{"title":"Regional disparities in emergency retinal surgery: interregional transfer and visual disability in a nationwide population-based study in Korea.","authors":"EunAh Kim, Seonghee Nam","doi":"10.4178/epih.e2026053","DOIUrl":"https://doi.org/10.4178/epih.e2026053","url":null,"abstract":"<p><strong>Objectives: </strong>To assess regional disparities in access to emergency surgery for rhegmatogenous retinal detachment (RRD) in South Korea and the association between interregional patient transfer and long-term visual disability.</p><p><strong>Methods: </strong>We used the Health Insurance Review and Assessment Service database to identify 54,269 patients aged ≥11 years who underwent RRD surgery within 30 days of diagnosis during 2014-2023. Interregional transfer was defined as discordance between the regions of residence and surgery across 6 administrative regions. Logistic regression and Cox proportional hazards models were used to assess associations of transfer with reoperation and visual disability registration, adjusting for demographic characteristics, comorbidities, and socioeconomic factors.</p><p><strong>Results: </strong>Overall, 5,224 patients (9.6%) underwent interregional transfer; 76.4% traveled to the Seoul metropolitan area, the only net recipient region (+12.2%). Jeju (-38.6%) and Gangwon (-28.8%) had the greatest outflow. Transfer was associated with a higher risk of visual disability (adjusted hazard ratio, 1.4; 95% confidence interval: 1.2-1.7; P < 0.001), but not with reoperation (P = 0.960). Surgical delay was more frequent among transferred patients (42.0% vs 33.6%; P < 0.001). Jeju's net outflow decreased from -69.8% in 2018 to -2.6% in 2023.</p><p><strong>Conclusion: </strong>Despite universal health insurance, regional disparities in access to retinal surgery persist in Korea, with services concentrated in the Seoul metropolitan area. Transfer was independently associated with visual disability but not reoperation. The underlying mechanism likely involves referral of complex cases, patient preference, and transfer-related delay, although claims data cannot distinguish their relative contributions. Jeju's rapid improvement in self-sufficiency illustrates the potential for targeted regional investment to reduce these disparities.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026053"},"PeriodicalIF":2.4,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intention to quit tobacco use within 1 month according to tobacco product use patterns among Korean adult men: Korea National Health and Nutrition Examination Survey, 2019-2022.","authors":"Da-Yeon Park, Ji-Yeon Shin","doi":"10.4178/epih.e2026052","DOIUrl":"https://doi.org/10.4178/epih.e2026052","url":null,"abstract":"<p><strong>Objectives: </strong>Novel tobacco products (NTPs), including heated tobacco products (HTPs) and liquid-type e-cigarettes, are widely used in Korea, but their relationship with cessation intentions remains unclear. We examined cross-sectional associations between tobacco product use patterns and intention to quit tobacco use within 1 month among Korean adult men.</p><p><strong>Methods: </strong>We used Korea National Health and Nutrition Examination Survey data (2019-2022) to analyze 3,218 men aged ≥19 years who currently used tobacco products. The primary analysis compared NTP users with conventional cigarette-only users; secondary analyses examined 7 mutually exclusive use patterns. We estimated associations using survey-weighted logistic regression, adjusting for age, education level, household income, residential area, binge drinking, aerobic physical activity, perceived stress, and survey year.</p><p><strong>Results: </strong>NTP use was associated with lower odds of intending to quit tobacco use within 1 month (adjusted odds ratio [aOR], 0.586; 95% confidence interval, 0.443-0.774; weighted prevalence, 12.1% vs. 18.0%). Across the 7 use patterns, adjusted estimates were below 1 for every NTP-containing pattern (aOR range, 0.387-0.677; global P = 0.020).</p><p><strong>Conclusion: </strong>Among Korean adult men who currently used tobacco products, NTP use was associated with lower odds of intending to quit tobacco use within 1 month. Cessation counseling and support services should give attention to users of HTPs and liquid-type e-cigarettes.