Children-Basel最新文献

{"title":"Pre-K-12 Teachers' Views on ASD+ADHD: Prevalence Estimates and Teaching Preparedness.","authors":"Sidni A Justus, Emily M Pogue, Victoria Simanovich","doi":"10.3390/children12030342","DOIUrl":"10.3390/children12030342","url":null,"abstract":"<p><strong>Background/objectives: </strong>Teachers play a significant role in the identification and intervention of neurodevelopmental disorders such as ASD and ADHD. However, their perceptions of ASD+ADHD comorbidity remain underexplored. This study investigates teachers' estimates of ASD+ADHD prevalence and their perceived preparedness to teach students with co-occurring diagnoses, exploring key predictors of both outcomes.</p><p><strong>Methods: </strong>Pre-K-12 teachers (<i>N</i> = 199) completed demographic questions and four additional questionnaires assessing ASD- and ADHD-specific knowledge, neurodiversity attitudes and overall teaching self-efficacy. Participants estimated the prevalence of ASD+ADHD comorbidity and rated their preparedness to instruct students with ASD+ADHD, ASD-only, and ADHD-only. Regression analyses examined factors predicting prevalence estimates and preparedness.</p><p><strong>Results: </strong>Teachers underestimated the lifetime prevalence of ASD+ADHD, though current prevalence estimates were more aligned with meta-analytic findings. Personal experience and current teaching of comorbid students predicted higher prevalence estimates, whereas greater ASD knowledge was associated with lower estimates. Preparedness to teach ASD+ADHD was rated lower than for ASD-only or ADHD-only students. Self-efficacy, neurodiversity attitudes, and professional training were predictors of preparedness. Current teaching of comorbid students, disorder-specific knowledge, and total years of teaching experience showed inconsistent associations across conditions.</p><p><strong>Conclusions: </strong>Findings suggest that while direct experience and training enhance both awareness and preparedness, disorder-specific knowledge alone does not consistently translate to confidence in supporting students with co-occurring diagnoses. Implications for teacher training and the need for comorbidity-focused professional development are discussed.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Osteomyelitis in a Paediatric Patient with a Novel <i>NTRK1</i> Mutation: A Case Report on Congenital Insensitivity to Pain with Anhidrosis.","authors":"Liena Gasina, Nityanand Jain, Arturs Viksne, Dzintars Ozols, Mohit Kakar, Uldis Bergmanis","doi":"10.3390/children12030344","DOIUrl":"10.3390/children12030344","url":null,"abstract":"<p><strong>Background: </strong>Congenital insensitivity to pain with anhidrosis (CIPA), also known as hereditary sensory and autonomic neuropathy type IV (HSAN IV), is an exceedingly rare genetic disorder characterized by the inability to perceive pain, inability to sweat, and various neurological and orthopaedic complications.</p><p><strong>Case presentation: </strong>This is a case report of a 3-year-old female patient as the first case in Latvia diagnosed with CIPA syndrome who repeatedly presented to Children's Clinical University Hospital (CCUH) in Riga, Latvia, with severe orthopaedic manifestations. The patient had repeated fractures, several surgeries, and extensive spread of the disease throughout the left leg, which caused significant functional impairment and decreased quality of life. Despite aggressive orthopaedic interventions, including surgical interventions and physical therapy, the patient's condition remained challenging to manage due to the inherent limitations posed by the insensitivity to pain. The Surgeon-Radiologist Council of Doctors discussed the patient's condition and clinical sequalae, deciding that reconstructive surgery is not feasible, and amputation is recommended.</p><p><strong>Conclusions: </strong>Through this case report, we aim to highlight the unique orthopaedic challenges encountered in the management of CIPA patients, emphasizing the importance of a multidisciplinary approach involving orthopaedic surgeons, paediatricians, geneticists, and physiotherapists. Additionally, we discuss the need for further research to elucidate optimal management strategies and improve outcomes in this rare and complex patient population.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Laser Pulpotomy vs. Conventional Vital Pulpotomy in Primary Teeth: A Comparative Clinical Analysis.","authors":"Jasna Simonoska, Roko Bjelica, Aleksandar Dimkov, Jasmina Simjanovska, Dragana Gabrić, Elizabeta Gjorgievska","doi":"10.3390/children12030341","DOIUrl":"10.3390/children12030341","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Vital pulpotomy involves the partial removal of the coronal pulp tissue in cases of vital pulp exposure, aiming to maintain the health and function of the remaining radicular pulp. The first aim of this study was to compare the effects of two different methodological approaches towards vital pulpotomy of the primary teeth-conventional and laser pulpotomy; thereafter, the aim was to perform a comparison of the effects of the application of calcium hydroxide (Ca(OH)₂) versus mineral trioxide aggregate (MTA); then, we analyzed and compared clinical and radiographic changes in pulpotomized teeth over a defined time