Richard M Oxborough PhD , Karen L Figueroa Chilito MSc , Filemon Tokponnon PhD , Louisa A Messenger PhD
{"title":"Malaria vector control in sub-Saharan Africa: complex trade-offs to combat the growing threat of insecticide resistance","authors":"Richard M Oxborough PhD , Karen L Figueroa Chilito MSc , Filemon Tokponnon PhD , Louisa A Messenger PhD","doi":"10.1016/S2542-5196(24)00172-4","DOIUrl":"10.1016/S2542-5196(24)00172-4","url":null,"abstract":"<div><div>Mass distribution of insecticide-treated nets (ITNs) has been a key factor in reducing malaria cases and deaths in sub-Saharan Africa. A shortcoming has been the over-reliance on pyrethroid insecticides, with more than 2·13 billion pyrethroid ITNs (PY ITNs) distributed in the past two decades, leading to widespread pyrethroid resistance. Progressive changes are occurring, with increased deployment of more effective pyrethroid-chlorfenapyr (PY-CFP) or pyrethroid-piperonyl butoxide (PY-PBO) ITNs in areas of pyrethroid resistance. In 2023, PY-PBO ITNs accounted for 58% of all ITNs shipped to sub-Saharan Africa. PY-PBO and PY-CFP ITNs are 30–37% more expensive than standard PY ITNs, equating to an additional US$132–159 million required per year in sub-Saharan Africa to fund the shift to more effective ITNs. Several countries are withdrawing or scaling back indoor residual spraying (IRS) programmes to cover the shortfall, which is reflected by the number of structures sprayed by the US President's Malaria Initiative decreasing by 30% from 5·67 million (2021) to 3·96 million (2023). Benin, located in West Africa, is a prime example of a country that ceased IRS in 2021 after 14 years of annual spraying. Our economic evaluation indicates that IRS in Benin cost $3·50 per person protected per year, around five times more per person protected per year compared with PY-PBO ($0·73) or PY-CFP ITNs ($0·76). Although costly to implement, a major advantage of IRS is the portfolio of at least three chemical classes for prospective resistance management. With loss of synergy to PBO developing rapidly, there is the danger of over-reliance on PY-CFP ITNs. As gains in global malaria control continue to reverse each year, current WHO projections estimate that key 2030 malaria incidence milestones will be missed by a staggering 89%. This Personal View explores contemporary malaria vector control trends in sub-Saharan Africa and cost implications for improved disease control and resistance management.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 10","pages":"Pages e804-e812"},"PeriodicalIF":24.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Ban PhD , Kailai Lu MSc , Yuanyuan Liu , Jiawei Zang MSc , Zhen Zhou MSc , Can Zhang PhD , Zhao Liu PhD , Jianbin Huang PhD , Yidan Chen PhD , Prof Xuejie Gao PhD , Prof Ying Xu PhD , Prof Can Wang PhD , Prof Wenjia Cai PhD , Prof Peng Gong PhD , Prof Yong Luo PhD , Prof Tiantian Li PhD
{"title":"Projecting future excess deaths associated with extreme precipitation events in China under changing climate: an integrated modelling study","authors":"Jie Ban PhD , Kailai Lu MSc , Yuanyuan Liu , Jiawei Zang MSc , Zhen Zhou MSc , Can Zhang PhD , Zhao Liu PhD , Jianbin Huang PhD , Yidan Chen PhD , Prof Xuejie Gao PhD , Prof Ying Xu PhD , Prof Can Wang PhD , Prof Wenjia Cai PhD , Prof Peng Gong PhD , Prof Yong Luo PhD , Prof Tiantian Li PhD","doi":"10.1016/S2542-5196(24)00202-X","DOIUrl":"10.1016/S2542-5196(24)00202-X","url":null,"abstract":"<div><h3>Background</h3><div>Climate-change-induced extreme precipitation events have attracted global attention; however, the associated excess deaths burden has been insufficiently explored and remains unclear.</div></div><div><h3>Methods</h3><div>We first defined an extreme precipitation event for each county when the daily total precipitation exceeded the county-specific 99·5th percentile of the daily precipitation from 1986 to 2005; then we estimated the associations between extreme precipitation events and cause-specific deaths in 280 Chinese counties using a two-stage time-series model. Second, we projected the excess deaths related to extreme precipitation events by combining the bias-corrected multi-model precipitation predictions derived under different combined emission-population scenarios of three representative concentration pathways (RCPs; RCP2·6, RCP4·5, and RCP8·5) and three shared socioeconomic pathways (SSP2, a business-as-usual scenario) populations (S1, low fertility rate; S2, medium fertility rate; and S3, high fertility rate). We quantified the climate and population contributions to the changes of future excess deaths nationwide and by climatic zones.