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026052"},"PeriodicalIF":2.4,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in kidney health before, during, and after the COVID-19 pandemic: a nationwide serial cross-sectional study in Korea.","authors":"Jaeuk Shin, Yu-Ji Lee","doi":"10.4178/epih.e2026051","DOIUrl":"https://doi.org/10.4178/epih.e2026051","url":null,"abstract":"<p><strong>Objectives: </strong>The population-level kidney consequences of the COVID-19 pandemic beyond confirmed infections remain uncertain. We examined temporal changes in chronic kidney disease (CKD), proteinuria, and kidney function in a nationally representative Korean population.</p><p><strong>Methods: </strong>We analyzed serial cross-sectional data from the Korea National Health and Nutrition Examination Survey (2017-2024), including adults aged ≥19 years with serum creatinine and proteinuria measurements. We classified survey periods as pre-pandemic (2017-2019), pandemic (2020-2021), and post-pandemic (2022-2024). Survey-weighted logistic and linear regression models were used to examine associations of pandemic period with CKD, proteinuria, and estimated glomerular filtration rate (eGFR), adjusting for demographic, socioeconomic, metabolic, and lifestyle factors. We also conducted age-stratified analyses.</p><p><strong>Results: </strong>The analysis included 44,831 adults (mean age, 52.8 years; 44.5% men). CKD prevalence rose from 4.65% before the pandemic to 7.88% during and 7.49% after it; proteinuria prevalence nearly doubled (3.27%, 6.68%, and 6.18%, respectively). Relative to the pre-pandemic period, the adjusted odds of CKD were higher during (odds ratio [OR], 1.22; 95% confidence interval [CI]: 1.09-1.37) and after (OR, 1.24; 95% CI: 1.10-1.39) the pandemic. The corresponding associations were larger for proteinuria (OR, 1.34; 95% CI: 1.17-1.53 and OR, 1.33; 95% CI: 1.17-1.51, respectively). Changes in eGFR were minimal, with no significant temporal trend. Associations were strongest among middle-aged and older adults, particularly for proteinuria among adults aged ≥65 years.</p><p><strong>Conclusion: </strong>CKD prevalence increased during and after the COVID-19 pandemic, largely reflecting a sustained increase in proteinuria rather than a decline in eGFR. These findings support ongoing kidney surveillance and measures to reduce cardiometabolic risk, particularly among middle-aged and older adults.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026051"},"PeriodicalIF":2.4,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nutritional status among North Korean refugee and immigrant children in South Korea: evidence of a double burden of malnutrition.","authors":"Seong Woo Choi, So-Yeong Kim, Sun-Hwa Kim","doi":"10.4178/epih.e2026049","DOIUrl":"https://doi.org/10.4178/epih.e2026049","url":null,"abstract":"<p><strong>Objectives: </strong>Children from migrant and refugee families may face a double burden of malnutrition, with undernutrition and obesity occurring within the same population. However, evidence on the nutritional status of North Korean refugee (NKR) and immigrant children in South Korea (SK) remains limited. This study compared nutritional status among SK, NKR, and immigrant children.</p><p><strong>Methods: </strong>Data for 2,856 SK children were obtained from the 2021-2023 Korea National Health and Nutrition Examination Survey. Separately, 336 NKR children and 597 immigrant children were recruited between 2021 and 2025. Nutritional status was evaluated using the World Health Organization AnthroPlus software.</p><p><strong>Results: </strong>After adjustment for sex and age, NKR and immigrant children had significantly higher odds than SK children of undernutrition (odds ratio [OR]: 3.18; 95% confidence interval [CI]: 1.90-5.31; and OR: 2.39; 95% CI: 1.50-3.80, respectively), stunting (OR: 5.16; 95% CI: 2.42-10.99; and OR: 4.13; 95% CI: 2.12-8.04, respectively), and obesity (OR: 1.58; 95% CI: 1.16-2.14; and OR: 1.54; 95% CI: 1.21-1.96, respectively). Among first-generation immigrant children, longer residence in SK was associated with higher odds of obesity (OR: 2.08; 95% CI: 1.02-4.24). Second-generation NKR children also had higher odds of obesity than first-generation NKR children (OR: 2.97; 95% CI: 1.61-5.48).</p><p><strong>Conclusion: </strong>NKR and immigrant children showed a double burden of malnutrition, with both persistent undernutrition and elevated obesity. Targeted nutrition interventions are needed to reduce nutritional disparities and improve outcomes among migrant and refugee children in SK.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026049"},"PeriodicalIF":2.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuri Chai, Soojin Im, Bora Lee, Sungho Won, Hyein Han
