Chronic Illness最新文献

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Beyond dyadic communication: Network of communication in inflammatory arthritis teams. 超越二元沟通:炎症性关节炎团队的沟通网络。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-29 DOI: 10.1177/17423953221102629
Parisa Ghanouni, Kristy Inouye, Chelsey Gowan, Wendy Hartford, Annette McKinnon, Shanon McQuitty, Catherine L Backman, Linda C Li, Laura Nimmon
{"title":"Beyond dyadic communication: Network of communication in inflammatory arthritis teams.","authors":"Parisa Ghanouni,&nbsp;Kristy Inouye,&nbsp;Chelsey Gowan,&nbsp;Wendy Hartford,&nbsp;Annette McKinnon,&nbsp;Shanon McQuitty,&nbsp;Catherine L Backman,&nbsp;Linda C Li,&nbsp;Laura Nimmon","doi":"10.1177/17423953221102629","DOIUrl":"https://doi.org/10.1177/17423953221102629","url":null,"abstract":"<p><strong>Objective: </strong>To explore how communication is perceived and care is negotiated amongst IA healthcare teams by drawing on the perspectives of each team member.</p><p><strong>Method: </strong>This analysis drew on data from an ongoing three-year study exploring team-based IA care. We interviewed 11 participants including two men with IA and their family care providers and healthcare providers. We used a three-staged analytic process and integrated broad tenets of social network theory to understand the relational dimensions of team members experiences.</p><p><strong>Result: </strong>Analysis revealed three themes regarding communication and care: (1) seeking/sharing information, (2) striving to coordinate unified care, and (3) providing patients a voice.</p><p><strong>Discussion: </strong>This study emphasizes the importance of understanding team dynamics beyond the dyad of patient and care provider. Negotiating power and decision-making in IA care is a dynamic process involving shifting levels of responsibility amongst a care team. Communication-based strategies that extend dyadic interactions may enhance teamwork and health outcomes in chronic conditions.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"591-604"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-cholecystectomy bile reflux gastritis: Prevalence, risk factors, and clinical characteristics. 胆囊切除术后胆汁反流性胃炎:患病率、危险因素和临床特征。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-04-25 DOI: 10.1177/17423953221097440
Amira Aa Othman, Amal Az Dwedar, Hany M ElSadek, Hesham R AbdElAziz, Abeer Af Abdelrahman
{"title":"Post-cholecystectomy bile reflux gastritis: Prevalence, risk factors, and clinical characteristics.","authors":"Amira Aa Othman,&nbsp;Amal Az Dwedar,&nbsp;Hany M ElSadek,&nbsp;Hesham R AbdElAziz,&nbsp;Abeer Af Abdelrahman","doi":"10.1177/17423953221097440","DOIUrl":"https://doi.org/10.1177/17423953221097440","url":null,"abstract":"<p><strong>Objective: </strong>Bile reflux gastritis is caused by the backward flow of duodenal fluid into the stomach. A retrospective cohort study was performed to estimate the prevalence and risk factors of bile reflux gastritis postcholecystectomy, and to evaluate the endoscopic and histopathologic changes in gastric mucosa.</p><p><strong>Methods: </strong>Patients with refractory upper abdominal pain right below the ribs with symptoms of bloating, burping, nausea, vomiting, and bile regurgitation during the period from January 2018 to December 2020, submitted to Zagazig University Hospitals were enrolled in this study. The studied 64 patients were divided into two groups; the control group (CG): 30 subjects who had never undergone any biliary interventions, and the post-cholecystectomy group (PCG): 34 patients who had undergone cholecystectomy.</p><p><strong>Results: </strong>The prevalence of bile reflux gastritis was (16.7%) and (61.8%) in CG and PCG, respectively. Diabetes, obesity, elevated gastric bilirubin, and elevated stomach pH were all risk factors for bile reflux gastritis in both groups (<i>r</i> <i>=</i> <i>.</i>28,.48,.78,.57 respectively)<i>.</i> Age, sex, epigastric pain, heartburn, vomiting, and the existence of bile reflux gastritis, on the other hand, had no correlation.</p><p><strong>Discussion: </strong>After a cholecystectomy, bile reflux gastritis is prevalent, especially among obese and diabetic patients.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"529-538"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association between excessive alcohol consumption and hypertension control in hypertensive patients. 高血压患者过度饮酒与高血压控制之间的关系。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-20 DOI: 10.1177/17423953221102626
Sinwoo Hwang, Jae Woo Choi
