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A large-scale audit of dataset licensing and attribution in AI 对人工智能中的数据集许可和归属进行大规模审计
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-30 DOI: 10.1038/s42256-024-00878-8
Shayne Longpre, Robert Mahari, Anthony Chen, Naana Obeng-Marnu, Damien Sileo, William Brannon, Niklas Muennighoff, Nathan Khazam, Jad Kabbara, Kartik Perisetla, Xinyi (Alexis) Wu, Enrico Shippole, Kurt Bollacker, Tongshuang Wu, Luis Villa, Sandy Pentland, Sara Hooker
{"title":"A large-scale audit of dataset licensing and attribution in AI","authors":"Shayne Longpre, Robert Mahari, Anthony Chen, Naana Obeng-Marnu, Damien Sileo, William Brannon, Niklas Muennighoff, Nathan Khazam, Jad Kabbara, Kartik Perisetla, Xinyi (Alexis) Wu, Enrico Shippole, Kurt Bollacker, Tongshuang Wu, Luis Villa, Sandy Pentland, Sara Hooker","doi":"10.1038/s42256-024-00878-8","DOIUrl":"10.1038/s42256-024-00878-8","url":null,"abstract":"The race to train language models on vast, diverse and inconsistently documented datasets raises pressing legal and ethical concerns. To improve data transparency and understanding, we convene a multi-disciplinary effort between legal and machine learning experts to systematically audit and trace more than 1,800 text datasets. We develop tools and standards to trace the lineage of these datasets, including their source, creators, licences and subsequent use. Our landscape analysis highlights sharp divides in the composition and focus of data licenced for commercial use. Important categories including low-resource languages, creative tasks and new synthetic data all tend to be restrictively licenced. We observe frequent miscategorization of licences on popular dataset hosting sites, with licence omission rates of more than 70% and error rates of more than 50%. This highlights a crisis in misattribution and informed use of popular datasets driving many recent breakthroughs. Our analysis of data sources also explains the application of copyright law and fair use to finetuning data. As a contribution to continuing improvements in dataset transparency and responsible use, we release our audit, with an interactive user interface, the Data Provenance Explorer, to enable practitioners to trace and filter on data provenance for the most popular finetuning data collections: www.dataprovenance.org . The Data Provenance Initiative audits over 1,800 text artificial intelligence (AI) datasets, analysing trends, permissions of use and global representation. It exposes frequent errors on several major data hosting sites and offers tools for transparent and informed use of AI training data.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42256-024-00878-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is in your LLM-based framework? 您的基于 LLM 的框架中有哪些内容?
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-30 DOI: 10.1038/s42256-024-00896-6
{"title":"What is in your LLM-based framework?","authors":"","doi":"10.1038/s42256-024-00896-6","DOIUrl":"10.1038/s42256-024-00896-6","url":null,"abstract":"To maintain high standards in clarity and reproducibility, authors need to clearly mention and describe the use of GPT-4 and other large language models in their work.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42256-024-00896-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A step forward in tracing and documenting dataset provenance 在追踪和记录数据集出处方面向前迈进了一步
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-30 DOI: 10.1038/s42256-024-00884-w
Nicholas Vincent
{"title":"A step forward in tracing and documenting dataset provenance","authors":"Nicholas Vincent","doi":"10.1038/s42256-024-00884-w","DOIUrl":"10.1038/s42256-024-00884-w","url":null,"abstract":"Training data are crucial for advancements in artificial intelligence, but many questions remain regarding the provenance of training datasets, license enforcement and creator consent. Mahari et al. provide a set of tools for tracing, documenting and sharing AI training data and highlight the importance for developers to engage with metadata of datasets.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning integral operators via neural integral equations 通过神经积分方程学习积分算子
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-29 DOI: 10.1038/s42256-024-00886-8
Emanuele Zappala, Antonio Henrique de Oliveira Fonseca, Josue Ortega Caro, Andrew Henry Moberly, Michael James Higley, Jessica Cardin, David van Dijk
