complementary Therapeutic Strategy in Stress of Children and Teenagers 6-18 Years Old.","authors":"Pelagia Tsakona, Ioannis Kitsatis, Thomas Apostolou, Ourania Papadopoulou, Alexandra Hristara-Papadopoulou","doi":"10.3390/children12010059","DOIUrl":"10.3390/children12010059","url":null,"abstract":"<p><strong>Background: </strong>Few studies are reported on interventions that have been carried out in children and adolescents using diaphragmatic breathing (DB) together with methods like counseling, muscle relaxation, therapeutic exercise, and music therapy.</p><p><strong>Objective: </strong>The goal of the review is to evaluate the effectiveness of DB as complementary therapy in the stress of the pediatric population (6-18 years old).</p><p><strong>Methods: </strong>Detailed research was carried out in the current literature to find relevant studies published from 2010 to October 2024 in PubMed and Cochrane Library. Thirteen studies that fulfilled the inclusion criteria were included in the study. Nine studies involved obese and overweight pediatric populations and the other four involved pediatric patients.</p><p><strong>Results: </strong>The interventions comprised two 8-week studies in an obese pediatric population, seven studies in healthy children and adolescents with normal weight. The studies were based on DB, muscle relaxation, nutrition, counseling, music therapy, and slow breathing exercises. The participants in the intervention group improved in comparison to those in the control group in terms of stress and depression in most included studies, in terms of school performance in two studies, in terms of better family relationships in one study, and showed improvement in anthropometric indicators in two studies. In four studies that involved pediatric patients, stress and fear of medical procedures were reduced.</p><p><strong>Conclusions: </strong>DB can effectively contribute on its own or in combination with other therapeutic methods to improving physiological and psychological indicators in the pediatric population. It is useful to integrate stress management programs that include DB training as clinical practice in primary healthcare and in school schedules for elementary and high-school students.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Lipoatrophy in a Growth Hormone Deficient Toddler Girl Treated with a Non-Pegylated Long-Acting Growth Hormone.","authors":"Atilla Büyükgebiz, And Demir","doi":"10.3390/children12010058","DOIUrl":"10.3390/children12010058","url":null,"abstract":"<p><strong>Background: </strong>Recombinant growth hormone (rhGH) has been used since 1985 to treat growth hormone (GH)-induced short stature, typically associated with transient adverse events. However, lipoatrophy, characterized by irreversible damage to subcutaneous fat, was first reported in 1999 and linked to antibody formation. In 2021, localized lipoatrophy was observed in 14.5% of patients receiving daily rhGH, with repeated injections at the same sites being a common contributing factor. Long-acting rhGH (LAGH) preparation offers the advantage of weekly injections, enhancing patient comfort and adherence to treatment.</p><p><strong>Methods: </strong>This case report discusses a 5.5-year-old girl born at 40 weeks of gestation with a birth weight of 2300 g, diagnosed with idiopathic short stature and borderline GH secretion, along with a history of mild intrauterine growth retardation.</p><p><strong>Results: </strong>After initiating treatment with somatrogon, a non-pegylated fusion protein formulation of LAGH at the standard dose of 0.66 mg/kg body weight weekly, administered by her family, she developed localized lipoatrophy at the injection site within eleven weeks. The injections were performed consistently in the same area of the right upper arm, where lipoatrophy emerged. Following the onset of this adverse effect, her treatment was adjusted to daily rhGH, with strict instructions to rotate injection sites. Despite these clear instructions, follow-up revealed that the parents continued to administer injections with the non-pegylated LAGH fusion protein formulation, this time in the left upper arm, leading to a recurrence of lipoatrophy within eight weeks.</p><p><strong>Conclusions: </strong>The recurrence underscores the importance of proper injection techniques, particularly site rotation, in preventing localized adverse effects. Given the limitations of this case, where the recommended adjustments were not followed by the parents, it is crucial to emphasize that the administration of the preparation should be discontinued immediately upon the appearance of side effects such as lipoatrophy. Individual reactions to drugs are always possible, and this highlights the need for clinician vigilance in monitoring and addressing adverse effects promptly during treatments with LAGH.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Insight into Congenital Hypothyroidism Among Children.","authors":"Hüseyin Anıl Korkmaz","doi":"10.3390/children12010055","DOIUrl":"10.3390/children12010055","url":null,"abstract":"<p><p>Molecular, genetic, and technological advances have led to increased knowledge regarding neonatal thyroid hormone metabolism disorders. Maternal and fetal hypothyroidism, which can cause psychomotor dysfunction syndromes or low IQ levels, can lead to brain damage, reduced fetal growth and incidental fetal death. The treatment of congenital hypothyroidism detected by screening programs performed during the neonatal period provides normalization of growth, IQ levels, and the physical, mental, and motor development of infants. Therefore, the early diagnosis and treatment of congenital hypothyroidism will prevent the development of complications. In this article, the classification and management of neonatal thyroid diseases are reviewed in light of the current scientific literature.