{"title":"Association between excessive alcohol consumption and hypertension control in hypertensive patients.","authors":"Sinwoo Hwang,&nbsp;Jae Woo Choi","doi":"10.1177/17423953221102626","DOIUrl":"https://doi.org/10.1177/17423953221102626","url":null,"abstract":"<p><strong>Objectives: </strong>The purposes of this study were to investigate the association between excessive alcohol consumption and control of hypertension and the associations stratified by sex, age, and duration of hypertension among Korean adults who were diagnosed with hypertension under medication.</p><p><strong>Methods: </strong>This study was cross-sectional design with a secondary data analysis using national data from the Korea National Health and Nutrition Evaluation Survey (KNHANES) collected from 2013 to 2018, including 4278 participants who were diagnosed with hypertension under medication. A multiple logistic regression analysis was conducted to evaluate the associations between excessive alcohol consumption and hypertension control while controlling for potential confounding variables.</p><p><strong>Results: </strong>The hypertensive patients who consumed excessive alcohol were more associated with uncontrolled hypertension (OR, 1.31; 95% CI, 1.04-1.65) than those who do not consumed excessive alcohol. Specially, Excessive consumption of alcohol in men and young adults (<65 years) and short duration of hypertension (<5 years) were significantly more associated with uncontrolled hypertension compared to their counterparts.</p><p><strong>Discussion: </strong>To improve blood pressure (BP) control in hypertensive patients, healthcare plan should be focused to modifiable risk factors and the intervention for unhealthy alcohol consumption should be part of comprehensive treatment for hypertension.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"625-634"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of smoking status on anticipated stigma and experience of care among smokers and ex-smokers with chronic illness in general practice. 吸烟状况对吸烟者和患有慢性病的戒烟者在全科医学中的预期耻辱感和护理体验的影响。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-15 DOI: 10.1177/17423953221101337
Sanduni Madawala, Joanne Enticott, Elizabeth Sturgiss, Melis Selamoglu, Chris Barton
{"title":"The impact of smoking status on anticipated stigma and experience of care among smokers and ex-smokers with chronic illness in general practice.","authors":"Sanduni Madawala,&nbsp;Joanne Enticott,&nbsp;Elizabeth Sturgiss,&nbsp;Melis Selamoglu,&nbsp;Chris Barton","doi":"10.1177/17423953221101337","DOIUrl":"https://doi.org/10.1177/17423953221101337","url":null,"abstract":"<p><strong>Objectives: </strong>To compare self-reported levels of 'anticipated' stigma and experience of care in general practice between current and ex-smokers living with COPD, other chronic illnesses, or those with no chronic conditions.</p><p><strong>Methods: </strong>Participants completed an online survey, advertised through social media, about their experience of care from general practitioners (GPs) in the past 12 months. Respondents self-reported doctor-diagnosed chronic illnesses. Experience of care and anticipated stigma was assessed using validated questions. Multi-nominal regressions were used to determine independent effect of smoking status on anticipated stigma and other indicators of patient experience in primary care.</p><p><strong>Results: </strong>Patients with COPD (n = 161) reported significantly higher anticipated stigma scores compared to those with other chronic conditions (n = 225) and this was strongly related to delayed or avoidance in seeking help from a GP when needed. This relationship remained irrespective of current smoking status. There was no difference between groups for relational components of experience of care.</p><p><strong>Discussion: </strong>Primary care patients living with COPD reported worse experience of care across several domains and were more likely to anticipate experiencing stigma in the GP setting irrespective of their current smoking status compared to those with other chronic illnesses or no chronic illnesses.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"557-570"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The effect of patient empowerment on patient activation level: A review of individuals with cardiovascular diseases. 患者赋权对患者激活水平的影响:心血管疾病患者综述。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2023-04-16 DOI: 10.1177/17423953231170400
Barış Düzel, Meltem Saygili, Özlem Özer, Melek Zubaroğlu Yanardağ
{"title":"The effect of patient empowerment on patient activation level: A review of individuals with cardiovascular diseases.","authors":"Barış Düzel,&nbsp;Meltem Saygili,&nbsp;Özlem Özer,&nbsp;Melek Zubaroğlu Yanardağ","doi":"10.1177/17423953231170400","DOIUrl":"10.1177/17423953231170400","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to examine the effect of patient empowerment on patient activation level in individuals with cardiovascular diseases.</p><p><strong>Methods: </strong>The population of the study is adult individuals receiving inpatient treatment in the Cardiology clinic of a city hospital operating in Turkey. In the study, convenience sampling method was applied, and a questionnaire was conducted from 543 patients.</p><p><strong>Results: </strong>As a result of the analyses made in the study, positive and low correlations were detected between the patient empowerment scale sub-dimensions and the patient activation level. According to regression analysis results, it was identified that the patient empowerment sub-dimensions together accounted for 6.4% of the total variance on the patient activation level, and the increase in the 'knowledge and understanding' levels of the patients statistically increased their perceptions of the patient activation level.</p><p><strong>Discussion: </strong>The results show that by providing patient empowerment in individuals with chronic diseases, their active participation can be increased in the treatment processes and consequently in the chronic disease management.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":" ","pages":"665-674"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9665474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linguistic adaptation and psychometric properties of the health literacy questionnaire in serbian language among people with chronic diseases. 慢性病患者塞尔维亚语健康素养问卷的语言适应和心理测量特性。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-17 DOI: 10.1177/17423953221102630
