Journal of Anxiety Disorders最新文献

{"title":"Emotion regulation difficulties in children and adolescents with obsessive-compulsive disorder: A multi-informant and multi-method study","authors":"Christine Lykke Thoustrup ,&nbsp;Robert James Blair ,&nbsp;Sofie Heidenheim Christensen ,&nbsp;Valdemar Uhre ,&nbsp;Linea Pretzmann ,&nbsp;Nicoline Løcke Jepsen Korsbjerg ,&nbsp;Camilla Uhre ,&nbsp;Anna-Rosa Cecilie Mora-Jensen ,&nbsp;Melanie Ritter ,&nbsp;Nicole Nadine Lønfeldt ,&nbsp;Emilie Damløv Thorsen ,&nbsp;Daniel S. Quintana ,&nbsp;Ahmad Sajadieh ,&nbsp;Jakob Hartvig Thomsen ,&nbsp;Kerstin Jessica Plessen ,&nbsp;Signe Vangkilde ,&nbsp;Anne Katrine Pagsberg ,&nbsp;Julie Hagstrøm","doi":"10.1016/j.janxdis.2025.103002","DOIUrl":"10.1016/j.janxdis.2025.103002","url":null,"abstract":"<div><div>Pediatric obsessive-compulsive disorder (OCD) is associated with emotion regulation (ER) difficulties. Most studies are based on self-reports, while few have examined how these difficulties are expressed across modalities, which may hold important diagnostic and therapeutic information. We applied a multi-informant and multi-method approach to examine ER difficulties in 211 children aged 8–17 years: 121 with OCD and 90 non-clinical controls. Child ER difficulties were assessed with The Difficulties in Emotion Regulation Scale (self-report and parent-report) and a Tangram frustration task with investigator-rated behavior, self-rated frustration, and heart rate variability (HRV). Children with OCD differed significantly from non-clinical controls in showing: (i) elevated child ER difficulties on self-report (partial eta squared =.068–.165) and parent-report (partial eta squared =.207–.369); (ii) more investigator-rated ER difficulties during the task (Cohen’s <em>d</em> = −.33); (iii) increased levels of self-rated frustration before and after the task (partial eta squared =.089); notably, the magnitude of this increase did not differ between children with and without OCD. Finally, (iv) all children, regardless of group, demonstrated significant HRV changes during the frustration task, with no discernible group differences in the magnitude of these changes. Results suggest the OCD-related experience of ER difficulties may not impact autonomic functioning.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103002"},"PeriodicalIF":4.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using machine learning methods to predict the outcome of psychological therapies for post-traumatic stress disorder: A systematic review","authors":"James Tait ,&nbsp;Stephen Kellett ,&nbsp;Jaime Delgadillo","doi":"10.1016/j.janxdis.2025.103003","DOIUrl":"10.1016/j.janxdis.2025.103003","url":null,"abstract":"<div><h3>Background</h3><div>A number of treatments are available for post-traumatic stress disorder (PTSD), however, there is currently a lack of data-driven treatment selection and adaptation methods for this condition. Machine learning (ML) could potentially help to improve the prediction of treatment outcomes and enable precision mental healthcare in practice.</div></div><div><h3>Objectives</h3><div>To systematically review studies that applied ML methods to predict outcomes of psychological therapy for PTSD in adults (e.g., change in symptoms, dropout rate), and evaluate their methodological rigour.</div></div><div><h3>Methods</h3><div>This was a pre-registered systematic review (CRD42022325021), which synthesised eligible clinical prediction studies found across four research databases. Risk of bias was assessed using the PROBAST tool. Study methods and findings were narratively synthesised, and adherence to ML best practice evaluated.</div></div><div><h3>Results</h3><div>Seventeen studies met the inclusion criteria, including samples derived from experimental and observational study designs. All studies were assessed as having a high risk of bias, notably due to inadequately powered samples and a lack of sample size calculations. Training sample size ranged from <em>N</em> &lt; 36–397. The studies applied a diverse range of ML methods such as decision trees, ensembling and boosting techniques. Five studies used unsupervised ML methods, while others used supervised ML. There was an inconsistency in the reporting of hyperparameter tuning and cross-validation methods. Only one study performed external validation.</div></div><div><h3>Conclusions</h3><div>ML has the potential to advance precision psychotherapy for PTSD, but to enable this, ML methods must be applied with greater adherence to best practice guidelines.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"112 ","pages":"Article 103003"},"PeriodicalIF":4.