Diabetes & Metabolic Syndrome-Clinical Research & Reviews最新文献

{"title":"Nanotechnology as a potential treatment for diabetes and its complications: A review","authors":"Kanika Manral ,&nbsp;Anita Singh ,&nbsp;Yuvraj Singh","doi":"10.1016/j.dsx.2024.103159","DOIUrl":"10.1016/j.dsx.2024.103159","url":null,"abstract":"<div><h3>Background and aim</h3><div>Diabetes mellitus is a chronic metabolic disorder that causes multiple complications in various organs, such as the kidney, liver and cardiovascular system. These complications are the main causes of morbidity and mortality in patients with diabetes. Nanotechnology offers new opportunities for the therapy of diabetes and its multiple complications through site-specific and precise drug delivery. This review summarizes the various studies demonstrating the potential applications of different nanoparticles in diabetes-associated complications.</div></div><div><h3>Method</h3><div>A literature search was conducted using PubMed, Google Scholar and Scopus databases, focusing on the role of nanoparticles in the improved delivery of various hypoglycemic agents for the treatment of microvascular and macrovascular diabetic complications.</div></div><div><h3>Results</h3><div>Numerous studies have shown that nanoparticles, such as nanoliposomes, polymeric micelles, dendrimers and metallic nanoparticles, improve the delivery of various hypoglycemic agents. Moreover, nanoparticles have been found to be safer, with improved pharmacokinetic and pharmacodynamic profiles.</div></div><div><h3>Conclusion</h3><div>This review outlines the significant role of nanotechnology in diabetes and related complications and its superiority over conventional drug delivery.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 11","pages":"Article 103159"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the upper airway anatomy using magnetic resonance imaging in Indian obese patients with obstructive sleep apnea - A pilot study.","authors":"Sanjeev Sinha, Bhavesh Mohan Lal, Maskani Nithya, Renuka Titiyal, Soumyadeep Datta, Surabhi Vyas, Sandeep Aggarwal, Brandon Nokes, Atul Malhotra","doi":"10.1016/j.dsx.2024.103169","DOIUrl":"10.1016/j.dsx.2024.103169","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is very common in obese patients. However, why some obese patients have severe OSA while others do not is unclear. Research is limited regarding which structures contribute to upper airway narrowing, especially in Asian patients where bony restrictions is thought to be important.</p><p><strong>Methods: </strong>Nineteen consecutive patients with BMI ≥35 kg/m², and newly diagnosed with OSA based on overnight polysomnography were studied using non-contrast magnetic resonance imaging (MRI) of the upper airway during wakefulness.</p><p><strong>Results: </strong>Patients were divided into two groups, one with severe OSA comprising 11 patients and one without severe OSA having 8 patients. The retro-palatal airway was narrowest in both groups. Patients with severe OSA had a significantly narrower retroglossal airway (0.99 ± 0.48 cm² vs 2.61 ± 2.02 cm², p = 0.02), primarily due to a narrower anteroposterior diameter at this level (p = 0.03). The tongue volume (p = 0.91), lateral pharyngeal wall volume (p = 0.26), tongue length (p = 0.93), soft palate length (p = 0.13), and dynamic change of upper airway with inspiration (p = 0.31) were not significantly different between the two groups.</p><p><strong>Conclusions: </strong>While the retro-palatal airway is equally narrow in both groups of patients, patients with severe OSA also have a significantly narrower retro-glossal airway. This finding could represent either a generalized reduction in airway area in whole of the oropharynx or multiple-level obstruction; probably aggravating upper airway collapse during sleep, predisposing some Asian obese patients to develop severe OSA.</p>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 11-12","pages":"103169"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary manganese intake with new-onset chronic kidney disease in participants with diabetes","authors":"Yu Huang ,&nbsp;Yanjun Zhang ,&nbsp;Chun Zhou ,&nbsp;Mengyi Liu ,&nbsp;Sisi Yang ,&nbsp;Hao Xiang ,&nbsp;Xiaoqin Gan ,&nbsp;Ziliang Ye ,&nbsp;Panpan He ,&nbsp;Yuanyuan Zhang ,&nbsp;Xianhui Qin","doi":"10.1016/j.dsx.2024.103138","DOIUrl":"10.1016/j.dsx.2024.103138","url":null,"abstract":"<div><h3>Background</h3><div>We explored the association of dietary manganese (Mn) with new-onset chronic kidney disease (CKD) in participants with diabetes on different glycemia control status and potential mechanisms.