Diabetes & Metabolic Syndrome-Clinical Research & Reviews最新文献

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Increasing trend in prediabetes and obesity among adolescent school children in Chennai city in Southern India 印度南部钦奈市青春期学龄儿童前驱糖尿病和肥胖症的增加趋势。
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-20 DOI: 10.1016/j.dsx.2026.103457
Ramachandran Nanditha, Priscilla Susairaj, Krishnamoorthy Satheesh, Ramachandran Vinitha, Chamukuttan Snehalatha, Ambady Ramachandran
{"title":"Increasing trend in prediabetes and obesity among adolescent school children in Chennai city in Southern India","authors":"Ramachandran Nanditha,&nbsp;Priscilla Susairaj,&nbsp;Krishnamoorthy Satheesh,&nbsp;Ramachandran Vinitha,&nbsp;Chamukuttan Snehalatha,&nbsp;Ambady Ramachandran","doi":"10.1016/j.dsx.2026.103457","DOIUrl":"10.1016/j.dsx.2026.103457","url":null,"abstract":"<div><h3>Background and aims</h3><div>In 2006, we reported presence of cardiometabolic abnormalities including impaired fasting glucose (IFG) in 85% of overweight adolescent children. In this study, we assessed the change in the prevalence of IFG and its association with cardiometabolic risk factors among adolescent school children in the low and middle income group after a period of 17 years.</div></div><div><h3>Methods</h3><div>The cross – sectional study was conducted in 2023 among students aged 12 to 19 years in Chennai city using a similar methodology as in 2006 survey. Demography, anthropometry, body composition and vital signs were recorded. Fasting blood sample was drawn to estimate blood glucose and lipid parameters.</div></div><div><h3>Results</h3><div>We enrolled a total of 954 students (girls, n = 587; boys, n = 367). In 2023, a higher proportion reported family history of diabetes, had higher body mass index (BMI), waist circumference (WC), systolic blood pressure and fasting blood glucose than in 2006. Girls continued to have higher BMI, body fat % and lipid parameters than boys. Prevalence of IFG was higher by several fold when compared with 2006 (28·1% vs. 3·1% in girls; 26·4% vs. 3·5% in boys, p &lt; 0.0001 for all). Younger age (≤15 years) was found to be significantly associated with IFG.</div></div><div><h3>Conclusions</h3><div>Prevalence of IFG and obesity increased simultaneously among adolescent children in Southern India. The rise in IFG in younger children could be attributed to early metabolic changes triggered by environmental factors; indicating a likelihood of further increase in the prevalence of diabetes and cardiovascular risk among young adults. ClinicalTrials.govIdentifier: NCT04015726.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103457"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive impairment in metabolic dysfunction-associated steatotic liver disease (MASLD): A systematic review and meta-analysis 代谢功能障碍相关脂肪变性肝病(MASLD)的认知障碍:系统回顾和荟萃分析
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.1016/j.dsx.2026.103467
Soe Thiha Maung, Solaphat Hemrungrojn, Roongruedee Chaiteerakij
{"title":"Cognitive impairment in metabolic dysfunction-associated steatotic liver disease (MASLD): A systematic review and meta-analysis","authors":"Soe Thiha Maung,&nbsp;Solaphat Hemrungrojn,&nbsp;Roongruedee Chaiteerakij","doi":"10.1016/j.dsx.2026.103467","DOIUrl":"10.1016/j.dsx.2026.103467","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis aimed to evaluate cognitive performance in individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) compared to controls and to explore how cognitive assessment methods and metabolic risk factors may influence the relationship between MASLD and cognitive impairment.</div></div><div><h3>Methods</h3><div>We systematically searched databases through June 2026 for studies comparing cognitive performance in MASLD patients using Mini-Mental State Examination (MMSE) or Montreal Cognitive Assessment (MoCA). We calculated pooled standardized mean differences (SMDs) using random-effects meta-analysis and explored heterogeneity via subgroup and meta-regression analyses.