Diabetes & Metabolic Syndrome-Clinical Research & Reviews最新文献_第10页

Computational approaches for clinical, genomic and proteomic markers of response to glucagon-like peptide-1 therapy in type-2 diabetes mellitus: An exploratory analysis with machine learning algorithms 2 型糖尿病患者对胰高血糖素样肽-1 治疗反应的临床、基因组和蛋白质组标记的计算方法：利用机器学习算法进行探索性分析。

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103086

Angelina Thomas Villikudathil , Declan H. Mc Guigan , Andrew English

{"title":"Computational approaches for clinical, genomic and proteomic markers of response to glucagon-like peptide-1 therapy in type-2 diabetes mellitus: An exploratory analysis with machine learning algorithms","authors":"Angelina Thomas Villikudathil , Declan H. Mc Guigan , Andrew English","doi":"10.1016/j.dsx.2024.103086","DOIUrl":"10.1016/j.dsx.2024.103086","url":null,"abstract":"<div><h3>Introduction</h3><p>In 2021, the International Diabetes Federation reported that 537 million people worldwide are living with diabetes. While glucagon-like peptide-1 agonists provide significant benefits in diabetes management, approximately 40 % of patients do not respond well to this therapy. This study aims to enhance treatment outcomes by using machine learning to predict individual response status to glucagon-like peptide-1 therapy.</p></div><div><h3>Methods</h3><p>We analysed a type-2 diabetes mellitus dataset from the Diastrat cohort, recruited at the Northern Ireland Centre for Stratified Medicine. The dataset included individuals prescribed glucagon-like peptide-1 therapy, with response status determined by glycated haemoglobin levels of ≤53 mmol/mol. We identified genomic and proteomic markers and developed machine learning models to predict therapy response.</p></div><div><h3>Results</h3><p>The study found 5 genomic variants and 45 proteomic markers that help differentiate glucagon-like peptide-1 therapy responders from non-responders, achieving 95 % prediction accuracy with a machine learning model.</p></div><div><h3>Conclusion</h3><p>This study demonstrates the potential of machine learning in predicting the response to glucagon-like peptide-1 therapy in individuals with type-2 diabetes mellitus. These findings suggest that integrating genomic and proteomic data can significantly enhance personalized treatment approaches, potentially improving outcomes for patients who might otherwise not respond well to glucagon-like peptide-1 therapy. Further research and validation in larger cohorts are necessary to confirm these results and translate them into clinical practice.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103086"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out-of-pocket direct cost of ambulatory care of type 2 diabetes in Delhi: Estimates from the Delhi diabetes community-II (DEDICOM-II) survey 德里 2 型糖尿病门诊护理的自付直接费用：德里糖尿病社区-II（DEDICOM-II）调查的估计值

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103089

Swapnil Rawat, Neetu Bansal, Ramasheesh Yadav, Siddhi Goyal, Jitender Nagpal

{"title":"Out-of-pocket direct cost of ambulatory care of type 2 diabetes in Delhi: Estimates from the Delhi diabetes community-II (DEDICOM-II) survey","authors":"Swapnil Rawat, Neetu Bansal, Ramasheesh Yadav, Siddhi Goyal, Jitender Nagpal","doi":"10.1016/j.dsx.2024.103089","DOIUrl":"10.1016/j.dsx.2024.103089","url":null,"abstract":"<div><h3>Background & aim</h3><p>Much of the cost data from India is restricted to patients recruited purely from healthcare institutions and do not explore determinants. Therefore, the out of pocket expenditure for ambulatory diabetes care was evaluated in Delhi.</p></div><div><h3>Methods</h3><p>The DEDICOM-II survey used a two-stage probability-proportionate-to-size(systematic) cluster design. Thirty clusters were chosen to recruit 25 to 30 subjects per area. We used questionnaires to estimate the direct out-of-pocket expenditure (OOPE) on drugs, investigations, consultation and travel, excluding hospitalization, and then analysed its determinants and impact on quality of care.</p></div><div><h3>Results</h3><p>We enrolled 843 subjects with a mean age of 53.1 years. The annual direct OOPE on ambulatory care of diabetes was US$ 116.3 (95 % CI 93.8–138.9) or INR 8074.8 (95 % CI 6512.9–9636.7), corresponding to 3.6 %(95 % CI 2.9–4.3) of the yearly family income. The burden of expenses was disproportionately higher for those visiting private providers from lower-income groups(19.1 %). Duration of disease and treatment with insulin predicted higher annual OOPE while care at public facilities was less expensive. Cost was higher for those adhering to the recommended processes of care. Quality of care was better for institutional care and worse for alternative medicine or self-care.</p></div><div><h3>Conclusions</h3><p>The study provides representative estimates of the high cost of diabetes management in Delhi across the socio-economic and care provider spectra. Poorer patients suffer a high financial burden from diabetes, highlighting the need for enhancing equity in diabetes care.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103089"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle modifies the associations of early-life smoking behaviors and genetic susceptibility with type 2 diabetes: A prospective cohort study involving 433,872 individuals from UK Biobank 生活方式可改变早年吸烟行为与 2 型糖尿病遗传易感性之间的关联：一项涉及英国生物库中 433,872 人的前瞻性队列研究