Sladjana Arsenović, Olufemi Oyewole, Goran Trajković, Richard H Osborne, Megan Wiltshire-Fletcher, Teodora Gazibara, Darija Kisić Tepavčević, Tatjana Pekmezović, Tatjana Gazibara
{"title":"Linguistic adaptation and psychometric properties of the health literacy questionnaire in serbian language among people with chronic diseases.","authors":"Sladjana Arsenović,&nbsp;Olufemi Oyewole,&nbsp;Goran Trajković,&nbsp;Richard H Osborne,&nbsp;Megan Wiltshire-Fletcher,&nbsp;Teodora Gazibara,&nbsp;Darija Kisić Tepavčević,&nbsp;Tatjana Pekmezović,&nbsp;Tatjana Gazibara","doi":"10.1177/17423953221102630","DOIUrl":"https://doi.org/10.1177/17423953221102630","url":null,"abstract":"<p><strong>Objective: </strong>To translate the Health Literacy Questionnaire (HLQ) to Serbian language and examine its psychometric characteristics.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among 295 people with chronic diseases from the Foča region (Republic of Srpska, Bosnia and Herzegovina). The HLQ was translated according to the translation integrity procedure. Construct validity was tested using confirmatory factor analysis (CFA) using the maximum likelihood estimator and reliability was estimated using the α and ω coefficients.</p><p><strong>Results: </strong>Minor linguistic differences in 17 items were observed between the original and the initial forward translation and were corrected. The parameters of one-factor CFA on domains 3 and 8 fitted well. The parameters of the CFA for domains 1, 2, 4, 5, 6, 7 and 9 were acceptable after modification using residuals' correlation. The α and ω coefficients for all domains were good to excellent (>0.80).</p><p><strong>Conclusion: </strong>Each domain of the HLQ in Serbian has acceptable construct validity and overall good reliability. This study adds to the growing evidence that the HLQ is a useful tool to provide in-depth multidimensional information on health literacy to improve researchers and policymakers understanding of the health literacy strengths, needs and preferences across cultures and languages.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"605-624"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Social support and diabetes distress: Does the messenger matter as much as the message? 社会支持和糖尿病困扰:信使和信息一样重要吗?
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-26 DOI: 10.1177/17423953221102622
Sorayya Seddigh, Tricia S Tang
{"title":"Social support and diabetes distress: Does the messenger matter as much as the message?","authors":"Sorayya Seddigh,&nbsp;Tricia S Tang","doi":"10.1177/17423953221102622","DOIUrl":"https://doi.org/10.1177/17423953221102622","url":null,"abstract":"<p><p>We explored the relationship between social support (family/friends and health care team) and four diabetes distress subscales in 196 adults with type 2 diabetes in a specialty care setting. Health care support was associated with lower physician- and regimen-related distress, while friends/family support was related to lower interpersonal distress. The study was registered on clinicaltrials.gov (NCT02804620).</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"681-685"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using latent class analysis to inform the design of an EHR-based national chronic disease surveillance model. 使用潜在类别分析为基于EHR的国家慢性病监测模型的设计提供信息。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-03 DOI: 10.1177/17423953221099043
Laura Nasuti, Bonnie Andrews, Wenjun Li, Jennifer Wiltz, Katherine H Hohman, Miriam Patanian
{"title":"Using latent class analysis to inform the design of an EHR-based national chronic disease surveillance model.","authors":"Laura Nasuti, Bonnie Andrews, Wenjun Li, Jennifer Wiltz, Katherine H Hohman, Miriam Patanian","doi":"10.1177/17423953221099043","DOIUrl":"10.1177/17423953221099043","url":null,"abstract":"<p><p>The Multi-state EHR-based Network for Disease Surveillance (MENDS) developed a pilot electronic health record (EHR) surveillance system capable of providing national chronic disease estimates. To strategically engage partner sites, MENDS conducted a latent class analysis (LCA) and grouped states by similarities in socioeconomics, demographics, chronic disease and behavioral risk factor prevalence, health outcomes, and health insurance coverage. Three latent classes of states were identified, which inform the recruitment of additional partner sites in conjunction with additional factors (e.g. partner site capacity and data availability, information technology infrastructure). This methodology can be used to inform other public health surveillance modernization efforts that leverage timely EHR data to address gaps, use existing technology, and advance surveillance.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"675-680"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/0f/10.1177_17423953221099043.PMC10515457.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urban-rural disparities in hypertension management among middle-aged and older patients: Results of a 2018 Chinese national study. 中老年患者高血压管理的城乡差异:2018年中国全国研究结果。