period; finally, we determined the degree of efficiency of different methods of vital pulpotomy of the primary teeth. <b>Methods</b>: This study analyzed 40 primary molars, 20 teeth treated with conventional pulpotomy and 20 teeth submitted to laser pulpotomy. Additionally, two pulpotomy agents-Ca(OH)₂ and MTA-were used. The following clinical parameters were examined: pain, percussion sensitivity, swelling, sinus tract presence and pathological mobility. Absence of apical radiolucency, external and internal root resorption, and periodontal ligament widening were key radiographic parameters of the success of the endodontic therapy. <b>Results</b>: The results showed that there was no statistically significant difference between the two pulpotomy agents-Ca(OH)₂ and MTA-and therefore both can be used as alternative pulpotomy agents in the primary teeth. <b>Conclusions</b>: The success rate of pulpotomy with Ca(OH)₂ is similar to that of pulpotomy with MTA. The combination of laser pulpotomy and the use of MTA gave the best results according to all clinical and radiographic criteria examined and in all analyzed periods.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychometric Properties of the ACE-IQ Questionnaire's Binary and Frequency Scoring Methods in a Chilean Community Sample.","authors":"Maria-Pia Santelices, Maria-Carolina Velasco-Hodgson, Catterina Ferreccio, Catalina Undurraga, Karla Carvajal-Araneda","doi":"10.3390/children12030340","DOIUrl":"10.3390/children12030340","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Adverse childhood experiences (ACEs) impact social, emotional, psychological, and physical development, often leading to health risk behaviors in adulthood. Instruments like the Adverse Childhood Experiences International Questionnaire (ACE-IQ) are essential for assessing ACEs globally and confirming their association with health outcomes in adulthood. <b>Methods:</b> This study evaluates the ACE-IQ's validity in a Chilean cohort by analyzing the prevalence of ACEs and the instrument's psychometric properties. Structural validity, internal consistency, and concurrent validity were assessed using the Marshall Scale as a comparative measure. Additionally, binary and frequency scoring methods were compared. <b>Results:</b> Structural validity analyses showed the best fit for three- and four-dimensional models using frequency scoring. The overall internal consistency of the scale was adequate (α > 0.7), although dimensions such as childhood neglect and violence outside the home demonstrated lower internal consistency. Concurrent validity showed significant positive correlations between ACE-IQ scores (both binary and frequency methods) and the Marshall Scale. <b>Conclusions:</b> The ACE-IQ demonstrates adequate reliability for the full scale, with strong evidence of construct validity using the frequency scoring method and concurrent validity for both scoring methods. These findings support the ACE-IQ's use for measuring childhood adversities in Chile and assessing their association with adult health outcomes.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor-Sensory Learning in Children with Disabilities: Does Piano Practice Help?","authors":"Simon Strübbe, Susmita Roy, Irina Sidorenko, Renée Lampe","doi":"10.3390/children12030335","DOIUrl":"10.3390/children12030335","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Patients with physical disabilities, like cerebral palsy, the most common movement disorder in childhood, can benefit from instrumental therapy using piano. Playing the piano promotes the interaction between different brain regions and integrates motor skills, sensory skills, musical hearing, and emotions. A pilot music study examined the effects of six months of piano lessons on hand motor skills and musical hearing in groups of children with motor disabilities. <b>Methods:</b> The allocation to the group was not randomized. Various tests, including the standardized Box and Block Test (BBT) and piano tests, assessed hand motor skills. Musical hearing was evaluated, and a questionnaire was used to determine the participants' enjoyment and experience with the piano lessons. The regularity, tempo of keystrokes, and synchronization between the two hands were assessed and compared to evaluate the effects of six months of piano training. <b>Results:</b> After six months of piano training, statistically significant improvements were observed in the BBT, as well as in the regularity and tempo of the non-dominant hand. The children showed significant improvement in hand-motor control, moving 27.3% more cubes in the BBT. Regularity and tempo in piano playing, especially in the non-dominant hand, also improved. Moreover, 55% of the children better recognized the correct pitches of notes. <b>Conclusions:</b> Thus, this study supports the concept that piano lessons are an effective form of physical therapy for the development of hand motor skills and musical hearing.