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal dynamics of costly avoidance in anxiety disorders: Faster threat and weaker reward impact during approach-avoidance decisions in patients","authors":"Juliane M. Boschet-Lange ,&nbsp;Valentina M. Glück ,&nbsp;Roxana Pittig ,&nbsp;Stefan Scherbaum ,&nbsp;Andre Pittig","doi":"10.1016/j.janxdis.2025.103005","DOIUrl":"10.1016/j.janxdis.2025.103005","url":null,"abstract":"<div><div>In anxiety disorders, approach-avoidance behavior is typically biased towards excessive, maladaptive avoidance despite costs and impairments (i.e., costly avoidance). Yet, little is known about the underlying decision dynamics that may contribute to such imbalanced behavior. The current study tested for altered temporal decision dynamics in patients with anxiety disorders compared to matched healthy controls in a task where avoiding an aversive stimulus conflicted with obtaining rewards. Participants chose repeatedly between a fixed safe/low reward and a threat/high reward option with varying threat (probability of an aversive stimulus presentation) and reward information (reward magnitude). Structured computer mouse movements required for choosing between options were tracked to capture the temporal dynamics of the decision process (i.e., when and how strongly threat and reward information influenced decision preference). The current study replicated elevated costly threat avoidance in patients with anxiety disorders compared to matched controls. Importantly, time-continuous multiple regression of mouse movements revealed altered temporal dynamics: patients showed a faster (but not stronger) impact of threat and a weaker impact of competing rewards. These findings highlight that not only biases in threat processes but also competing rewards may guide excessive avoidance and could be important treatment targets in anxiety disorders. Future research may support the external validity of these findings in real-life decisions and try to identify therapeutic strategies that allow to specifically target the attenuated impact of rewards and the accelerated impact of threat in patients.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103005"},"PeriodicalIF":4.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized clinical trial investigating the clinical impact of a game-based digital therapeutic for social anxiety disorder","authors":"Jennifer de Rutte ,&nbsp;Sarah Myruski ,&nbsp;Elizabeth Davis ,&nbsp;Abigail Findley ,&nbsp;Tracy A. Dennis-Tiwary","doi":"10.1016/j.janxdis.2025.103000","DOIUrl":"10.1016/j.janxdis.2025.103000","url":null,"abstract":"<div><div>The objective of this study was to determine if a novel game-based digital therapeutic intervention reduced anxiety symptom severity in adults with clinically elevated symptoms of social anxiety disorder (SAD). Participants were randomly allocated (1:1) to receive four weeks of either the active intervention, a game-based form of attention bias modification (Active ABM) for anxiety, or the sham control training (Control). Between June 2022 to June 2023, 104 participants were enrolled with 93 completing the trial per-protocol and 104 included in the final intention-to-treat analysis (54 intervention, 50 control); mean age was 38.08 (10.56) years and 79 were female. The dependent variable was reduction in SAD symptoms, measured via the Liebowitz SAD Scale (LSAS). Participants were classified as having clinically elevated SAD symptoms only, or both SAD and Generalized Anxiety Disorder (GAD) symptoms (comorbid). The Active condition induced significantly greater reductions in SAD symptoms compared to the Control condition between Baseline and Post-Treatment [Active: <em>M</em> = -29.71, <em>SD</em> = 23.68; Control: <em>M</em> = -14.59, <em>SD</em> = 21.52, <em>d</em> = .67, <em>t</em>(102) = -3.40, <em>p</em> &lt; .001] across the four-week study period. While no significant between-groups differences emerged at each timepoint individually, the Active condition induced significantly greater change over time in SAD symptoms compared to the Control condition. Use of this game-based digital ABM intervention showed benefits in the reduction of anxiety symptoms.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 103000"},"PeriodicalIF":4.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD","authors":"Anna-Rosa Cecilie Mora-Jensen ,&nbsp;Christine Lykke Thoustrup ,&nbsp;Eli R. Lebowitz ,&nbsp;Julie Hagstrøm ,&nbsp;Linea Pretzmann ,&nbsp;Nicoline Løcke Jepsen Korsbjerg ,&nbsp;Emilie Damløv Thorsen ,&nbsp;Valdemar Funch Uhre ,&nbsp;Sofie Heidenheim Christensen ,&nbsp;Camilla Uhre ,&nbsp;Melanie Ritter ,&nbsp;Kerstin J. Plessen ,&nbsp;Anne Katrine Pagsberg ,&nbsp;Line Katrine Harder Clemmensen ,&nbsp;Nicole Nadine Lønfeldt","doi":"10.1016/j.janxdis.2025.102996","DOIUrl":"10.1016/j.janxdis.2025.102996","url":null,"abstract":"<div><h3>Background</h3><div>Parent-child interactive processes are important factors in pediatric OCD. Understanding biological mechanisms of parent-child interactive behaviors could help improve treatment of pediatric OCD. Oxytocin has been suggested as a biological mechanism in parent-child interactions. However, no studies in pediatric OCD exist. We used machine learning to discover latent patterns in parent-child interactive behaviors and explored associations with oxytocin in children with and without OCD.