{"title":"Sex-specific predictors of first major chronic disease or cancer events in Korean adults: a linked health screening and claims-based cohort study.","authors":"Yuri Chai, Soojin Im, Bora Lee, Sungho Won, Hyein Han","doi":"10.4178/epih.e2026050","DOIUrl":"https://doi.org/10.4178/epih.e2026050","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to identify sex- and age-specific predictors of the first onset of major chronic disease or cancer among Korean adults using linked National Health Insurance Service (NHIS)-Korean Association of Health Promotion (KAHP) data and a competing risk framework that accounts for death before disease onset.</p><p><strong>Methods: </strong>A total of 102,870 adults who underwent KAHP health examinations in 2013 were followed through NHIS claims data until 2022. Nine major chronic diseases and cancers were identified using International Classification of Diseases, 10th Revision codes and clinical criteria. Sex-specific Fine-Gray subdistribution hazard models were fitted to estimate subdistribution hazard ratios. Model performance was evaluated using the time-dependent area under the receiver operating characteristic curve (AUROC) at 5 and 9.5 years.</p><p><strong>Results: </strong>Age was the strongest predictor of first disease onset in both sexes. Cardiometabolic, inflammatory, liver-related, and lifestyle-related markers showed sex-specific associations. Ischemic heart disease was the most frequent first-occurring disease, accounting for 50.3% and 46.8% of first events in males and females, respectively. Time-dependent AUROC values ranged from 0.72 to 0.73, indicating moderate and stable discrimination.</p><p><strong>Conclusion: </strong>Using linked NHIS-KAHP data and a competing risk framework, this study identified sex-specific predictors of first major chronic disease or cancer onset. The models showed moderate and stable discrimination, supporting the value of sex-specific risk assessment for chronic disease prevention and healthy aging.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026050"},"PeriodicalIF":2.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jina Chung, Hyojee Joung, Sang Min Park, Soo-Hyun Park, Hee-Joo Kang, Jin-Hee Kim, Jae-Ho Park, Sangah Shin
{"title":"Validity and reproducibility of a semi-quantitative food frequency questionnaire for Korean adults with obesity.","authors":"Jina Chung, Hyojee Joung, Sang Min Park, Soo-Hyun Park, Hee-Joo Kang, Jin-Hee Kim, Jae-Ho Park, Sangah Shin","doi":"10.4178/epih.e2026048","DOIUrl":"https://doi.org/10.4178/epih.e2026048","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the validity and reproducibility of a newly developed 129-item semi-quantitative food frequency questionnaire (FFQ) for Korean adults with obesity.</p><p><strong>Methods: </strong>Ninety-seven Korean adults aged 19-64 years with obesity participated. To assess validity, FFQ estimates were compared with 4 seasonal sets of 3-day dietary records (3DRs). Reproducibility was assessed by administering the FFQ twice, as FFQ1 and FFQ2. Agreement was evaluated using quartile cross-classification, weighted kappa statistics, and crude and energy-adjusted Spearman correlation coefficients. Bland-Altman plots evaluated individual-level agreement. Nutrient and food-group intakes were compared between FFQ1 and FFQ2.</p><p><strong>Results: </strong>The FFQ demonstrated modest relative validity for ranking individuals. Compared with mean 3DR values, same-or-adjacent quartile agreement for energy and 10 nutrients ranged from 68.0% to 82.5%, and crude correlation coefficients ranged from 0.30 to 0.56. Averaging FFQ1 and FFQ2 improved validity metrics, including the energy-adjusted correlation for sugar intake (r=0.54). Bland-Altman plots showed relatively small mean differences for most nutrients, although the limits of agreement were wide and flavonoid intake was generally overestimated. Reproducibility was good, with same-or-adjacent quartile agreement of 81.4% to 90.7% between FFQ1 and FFQ2 and nutrient correlation coefficients of 0.50 to 0.69. Similar consistency was observed for food and dish categories.