</div></div><div><h3>Methods</h3><div>The study included 7248 adults with diabetes from the UK Biobank who had complete dietary data and were free of CKD at baseline. Dietary information was collected by the online 24-h diet recall questionnaires. The primary outcome was new-onset CKD.</div></div><div><h3>Results</h3><div>565 (7.8 %) participants developed new-onset CKD during a median follow-up of 11.96 years. Overall, there was a significantly inverse relationship of dietary Mn intake with new-onset CKD in individuals with diabetes at glycated hemoglobin (HbA1c) ≥6.5 % (per SD increment, HR [95%CI]: 0.79 [0.68-0.91]), but not in people with diabetes at HbA1c &lt;6.5 % (per SD increment, HR [95%CI]: 1.07 [0.90-1.29]; <em>P</em> for interaction = 0.004). In individuals with diabetes at HbA1c ≥6.5 %, body mass index and waist circumference significantly mediated the association between dietary Mn intake and new-onset CKD, with mediated proportions of 17.5 % and 17.4 %, respectively.</div></div><div><h3>Conclusions</h3><div>Higher dietary Mn intake was significantly associated with a lower new-onset CKD risk in participants with diabetes at poor glycemic control status. The inverse association was mainly mediated by obesity. If further confirmed, our findings underscore the importance of maintaining adequate dietary Mn intake for the primary prevention of new-onset CKD in patients with diabetes, especially those with poor glycemic control.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103138"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142438111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of patatin-like phospholipase domain-containing 3 gene for decreasing kidney function in recently diagnosed diabetes mellitus","authors":"Oana Patricia Zaharia ,&nbsp;Klaus Strassburger ,&nbsp;Birgit Knebel ,&nbsp;Christian Binsch ,&nbsp;Yuliya Kupriyanova ,&nbsp;Clara Möser ,&nbsp;Kálmán Bódis ,&nbsp;Katsiaryna Prystupa ,&nbsp;Iryna Yurchenko ,&nbsp;Dania Marel Mendez Cardenas ,&nbsp;Martin Schön ,&nbsp;Christian Herder ,&nbsp;Hadi Al-Hasani ,&nbsp;Vera Schrauwen-Hinderling ,&nbsp;Karin Jandeleit-Dahm ,&nbsp;Robert Wagner ,&nbsp;Michael Roden ,&nbsp;GDS Group","doi":"10.1016/j.dsx.2024.103137","DOIUrl":"10.1016/j.dsx.2024.103137","url":null,"abstract":"<div><h3>Aims</h3><div>We examined the association of the G allele in the single-nucleotide polymorphism (SNP) rs738409 in the third exon of patatin-like phospholipase domain-containing 3 gene (<em>PNPLA3)</em> gene, with chronic kidney disease in diabetes endotypes.</div></div><div><h3>Methods</h3><div>Participants with recent-onset diabetes (n = 707) from the prospective German Diabetes Study (GDS) underwent cluster assignment, detailed phenotyping, genotyping and magnetic resonance spectroscopy to quantify hepatocellular lipid content (HCL).</div></div><div><h3>Results</h3><div>Severe insulin-resistant diabetes (SIRD) had the lowest glomerular filtration rates (eGFR) and highest HCL compared to severe insulin-deficient, moderate obesity-related, moderate age-related and severe autoimmune diabetes endotypes (all p &lt; 0.05). HCL was negatively associated with eGFR (r = −0.287, p &lt; 0.01) across all groups. Stratification by G-allele carrier status did not reveal any association between HCL and eGFR among the endotypes. However, the proportion of G-allele carriers increased from 44 % for eGFR &gt;60 ml/min to 52 % for eGFR &lt;60 ml/min (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The <em>PNPLA3</em> polymorphism may contribute to declining kidney function independently of liver lipids.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103137"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142477956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends and hotspots in gestational diabetes and long-term cardiovascular health: A bibliometric analysis","authors":"Yanxi Jia ,&nbsp;Qing Hu ,&nbsp;Hua Liao ,&nbsp;Hongyan Liu ,&nbsp;Zhaomin Zeng ,&nbsp;Haiyan Yu","doi":"10.1016/j.dsx.2024.103144","DOIUrl":"10.1016/j.dsx.2024.103144","url":null,"abstract":"<div><h3>Aims</h3><div>To identify emerging trends and hotspots in research regarding cardiovascular disease (CVD) risk linked to gestational diabetes mellitus (GDM).