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal Behaviors Among United States Adolescents: Increasing Clinical and Public Health Challenges.","authors":"Jhon Ostanin, Helena Miranda, Simon Shugar, Dina Abdo, Maria Carmenza Mejia, Charles H Hennekens, Panagiota Kitsantas","doi":"10.3390/children12010057","DOIUrl":"10.3390/children12010057","url":null,"abstract":"<p><strong>Background/objectives: </strong>Suicide in the United States (US) adolescents is a major clinical and public health problem. In this original investigation, we explored trends in suicidal behaviors (ideation, planning, and attempts) among US adolescents from 2011 to 2021.</p><p><strong>Methods: </strong>The study sample included 90,306 adolescents from the 2011-2021 Youth Risk Behavior Surveillance System. Descriptive statistics and the chi-squared test were used to assess differences in suicidal behaviors across gender, race/ethnicity, and grade between 2011 and 2021.</p><p><strong>Results: </strong>The overall percentage of female adolescents reporting suicidal behaviors increased significantly between 2011 and 2021, and it was higher than males. In 2021, females exhibited significantly higher rates of considering suicide (30.0% vs. 14.3%), planning (23.6% vs. 11.6%), and attempts (13.3% vs. 6.6%) compared to their male counterparts. Whites were more likely to report suicidal ideation (22.7%) while Black non-Hispanic youth had a higher likelihood of making a suicide plan (17.7%), attempting suicide (14.5%), or making a suicide attempt requiring medical treatment (4.4%) relative to other racial/ethnic groups. Overall, ninth graders were more likely to report suicide attempts (11.6%) compared to 12th graders (8.6%).</p><p><strong>Conclusions: </strong>The results demonstrate significant increases in suicidal behavior among US adolescents, particularly in females. They suggest the need for gender-sensitive approaches in mental health support and prevention strategies. Overall, given the significant increase in suicidal behaviors, healthcare providers as well as public health professionals should prioritize mental health initiatives, promote awareness, and ensure access to mental health resources for adolescents.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of a Web-Based Need-Supportive Intervention for Physical Education Teachers on Students' Physical Activity and Related Outcomes: A Randomized Controlled Trial.","authors":"Hasso Paap, Andre Koka, Pille-Riin Meerits, Henri Tilga","doi":"10.3390/children12010056","DOIUrl":"10.3390/children12010056","url":null,"abstract":"<p><strong>Background/objectives: </strong>Globally, adolescents are insufficiently active, highlighting the need for effective strategies to enhance their activity levels. This study evaluated a web-based intervention program designed for physical education (PE) teachers, aimed at fostering students' basic psychological needs-autonomy, competence, and relatedness-in PE settings.</p><p><strong>Methods: </strong>Secondary school PE teachers and their students were randomly assigned into either an experimental (teachers <i>n</i> = 36; students <i>n</i> = 463, Mage = 13.94, SD = 0.88) or a control group (teachers <i>n</i> = 49; students <i>n</i> = 820, Mage = 13.93, SD = 0.87). Teachers in the experimental group underwent a 4-week web-based intervention program focused on autonomy-, competence-, and relatedness-supportive motivational techniques. Students completed questionnaires assessing psychological measures and self-reported physical activity (PA) before and after the teachers' training.</p><p><strong>Results: </strong>Results indicated that students in the experimental group perceived significantly higher autonomy, competence, and relatedness support compared to their control group counterparts at post-test.</p><p><strong>Conclusions: </strong>Consequently, the web-based need-supportive intervention was effective in promoting need-supportive teacher behavior. As the developed training for PE teachers increased students' perceptions of need support from their PE teachers, it holds promise for future PE teacher education. Furthermore, the web-based format offers scalability for broader implementation.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relations Between Parental Emotion Talk and Preschoolers' Emotion Expressions in Low-Income Chinese American and Mexican American Families.","authors":"Megan Chan, Michelle Taw, Nancy Eisenberg, Qing Zhou","doi":"10.3390/children12010052","DOIUrl":"10.3390/children12010052","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Preschool children learn to express emotions in accordance with sociocultural norms. Parental emotion talk (ET) has been theorized to shape these processes. Limited research has examined preschoolers' observed emotion expressions and emotion-related behaviors in culturally diverse samples. We sought to explore the following: (1) cultural group differences and similarities in observed emotion expressions (anger, sadness, and positive emotions) and emotion-related behaviors between Chinese American and Mexican American preschoolers, and (2) the concurrent links between parental ET and children's emotion expressions. <b>Methods</b>: In a sample of 86 children (age range = 38 to 70 months, 62% girls) from low-income immigrant families (Mexican Americans/MA = 43 and Chinese Americans/CA = 43), the observed children's emotion expressions and emotion-related behaviors were coded based on a frustration-eliciting task. Parental ET quality and quantity were coded from transcripts of a parent-child shared reading task. <b>Results</b>: MA children expressed more anger and sadness, but the two groups did not differ on positive emotions or emotion-related behaviors. Multiple regressions showed that children whose parents engaged in more ET expressed higher levels of anger and sadness and used more non-feeling state languages than children whose parents engaged in less ET. <b>Conclusions</b>: The results revealed cultural variations in preschool-age children's emotion expressions and provided support for associations between parental ET and children's emotion expressions.