Cohort profile update: the Korean Cancer Prevention Study-II (KCPS-II) biobank.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Epidemiology and Health Pub Date : 2025-01-01 Epub Date: 2025-07-29 DOI:10.4178/epih.e2025040

Heejin Kimm, Keum Ji Jung, Wes Spiller, Yeun Soo Yang, So Young Kim, Min Young Park, Sun Mi Lee, Sun Ha Jee

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引用次数: 0

Abstract

Chronic diseases such as cancer and cardiovascular disease have a substantial impact on mortality and global disease burden. The Korean Cancer Prevention Study-II (KCPS-II) biobank was established to investigate these chronic diseases, with a particular focus on metabolic risk factors. Recently, genetic information reflecting diverse ancestries has been incorporated to support a precision medicine approach. These data can be leveraged to identify variation in causal effects among different ancestral groups, thereby informing the development of more effective, ancestry-specific treatments. From 2004 to 2013, baseline data were collected from 156,701 individuals aged 20-85 years, recruited from 18 health promotion centers across Korea. Outcome data are routinely obtained from Statistics Korea (mortality data), the National Cancer Center (cancer registry data), and the National Health Insurance Service (morbidity data). Additionally, new participants have been enrolled since 2022 as part of an ongoing expansion. This population-based cohort, enriched with genetic data, provides a robust foundation for research aimed at elucidating causal relationships in chronic disease.

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队列简介更新：韩国癌症预防研究ii （KCPS-II）生物库。

癌症和心血管疾病等慢性病对死亡率和全球疾病负担产生重大影响。韩国癌症预防研究ii （KCPS-II）生物库的建立是为了调查这些慢性疾病，特别关注代谢危险因素。最近，反映不同祖先的遗传信息已被纳入支持精准医疗方法。可以利用这些数据来确定不同祖先群体之间因果效应的差异，从而为开发更有效的、针对祖先的治疗提供信息。从2004年到2013年，从韩国18个健康促进中心招募的156,701名年龄在20-85岁之间的人收集了基线数据。结果数据通常从韩国统计局（死亡率数据）、国家癌症中心（癌症登记数据）和国民健康保险局（发病率数据）获得。此外，自2022年以来，作为持续扩张的一部分，新的参与者已经注册。这个以人群为基础的队列，丰富了遗传数据，为旨在阐明慢性疾病因果关系的研究提供了坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epidemiology and Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

6.30

自引率

2.60%

发文量

106

审稿时长

4 weeks

期刊介绍： Epidemiology and Health (epiH) is an electronic journal publishing papers in all areas of epidemiology and public health. It is indexed on PubMed Central and the scope is wide-ranging: including descriptive, analytical and molecular epidemiology; primary preventive measures; screening approaches and secondary prevention; clinical epidemiology; and all aspects of communicable and non-communicable diseases prevention. The epiH publishes original research, and also welcomes review articles and meta-analyses, cohort profiles and data profiles, epidemic and case investigations, descriptions and applications of new methods, and discussions of research theory or public health policy. We give special consideration to papers from developing countries.