{"title":"Learning integral operators via neural integral equations","authors":"Emanuele Zappala, Antonio Henrique de Oliveira Fonseca, Josue Ortega Caro, Andrew Henry Moberly, Michael James Higley, Jessica Cardin, David van Dijk","doi":"10.1038/s42256-024-00886-8","DOIUrl":"10.1038/s42256-024-00886-8","url":null,"abstract":"Nonlinear operators with long-distance spatiotemporal dependencies are fundamental in modelling complex systems across sciences; yet, learning these non-local operators remains challenging in machine learning. Integral equations, which model such non-local systems, have wide-ranging applications in physics, chemistry, biology and engineering. We introduce the neural integral equation, a method for learning unknown integral operators from data using an integral equation solver. To improve scalability and model capacity, we also present the attentional neural integral equation, which replaces the integral with self-attention. Both models are grounded in the theory of second-kind integral equations, where the indeterminate appears both inside and outside the integral operator. We provide a theoretical analysis showing how self-attention can approximate integral operators under mild regularity assumptions, further deepening previously reported connections between transformers and integration, as well as deriving corresponding approximation results for integral operators. Through numerical benchmarks on synthetic and real-world data, including Lotka–Volterra, Navier–Stokes and Burgers’ equations, as well as brain dynamics and integral equations, we showcase the models’ capabilities and their ability to derive interpretable dynamics embeddings. Our experiments demonstrate that attentional neural integral equations outperform existing methods, especially for longer time intervals and higher-dimensional problems. Our work addresses a critical gap in machine learning for non-local operators and offers a powerful tool for studying unknown complex systems with long-range dependencies. Integral equations are used in science and engineering to model complex systems with non-local dependencies; however, existing traditional and machine-learning-based methods cannot yield accurate or efficient solutions in several complex cases. Zappala and colleagues introduce a neural-network-based method that can learn an integral operator and its dynamics from data, demonstrating higher accuracy or scalability compared with several state-of-the-art methods.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42256-024-00886-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142090186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning motif-based graphs for drug–drug interaction prediction via local–global self-attention 通过局部-全局自我关注,学习基于图案的药物相互作用预测图谱
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-27 DOI: 10.1038/s42256-024-00888-6
Yi Zhong, Gaozheng Li, Ji Yang, Houbing Zheng, Yongqiang Yu, Jiheng Zhang, Heng Luo, Biao Wang, Zuquan Weng
{"title":"Learning motif-based graphs for drug–drug interaction prediction via local–global self-attention","authors":"Yi Zhong, Gaozheng Li, Ji Yang, Houbing Zheng, Yongqiang Yu, Jiheng Zhang, Heng Luo, Biao Wang, Zuquan Weng","doi":"10.1038/s42256-024-00888-6","DOIUrl":"10.1038/s42256-024-00888-6","url":null,"abstract":"Unexpected drug–drug interactions (DDIs) are important issues for both pharmaceutical research and clinical applications due to the high risk of causing severe adverse drug reactions or drug withdrawals. Many deep learning models have achieved high performance in DDI prediction, but model interpretability to reveal the underlying causes of DDIs has not been extensively explored. Here we propose MeTDDI—a deep learning framework with local–global self-attention and co-attention to learn motif-based graphs for DDI prediction. MeTDDI achieved competitive performance compared with state-of-the-art models. Regarding interpretability, we conducted extensive assessments on 73 drugs with 13,786 DDIs and MeTDDI can precisely explain the structural mechanisms for 5,602 DDIs involving 58 drugs. Besides, MeTDDI shows potential to explain complex DDI mechanisms and mitigate DDI risks. To summarize, MeTDDI provides a new perspective on exploring DDI mechanisms, which will benefit both drug discovery and polypharmacy for safer therapies for patients. A transformer-based approach that predicts drug–drug interactions in polypharmacy has been shown, which also identifies perpetrator drugs and the chemical mechanisms causing the interactions. The method could facilitate high-throughput optimization of drug combinations and mitigate adverse drug–drug interaction risks.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A deep learning method that identifies cellular heterogeneity using nanoscale nuclear features 利用纳米级核特征识别细胞异质性的深度学习方法