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Understanding of Primary School Teachers in the Rural Communities of Limpopo Province, South Africa-Are We Trauma Informed?","authors":"Muimeleli Munyadziwa, Lufuno Makhado, Angelina Maphula","doi":"10.3390/children12010054","DOIUrl":"10.3390/children12010054","url":null,"abstract":"<p><strong>Background/objectives: </strong>To effectively support children's learning and well-being, primary educators must thoroughly understand child trauma. Being 'trauma informed' means recognizing the impact of trauma and responding supportively, which can help mitigate its adverse effects on learners. This study explored the understanding of childhood trauma among primary school teachers in Limpopo province, focusing on the circuits of Mvudi and Dzindi due to their high prevalence of childhood traumatic experiences.</p><p><strong>Methods: </strong>An exploratory descriptive and contextual design was used in this study. Data were collected through semi-structured interviews with 26 teachers, utilizing total population sampling for schools and purposive sampling for respondents.</p><p><strong>Results: </strong>The findings revealed that teachers typically define trauma in terms of domestic issues and abuse and identify symptoms in learners' behavior, emotions, and academic performance. Teachers employ strategies to assist affected learners, such as building rapport and involving social workers or school authorities when needed.</p><p><strong>Conclusions: </strong>This study highlighted teachers' critical role in identifying and assisting traumatized children and underlined the necessity for effective training programs and school-based support systems. A comprehensive strategy is necessary, including advocacy for equitable support services and standardized training on trauma-informed practices.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Composition in Preterm Infants: Current Insights and Emerging Perspectives.","authors":"Sreekanth Viswanathan, Melissa Thoene, Zaineh Alja'nini, Pradeep Alur, Kera McNelis","doi":"10.3390/children12010053","DOIUrl":"10.3390/children12010053","url":null,"abstract":"<p><p>In recent years, significant advancements in respiratory and nutritional care have markedly improved the survival rates of preterm infants and enhanced long-term health outcomes. Despite these improvements, emerging research highlights the lasting impacts of early growth patterns on an individual's health trajectory. Adults born prematurely face a higher incidence of health issues related to their early birth. The American Academy of Pediatrics recommends that preterm infants should achieve growth rates similar to those of fetuses, with clinicians emphasizing nutrition delivery to help these infants reach their expected weight for gestational age. However, this approach often results in altered body composition, characterized by increased fat mass and decreased fat-free mass compared to full-term infants. Air displacement plethysmography stands out as a highly reliable method for measuring preterm body composition, while DEXA scans, despite their reliability, tend to overestimate body fat. Other methods include bioelectric impedance, isotope dilution, MRI, ultrasound, and skinfold thickness, each with its own strengths and limitations. In this paper, we aim to raise awareness among neonatal clinicians about the importance of achieving acceptable neonatal body composition. We discuss the pros and cons of different body composition measurement methods, the impact of nutrition and other factors on body composition in preterm infants, long-term follow-up data, and the potential use of body composition data to tailor nutritional interventions in NICU and post-discharge settings. This comprehensive approach is designed to optimize health outcomes for preterm newborns by focusing on their body composition from an early stage.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Trochanteric Flip Osteotomy in Varus Intertrochanteric Osteotomy for Treatment of Legg-Calvé-Perthes Disease.","authors":"Andrea Laufer, Carina Antfang, Georg Gosheger, Adrien Frommer, Gregor Toporowski, Henning Tretow, Robert Roedl, Bjoern Vogt","doi":"10.3390/children12010051","DOIUrl":"10.3390/children12010051","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Legg-Calvé-Perthes disease (LCPD) presents challenges in treatment due to its varied course and unclear etiology. This study aimed to evaluate the efficacy of combining proximal femoral varus osteotomy (PFVO) with a modified trochanteric flip osteotomy to address biomechanical consequences and improve hip abductor muscle strength. <b>Methods</b>: We present a modified approach combining PFVO with a trochanteric flip osteotomy. In this technique, the greater trochanter in compound with its muscular insertions is separated from the femur and attached distally using a varization blade plate. Nine patients (ten hips, mean age 8 years) with LCPD were treated using this technique. Clinical examination findings and radiographic evaluations were retrospectively analyzed. The median follow-up was 33 months. <b>Results</b>: At the last follow-up, two patients exhibited Trendelenburg gait, but hip abduction was improved in all patients. Radiographically, consolidation at the osteotomy site was observed in all cases with no delayed union or non-union. The median CE angle improved by 7°, while the median CCD decreased by 18°. The median MPFA decreased by 13°, resulting in a median of 82°. <b>Conclusions</b>: Combining PFVO with a modified trochanteric flip osteotomy addresses biomechanical issues associated with PFVO, potentially improving hip containment and abductor muscle strength. This approach may offer advantages over traditional osteotomy techniques in treating LCPD, and it appears to produce a superior functional outcome in particular in regard to limping when compared to conventional PFVO. Despite satisfactory radiological outcomes in most cases, further research is needed to assess long-term effectiveness and address challenges such as femoral head enlargement and persistent gait abnormalities.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}