</p><p><strong>Conclusion: </strong>The tailored 129-item FFQ for Korean adults with obesity showed modest validity for ranking individuals and good reproducibility. Although caution is needed when estimating precise absolute intake at the individual level, this FFQ may support epidemiological studies of diet, obesity, and related chronic diseases in Korean adults.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026048"},"PeriodicalIF":2.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship between handgrip strength and mortality among Korean adults.","authors":"Hoyong Sung, Harim Choe","doi":"10.4178/epih.e2026047","DOIUrl":"https://doi.org/10.4178/epih.e2026047","url":null,"abstract":"<p><strong>Objectives: </strong>Handgrip strength is associated with all-cause mortality, but evidence from nationally representative Asian adult populations remains limited.</p><p><strong>Methods: </strong>This study analyzed data from 27,679 adults aged ≥19 years who participated in the Korea National Health and Nutrition Examination Survey from 2014 to 2018 and were linked to Cause of Death Statistics from Statistics Korea through 2022. Handgrip strength was categorized into sex-specific quartiles. Cox proportional hazards models assessed the association between handgrip strength and all-cause mortality after covariate adjustment. Sex-stratified and sensitivity analyses, including lagged analyses and time-varying coefficient models, were conducted.</p><p><strong>Results: </strong>During a mean follow-up of 75.6 months, 1,237 deaths occurred. All-cause mortality decreased markedly across increasing handgrip strength quartiles, from 9.2% in quartile 1 (Q1) to 0.6% in Q4. In the fully adjusted model, Q1 was associated with significantly higher mortality risk than Q4 (hazard ratio [HR], 2.9; 95% confidence interval [CI], 2.1 to 3.9). Sex-stratified analyses showed a stronger association in men (Q1 vs. Q4: HR, 3.4; 95% CI, 2.2 to 5.3) than in women (HR, 2.3; 95% CI, 1.5 to 3.5), although the interaction was not statistically significant (p=0.219). Age-stratified sensitivity analyses confirmed the inverse association in younger adults aged <65 years and older adults aged ≥65 years.</p><p><strong>Conclusion: </strong>Lower handgrip strength was independently associated with higher all-cause mortality among Korean adults, and this association persisted after comprehensive covariate adjustment. These findings support the use of handgrip strength as a simple predictor of long-term mortality risk across the adult lifespan in an Asian population.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026047"},"PeriodicalIF":2.4,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Watanabe, Akihiro Shiroshita, Kazuhiko Kotani, Shizukiyo Ishikawa
{"title":"Short-term and long-term ambient NO2 exposure, dietary effect modification, and incident cardiovascular disease in rural Japan: a population-based cohort study.","authors":"Jun Watanabe, Akihiro Shiroshita, Kazuhiko Kotani, Shizukiyo Ishikawa","doi":"10.4178/epih.e2026046","DOIUrl":"https://doi.org/10.4178/epih.e2026046","url":null,"abstract":"<p><strong>Objectives: </strong>The contributions of short- and long-term nitrogen dioxide (NO2) exposure to cardiovascular disease (CVD) in rural areas remain unclear. Dietary intake may modify these associations, but this role remains understudied.</p><p><strong>Methods: </strong>We conducted a secondary analysis of a population-based prospective cohort study in 12 rural Japanese municipalities. Adults without CVD enrolled in 1992-1995 were followed until 2005. Daily municipality-level NO2 concentrations were estimated using generalized random forests. The primary outcome was time to first incident CVD (stroke or myocardial infarction). Short-term effects were estimated using extended Cox regression models with daily NO2 exposure, adjusted for confounders and CVD predictors. Long-term effects were estimated using conventional Cox regression models with average follow-up NO2 exposure. Interactions between NO2 exposure and baseline food intake were evaluated.</p><p><strong>Results: </strong>Among 10,032 individuals with complete data (116,759 person-years), 458 incident CVD cases were identified (390 strokes and 68 myocardial infarctions). In the short-term exposure analysis, each 10-ppb increase in daily NO2 exposure was associated with increased CVD risk (hazard ratio [HR], 1.26; 95% confidence interval [CI], 1.05 to 1.51; p=0.01). In the long-term analysis, each 1-ppb increase in average NO2 exposure during follow-up was associated with increased CVD risk (HR, 3.18; 95% CI, 1.54 to 6.59). For interactions between NO2 exposure and dietary intake, no associations remained significant after controlling for multiple comparisons using the false discovery rate.</p><p><strong>Conclusion: </strong>This study suggests that short- and long-term NO2 exposure may contribute to CVD risk. Long-term average exposure showed a larger effect estimate than short-term exposure.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026046"},"PeriodicalIF":2.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hae Dong Woo, Sohyun Lee, Ji Hyun Kim, Jae-Pil Jeon, Joong-Yeon Lim
