Sun-Ja Kim, Sihyun Park, Sunja Kim, Suyeon Park, Yoonjung Kim, Yunjung Choi, Sungha Yun, Kyungwon Oh
{"title":"Plan and operations of the 10th Korea National Health and Nutrition Examination Survey (2025-2027).","authors":"Sun-Ja Kim, Sihyun Park, Sunja Kim, Suyeon Park, Yoonjung Kim, Yunjung Choi, Sungha Yun, Kyungwon Oh","doi":"10.4178/epih.e2026001","DOIUrl":"10.4178/epih.e2026001","url":null,"abstract":"<p><p>The Korea National Health and Nutrition Examination Survey (KNHANES) is a national health survey mandated by Article 16 of the National Health Promotion Act to assess the health and nutritional status of the Korean population. Over the past 2 decades, the survey has continuously introduced timely survey components while strengthening its survey methodology and operational systems to enhance both the policy relevance and scientific utility of its findings. The 10th KNHANES (2025-2027) preserves the statistical representativeness of its sampling design while expanding the use of web-based self-administered questionnaires to improve participant convenience. In response to Korea's transition into a super-aged society, the 10th KNHANES incorporates enhanced older-adult health surveys, including osteoporosis assessment and older adults' life functioning, and newly introduces items addressing social support as part of the social determinants of health. In addition, a longitudinal follow-up survey system has been established to monitor long-term changes in population health. Collectively, these changes are expected to improve understanding of aging-related health issues, support evidence-based national health policy development, and expand the applicability of KNHANES data for academic research.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026001"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeong Hyun Ahn, Hyejin Kim, Hyeon Chang Kim, Hokyou Lee, Younga Heather Lee, Donald M Lloyd-Jones, Sun Jae Jung
{"title":"Association between cardiovascular health measured by Life's Essential 8 and depressive symptoms.","authors":"Jeong Hyun Ahn, Hyejin Kim, Hyeon Chang Kim, Hokyou Lee, Younga Heather Lee, Donald M Lloyd-Jones, Sun Jae Jung","doi":"10.4178/epih.e2026013","DOIUrl":"10.4178/epih.e2026013","url":null,"abstract":"<p><strong>Objectives: </strong>Poor cardiovascular health (CVH) and the high prevalence of depressive symptoms represent significant public health concerns, underscoring the importance of examining their association. This study aimed to investigate the association between CVH, as defined by the American Heart Association's 2022 Life's Essential 8 (LE8) framework, and depressive symptoms.</p><p><strong>Methods: </strong>This study used data from the 2014, 2016, 2018, and 2020 Korea National Health and Nutrition Examination Survey. Overall CVH, measured using LE8, was categorized into 3 groups: low score (0-<50), moderate score (50-<80), and high score (80-100). LE8 comprises 2 subdomains: health behaviors and health factors. Depressive symptoms were defined as a total score ≥10 on the Patient Health Questionnaire-9. Multiple logistic regression analyses were performed, adjusting for sex, age, socioeconomic status, and current drinking status.</p><p><strong>Results: </strong>Among 17,294 adults, 257 male and 681 female reported significant depressive symptoms. Compared with individuals in the low LE8 category (reference), the odds ratio (OR) for depressive symptoms was 0.29 (95% confidence interval [CI], 0.21 to 0.40) for those in the high LE8 category. The OR for depressive symptoms was 0.39 (95% CI, 0.29 to 0.53) for individuals with a high health behavior score compared with those with a low health behavior score. In contrast, the health factor score was not significantly associated with depressive symptoms.</p><p><strong>Conclusions: </strong>These findings suggest that overall CVH, particularly the health behavior subdomain, was associated with lower odds of depressive symptoms. Prospective longitudinal studies are warranted to validate these findings and clarify the directionality of the observed associations.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026013"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yujin Lee, Ji Su Yang, Alexander C Tsai, Jee In Kang, Hearan Koo, Hyeon Woo Yim, Hyeon Chang Kim, Sun Jae Jung
{"title":"Comorbidity network of post-traumatic stress and depressive symptoms during the COVID-19 pandemic in Korea.","authors":"Yujin Lee, Ji Su Yang, Alexander C Tsai, Jee In Kang, Hearan Koo, Hyeon Woo Yim, Hyeon Chang Kim, Sun Jae Jung","doi":"10.4178/epih.e2026006","DOIUrl":"10.4178/epih.e2026006","url":null,"abstract":"<p><strong>Objectives: </strong>The coronavirus disease 2019 (COVID-19) pandemic had direct effects on population health through infection and morbidity, as well as indirect effects on population mental health. We estimated the network structure of post-traumatic stress symptoms (PTSS) and depressive symptoms throughout the pandemic in Korea and aimed to identify the most central and bridging symptoms.</p><p><strong>Methods: </strong>Participants aged 30-64 years completed mental health surveys across 3 phases of the COVID-19 pandemic: March 2020 (n=1,925), February-March 2021 (n=1,754), and December 2021-January 2022 (n=1,595). Using PTSS and depressive symptom data, we conducted network analyses, and the primary measures of symptom importance (centrality) were expected influence and bridge expected influence.