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music Therapy with Preterm Infants During Kangaroo Care: A Mixed-Methods Feasibility Study on Physiological and Electroencephalographic Parameters and Parental Perspectives.","authors":"Anna Carina Kriechbaum, Bernhard Csillag, Claudia Wenzel, Friederike Barbara Haslbeck","doi":"10.3390/children12030334","DOIUrl":"10.3390/children12030334","url":null,"abstract":"<p><p><b>Background:</b> Music therapy in neonatal care is a rising interdisciplinary interest in clinical practice and research. Studies showed that music therapy benefits preterm infants and their parents. We aimed to explore the possible influence of music therapy on physiological parameters in premature infants during skin-to-skin care and to assess the parents' perspectives on music therapy and participation in the research project. <b>Methods:</b> The feasibility project was conducted in an Austrian neonatal intensive care unit with a mixed-methods design. The subjects were six preterm infants and their parents. We collected quantitative data on heart rate, oxygen saturation, and brain activity (EEG) and analyzed them descriptively. Qualitative interviews were conducted to explore the parents' perspectives on music therapy and study participation and analyzed by using grounded theory coding. <b>Results:</b> The results of the quantitative data indicated a stabilizing effect on the vital parameters in the included premature infants. EEGs showed interburst intervals were longer during music therapy than before its application. Parents reported a great interest in the research project, an experience of deep relaxation through music therapy, and an intensification of their relationship with their infants. <b>Discussion/Conclusions:</b> Our feasibility sample indicates positive changes in the vital parameters and brain activity tendencies. The parents reported positive experiences and observations in their infants related to music therapy, and they enjoyed participating in the research project. However, the small number of subjects means that our descriptions should be interpreted cautiously, and more extensive investigations into EEG measurements in preterm infants are needed.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Physical Activity in ADHD Management: Diagnostic, Digital and Non-Digital Interventions, and Lifespan Considerations.","authors":"Alexandra Martín-Rodríguez, Silvia Herrero-Roldán, Vicente Javier Clemente-Suárez","doi":"10.3390/children12030338","DOIUrl":"10.3390/children12030338","url":null,"abstract":"<p><p><b>Background:</b> Attention Deficit Hyperactivity Disorder (ADHD) has been described as a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity affecting cognitive, emotional, and social functioning. While pharmacological and behavioral treatments remain primary, physical activity (PA) (digital and non-digital versions) has emerged as a great complementary intervention due to its potential impact on executive functions, emotional regulation, and neurobiological markers. <b>Objectives:</b> This study aimed to assess the effects of PA on ADHD symptoms, executive function, and emotional regulation, exploring its potential impact and new practical applications in digital and non-digital treatment. <b>Methods:</b> This narrative review assessed 132 studies published between 1 January 2010 and January 2025, ensuring the inclusion of the most recent and relevant findings. The review was conducted in Scopus, PubMed, and Web of Science, using a predefined combination of terms related to ADHD, physical activity, executive function, neuroplasticity, and emotional regulation. <b>Results:</b> Regular PA improves executive functions, attention, inhibitory control, and cognitive flexibility in ADHD. Aerobic exercise enhances sustained attention, high-intensity training improves impulse control, and coordinative activities boost cognitive flexibility. Non-digital and digital innovations, such as exergaming and wearable fitness trackers, offer promising solutions to improve adherence to PA regimens, reinforcing their role as a key intervention in ADHD management. <b>Conclusions:</b> PA could be a valuable complementary intervention for ADHD through a hybrid approach that may improve cognitive and emotional functioning while addressing comorbidities.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium Patterns and Their Variables in a Cohort of ELBW Infants in the First 10 Days of Life.","authors":"Stijn van Sas, Myrna Pace, Thomas Salaets, Annouschka Laenen, Anke Raaijmakers, Karel Allegaert","doi":"10.3390/children12030337","DOIUrl":"10.3390/children12030337","url":null,"abstract":"<p><p><b>Background</b>: Sodium regulation is critical in extremely low-birth-weight (ELBW, <1000 g) infants. In a recent systematic review, a sodium pattern over postnatal age and its variables (care factors, fluid regimens, and maturational factors) has been summarized. However, this systematic review also illustrated the shortages and limitations of reported cohorts, and the need to report on additional datasets. This study therefore aims to describe the postnatal sodium patterns and their variables in a cohort of ELBW neonates in the first 10 days of postnatal life. <b>Methods</b>: Data on 1704 serum sodium observations in the first 10 days of life from 211 ELBW infants hospitalized in a single neonatal intensive care unit were available to explore associations between serum sodium and perinatal variables. Multivariate linear models with sodium as a response variable and postnatal day as a factor were hereby applied. Baseline and treatment characteristics were included