</div></div><div><h3>Findings</h3><div>Compared with the non-extreme precipitation days, the percentage increase of deaths associated with exposure to extreme precipitation days is 13·0% (95% CI 7·0–19·3) for accidental cause, 4·3% (2·0–6·6) for circulatory disease, and 6·8% (2·8–10·9) for respiratory disease. The number of annual average excess deaths related to extreme precipitation events during 1986–2005 was 2644 (95% CI 1496–3730) for accidental cause, 69 (33–105) for circulatory disease, and 181 (79–279) for respiratory disease. In the 2030s, the total number of excess deaths of these three causes will increase by 1244 (43%), 1756 (61%), and 2008 (69%) under RCP2·6, RCP4·5, and RCP8·5 scenarios combined with a medium-fertility-rate population (SSP2-S2), respectively, but will decrease by 3% under RCP2·6–SSP2-S2 and increase by 25% under RCP8·5–SSP2-S2 in the 2090s. Humid and water-limited regions in subtropical, middle-temperate, and plateau climate zones will face highly increased risks. Climate and population factors contributed disproportionally among the five climate zones.</div></div><div><h3>Interpretation</h3><div>This study is the largest integrated projection exploring the disease burden associated with extreme precipitation events. The excess deaths will be amplified by climate and population changes. Improving mitigation and adaptation capacities is crucial when responding to precipitation extremes.</div></div><div><h3>Funding</h3><div>National Natural Science Foundation of China and Wellcome Trust.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 10","pages":"Pages e723-e733"},"PeriodicalIF":24.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prof Ding Ding PhD , Mengyun Luo PhD , Maria Florencia Petrelli Infante MSc , Lucy Gunn PhD , Deborah Salvo PhD , Belen Zapata-Diomedi PhD , Prof Ben Smith PhD , Prof William Bellew PhD , Prof Adrian Bauman PhD , Tracy Nau BSc , Binh Nguyen PhD
{"title":"The co-benefits of active travel interventions beyond physical activity: a systematic review","authors":"Prof Ding Ding PhD , Mengyun Luo PhD , Maria Florencia Petrelli Infante MSc , Lucy Gunn PhD , Deborah Salvo PhD , Belen Zapata-Diomedi PhD , Prof Ben Smith PhD , Prof William Bellew PhD , Prof Adrian Bauman PhD , Tracy Nau BSc , Binh Nguyen PhD","doi":"10.1016/S2542-5196(24)00201-8","DOIUrl":"10.1016/S2542-5196(24)00201-8","url":null,"abstract":"<div><div>Active travel is a widely recognised strategy for promoting active living but its co-benefits beyond increasing physical activity, such as broader health, environmental, and social benefits, have rarely been synthesised. We conducted a systematic review to examine the co-benefits of active travel interventions. Following a preregistered protocol (PROSPERO CRD42022359059), we identified 80 studies for the search period from Jan 1, 2000, to Sept 13, 2022. Across studies, there was consistent evidence that active travel interventions offered co-benefits beyond physical activity. Particularly, 25 (71%) of 35 studies favoured improved safety outcomes, 20 (67%) of 30 showed improved health, 17 (85%) of 20 supported economic benefits, 16 (84%) of 19 highlighted improved transport quality, 12 (92%) of 13 showed environmental benefits, and four (80%) of five documented social benefits. Despite the overall low-certainty evidence, mostly limited by the quasi-experimental design and natural-experimental design of many of the studies, active travel interventions offer unique opportunities to engage stakeholders across sectors to jointly address major societal issues, such as physical inactivity, traffic safety, and carbon emissions. This evidence can inform the design, implementation, and evaluation of active travel interventions.</div></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 10","pages":"Pages e790-e803"},"PeriodicalIF":24.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronan Adler Tavella , Fernando Rafael de Moura , Simone Georges El Khouri Miraglia , Flavio Manoel Rodrigues da Silva Júnior
{"title":"A New Dawn for Air Quality in Brazil","authors":"Ronan Adler Tavella , Fernando Rafael de Moura , Simone Georges El Khouri Miraglia , Flavio Manoel Rodrigues da Silva Júnior","doi":"10.1016/S2542-5196(24)00203-1","DOIUrl":"10.1016/S2542-5196(24)00203-1","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 10","pages":"Pages e717-e718"},"PeriodicalIF":24.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Bonell PhD , Prof Ana M Vicedo-Cabrera PhD , Giovenale Moirano PhD , Bakary Sonko BSc , David Jeffries PhD , Prof Sophie E Moore PhD , Prof Andy Haines F Med Sci , Prof Andrew M Prentice PhD , Prof Kris A Murray PhD