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103090

Xuanwei Jiang, Guangrui Yang, Nannan Feng, Xihao Du, Lan Xu, Victor W. Zhong

{"title":"Lifestyle modifies the associations of early-life smoking behaviors and genetic susceptibility with type 2 diabetes: A prospective cohort study involving 433,872 individuals from UK Biobank","authors":"Xuanwei Jiang, Guangrui Yang, Nannan Feng, Xihao Du, Lan Xu, Victor W. Zhong","doi":"10.1016/j.dsx.2024.103090","DOIUrl":"10.1016/j.dsx.2024.103090","url":null,"abstract":"<div><h3>Background</h3><p>To investigate whether and what lifestyle factors in later life modify the associations of early-life smoking behaviors and genetic susceptibility with type 2 diabetes (T2D).</p></div><div><h3>Methods</h3><p>In the UK Biobank, in utero tobacco exposure (n = 354,493) and age of smoking initiation (n = 353,557) were self-reported. A composite lifestyle score was calculated based on diet, physical activity, nicotine exposure, sleep duration, and BMI. Hazard ratio (HR) and absolute risk difference (ARD) were used to estimate the associations of early-life smoking behaviors and genetic risk with incident T2D, as well as the effect modification of the lifestyle score.</p></div><div><h3>Results</h3><p>During a median follow-up of 14.6 years, the HRs (95 % CIs) of T2D for in utero tobacco exposure, and smoking initiation in adulthood, adolescence, and childhood, compared with no smoking behavior, were 1.19 (1.16–1.23), 1.34 (1.29–1.39), 1.58 (1.53–1.64), 2.22 (2.11–2.32), respectively (<em>P</em> for trend<0.001). Early-life smoking behaviors and high genetic risk (vs no smoking behavior and low genetic risk) were associated with a 302%–593 % higher T2D risk (<em>P</em> for additive interaction<0.05). Compared to participants with early-life smoking behaviors, high genetic risk, and an unfavorable lifestyle, those who adhered to a favorable lifestyle had a lower T2D risk in all subgroups (HRs from 0.05 to 0.36 and ARD from −14.97 % to −9.51 %), with the highest ARD attributable to lifestyle in participants with early-life smoking behaviors and high genetic risk.</p></div><div><h3>Conclusions</h3><p>The T2D risk associated with early-life smoking behaviors and genetic risk was modified by a favorable lifestyle.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103090"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

District-level epidemiology and sociodemographic determinants of noncommunicable diseases - results the National Family Health Survey −5 (2019–21) 县级流行病学和非传染性疾病（NCDs）的社会人口决定因素--全国家庭健康调查-5（2019-21）的结果。