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-27 DOI: 10.1038/s42256-024-00883-x
Davide Carnevali, Limei Zhong, Esther González-Almela, Carlotta Viana, Mikhail Rotkevich, Aiping Wang, Daniel Franco-Barranco, Aitor Gonzalez-Marfil, Maria Victoria Neguembor, Alvaro Castells-Garcia, Ignacio Arganda-Carreras, Maria Pia Cosma
{"title":"A deep learning method that identifies cellular heterogeneity using nanoscale nuclear features","authors":"Davide Carnevali, Limei Zhong, Esther González-Almela, Carlotta Viana, Mikhail Rotkevich, Aiping Wang, Daniel Franco-Barranco, Aitor Gonzalez-Marfil, Maria Victoria Neguembor, Alvaro Castells-Garcia, Ignacio Arganda-Carreras, Maria Pia Cosma","doi":"10.1038/s42256-024-00883-x","DOIUrl":"10.1038/s42256-024-00883-x","url":null,"abstract":"Cellular phenotypic heterogeneity is an important hallmark of many biological processes and understanding its origins remains a substantial challenge. This heterogeneity often reflects variations in the chromatin structure, influenced by factors such as viral infections and cancer, which dramatically reshape the cellular landscape. To address the challenge of identifying distinct cell states, we developed artificial intelligence of the nucleus (AINU), a deep learning method that can identify specific nuclear signatures at the nanoscale resolution. AINU can distinguish different cell states based on the spatial arrangement of core histone H3, RNA polymerase II or DNA from super-resolution microscopy images. With only a small number of images as the training data, AINU correctly identifies human somatic cells, human-induced pluripotent stem cells, very early stage infected cells transduced with DNA herpes simplex virus type 1 and even cancer cells after appropriate retraining. Finally, using AI interpretability methods, we find that the RNA polymerase II localizations in the nucleoli aid in distinguishing human-induced pluripotent stem cells from their somatic cells. Overall, AINU coupled with super-resolution microscopy of nuclear structures provides a robust tool for the precise detection of cellular heterogeneity, with considerable potential for advancing diagnostics and therapies in regenerative medicine, virology and cancer biology. Cellular phenotypic heterogeneity is a key determinant of biological functions and is challenging to identify. A deep learning method that recognizes specific nuclear signatures is discussed, which can identify cellular heterogeneity and differentiate between various cell states using a small amount of super-resolution microscopy data.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42256-024-00883-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factuality challenges in the era of large language models and opportunities for fact-checking 大型语言模型时代的事实挑战与事实核查机遇
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-22 DOI: 10.1038/s42256-024-00881-z
Isabelle Augenstein, Timothy Baldwin, Meeyoung Cha, Tanmoy Chakraborty, Giovanni Luca Ciampaglia, David Corney, Renee DiResta, Emilio Ferrara, Scott Hale, Alon Halevy, Eduard Hovy, Heng Ji, Filippo Menczer, Ruben Miguez, Preslav Nakov, Dietram Scheufele, Shivam Sharma, Giovanni Zagni
{"title":"Factuality challenges in the era of large language models and opportunities for fact-checking","authors":"Isabelle Augenstein, Timothy Baldwin, Meeyoung Cha, Tanmoy Chakraborty, Giovanni Luca Ciampaglia, David Corney, Renee DiResta, Emilio Ferrara, Scott Hale, Alon Halevy, Eduard Hovy, Heng Ji, Filippo Menczer, Ruben Miguez, Preslav Nakov, Dietram Scheufele, Shivam Sharma, Giovanni Zagni","doi":"10.1038/s42256-024-00881-z","DOIUrl":"10.1038/s42256-024-00881-z","url":null,"abstract":"The emergence of tools based on large language models (LLMs), such as OpenAI’s ChatGPT and Google’s Gemini, has garnered immense public attention owing to their advanced natural language generation capabilities. These remarkably natural-sounding tools have the potential to be highly useful for various tasks. However, they also tend to produce false, erroneous or misleading content—commonly referred to as hallucinations. Moreover, LLMs can be misused to generate convincing, yet false, content and profiles on a large scale, posing a substantial societal challenge by potentially deceiving users and spreading inaccurate information. This makes fact-checking increasingly important. Despite their issues with factual accuracy, LLMs have shown proficiency in various subtasks