</p><p><strong>Results: </strong>In the comorbidity network, although the most central symptoms fluctuated over the course of the pandemic, sleep problems were consistently identified as the most influential bridge symptoms throughout. The symptom network structure differed between the subacute and chronic phases of the pandemic.</p><p><strong>Conclusions: </strong>We found evidence of changes in the network structure of PTSS and depressive symptoms, even as sleep problems retained a consistent role as a bridging symptom. Although overall network structures varied across phases of the pandemic, the bridging role of sleep-related symptoms remained consistently strong, suggesting that sleep problems may represent a general and enduring mechanism underlying PTSS-depression comorbidity. During future pandemics, prompt screening for sleep problems may help prevent the development of comorbidity between PTSS and depressive symptoms.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026006"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eun Jung Park, Kyoungyeol Yuk, Jaeho Jeong, Won Jin Lee
{"title":"Confounding and the healthy worker survivor effect in studies of medical radiation workers: a systematic review of methodological approaches.","authors":"Eun Jung Park, Kyoungyeol Yuk, Jaeho Jeong, Won Jin Lee","doi":"10.4178/epih.e2026009","DOIUrl":"10.4178/epih.e2026009","url":null,"abstract":"<p><p>Confounding and the healthy worker survivor effect (HWSE) represent major methodological challenges in epidemiology, particularly in studies of low-dose exposures, where effect sizes are small and risk estimates can be readily distorted by bias. This systematic review aimed to summarize the methods used to adjust for confounding and the HWSE in studies of medical radiation workers. We systematically searched PubMed and Embase for studies of medical radiation workers from inception through June 30, 2025. Studies reporting excess risk estimates for any health outcomes associated with occupational radiation exposure were included. Study selection followed the PECO (Population, Exposure, Comparator, Outcome) criteria, and data were synthesized descriptively. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD42024589851). Sixteen eligible studies from 3 countries were identified, all of which were rated as high quality. To control for confounding, regression was used in all studies, followed by stratification (62.5%) and restriction (18.8%). Age, sex, and birth year were adjusted for in all models, with smoking being the next most frequently controlled variable. To mitigate the HWSE, only a single approach, adjustment for employment characteristics, was identified, and it was applied in 3 studies (18.8%). No other approaches, including restriction or g-methods, were employed. Although confounding is generally addressed using conventional analytical approaches, the HWSE has rarely been considered in studies of medical radiation workers. More comprehensive strategies that explicitly account for the HWSE are needed to improve the validity of risk estimates, particularly in low-dose occupational studies.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026009"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Eugenia Galeano, Magaly Martínez, Anibal Francisco Espínola, Eliana Andrea Alvarenga, Margarita Samudio
{"title":"Childhood mortality from acute diarrheal disease in Paraguay and vaccination impact: a 31-year ecological study.","authors":"María Eugenia Galeano, Magaly Martínez, Anibal Francisco Espínola, Eliana Andrea Alvarenga, Margarita Samudio","doi":"10.4178/epih.e2026010","DOIUrl":"10.4178/epih.e2026010","url":null,"abstract":"<p><strong>Objectives: </strong>Acute diarrheal disease (ADD) remains a leading cause of morbidity and mortality in children under 5 worldwide. In Paraguay, the introduction of the rotavirus vaccine in 2010 aimed to reduce the burden of ADD in infants and young children. This study analyzed 31 years of public data on ADD morbidity and mortality in Paraguayan children under 5 and evaluated the impact of rotavirus vaccination.</p><p><strong>Methods: </strong>Annual ADD incidence, total deaths, and mortality rates from 1993 to 2023 were obtained from public databases. Proportionate mortality due to ADD, cause-specific mortality rates, absolute risk reduction (ARR) and relative risk reduction (RRR), and joinpoint regression were calculated using EPIDAT 4.2 and Joinpoint 5.3.0 software, with data stratified by age group and vaccination period.</p><p><strong>Results: </strong>Between 1993 and 2021, pediatric mortality in Paraguay declined steadily across all age groups. Following the introduction of Rotarix in 2010, infant mortality dropped from 2.36 to 0.19 deaths per 1,000 live births (ARR, 0.83; RRR, 81.4%). Joinpoint analysis showed a decline in under-5 mortality between 2009 and 2012 (annual percentage change=-35.2%, p<0.05), followed by stabilization. ADD incidence increased until 2019 and then declined, while vaccine coverage exceeded 70%.