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103085

Vaitheeswaran Kulothungan, Leena Mascarenhas, Priyanka Das, Prashant Mathur

{"title":"District-level epidemiology and sociodemographic determinants of noncommunicable diseases - results the National Family Health Survey −5 (2019–21)","authors":"Vaitheeswaran Kulothungan, Leena Mascarenhas, Priyanka Das, Prashant Mathur","doi":"10.1016/j.dsx.2024.103085","DOIUrl":"10.1016/j.dsx.2024.103085","url":null,"abstract":"<div><h3>Background</h3><p>Noncommunicable diseases (NCDs) are the leading cause of adult mortality in India. However, the data regarding the prevalence of NCD risk factors at district level is scarce. This study aims to analyse and map NCD risk factors at the state and district levels, exploring sociodemographic influences on these risks in Indian males and females.</p></div><div><h3>Methods</h3><p>We analyzed National Family Health Survey-5 database and used the prevalence estimates to create choropleth maps, enabling us to examine the geographical variations in NCD risk factors at the district level in India.</p></div><div><h3>Results</h3><p>Districts in the Satluj-Yamuna plains, western Rajasthan, and the northeastern regions exhibited clusters with a prevalence of high blood pressure exceeding 30.1 %. Northeastern districts showed over 40 % prevalence of current tobacco use, while high alcohol consumption clusters were observed in the northeastern and Telangana districts. Southern districts showed clusters of both obesity (as measured by BMI) and highest rates of oral, breast, and cervical cancer screening, moreover districts in Tamil Nadu exhibited notable clusters of raised blood glucose prevalence.</p></div><div><h3>Conclusion</h3><p>Our analysis revealed variations in the prevalence of NCD risk factors at both the state and district levels. Accordingly, this study ranks districts based on the NCD burden, offering valuable insights to state and district teams to devise targeted measures for the prevention and control of NCDs, particularly in the most heavily affected districts.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103085"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chorionicity and gestational diabetes mellitus in twin pregnancies in relation to placental weight 双胎妊娠的绒毛膜性和妊娠糖尿病与胎盘重量的关系。

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103093

Mohammed Rohi Khalil , Fatma Demircioglu , Catherine Vinge François , Sören Möller , Erling Andreasen

{"title":"Chorionicity and gestational diabetes mellitus in twin pregnancies in relation to placental weight","authors":"Mohammed Rohi Khalil , Fatma Demircioglu , Catherine Vinge François , Sören Möller , Erling Andreasen","doi":"10.1016/j.dsx.2024.103093","DOIUrl":"10.1016/j.dsx.2024.103093","url":null,"abstract":"<div><h3>Background</h3><p>Gestational diabetes mellitus (GDM) is glucose intolerance first detected during pregnancy. Twin pregnancies have a higher risk of GDM, likely due to increased placental mass and elevated placental lactogen levels.</p></div><div><h3>Objective</h3><p>The aims of this study were 1) to assess the impact of chorionicity on the development of GDM in twin pregnancies and 2) to assess a possible association between placenta weight and the development of GDM.</p></div><div><h3>Methods</h3><p>We conducted a prospective cohort study of all women with twin pregnancies (N = 819) at the department of Obstetrics and Gynecology, Lillebaelt University Hospital, Kolding, Denmark, between January 1, 2007 and April 30, 2019. Information on chronicity was determined at the first visit with ultrasonic imaging, during weeks’ gestation 11–13. Oral glucose-tolerance test was performed to diagnose gestational diabetes mellitus.</p></div><div><h3>Results</h3><p>Among 819 twins, 17.8 % were monochorionic twins and 82.2 % were dichorionic twins. There were no statistically significant difference of GDM prevalence between monochorionic twins group 7.4 % and dichorionic twins group 9.8 % (P = 0.42). Placenta's weight in dichorionic twins was larger compared with monochorionic twins. No association was found between the weight of placenta and the prevalence of GDM (P = 0.21), even after adjustment for body mass index, gestational age, and fertility treatment (P = 0.87).</p></div><div><h3>Conclusions</h3><p>Our study could not find an association between chorionicity, placental weight, and GDM. It is, therefore, possible that twin pregnancies, regardless of chorionicity and placental weight, have the same risk for GDM.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103093"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of stevia on blood glucose and HbA1C: A meta-analysis 甜菊糖对血糖和 HbA1C 的影响：一项荟萃分析。

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103092

Marzieh Zare , Mobina Zeinalabedini , Soraiya Ebrahimpour-Koujan , Nick Bellissimo , Leila Azadbakht