</div></div><div><h3>Methods</h3><div>A systematic bibliometric review of the literature on the risk of long-term CVD in patients with GDM between 1990 and 2022 from the Web of Science Core Collection (WoSCC) was performed by using Citespace and VOSviewer.</div></div><div><h3>Results</h3><div>This analysis gathered a total of 1185 articles, with 77 publications in 2019 and 119 in 2022, demonstrating a steady growth in the amount of research on the relationship between GDM and CVD in recent years. The United States of America (USA) led in national publications, followed by the United Kingdom (UK) and Canada. Key institutions included Harvard University, the University of Toronto, and the University of Oslo, with Prof. Ravi Retnakaran and Prof. Jane W. Rich-Edwards being prominent figures. The most productive journal was the <em>Journal of Clinical Endocrinology &amp;Metabolism</em>, while <em>Diabetes Care</em> was the most influential and most co-cited journal. Common terms over the last 20 years included “risk,” “type 2 diabetes,” “cardiovascular disease,” and “gestational diabetes,” with recent focus shifting towards “prevention,” “gene expression,” and “DNA methylation”.</div></div><div><h3>Conclusion</h3><div>This is the first bibliometric analysis linking CVD and GDM. Future research should investigate pathways between GDM and CVD, emphasizing gene expression and inflammation, while advocating for collaborative prevention strategies.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103144"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational diabetes mellitus - Neonatal and maternal outcomes in women treated with insulin or diet: A propensity matched analysis","authors":"Sunil S. Gupta ,&nbsp;Shlok S. Gupta ,&nbsp;Rajeev Chawla ,&nbsp;Kavita S. Gupta ,&nbsp;Parvinder R. Bamrah ,&nbsp;Rutul A. Gokalani","doi":"10.1016/j.dsx.2024.103145","DOIUrl":"10.1016/j.dsx.2024.103145","url":null,"abstract":"<div><h3>Aims</h3><div>Pregnant women worldwide face the risk of developing gestational diabetes mellitus (GDM), if left untreated, can cause complications. The study explores factors influencing the choice between diet control and insulin therapy for pregnant women with GDM. It aims to understand how these choices impact maternal and neonatal outcomes.</div></div><div><h3>Methods</h3><div>In this quasi-experimental study, clinicians determined treatment (diet control or insulin) for 1030 individuals with GDM at a private practice from 2010 to 2020 based on baseline characteristics. Propensity scores (PS), reflecting the probability of treatment allocation, were derived through multiple logistic regression.</div></div><div><h3>Results</h3><div>After PS matching, 386 individuals were paired from two study groups. The insulin-treated group exhibited a 4.43 times higher risk of neonatal hypoglycemia than the diet group. Insulin-treated individuals, stratified by PS, revealed that the high-risk quartile had significantly higher mean insulin requirements and a doubled dose at full term compared to the lower-risk quartiles. The mean insulin dose did not significantly differ in the first three quartiles, but the last quartile showed a significant increase (p = 0.008), particularly for individuals with PS exceeding 0.70, indicating a higher insulin dose requirement for effective glucose control.</div></div><div><h3>Conclusion</h3><div>This study reveals that individuals with a bad obstetrics history, a family history of diabetes, obesity, and elevated baseline glycemic parameters necessitate higher insulin doses. This insight improves clinicians' decision-making in diagnosis and treatment planning, enhancing the precision of medical practices.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103145"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of and barriers to diabetes care among patients with serious mental illness: A scoping review with recommendations","authors":"A.S. Prathiksha ,&nbsp;Pawar Mansi Shantaram ,&nbsp;Muhammed Rashid ,&nbsp;Pooja Gopal Poojari ,&nbsp;Sreedharan Nair ,&nbsp;Leelavathi D. Acharya ,&nbsp;Girish Thunga","doi":"10.1016/j.dsx.2024.103139","DOIUrl":"10.1016/j.dsx.2024.103139","url":null,"abstract":"<div><h3>Aim</h3><div>We performed a scoping review to identify the diabetes care determinants and barriers in patients with serious mental illness (SMI), in view of limited evidence and clarity.