{"title":"Mortality and causes of death in the Korean Genome and Epidemiology Study (KoGES), 2001-2023.","authors":"Hae Dong Woo, Sohyun Lee, Ji Hyun Kim, Jae-Pil Jeon, Joong-Yeon Lim","doi":"10.4178/epih.e2026045","DOIUrl":"https://doi.org/10.4178/epih.e2026045","url":null,"abstract":"<p><p>The Korean Genome and Epidemiology Study (KoGES) is a large prospective cohort study established to investigate determinants of chronic disease. To evaluate overall and cause-specific mortality, KoGES records were linked to the official Causes of Death Statistics compiled by Statistics Korea. Of 211,562 participants the KoGES population-based cohorts, 211,428 were successfully linked to official mortality data through December 31, 2023, using resident registration numbers. Over a mean follow-up of 14.9 years, the linked cohort had an overall mortality rate of 5.8 deaths per 1,000 person-years; the rate was higher among men than among women (9.6 vs. 3.9 deaths per 1,000 person-years). Malignant neoplasms, heart disease, and cerebrovascular disease were the leading causes of death. As the cohort aged, deaths from causes such as pneumonia increased substantially, a pattern consistent with national mortality statistics. This linked dataset provides a basis for longitudinal analyses of chronic disease progression, survival outcomes, and cause-specific mortality using repeated epidemiologic measurements collected over more than 2 decades of follow-up.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026045"},"PeriodicalIF":2.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"National trends in prevalence and healthcare expenditures of pediatric endocrine disorders in South Korea: a claims-based analysis.","authors":"Boram Sim, Hyun Joo Kim","doi":"10.4178/epih.e2026044","DOIUrl":"https://doi.org/10.4178/epih.e2026044","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined national trends in diagnosed patient counts, claims-based annual prevalence, and healthcare expenditures for pediatric diabetes, obesity, and precocious puberty in South Korea from 2017 to 2023 using National Health Insurance (NHI) claims data.</p><p><strong>Methods: </strong>Aggregated Health Insurance Review and Assessment Service claims data for individuals aged 0-19 years with a primary diagnosis of diabetes (E10-E14), obesity (E66), or precocious puberty (E30.1) were included. Diagnosed patient counts, claims-based annual prevalence, and expenditures were calculated for each condition. Exploratory segmented negative binomial regression assessed changes around 2020.</p><p><strong>Results: </strong>Diagnosed patient counts increased for diabetes (12,839 to 16,747), obesity (2,253 to 3,468), and precocious puberty (106,238 to 206,251); among males aged 5-9 years with precocious puberty, counts increased 5.5-fold. Claims-based annual prevalence increased for diabetes (0.13% to 0.21%) and precocious puberty (1.11% to 2.60%), whereas obesity peaked at 0.09% in 2021 before declining to 0.04% in 2023. All conditions showed significant pre-2020 upward trends. Diabetes showed no significant level or slope change; obesity showed no significant immediate level change but a significant downward slope change relative to the pre-2020 trend; and precocious puberty showed a significant level increase in 2020 without a significant subsequent slope change. Total NHI-covered expenditures increased by 58.0%.</p><p><strong>Conclusion: </strong>Pediatric endocrine care burden increased despite a declining pediatric population, with condition-specific post-2020 patterns. Continued surveillance is needed to monitor emerging trends and potential care gaps.</p>","PeriodicalId":48543,"journal":{"name":"Epidemiology and Health","volume":" ","pages":"e2026044"},"PeriodicalIF":2.4,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}