{"title":"Effect of stevia on blood glucose and HbA1C: A meta-analysis","authors":"Marzieh Zare , Mobina Zeinalabedini , Soraiya Ebrahimpour-Koujan , Nick Bellissimo , Leila Azadbakht","doi":"10.1016/j.dsx.2024.103092","DOIUrl":"10.1016/j.dsx.2024.103092","url":null,"abstract":"<div><h3>Background</h3><p>The study investigates substituting non-nutritive sweeteners (NNS) for sugar to address health concerns related to excess sugar intake. It specifically examines how stevia affects insulin and blood glucose levels. The systematic review and meta-analysis aim to evaluate stevia's impact on glycemic indices.</p></div><div><h3>Methods</h3><p>We conducted a systematic review and meta-analysis following PRISMA guidelines, including 26 studies with 1439 participants. The PROSPERO registration number for this research is CRD42023414411. We systematically searched PubMed (MEDLINE), Scopus, Web of Science, and Google Scholar. Additionally, we thoroughly reviewed the reference lists of the articles we extracted and relevant reviews. Two evaluators independently carried out screening, quality assessment, and data extraction. The GRADE (grading of recommendations, assessment, development, and evaluation) approach was utilized to evaluate the certainty of the evidence.</p></div><div><h3>Results</h3><p>Stevia consumption was associated with significantly reducing blood glucose levels (WMD: −3.84; 95 % CI: −7.15, −0.53; P = 0.02, low certainty), especially in individuals with higher BMI, diabetes, and hypertension. Dose-response analysis revealed a decrease in blood glucose for ≥3342 mg/day of stevia consumption. Stevia consumption has been shown to reduce blood glucose levels within 1–4 months, as evidenced by dose-response analysis (less than 120 days) and subgroup analysis (more than four weeks). However, stevia did not significantly affect insulin concentration or HbA1C levels (very low and low certainty, respectively).</p></div><div><h3>Conclusions</h3><p>Low certainty evidence showed that stevia improved blood glucose control, especially when consumed for less than 120 days. However, more randomized trials with higher stevia dosages are required.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103092"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enrollment of Black, Indigenous and People of Color (BIPOC) and female participants in the US diabetes trials spanning 2000 to 2020: A chronological survey 2000 年至 2020 年美国糖尿病试验中黑人、原住民、有色人种 (BIPOC) 和女性参与者的注册情况：按时间顺序进行的调查

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103074

Jingyi Zhang , Miaoguan Peng , Jianfeng Li , Likang Li , Xuerui Bai , Lehana Thabane , Gregory Yh Lip , Harriette GC. Van Spall , Guowei Li

{"title":"Enrollment of Black, Indigenous and People of Color (BIPOC) and female participants in the US diabetes trials spanning 2000 to 2020: A chronological survey","authors":"Jingyi Zhang , Miaoguan Peng , Jianfeng Li , Likang Li , Xuerui Bai , Lehana Thabane , Gregory Yh Lip , Harriette GC. Van Spall , Guowei Li","doi":"10.1016/j.dsx.2024.103074","DOIUrl":"10.1016/j.dsx.2024.103074","url":null,"abstract":"<div><h3>Aims</h3><p>Little is known about the enrollment practice of both Black, Indigenous and People of Color (BIPOC) and females in the US diabetes trials. We aimed to perform a chronological survey to evaluate the enrollment of BIPOC and female participants in the US diabetes randomized controlled trials (RCTs) over the past two decades.</p></div><div><h3>Methods</h3><p>We searched databases to systematically include the US diabetes RCTs from 2000 January 1st to 2020 December 31st. Primary outcome was the adequate enrollment of both BIPOC and females, defined by the participation to prevalence ratio (PPR) > 0.8. We tested the temporal trend in adequate enrollment over time and used logistic regression analysis to explore the relationship between adequate enrollment and trial characteristics.</p></div><div><h3>Results</h3><p>A total of 69 US diabetes trials were included for analyses, with a median BIPOC and female enrollment percentage of 29.0 % and 45.4 % respectively. There were 22 (31.9 %) trials with adequate enrollment of both BIPOC and females. No significant trend of adequate enrollment percentage of BIPOC and females over time was observed (<em>P</em> = 0.16). Of trial types, those with medication interventions were significantly related to decreased odds of adequate enrollment, when compared to trials with non-drug interventions (odds ratio = 0.29, 95 % confidence interval: 0.11–0.84).</p></div><div><h3>Conclusions</h3><p>Less than one third of the US diabetes trials adequately enrolled both BIPOC and females over the past two decades, and no temporal improvement in BIPOC and female participant enrollment was observed. These results highlight the need for more endeavors to mitigate inadequate representation regarding BIPOC and female enrollment in diabetes trials.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103074"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of coffee and its bioactive compounds on the risks of type 2 diabetes and its complications: A comprehensive review 咖啡及其生物活性化合物对 2 型糖尿病及其并发症风险的影响：全面综述