</p><p><strong>Conclusions: </strong>Paraguay has sustained declines in infant and childhood mortality over 3 decades through improvements in healthcare and immunization, with the 2010 introduction of Rotarix reducing the mortality rate by 43 deaths per 100,000 infants under 12 months. These results underscore the impact of vaccination and health system strengthening, while highlighting the need to monitor emerging threats.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026010"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of work-time control with burnout and turnover intention: a cross-sectional analysis of a general working population in Korea.","authors":"Hye-Eun Lee, Seong-Sik Cho, Mo-Yeol Kang","doi":"10.4178/epih.e2026011","DOIUrl":"10.4178/epih.e2026011","url":null,"abstract":"<p><strong>Objectives: </strong>For employees, work-time control (WTC) may protect against burnout and turnover. However, evidence from Korean workplaces is limited. This study aimed to examine whether WTC is associated with burnout and turnover intention and to test whether burnout mediates this relationship.</p><p><strong>Methods: </strong>We analyzed data from 4,745 wage workers in the 2024 wave of the Korean Work, Sleep, and Health Study. WTC was assessed across 6 domains, burnout was measured using the Korean Burnout Syndrome Scale, and turnover intention was assessed using a validated 4-item scale. Logistic regression was used to estimate the associations of WTC quartile with burnout and turnover intention, and mediation analysis was used to decompose the association between WTC and turnover intention through burnout.</p><p><strong>Results: </strong>Among 4,745 workers, the prevalence of burnout was 3.9% and turnover intention was 34.5%; both increased stepwise across lower WTC quartiles. In adjusted models, workers in the lowest WTC quartile had higher odds of burnout (odds ratio [OR], 3.95; 95% confidence interval [CI], 2.41 to 6.47) and turnover intention (OR, 2.24; 95% CI, 1.85 to 2.71) than those in the highest quartile. Mediation analysis showed that burnout explained 36.6% (95% CI, 22.3 to 51.0) of the association between WTC and turnover intention.</p><p><strong>Conclusions: </strong>Lower WTC was linked to higher burnout and turnover intention, with burnout explaining more than one-third of this relationship.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026011"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ju Young Jung, Chang-Mo Oh, Jae-Hong Ryoo, Sung Keun Park
{"title":"Hematological inflammatory indices and their relationship to the risk of hypertension.","authors":"Ju Young Jung, Chang-Mo Oh, Jae-Hong Ryoo, Sung Keun Park","doi":"10.4178/epih.e2026008","DOIUrl":"10.4178/epih.e2026008","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic inflammation has been implicated in the development of hypertension in numerous previous studies. However, evidence regarding the association between hematological inflammatory indices derived from complete blood count tests and the long-term risk of hypertension remains limited. Therefore, this study aimed to investigate the association between various hematological inflammatory indices and the risk of incident hypertension in a large cohort study.</p><p><strong>Methods: </strong>We analyzed data from a large Korean cohort (n=128,241). The incident risk of hypertension was evaluated according to quartiles of the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) using Cox proportional hazards models. Additional analyses were conducted for high-sensitivity C-reactive protein (hsCRP) levels and stratified by gender.</p><p><strong>Results: </strong>During a median follow-up of 6.8 years, 18,503 participants (14.4%) developed hypertension. Higher quartiles of SII, SIRI, and NLR were significantly associated with an increased risk of incident hypertension in both genders. PLR showed a clearer positive association in women, whereas MLR demonstrated only marginal associations. These patterns were consistent with the associations observed for hsCRP.</p><p><strong>Conclusions: </strong>These findings suggest that elevated hematological inflammatory indices above certain thresholds are associated with an increased risk of hypertension, even among young and generally healthy individuals.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026008"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young Kyu Shim, Young Hwa Lee, Young June Choe, Yoonsun Yoon, Yun-Kyung Kim
{"title":"Cohort profile: Korean Varicella Immunization Monitoring (K-VIM) Scheme: a national cohort of children born 2011-2022.","authors":"Young Kyu Shim, Young Hwa Lee, Young June Choe, Yoonsun Yoon, Yun-Kyung Kim","doi":"10.4178/epih.e2026005","DOIUrl":"10.4178/epih.e2026005","url":null,"abstract":"<p><p>Varicella, caused by the varicella-zoster virus, was once nearly universal in childhood before the advent of vaccination and may lead to severe complications and even fatalities. Monitoring varicella vaccine effectiveness is crucial yet often overlooked in settings with limited surveillance infrastructure. The Korean Varicella Immunization Monitoring (K-VIM) Scheme was established to address this gap by assembling a national, insurance-based birth cohort of children born between 2011 and 2022 (n=4,505,165). This cohort leverages comprehensive healthcare databases in Korea to capture