{"title":"Effect of heat stress in the first 1000 days of life on fetal and infant growth: a secondary analysis of the ENID randomised controlled trial","authors":"Ana Bonell PhD , Prof Ana M Vicedo-Cabrera PhD , Giovenale Moirano PhD , Bakary Sonko BSc , David Jeffries PhD , Prof Sophie E Moore PhD , Prof Andy Haines F Med Sci , Prof Andrew M Prentice PhD , Prof Kris A Murray PhD","doi":"10.1016/S2542-5196(24)00208-0","DOIUrl":"10.1016/S2542-5196(24)00208-0","url":null,"abstract":"<div><h3>Background</h3><div>The intersecting crises of climate change, food insecurity, and undernutrition disproportionately affect children. Understanding the effect of heat on growth from conception to 2 years of age is important because of mortality and morbidity implications in the near term and over the life course.</div></div><div><h3>Methods</h3><div>In this secondary analysis, we used longitudinal pregnancy cohort data from the Early Nutrition and Immunity Development (ENID) randomised controlled trial in West Kiang, The Gambia, which occurred between Jan 20, 2010, and Feb 10, 2015. The ENID trial assessed micronutrient supplementation in the first 1000 days of life starting from 20 weeks’ gestation, during which anthropometric measurements were collected prospectively. We used multivariable linear regression to assess the effect of heat stress (defined by Universal Thermal Climate Index [UTCI]) on intrauterine growth restriction based on length-for-gestational age Z score (LGAZ), weight-for-gestational age Z score (WGAZ), and head circumference-for-gestational age Z score (HCGAZ) at birth, and assessed for effect modification of supplement intervention on the relationship between heat stress and infant anthropometry. We used multivariable, multilevel linear regression to evaluate the effect of heat stress on infant growth postnatally based on weight-for-height Z score (WHZ), weight-for-age Z score (WAZ), and height-for-age Z score (HAZ) from 0 to 2 years of age.</div></div><div><h3>Findings</h3><div>Complete data were available for 668 livebirth outcomes (329 [49%] female infants and 339 [51%] male infants). With each 1°C increase in mean daily maximum UTCI exposure, in the first trimester, we observed a reduction in WGAZ (–0·04 [95% CI –0·09 to 0·00]), whereas in the third trimester, we observed an increase in HCGAZ (0·06 [95% CI 0·00 to 0·12]), although 95% CIs included 0. Maternal protein-energy supplementation in the third trimester was associated with reduced WGAZ (–0·16 [–0·30 to –0·02]) with each 1°C increase in mean daily maximum UTCI exposure, while no effect of heat stress on WGAZ was found with either standard care (iron and folate) or multiple micronutrient supplementation. For the postnatal analysis, complete anthropometric data at 2 years were available for 645 infants (316 [49%] female infants and 329 [51%] male infants). Postnatally, heat stress effect varied by infant age, with infants aged 6–18 months being the most affected. In infants aged 12 months exposed to a mean daily UTCI of 30°C (preceding 90-day period) versus 25°C UTCI, we observed reductions in mean WHZ (–0·43 [95% CI –0·57 to –0·29]) and mean WAZ (–0·35 [95% CI –0·45 to –0·26]). We observed a marginal increase in HAZ with increasing heat stress exposure at age 6 months, but no effect at older ages.</div></div><div><h3>Interpretation</h3><div>Our results suggest that heat stress impacts prenatal and postnatal growth up to 2 years of age but sensitivity mig","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 10","pages":"Pages e734-e743"},"PeriodicalIF":24.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joost D Piët , Amy Booth , Erik M Donker , Fabrizio de Ponti , Carlotta Lunghi , Elisabetta Poluzzi , Ben J A Janssen , SanYuMay Tun , Charlotte Bekker , Lorena Dima , João Costa , Mathilde Jalving , Thijs H Oude Munnink , Patricia M L A van den Bemt , Marc Labriffe , Tomás van Emden , Vera van Waardenburg , Robert Likic , Milan Richir , Michiel A van Agtmael , Jelle Tichelaar
{"title":"Environmentally sustainable prescribing: recommendations for EU pharmaceutical legislation","authors":"Joost D Piët , Amy Booth , Erik M Donker , Fabrizio de Ponti , Carlotta Lunghi , Elisabetta Poluzzi , Ben J A Janssen , SanYuMay Tun , Charlotte Bekker , Lorena Dima , João Costa , Mathilde Jalving , Thijs H Oude Munnink , Patricia M L A van den Bemt , Marc Labriffe , Tomás van Emden , Vera van Waardenburg , Robert Likic , Milan Richir , Michiel A van Agtmael , Jelle Tichelaar","doi":"10.1016/S2542-5196(24)00230-4","DOIUrl":"10.1016/S2542-5196(24)00230-4","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 10","pages":"Pages e715-e716"},"PeriodicalIF":24.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Planetary Health and Disaster Risk Reduction: the Sendai Framework at its Midpoint","authors":"Liz Willetts","doi":"10.1016/S2542-5196(24)00200-6","DOIUrl":"10.1016/S2542-5196(24)00200-6","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 9","pages":"Pages e613-e615"},"PeriodicalIF":24.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542519624002006/pdfft?md5=d776028120d7c9cd16512ab89146cc07&pid=1-s2.0-S2542519624002006-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}