</div></div><div><h3>Results</h3><div>We included 13 studies involving 15,545 participants. The pooled SMD for cognitive scores in NAFLD/MASLD patients vs. controls was −0.43 (95%CI: −0.61 to −0.25; p &lt; 0.0001; <em>I</em><sup><em>2</em></sup> = 83%), indicating a statistically significant association with poorer cognitive performance. Subgroup analysis showed significant effects in both MoCA-based (SMD = −0.59; 95%CI: −0.93 to −0.25; p &lt; 0.001; <em>I</em><sup><em>2</em></sup> = 90%) and MMSE-based studies (SMD = −0.20; 95%CI: −0.24 to −0.16; p &lt; 0.001; <em>I</em><sup><em>2</em></sup> = 53%), with a significant between-subgroup difference (p = 0.024). Cross-sectional studies reported stronger effects with higher heterogeneity (SMD = −0.52; 95%CI: −0.75 to −0.29; p &lt; 0.001), whereas cohort studies showed smaller but consistent results (SMD = −0.19; 95%CI: −0.25 to −0.13; p &lt; 0.001). Meta-regression identified that higher BMI (β = −0.071; R<sup>2</sup> = 81%) and increased liver enzymes, specifically AST (β = −0.038; R<sup>2</sup> = 98%), ALT (β = −0.018; R<sup>2</sup> = 100%), and GGT (β = −0.012; R<sup>2</sup> = 90%), were strongly associated with lower cognitive scores.</div></div><div><h3>Conclusion</h3><div>This meta-analysis demonstrated a statistically significant association between NAFLD/MASLD and poorer cognitive performance, with BMI and elevated liver enzymes identified as key moderators, supporting for routine MoCA-based cognitive screening in high-risk populations and standardized longitudinal research.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103467"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body shape index and body roundness index: Novel anthropometric indices to identify diabetes mellitus among the Indian population 体型指数和身体圆度指数:在印度人群中识别糖尿病的新型人体测量指标。
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-28 DOI: 10.1016/j.dsx.2026.103468
Madhur Verma, Pritam Halder, Girish Jeer, Nitin Kapoor, Sonia Kochhar, Indu Prabha, Rakesh Kakkar, Sanjay Kalra
{"title":"Body shape index and body roundness index: Novel anthropometric indices to identify diabetes mellitus among the Indian population","authors":"Madhur Verma,&nbsp;Pritam Halder,&nbsp;Girish Jeer,&nbsp;Nitin Kapoor,&nbsp;Sonia Kochhar,&nbsp;Indu Prabha,&nbsp;Rakesh Kakkar,&nbsp;Sanjay Kalra","doi":"10.1016/j.dsx.2026.103468","DOIUrl":"10.1016/j.dsx.2026.103468","url":null,"abstract":"<div><h3>Aims</h3><div>We aimed to compare the discriminatory performance of Body Shape Index and Body Roundness Index with traditional anthropometric measures, including body mass index, waist circumference, and waist-to-height ratio, for identifying prevalent diabetes among Indian adults.</div></div><div><h3>Methods</h3><div>Data from the fifth round of the National Family Health Survey were analyzed, including 574,099 women and 74,761 men (aged 15-49 years). Diabetes was defined by self-reported diagnosis, current use of glucose-lowering medication, or a random blood glucose ≥200 mg/dL. Anthropometric indices were derived from measured height, weight, and waist circumference. Survey-weighted prevalence estimates, multivariable logistic regression, receiver operating characteristic analysis, DeLong tests, and trend tests were used.</div></div><div><h3>Results</h3><div>The weighted prevalence of diabetes was 13.6% and increased with age, urban residence, higher wealth, education, obesity, and hypertension. Waist circumference showed the highest correlation with diabetes (r = 0.1446) and the highest, though modest, discrimination (area under the curve = 0.61). Body mass index, Body Roundness Index, and waist-to-height ratio performed similarly (area under the curve = 0.60 each), whereas Body Shape Index showed the lowest discrimination (area under the curve = 0.55). DeLong comparisons showed that waist circumference and Body Roundness Index performed significantly better than Body Shape Index, while Body Roundness Index showed no meaningful incremental discrimination beyond waist-to-height ratio.</div></div><div><h3>Conclusions</h3><div>Waist circumference, waist-to-height ratio, and Body Roundness Index performed similarly to, and modestly better than, the Body Shape Index for identifying prevalent diabetes in Indian adults. Simpler waist-based measures, particularly waist circumference and waist-to-height ratio, may be sufficient for population-level diabetes risk screening.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103468"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights of the Current Issue 本期重点报道
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-08-11 DOI: 10.1016/j.dsx.2026.103471
Ningjian Wang (Associate Editor), Anoop Misra (Editor-in-Chief)
{"title":"Highlights of the Current Issue","authors":"Ningjian Wang (Associate Editor),&nbsp;Anoop Misra (Editor-in-Chief)","doi":"10.1016/j.dsx.2026.103471","DOIUrl":"10.1016/j.dsx.2026.103471","url":null,"abstract":"","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103471"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148742744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skeletal muscle health and the development of prediabetes in middle-aged and older adults: mediated by inflammation and lipid indices 中老年人骨骼肌健康和前驱糖尿病的发展:由炎症和脂质指数介导