</div></div><div><h3>Methods</h3><div>We used parent and child salivary oxytocin levels measured with enzyme-linked immunosorbent assay (ELISA) and investigator-rated parent-child behaviors during a frustration task. Children with or without OCD and their parents – 107 mother-child and 62 father-child pairs were included. We used two machine learning techniques, principal component analysis and archetypal analysis, to generate data-driven, theory-agnostic behavioral variables, and regression to estimate their associations with oxytocin.</div></div><div><h3>Results</h3><div>Principal component and archetype analyses identified behavioral patterns describing the mother-child and father-child interactions. We found a positive association between child and mother oxytocin and the interaction patterns \"overinvolved interaction\" and \"emotional interaction\" and a negative association with \"distant interaction\". Additionally, mother oxytocin was positively associated with \"supportive interaction\" and \"varied-coping interaction\", and negatively associated with \"conflictual interaction\" and \"negative-low support interaction\". Father oxytocin was associated with “supportive interactions” only in the presence of child OCD.</div></div><div><h3>Conclusion</h3><div>Child and mother oxytocin appear related with mother-child interactive patterns. Fathers’ oxytocin was related with interaction patterns only in children with OCD. Our exploratory findings can be used to generate hypothesis for future research regarding the relationship between oxytocin and maladaptive family engagement in OCD and differences between mothers and fathers’ behaviors when the child has OCD.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102996"},"PeriodicalIF":4.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic utility of the PCL-5 in a traumatically injured black population","authors":"Timothy J. Geier ,&nbsp;Kaylen Vine ,&nbsp;Lucas Torres ,&nbsp;Christine L. Larson ,&nbsp;Terri A. deRoon-Cassini","doi":"10.1016/j.janxdis.2025.102988","DOIUrl":"10.1016/j.janxdis.2025.102988","url":null,"abstract":"<div><h3>Background</h3><div>Posttraumatic stress disorder (PTSD) is common after traumatic injury, negatively impacting recovery. Black Americans face elevated PTSD risk following traumatic injury, yet diagnostic accuracy of assessments in trauma center settings serving this population is unknown. The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) exhibits strong psychometric properties but optimal cut-scores by race require examination.</div></div><div><h3>Methods</h3><div>Data were combined from three ongoing projects of injured Black American adults (N = 270). Participants completed the PCL-5 and Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) six months post-injury. Receiver operating characteristic analysis determined the PCL-5's diagnostic utility against the CAPS-5. Sensitivity, specificity, predictive values, and diagnostic efficiency were calculated across cut scores.</div></div><div><h3>Results</h3><div>Prevalence of CAPS-5 PTSD at 6-months post-injury was 34.4 %. The PCL-5 demonstrated good accuracy in detecting PTSD (AUC=.931). A PCL-5 cut-score of &gt; 33 maximized diagnostic efficiency (89.1 %), with sensitivity of 89.1 % and specificity of 87.6 %.</div></div><div><h3>Conclusions</h3><div>The PCL-5 is an accurate PTSD screening tool for injured Black Americans using an appropriate threshold. Findings have implications for improving mental health care access in trauma settings serving marginalized groups.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102988"},"PeriodicalIF":4.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear of positive evaluation and the bivalent fear of evaluation model of social anxiety: An Integration","authors":"Stefan G. Hofmann","doi":"10.1016/j.janxdis.2025.102986","DOIUrl":"10.1016/j.janxdis.2025.102986","url":null,"abstract":"<div><div>Humans have an inherent need to belong to a social group, and ostracism can lead to significant personal costs. Therefore, the fear of negative evaluation by others, along with its associated consequence of social anxiety, appears to be evolutionarily adaptive. Numerous studies have demonstrated that social anxiety, as well as its clinical manifestation, social anxiety disorder (SAD), is not only linked to an intense fear of negative evaluation but also to a fear of positive evaluation. This phenomenon has been termed the Bivalent Fear of Evaluation (BFOE) model of social anxiety. While the fear of negative evaluation can be understood from an evolutionary standpoint, the fear of positive evaluation poses a challenge for such an account. Clarifying the relationship between these two fears—positive and negative evaluation—may provide new insights into the nature of social anxiety and SAD. After summarizing and reviewing studies comprising this special issue, I will conclude that any form of evaluative feedback rising self-focused attention—whether positive, negative, or even neutral—can cause distress due to heightened sensitivity to social feedback in general. However, different mechanisms and contextual factors are implicated. In line with cognitive models of SAD, the self and self-perception are central to both social anxiety and SAD. This has significant theoretical and clinical implications.