that support fact-checking, which is essential to ensure factually accurate responses. In light of these concerns, we explore issues related to factuality in LLMs and their impact on fact-checking. We identify key challenges, imminent threats and possible solutions to these factuality issues. We also thoroughly examine these challenges, existing solutions and potential prospects for fact-checking. By analysing the factuality constraints within LLMs and their impact on fact-checking, we aim to contribute to a path towards maintaining accuracy at a time of confluence of generative artificial intelligence and misinformation. Large language models (LLMs) present challenges, including a tendency to produce false or misleading content and the potential to create misinformation or disinformation. Augenstein and colleagues explore issues related to factuality in LLMs and their impact on fact-checking.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142022075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A bioactivity foundation model using pairwise meta-learning 使用成对元学习的生物活性基础模型
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-14 DOI: 10.1038/s42256-024-00876-w
Bin Feng, Zequn Liu, Nanlan Huang, Zhiping Xiao, Haomiao Zhang, Srbuhi Mirzoyan, Hanwen Xu, Jiaran Hao, Yinghui Xu, Ming Zhang, Sheng Wang
{"title":"A bioactivity foundation model using pairwise meta-learning","authors":"Bin Feng, Zequn Liu, Nanlan Huang, Zhiping Xiao, Haomiao Zhang, Srbuhi Mirzoyan, Hanwen Xu, Jiaran Hao, Yinghui Xu, Ming Zhang, Sheng Wang","doi":"10.1038/s42256-024-00876-w","DOIUrl":"10.1038/s42256-024-00876-w","url":null,"abstract":"The bioactivity of compounds plays an important role in drug development and discovery. Existing machine learning approaches have poor generalizability in bioactivity prediction due to the small number of compounds in each assay and incompatible measurements among assays. In this paper, we propose ActFound, a bioactivity foundation model trained on 1.6 million experimentally measured bioactivities and 35,644 assays from ChEMBL. The key idea of ActFound is to use pairwise learning to learn the relative bioactivity differences between two compounds within the same assay to circumvent the incompatibility among assays. ActFound further exploits meta-learning to jointly optimize the model from all assays. On six real-world bioactivity datasets, ActFound demonstrates accurate in-domain prediction and strong generalization across assay types and molecular scaffolds. We also demonstrate that ActFound can be used as an accurate alternative to the leading physics-based computational tool FEP+(OPLS4) by achieving comparable performance when using only a few data points for fine-tuning. Our promising results indicate that ActFound could be an effective bioactivity foundation model for compound bioactivity prediction, paving the way for machine-learning-based drug development and discovery. Traditional machine learning methods for drug development struggle with bioactivity prediction due to the limited number of compounds in each assay and assay incompatibilities. Feng et al. developed ActFound, a bioactivity foundation model trained by pairwise learning and meta-learning, that improves the accuracy and generalization of bioactivity prediction.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On responsible machine learning datasets emphasizing fairness, privacy and regulatory norms with examples in biometrics and healthcare 以生物识别和医疗保健领域为例,介绍强调公平、隐私和监管规范的负责任机器学习数据集
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-12 DOI: 10.1038/s42256-024-00874-y
Surbhi Mittal, Kartik Thakral, Richa Singh, Mayank Vatsa, Tamar Glaser, Cristian Canton Ferrer, Tal Hassner
{"title":"On responsible machine learning datasets emphasizing fairness, privacy and regulatory norms with examples in biometrics and healthcare","authors":"Surbhi Mittal, Kartik Thakral, Richa Singh, Mayank Vatsa, Tamar Glaser, Cristian Canton Ferrer, Tal Hassner","doi":"10.1038/s42256-024-00874-y","DOIUrl":"10.1038/s42256-024-00874-y","url":null,"abstract":"Artificial Intelligence (AI) has seamlessly integrated into numerous scientific domains, catalysing unparalleled enhancements across a broad spectrum of tasks; however, its integrity and trustworthiness have emerged as notable concerns. The scientific community has focused on the development of trustworthy AI algorithms; however, machine learning and deep learning algorithms, popular in the AI community today, intrinsically rely on the quality of their training data. These algorithms are designed