IF 1.3 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-22 DOI: 10.1177/17423953221102627
Hon Lon Tam, Siu Fung Chung, Qun Wang
{"title":"Urban-rural disparities in hypertension management among middle-aged and older patients: Results of a 2018 Chinese national study.","authors":"Hon Lon Tam,&nbsp;Siu Fung Chung,&nbsp;Qun Wang","doi":"10.1177/17423953221102627","DOIUrl":"https://doi.org/10.1177/17423953221102627","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertension is a well-known global risk factor associated with significant morbidity and mortality. Medication use and urban-rural disparities in medication usage patterns affect hypertension management. We investigated patient characteristics across different geographical areas to determine factors that affect medication use among Chinese patients aged ≥ 45 years, diagnosed with hypertension.</p><p><strong>Methods: </strong>Data were extracted from the China Health and Retirement Longitudinal Study 2018. We recorded differences in medication use, advice from healthcare providers, and health-related behaviors between urban and rural areas.</p><p><strong>Results: </strong>The study included 2115 patients with hypertension (mean age 62.06 years). Advice received and medication use were significantly lower in patients from rural areas than in those from urban areas. Our findings showed that urban residence, comorbidities, advice regarding lifestyle changes, and smoking were positive predictors of medication use, whereas alcohol consumption and regular exercise reduced the likelihood of medication use.</p><p><strong>Discussion: </strong>We observed urban-rural disparities in hypertension management, and several strategies, including distribution of reminders and written materials can be integrated into current clinical practice to improve the rate of medication use among rural residents with hypertension.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"581-590"},"PeriodicalIF":1.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Cytokine network analysis in a community-based pediatric sample of patients with myalgic encephalomyelitis/chronic fatigue syndrome. 肌痛性脑脊髓炎/慢性疲劳综合征患者社区儿科样本中的细胞因子网络分析。
IF 1.8 4区 医学
Chronic Illness Pub Date : 2023-09-01 Epub Date: 2022-05-16 DOI: 10.1177/17423953221101606
Leonard A Jason, Caroline L Gaglio, Jacob Furst, Mohammed Islam, Matthew Sorenson, Karl E Conroy, Ben Z Katz
{"title":"Cytokine network analysis in a community-based pediatric sample of patients with myalgic encephalomyelitis/chronic fatigue syndrome.","authors":"Leonard A Jason, Caroline L Gaglio, Jacob Furst, Mohammed Islam, Matthew Sorenson, Karl E Conroy, Ben Z Katz","doi":"10.1177/17423953221101606","DOIUrl":"10.1177/17423953221101606","url":null,"abstract":"<p><strong>Objectives: </strong>Studies have demonstrated immune dysfunction in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); however, evidence is varied. The current study used network analysis to examine relationships between cytokines among a sample of pediatric participants with ME/CFS.</p><p><strong>Methods: </strong>10,119 youth aged 5-17 in the Chicagoland area were screened for ME/CFS; 111 subjects and controls were brought in for a physician examination and completed a blood draw. Youth were classified as controls (Cs, N = 43), ME/CFS (N = 23) or severe (S-ME/CFS, N = 45). Patterns of plasma cytokine networks were analyzed.</p><p><strong>Results: </strong>All participant groups displayed a primary network of interconnected cytokines. In the ME/CFS group, inflammatory cytokines IL-12p70, IL-17A, and IFN-γ were connected and included in the primary membership, suggesting activation of inflammatory mechanisms. The S-ME/CFS group demonstrated a strong relationship between IL-17A and IL-23, a connection associated with chronic inflammation. The relationships of IL-6 and IL-8 in ME/CFS and S-ME/CFS participants also differed from Cs. Together, these results indicate pro-inflammatory responses in our illness populations.</p><p><strong>Discussion: </strong>Our data imply biological differences between our three participant groups, with ME/CFS and S-ME/CFS participants demonstrating an inflammatory profile. Examining co-expression of cytokines may aid in the identification of a biomarker for pediatric ME/CFS.</p>","PeriodicalId":48530,"journal":{"name":"Chronic Illness","volume":"19 3","pages":"571-580"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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