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102986"},"PeriodicalIF":4.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A temporal investigation of the relationship between difficulty concentrating and perseverative thought","authors":"Paige L. DeGennaro,&nbsp;Mary Blendermann,&nbsp;Brittany Alberts,&nbsp;Jennifer S. Silk,&nbsp;Peter J. Gianaros,&nbsp;Lauren S. Hallion","doi":"10.1016/j.janxdis.2025.102987","DOIUrl":"10.1016/j.janxdis.2025.102987","url":null,"abstract":"<div><div>Perseverative thought (also known as repetitive thought) is an established transdiagnostic mechanism of internalizing psychopathology characterized primarily by its repetitive, difficult to control quality. Subjective difficulty concentrating frequently coincides with perseverative thought and may function as both mechanism and clinical consequence of perseverative thought. Although cognitive theories suggest a bidirectional relationship between perseverative thought and difficulty concentrating, experimental and longitudinal investigations provide mixed evidence. The current study addresses this gap by testing a bidirectional relationship between momentary perseverative thought and difficulty concentrating using ecological momentary assessment (EMA) (8 surveys per day for 14 days) with 200 adult community participants (<em>N</em> = 155 with compliance ≥ 70 %) oversampled for moderate/severe perseverative thought. Multilevel modeling tested concurrent and time-lagged associations. Difficulty concentrating and perseverative thought were concurrently and prospectively related within-person: higher difficulty concentrating at <em>T</em>-1 predicted higher perseverative thought at <em>T</em>, and higher perseverative thought at <em>T</em>-1 predicted higher difficulty concentrating at <em>T</em> (<em>β =</em>.19 –.20, <em>p &lt; .</em>001). Findings held when controlling for the outcome at <em>T</em>-1 (<em>β</em> =.02 – <em>.</em>06, <em>p</em> &lt; .001). These findings demonstrate covariation between difficulty concentrating and perseverative thought within-person in daily life consistent with theoretical models that predict bidirectional relationships. Findings suggest that intervening on difficulty concentrating and/or perseverative thought may reduce the “vicious cycle” of perseverative thought episodes.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102987"},"PeriodicalIF":4.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Bivalent fear of evaluation model of social anxiety: The state of the science and future directions","authors":"Justin W. Weeks,&nbsp;Andres De Los Reyes","doi":"10.1016/j.janxdis.2025.102984","DOIUrl":"10.1016/j.janxdis.2025.102984","url":null,"abstract":"","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"111 ","pages":"Article 102984"},"PeriodicalIF":4.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding emotion dysregulation in PTSD – GAD comorbidity","authors":"Lucy J. Allbaugh ,&nbsp;Lucas Marinack ,&nbsp;Alison M. Pickover ,&nbsp;Abigail Powers ,&nbsp;Erica D. Marshall Lee ,&nbsp;Marylène Cloitre ,&nbsp;Nadine J. Kaslow","doi":"10.1016/j.janxdis.2025.102985","DOIUrl":"10.1016/j.janxdis.2025.102985","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) frequently co-occurs with myriad mood and anxiety disorders including generalized anxiety disorder (GAD). Despite this comorbidity’s prevalence, mechanisms underlying the co-occurrence of PTSD and GAD remains understudied. An emotion dysregulation framework routinely is used to understand both PTSD and GAD but has not been applied to the PTSD-GAD comorbidity. Using MANOVA, the present study tested domains of emotion dysregulation (DERS) and of positive emotion regulation (AEQ) as differentiators of PTSD alone versus PTSD with GAD using pre-intervention data from a randomized controlled trial including 292 women with PTSD secondary to interpersonal violence. Five of six emotion dysregulation domains differentiated the two groups: fewer regulation strategies, nonacceptance of emotional responses, impulse control difficulties, lack of emotional awareness, and lack of emotional clarity were associated with comorbidity. Of three positive emotion regulation domains, participants with PTSD alone reported more positive emotionality than those with PTSD and GAD, and those with comorbid PTSD and GAD reported more negative affective interference than those with PTSD only. Rather than specific domains underlying unique presentations, findings indicate a general dysregulation factor, where PTSD-GAD comorbidity is supported by an overall higher level of emotion dysregulation as compared to PTSD alone.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"110 ","pages":"Article 102985"},"PeriodicalIF":4.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}