as variables, applying an unstructured covariance matrix to account for the longitudinal data. <b>Results</b>: Gestational age, birth weight, and length showed variable correlations with serum sodium concentrations over postnatal age. Interestingly, the analysis of sodium patterns in this ELBW cohort also revealed significant associations between prenatal betamethasone use, delivery mode, ibuprofen, or the use of inotropes and the postnatal serum sodium concentrations patterns. Multivariate analyses confirmed that gestational age and birth weight independently impacted sodium concentration patterns, and that ibuprofen use remained a significant variable after adjusting for these variables. <b>Conclusions</b>: Gestational age and birth weight complexities emphasize the need for nuanced understanding and standardized methodologies. Sodium patterns in the current ELBW cohort provide support for previously published sodium reference patterns in this population. New variables associated with sodium levels include ibuprofen administration and the use of inotropic agents.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of GnRH Analogs on Body Mass Index in Girls with Central Precocious Puberty: A Single-Center Retrospective Study with a Literature Review.","authors":"Ignazio Cammisa, Elena Malavolta, Federica Arzilli, Giulia Rotunno, Donato Rigante, Clelia Cipolla","doi":"10.3390/children12030336","DOIUrl":"10.3390/children12030336","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Central precocious puberty (CPP) is defined by the premature onset of secondary sexual characteristics prior to the age of 8 and 9 years in girls and boys, respectively. The administration of GnRH analogs (GnRH-a) has become a cornerstone in the management of CPP, but effects on metabolic processes, particularly body mass index (BMI), remain a subject of ongoing investigation. This study aimed to investigate the relationship between GnRH-a treatment and BMI changes in a cohort of Italian children with CPP. <b>Methods:</b> We conducted a retrospective cohort study of 34 girls with idiopathic CPP, all treated with GnRH-a. Anthropometric parameters including BMI were collected at three time points: baseline, one year after treatment, and one year after treatment cessation. A comprehensive review of the medical literature concerning GnRH-a and BMI was performed. <b>Results:</b> Statistical analysis using the Wilcoxon and McNemar tests revealed a significant increase in BMI-for-age <i>z</i>-scores after one year of GnRH-a, with a slight increase also observed one year post-treatment of CPP. These findings suggest that GnRH-a treatment contributes to an increase in BMI, particularly in CPP children with a normal weight at baseline, although the overall impact on the progression of obesity remains minimal. A review of the existing literature supports the notion that changes in BMI during GnRH-a treatment are influenced by various factors, including baseline BMI, gender, and metabolic processes. <b>Conclusions:</b> Despite our findings suggesting the potential impact of GnRH-a on BMI, further longitudinal studies are necessary to fully understand the long-term metabolic consequences of GnRH-a therapy in children with CPP.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Kidney Function, Injury and Drug Dosing: A Contemporary Review.","authors":"Eveline Staub, Srinivas Bolisetty, Karel Allegaert, Anke Raaijmakers","doi":"10.3390/children12030339","DOIUrl":"10.3390/children12030339","url":null,"abstract":"<p><p>In neonates, estimation of the glomerular filtration rate is problematic, and assessment of renal impairment is challenging. Serum creatinine is a widely used marker, and urine output is an important vital parameter monitored in intensive care settings, particularly in unwell neonates. However, the rapid changes after birth with adaptation to the extrauterine environment is a unique situation in which absolute serum creatinine is not a reliable indicator of renal function. A rise in serum creatinine from the previous value during the neonatal period can be a result of worsening renal function in neonates but is dependent on many other factors. In addition, urine output can be difficult to measure in sick neonates during their intensive care stay. Despite a high prevalence of acute kidney injury (AKI) in preterm and/or unwell infants, the current definitions are not straightforward and do not take postnatal adaptation processes into account. The management of AKI is challenging in very young and small patients because the assessment of fluid status as well as balancing nutritional needs with fluid restriction can be problematic. The Australian Neonatal Medicines Formulary provides advice on drug dosing in the face of reduced renal function in neonates. Predictors (or long-term outcome, or recovery) after AKI diagnosis are still poorly described. Therefore, the diagnosis of neonatal AKI needs to be documented and transferred to the paediatrician responsible for the follow-up of the child. This educational review aims to give a perspective on neonatal kidney function and AKI, the relation of fluid balance and creatinine, the management of neonatal AKI and the consequences for drug dosing and long-term outcomes.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}