</div></div><div><h3>Methods</h3><div>We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Guidelines. PubMed, EMBASE, and Scopus were searched from inception to September 2023 to identify eligible studies. Observational studies that reported the determinants of and barriers to diabetes care among SMI patients were considered. A narrative synthesis of review results was performed to gather evidence. Recommendations were framed in the context of this evidence.</div></div><div><h3>Results</h3><div>Of the 8727 non-duplicate records, only 10 studies that met the inclusion criteria were considered for this review. Of these, four were cohort, two were case-control, and four were cross-sectional in design. All 10 studies were observed to have robust methodologies. Diabetes measures examined in these studies included not only the Healthcare Effectiveness Data and Information Set (HEDIS) measures (HbA1c, retinopathy, nephropathy, and blood pressure), but also lipid, foot, and BMI. Factors contributing to inadequate diabetes care can be attributed to the healthcare system, healthcare providers, and at the patient-level.</div></div><div><h3>Conclusion</h3><div>Currently, there is lack of evidence on determinants of quality diabetes care among SMI patients. Further, adequately powered long term follow-up studies are needed to understand the impact of diabetes care on their clinical outcomes.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103139"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-34a and promoter methylation contribute to peroxisome proliferator-activated receptor gamma gene expression in patients with type 2 diabetes","authors":"Mona Moghadasi ,&nbsp;Mozhgan Taherimoghaddam ,&nbsp;Esmaeel Babaeenezhad ,&nbsp;Mehdi Birjandi ,&nbsp;Mozhgan Kaviani ,&nbsp;Mostafa Moradi Sarabi","doi":"10.1016/j.dsx.2024.103156","DOIUrl":"10.1016/j.dsx.2024.103156","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to investigate the roles of DNA methylation and miR-34a in the regulation of peroxisome proliferator-activated receptor gamma (<em>PPARγ</em>) in patients with type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>We investigated the methylation status of four regions of the <em>PPARγ</em> promoter and <em>PPARγ</em> expression in a panel of 84 T2D patients using methylation-specific PCR (MSP) and RT-qPCR, respectively. Moreover, we quantified DNA methyltransferases (<em>DNMTs</em>) expression and global DNA methylation levels by RT-qPCR and ELISA, respectively. We measured the expression levels of miR-34a and protein expression of PPARγ by stem-loop RT-qPCR and ELISA, respectively.</div></div><div><h3>Results</h3><div>We found significant DNA hypermethylation in the R2 and R3 regions of the <em>PPARγ</em> promoter in people with diabetes. Functionally, this was associated with a significant reduction in <em>PPARγ</em> expression. In addition, we observed a significant increase in 5-methylcytosine levels in people with diabetes. A marked increase in circulating miR-34a in the early stages of T2D (up to 10 years) and a significant decrease in circulating miR-34a with increasing diabetes duration from 10 years after the onset of diabetes. Interestingly, upregulation of DNA methyltransferases 1 (<em>DNMT1</em>), <em>DNMT3A</em>, and <em>DNMT3B</em> was observed in people with diabetes, and the average expression of <em>DNMTs</em> was negatively correlated with circulating miR-34a levels. In contrast, the serum protein level of PPARγ, a direct target of miR-34a, increased considerably with diabetes duration and showed a negative correlation with circulating miR-34a, cholesterol, triglyceride, and low-density lipoprotein.</div></div><div><h3>Conclusion</h3><div><em>PPARγ</em> promoter hypermethylation and miR-34a upregulation are associated with T2D pathogenesis through <em>PPARγ</em> dysregulation.