to detect patterns within the data, thereby learning the intended behavioural objectives. Any inadequacy in the data has the potential to translate directly into algorithms. In this study we discuss the importance of responsible machine learning datasets through the lens of fairness, privacy and regulatory compliance, and present a large audit of computer vision datasets. Despite the ubiquity of fairness and privacy challenges across diverse data domains, current regulatory frameworks primarily address human-centric data concerns. We therefore focus our discussion on biometric and healthcare datasets, although the principles we outline are broadly applicable across various domains. The audit is conducted through evaluation of the proposed responsible rubric. After surveying over 100 datasets, our detailed analysis of 60 distinct datasets highlights a universal susceptibility to fairness, privacy and regulatory compliance issues. This finding emphasizes the urgent need for revising dataset creation methodologies within the scientific community, especially in light of global advancements in data protection legislation. We assert that our study is critically relevant in the contemporary AI context, offering insights and recommendations that are both timely and essential for the ongoing evolution of AI technologies. There are pervasive concerns related to fairness, privacy and regulatory compliance in machine learning applications in healthcare, necessitating a reevaluation of dataset creation practices. Mittal et al. examine various computer vision datasets, providing insights to foster responsible AI development.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42256-024-00874-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data-driven discovery of movement-linked heterogeneity in neurodegenerative diseases 数据驱动发现神经退行性疾病中与运动相关的异质性
IF 18.8 1区 计算机科学
Nature Machine Intelligence Pub Date : 2024-08-09 DOI: 10.1038/s42256-024-00882-y
Mark Endo, Favour Nerrise, Qingyu Zhao, Edith V. Sullivan, Li Fei-Fei, Victor W. Henderson, Kilian M. Pohl, Kathleen L. Poston, Ehsan Adeli
{"title":"Data-driven discovery of movement-linked heterogeneity in neurodegenerative diseases","authors":"Mark Endo, Favour Nerrise, Qingyu Zhao, Edith V. Sullivan, Li Fei-Fei, Victor W. Henderson, Kilian M. Pohl, Kathleen L. Poston, Ehsan Adeli","doi":"10.1038/s42256-024-00882-y","DOIUrl":"10.1038/s42256-024-00882-y","url":null,"abstract":"Neurodegenerative diseases manifest different motor and cognitive signs and symptoms that are highly heterogeneous. Parsing these heterogeneities may lead to an improved understanding of underlying disease mechanisms; however, current methods are dependent on clinical assessments and an arbitrary choice of behavioural tests. Here we present a data-driven subtyping approach using video-captured human motion and brain functional connectivity from resting-state functional magnetic resonance imaging. We applied our framework to a cohort of individuals at different stages of Parkinson’s disease. The process mapped the data to low-dimensional measures by projecting them onto a canonical correlation space that identified three Parkinson’s disease subtypes: subtype I was characterized by motor difficulties and poor visuospatial abilities; subtype II exhibited difficulties in non-motor components of activities of daily living and motor complications (dyskinesias and motor fluctuations) and subtype III was characterized by predominant tremor symptoms. We conducted a convergent validity analysis by comparing our approach to existing and widely used approaches. The compared approaches yielded subtypes that were adequately well-clustered in the motion-brain representation space we created to delineate subtypes. Our data-driven approach, contrary to other forms of subtyping, derived biomarkers predictive of motion impairment and subtype memberships that were captured objectively by digital videos. Diagnostic strategies for neurodegenerative diseases involve various data types, related to motor and cognitive signals. Endo et al. describe a data-driven subtyping approach for Parkinson’s disease, combining motion data (from videos) and brain functional connectivity data. The method reveals clinically relevant subtypes and digital biomarkers, uncovering movement-linked heterogeneities of Parkinson’s disease.","PeriodicalId":48533,"journal":{"name":"Nature Machine Intelligence","volume":null,"pages":null},"PeriodicalIF":18.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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