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-17 DOI: 10.1016/j.dsx.2026.103453
Xuezhong Shi, Yuting Xie, Yongli Yang, Chaojun Yang, Nana Wang, Shijia Wang, Xiaocan Jia
{"title":"Skeletal muscle health and the development of prediabetes in middle-aged and older adults: mediated by inflammation and lipid indices","authors":"Xuezhong Shi,&nbsp;Yuting Xie,&nbsp;Yongli Yang,&nbsp;Chaojun Yang,&nbsp;Nana Wang,&nbsp;Shijia Wang,&nbsp;Xiaocan Jia","doi":"10.1016/j.dsx.2026.103453","DOIUrl":"10.1016/j.dsx.2026.103453","url":null,"abstract":"<div><h3>Aims</h3><div>This study aims to examine the effect of relative muscle strength (RMS) on the progression to diabetes or regression to normoglycemia in individuals with prediabetes.</div></div><div><h3>Methods</h3><div>Data were sourced from the China Health and Retirement Longitudinal Study (CHARLS), which followed 3250 individuals aged ≥45 years with prediabetes. RMS was calculated as the ratio of grip to appendicular skeletal muscle mass (ASM). Multinomial logistic regression was used to assess the association of RMS with subsequent glycemic transitions, including regression to normoglycemia, persistence of prediabetes, and progression to diabetes. Mediation analysis explored the role of inflammation and lipid profiles in this association.</div></div><div><h3>Results</h3><div>During the follow-up period, 1953 participants remained in the prediabetes stage, 698 reverted to normoglycemia, and 599 progressed to diabetes. Participants regressing to normoglycemia exhibited significantly higher RMS than those remaining prediabetic [M (IQR): 2.25 (1.85, 2.62) vs. 2.16 (1.78, 2.55)], whereas those who progressed to diabetes showed lower RMS [1.97 (1.61, 2.32)]. Compared to the low RMS group, the OR (95% CI) for the high RMS group was 0.49(0.38, 0.64). Mediation analysis showed that high-density lipoprotein (HDL), triglycerides (TG), and C-reactive protein (CRP) partially mediated the effect between RMS and prediabetes progression, accounting for 14.47%, 4.41%, and 0.21% of the overall effect, respectively.</div></div><div><h3>Conclusions</h3><div>Higher RMS independently protects against prediabetes progression and may aid regression, mediated by HDL, TG, and CRP.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103453"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-sex effect on concurrent prevalence of hypertension and diabetes in Indian subjects: A hospital-based study of more than 56000 adults visiting for preventive checkup 年龄性别对印度高血压和糖尿病并发患病率的影响:一项基于医院的研究,超过56000名成年人前来进行预防性检查。
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-25 DOI: 10.1016/j.dsx.2026.103458
Abhaya Indrayan, Shivani Saini, Pushpender Kumar, Ruchi Verma, Rajesh Saxena, Vinitaa Jha, Sandeep Budhiraja, Akhilesh Srivastava
{"title":"Age-sex effect on concurrent prevalence of hypertension and diabetes in Indian subjects: A hospital-based study of more than 56000 adults visiting for preventive checkup","authors":"Abhaya Indrayan,&nbsp;Shivani Saini,&nbsp;Pushpender Kumar,&nbsp;Ruchi Verma,&nbsp;Rajesh Saxena,&nbsp;Vinitaa Jha,&nbsp;Sandeep Budhiraja,&nbsp;Akhilesh Srivastava","doi":"10.1016/j.dsx.2026.103458","DOIUrl":"10.1016/j.dsx.2026.103458","url":null,"abstract":"<div><h3>Aim</h3><div>In view of the substantially increased risk of adverse outcomes, this study aims to determine the concurrent prevalence of hypertension and diabetes, quantify the synergy factor, and assess its age trend in a segment of the Indian population.</div></div><div><h3>Methods</h3><div>Electronic health records of more than 56000 persons undergoing health check-up in a group of hospitals were analysed for age-trend and sex differences for hypertension in cases with diabetes and diabetes in cases with hypertension, in addition to the concurrent prevalence. The synergy factor between the two diseases was determined as the occurrence in excess of their joint occurrence by chance.</div></div><div><h3>Results</h3><div>The overall concurrent prevalence was around 5% – nearly twice of that expected by chance if they were independent diseases – thus measuring their synergy. This synergy started to rise rapidly at age around 40 years in either sex, continued to rise until around to 58 years, and then slowed down to plateau at nearly 17% at around 70 years. Hypertension in cases with diabetes was about 4 times as common as in those without diabetes, and diabetes in hypertensive cases was about 2½ times as common as in those without hypertension.