vaccination records, medical visits, and varicella infection outcomes for virtually all children within the target birth years. We describe the enrollment and key characteristics of the K-VIM cohort, including vaccination coverage, demographic features, and varicella incidence to date. The structure and completeness of Korea's national health insurance and immunization registries enable robust longitudinal tracking of varicella infections among vaccinated versus unvaccinated children. Early findings demonstrate distinct patterns in infection rates and disease severity according to vaccination status. The K-VIM Scheme provides a foundation for ongoing epidemiological studies of varicella vaccine effectiveness and public health impact in Korea. Future plans include evaluating the long-term effects of varicella vaccination, including potential impacts on herpes zoster incidence, using diverse study designs to strengthen causal inference and inform immunization policy.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026005"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taeyoung Kim, Yoonhee Jung, Koun Kim, Jung Wan Park, Jeonghee Yu, Sung-Il Cho
{"title":"Cohort profile: a nationwide retrospective cohort of mortality in people living with HIV in Korea, 1985-2020.","authors":"Taeyoung Kim, Yoonhee Jung, Koun Kim, Jung Wan Park, Jeonghee Yu, Sung-Il Cho","doi":"10.4178/epih.e2025002","DOIUrl":"10.4178/epih.e2025002","url":null,"abstract":"<p><p>The increasing number of people living with human immunodeficiency virus (HIV) in Korea has prompted interest in using the national surveillance system as a database for studying their health. To investigate the relationships between socio-demographic and epidemiological characteristics and mortality rates, a nationwide retrospective cohort was formed by integrating surveillance data with the Cause of Death Statistics from Statistics Korea. This integration included incidence reports, epidemiological investigations, and death reports from the surveillance data, enriched with detailed mortality information from the Cause of Death data. The cohort comprised 17,199 adult Korean individuals diagnosed with HIV infection from 1985 to 2020. By the end of 2020, 2,721 of these individuals were confirmed deceased. The sex ratio of the study participants was 14.3:1.0 (male to female), with 78.2% being under 50 years old at the time of diagnosis. Sexual contact was identified as the primary transmission route, accounting for 75.7% of cases. HIV disease emerged as the predominant cause of death, representing two-thirds (1,817 of 2,721) of the fatalities, followed by injuries and trauma, malignancies, and cardiovascular diseases. Recommendations for further cohort studies may be submitted to the Korea Disease Control and Prevention Agency.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2025002"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sungsub Choo, Ranyeong Kim, Hyemin Lee, Horim Yi, Rockli Kim, Seung-Sup Kim
{"title":"Being trans in Korea: key milestones and stigmatization across life stages in a nationwide survey of 585 transgender and non-binary young adults.","authors":"Sungsub Choo, Ranyeong Kim, Hyemin Lee, Horim Yi, Rockli Kim, Seung-Sup Kim","doi":"10.4178/epih.e2025032","DOIUrl":"10.4178/epih.e2025032","url":null,"abstract":"<p><strong>Objectives: </strong>Understanding the experiences of transgender and non-binary (TGNB) individuals from a life-course perspective is essential. This article aims to identify ages at key milestones related to transgender identity and assess experiences of stigmatization among TGNB individuals across different life stages.</p><p><strong>Methods: </strong>We analyzed data from a nationwide longitudinal survey of 585 TGNB adults in Korea collected in 2020 and 2021. Analysis of variance and chi-square test were used to compare mean ages at transgender identity developmental milestones and experiences of anti-transgender stigma across transgender identities.</p><p><strong>Results: </strong>On average, TGNB Koreans realized their transgender identity at age 13, accepted it at age 20, and came out to others at age 21. Regarding experiences of stigmatization across different life stages, 67.4% reported hearing homophobic and transphobic remarks from teachers in secondary school. Among TGNB individuals assigned male at birth (AMAB) who served mandatory military service, 29.0% were classified as maladjusted soldiers, and 12.1% experienced sexual harassment or violence. When asked about the job application process, 57.0% reported discontinuing their job search due to their transgender identity. Financial burden represented the primary barrier to psychiatric evaluations, hormone treatment, and gender-affirming surgery.</p><p><strong>Conclusions: </strong>Our study identifies key milestone ages related to transgender identity and experiences of stigmatization across life stages among TGNB adults in Korea. With 97.6% of participants under 40 years old, these findings primarily reflect the experiences of TGNB young adults. Further research is necessary to better understand the experiences of middle-aged and elderly TGNB individuals in Korea.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2025032"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}