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103156"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of delivery modalities of non-pharmacological diabetes prevention programs: A systematic review and component network meta-analysis","authors":"Ellesha A. Smith ,&nbsp;Stephanie J. Hubbard ,&nbsp;Suzanne C. Freeman ,&nbsp;Daniel S. March ,&nbsp;Molly Wells ,&nbsp;Elnaz Saeedi ,&nbsp;Louise Haddon ,&nbsp;Kamlesh Khunti ,&nbsp;Laura J. Gray","doi":"10.1016/j.dsx.2024.103136","DOIUrl":"10.1016/j.dsx.2024.103136","url":null,"abstract":"<div><h3>Background and aims</h3><div>Type 2 diabetes prevention programs are effective but costly and intensive, making translation into routine primary care and community settings challenging. Identifying drivers of intervention effectiveness can inform pragmatic future implementation whilst maintaining effectiveness. Translational studies have demonstrated that delivery modalities impact their effectiveness. This systematic review and component network meta-analysis assessed which delivery modality components of non-pharmacological diabetes prevention programs are associated with reductions in type 2 diabetes incidence for individuals at high risk of type 2 diabetes (or pre-diabetes).</div></div><div><h3>Methods</h3><div>We searched MEDLINE, The Cochrane Library, Opengrey and <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> from inception to November 17, 2022 for translational studies comparing lifestyle interventions with a minimum 12-month follow-up. Two investigators extracted the data. Random effects network meta-analyses and component network meta-analyses estimated the intervention effects.</div></div><div><h3>Results</h3><div>We identified 50 eligible studies involving 29,286 participants including thirty-six (72.0 %) randomized controlled trials, 10 (20.0 %) cluster randomized controlled trials, and four (8.0 %) observational studies. Component network meta-analyses found in-person (individually) delivery was associated with greater reduction in incidence of type 2 diabetes (hazard ratio: 0.66, 95 % credible interval: 0.41, 0.96) and in-person (group-based) delivery was associated with greater reductions in weight (mean difference: −1.53 kg, 95 % credible interval: −2.18, −0.85) and HbA1c (mean difference: −0.74 mmol/mol, 95 % credible interval: −1.28, −0.17), relative to usual care.</div></div><div><h3>Conclusions</h3><div>This analysis suggests in-person delivery modalities are most effective for diabetes prevention. Future research should focus on improving the effectiveness of digital programs and ensuring preferential delivery for target populations to reduce health inequalities.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103136"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The triglyceride-glucose index, blood glucose levels, and metabolic syndrome are associated with all-cause mortality in obesity","authors":"Antonio E. Pontiroli ,&nbsp;Lucia Centofanti ,&nbsp;Ahmed S. Zakaria ,&nbsp;Simona Cerutti ,&nbsp;Michele Dei Cas ,&nbsp;Rita Paroni ,&nbsp;Lucia La Sala ,&nbsp;Elena Tagliabue ,&nbsp;Silvia Magnani ,&nbsp;Franco Folli","doi":"10.1016/j.dsx.2024.103146","DOIUrl":"10.1016/j.dsx.2024.103146","url":null,"abstract":"<div><h3>Background</h3><div>The Triglyceride-Glucose Index (TYG) has been proposed as a prognostic index for mortality in the general population, in T2DM, and in patients with cardiovascular diseases. However, data on the respective predictive roles of TYG, glucose tolerance (GT), and metabolic syndrome (MS) for mortality in obesity are lacking.</div></div><div><h3>Methods</h3><div>We analyzed 1359 obese patients (371 men and 988 women), aged 44.1 ± 12.64 years, followed for 14.3 ± 4.44 years. They were subdivided according to glucose tolerance, in normal glucose tolerance (NGT), impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM). We analyzed the risk of death associated with blood glucose (BG) quartiles, TYG quartiles and MS quartiles. Cox proportional-hazard models were used to evaluate the risk of death associated with independent variables that were highly statistically significant at univariate analysis.</div></div><div><h3>Results</h3><div>Different degrees of glucose tolerance were associated with a progressive deterioration of clinical outcomes, and increased all-cause mortality (6.3 %, 10.1 %, and 20.4 %, respectively). In all groups, age and male sex were associated with increased mortality. Higher TYG or TYG quartiles, BG or BG quartiles, and MS or MS quartiles were all associated with increased all-cause mortality in the whole cohort.</div></div><div><h3>Conclusion</h3><div>TYG, blood glucose and MS are risk factors for mortality in obesity, with a progressively stronger value in IFG and T2DM as compared to NGT.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 10","pages":"Article 103146"},"PeriodicalIF":4.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}