</div></div><div><h3>Conclusion</h3><div>The findings quantify the inter-dependence of hypertension and diabetes in a segment of the Indian population and underscore the need for integrated screening strategies, especially around the age of 40 years, to mitigate the dual burden.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103458"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological and clinical insights from Type 1 Diabetes Global Registries: A systematic review and meta-analysis 来自1型糖尿病全球登记的流行病学和临床见解:系统回顾和荟萃分析。
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-23 DOI: 10.1016/j.dsx.2026.103455
Rupali Chauhan, Riddhi Solanki, Mahira Saiyed, Banshi Saboo, Komal Shah
{"title":"Epidemiological and clinical insights from Type 1 Diabetes Global Registries: A systematic review and meta-analysis","authors":"Rupali Chauhan,&nbsp;Riddhi Solanki,&nbsp;Mahira Saiyed,&nbsp;Banshi Saboo,&nbsp;Komal Shah","doi":"10.1016/j.dsx.2026.103455","DOIUrl":"10.1016/j.dsx.2026.103455","url":null,"abstract":"<div><h3>Background</h3><div>Type 1 diabetes (T1D) incidence is rising globally, especially among children, with Systematic evaluation of these registries can highlight disparities in diagnosis, access, and management while supporting cross-regional learning to improve care delivery.</div></div><div><h3>Objective</h3><div>To assess the global burden of T1D by synthesizing key epidemiological indicators, including incidence, complications, and management approaches in children aged 0-14 years, and to characterize registry populations by sociodemographic and clinical features to identify care disparities.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis of five databases identified 51 eligible studies (1969–2023). Data on incidence, diabetic ketoacidosis (DKA), and continuous glucose monitoring (CGM) use were pooled from 39 studies.</div></div><div><h3>Results</h3><div>51 studies comprising 433,727 participants from 38 countries were analysed. Registries included 20 national, 11 regional, and 7 hospital-based datasets. The pooled global incidence of T1D was 20.16 per 100,000 population (95% CI: 16.49–23.84; I<sup>2</sup> = 89%). Incidence varied geographically, with higher estimates reported in Europe (22.2/100,000) compared with Asia (8.90/100,000). Registries applying ISPAD criteria reported higher incidence estimates (26.45/100,000) compared with EURODIAB criteria (19.15/100,000), although diagnostic criteria subgroup differences were not statistically significant. No significant gender differences were observed. DKA at diagnosis occurred in 38% of children, with substantial variability across settings. CGM use was reported in only four registries, with a pooled prevalence of 12.5%, highlighting gaps in access and adoption of diabetes technologies.</div></div><div><h3>Conclusion</h3><div>Global T1D registries demonstrate substantial heterogeneity in incidence and persistent disparities in diagnosis and diabetes care. Harmonized registry standards and equitable access to diabetes technologies are needed to strengthen surveillance and improve outcomes.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103455"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional intake changes during GLP-1 receptor agonist therapy: A systematic review and meta-analysis GLP-1受体激动剂治疗期间营养摄入的变化:一项系统回顾和荟萃分析。
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-25 DOI: 10.1016/j.dsx.2026.103466
Anh Tuan Quan, Hoang Linh Nguyen, Tran My Thanh Nguyen
{"title":"Nutritional intake changes during GLP-1 receptor agonist therapy: A systematic review and meta-analysis","authors":"Anh Tuan Quan,&nbsp;Hoang Linh Nguyen,&nbsp;Tran My Thanh Nguyen","doi":"10.1016/j.dsx.2026.103466","DOIUrl":"10.1016/j.dsx.2026.103466","url":null,"abstract":"<div><h3>Background and aims</h3><div>Glucagon-like peptide-1 (GLP-1) receptor agonists, including the dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist tirzepatide, produce substantial weight loss, yet their effect on objectively measured dietary intake has not been quantitatively synthesized. We assessed their impact on <em>ad libitum</em> lunch energy intake.</div></div><div><h3>Methods</h3><div>We searched six databases through March 31, 2026, for studies reporting quantitative dietary outcomes in adults receiving a GLP-1 or dual GIP/GLP-1 receptor agonist. Randomized or crossover placebo-controlled trials lasting at least four weeks that reported standardized <em>ad libitum</em> lunch intake were pooled using a DerSimonian-Laird random-effects model. Prespecified sensitivity analyses included restricted maximum likelihood (REML) and Paule-Mandel estimators, a 95% prediction interval, a subgroup analysis, a leave-one-out analysis, and an exploratory three-week phase 1 tirzepatide trial.</div></div><div><h3>Results</h3><div>Sixteen studies were included in the systematic review; four arms from three trials (209 participants) contributed to the primary meta-analysis. The pooled treatment difference in <em>ad libitum</em> lunch energy intake was −1132 kJ (95% confidence interval [CI] −1449 to −815), approximately −271 kcal, with no heterogeneity (I-squared = 0%; 95% prediction interval −1828 to −436 kJ). Adding the phase 1 trial (k = 5) increased the effect to −1421 kJ but introduced substantial heterogeneity (I-squared = 70%). The semaglutide-versus-tirzepatide difference was not significant (p = 0.154).</div></div><div><h3>Conclusions</h3><div>GLP-1 receptor agonist therapy markedly reduces acute energy intake under standardized meal tests, but real-world habitual intake remains underreported. Structured nutritional counseling emphasizing adequate protein should complement pharmacotherapy.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103466"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationships between figure rating scale, anthropometric measures, and cardiometabolic outcomes: the AADM study 身材评定量表、人体测量和心脏代谢结果之间的关系:AADM研究。
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-25 DOI: 10.1016/j.dsx.2026.103456
Ayo P. Doumatey, Amira Idris, Jie Zhou, Adebowale Adeyemo, Charles Rotimi
{"title":"The relationships between figure rating scale, anthropometric measures, and cardiometabolic outcomes: the AADM study","authors":"Ayo P. Doumatey,&nbsp;Amira Idris,&nbsp;Jie Zhou,&nbsp;Adebowale Adeyemo,&nbsp;Charles Rotimi","doi":"10.1016/j.dsx.2026.103456","DOIUrl":"10.1016/j.dsx.2026.103456","url":null,"abstract":"<div><h3>Introduction</h3><div>Direct measurement of anthropometrics can be impractical in research. Validated Figure Rating Scales (FRS) offer an alternative, but their validity across populations remains limited.</div></div><div><h3>Objectives</h3><div>This study aimed to analyze the relationships between figure rating scale (FRS) and anthropometric measures (body mass index (BMI); waist circumference (WC), and waist-to-hip ratio (WHR)) and to specifically evaluate FRS at the time of enrollment and lifetime body size, an FRS-derived score as risk factors for cardiometabolic traits including type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>Participants consisted of 650 adults from the America Africa Diabetes Mellitus study. Kendall's tau coefficient (τ) was used to analyze correlations between FRS at the time of enrollment, overall obesity, and abdominal obesity. Regression models were used to evaluate FRS at the time of enrollment and lifetime body size as risk factors for T2D, and related traits.</div></div><div><h3>Results</h3><div>BMI and WHR increased monotonically with increasing body size. FRS at the time of enrollment showed a stronger correlation with BMI (τ = 0.48, p &lt; 0.0001) than with WHR (τ = 0.17, p &lt; 0.0001) in women. Lifetime body size was significantly associated with T2D (OR = 1.044, 95% Confidence Limit: [1.006, 1.08]; both FRS at the time of enrollment and lifetime body size were associated with insulin resistance. Diastolic blood pressure was associated with FRS at the time of enrollment.</div></div><div><h3>Conclusions</h3><div>FRS at the time of enrollment is significantly associated with BMI and WHR in this population and lifetime body size, a novel composite score, shows promising utility as a predictor of T2D.</div></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"20 7","pages":"Article 103456"},"PeriodicalIF":4.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on “Effect of combined aerobic and resistance training on kidney health in adults with type 2 diabetes: A randomized controlled trial” 《有氧与抗阻联合训练对成人2型糖尿病患者肾脏健康的影响:一项随机对照试验》评论
IF 4.4
Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-06-01 Epub Date: 2026-06-20 DOI: 10.1016/j.dsx.2026.103417
K V Vijay Kumar, Pankaj Kshirsagar, Mansi Mishra, Surbhi Panwar
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