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103075

Almahi I. Mohamed , Ochuko L. Erukainure , Veronica F. Salau , Md Shahidul Islam

{"title":"Impact of coffee and its bioactive compounds on the risks of type 2 diabetes and its complications: A comprehensive review","authors":"Almahi I. Mohamed , Ochuko L. Erukainure , Veronica F. Salau , Md Shahidul Islam","doi":"10.1016/j.dsx.2024.103075","DOIUrl":"10.1016/j.dsx.2024.103075","url":null,"abstract":"<div><h3>Background</h3><p>Coffee beans have a long history of use as traditional medicine by various indigenous people. Recent focus has been given to the health benefits of coffee beans and its bioactive compounds. Research on the bioactivities, applications, and effects of processing methods on coffee beans' phytochemical composition and activities has been conducted extensively. The current review attempts to provide an update on the biological effects of coffee on type 2 diabetes (T2D) and its comorbidities.</p></div><div><h3>Methods</h3><p>Comprehensive literature search was carried out on peer-reviewed published data on biological activities of coffee on <em>in vitro</em>, <em>in vivo</em> and epidemiological research results published from January 2015 to December 2022, using online databases such as PubMed, Google Scholar and ScienceDirect for our searches.</p></div><div><h3>Results</h3><p>The main findings were: firstly, coffee may contribute to the prevention of oxidative stress and T2D-related illnesses such as cardiovascular disease, retinopathy, obesity, and metabolic syndrome; secondly, consuming up to 400 mg/day (1–4 cups per day) of coffee is associated with lower risks of T2D; thirdly, caffeine consumed between 0.5 and 4 h before a meal may inhibit acute metabolic rate; and finally, both caffeinated and decaffeinated coffee are associated with reducing the risks of T2D.</p></div><div><h3>Conclusion</h3><p>Available evidence indicates that long-term consumption of coffee is associated with decreased risk of T2D and its complications as well as decreased body weight. This has been attributed to the consumption of coffee with the abundance of bioactive chemicals.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103075"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187140212400136X/pdfft?md5=eb0e2a8cd5e009c11ab31f87f64a5067&pid=1-s2.0-S187140212400136X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive investigation of insulin-induced amyloidosis lesions in patients with diabetes at clinical and histological levels: A systematic review 从临床和组织学层面全面研究糖尿病患者的胰岛素诱导淀粉样变性病变：系统综述

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103083

Leyla Karkhaneh , Shaghayegh Hosseinkhani , Hossein Azami , Yalda Karamlou , Ali Sheidaei , Ensieh Nasli-Esfahani , Farideh Razi , Azadeh Ebrahim-Habibi

{"title":"Comprehensive investigation of insulin-induced amyloidosis lesions in patients with diabetes at clinical and histological levels: A systematic review","authors":"Leyla Karkhaneh , Shaghayegh Hosseinkhani , Hossein Azami , Yalda Karamlou , Ali Sheidaei , Ensieh Nasli-Esfahani , Farideh Razi , Azadeh Ebrahim-Habibi","doi":"10.1016/j.dsx.2024.103083","DOIUrl":"10.1016/j.dsx.2024.103083","url":null,"abstract":"<div><h3>Introduction</h3><p>Insulin-derived amyloidosis (AIns), a skin complication in patients with diabetes, causes impaired insulin absorption. This systematic review aims to get a better understanding of this overlooked condition.</p></div><div><h3>Methods</h3><p>Comprehensive literature searches were performed in Scopus, PubMed, EMBASE, and Web of Science databases until June 17, 2023. From 19,343 publications, duplicate and irrelevant records were eliminated by title, and the full texts of the remaining studies were examined for validity. Clinical, pathological, and therapeutic findings were extracted from 44 papers.</p></div><div><h3>Results</h3><p>Forty-four articles were studied that covered 127 insulin-treated patients with diabetes. From the 62 patients with reported age and sex, males had a mean age of 58 years, and females 68.5 years. While AIns were twice as likely to develop in men (66.13 %) as in women (33.87 %), the administered insulin dose was significantly higher in males (p = 0.017). The most common insulin injection site was the abdominal wall (77.63 %). Histological findings showed the presence of amorphous material with the occasional presence of lymphocytes, plasma cells, macrophages, adipocytes, histocytes, and giant cells. The mean HbA1c level was 8.8 % and the need for receiving insulin was increased in AIns. Changing the site of insulin injections and/or surgically removing the nodules were the most common treatments to obtain better insulin uptake and controlled serum glucose levels.</p></div><div><h3>Conclusion</h3><p>This study highlights the importance of AIns, proper rotation of insulin injection site, and post-treatment patient follow-up to recognize and prevent the development of amyloid nodules.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 7","pages":"Article 103083"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yoga and prevention of type 2 diabetes - The Indian Prevention of Diabetes Study (IPDS) 瑜伽与 2 型糖尿病的预防--印度预防糖尿病研究（IPDS）

IF 4.3

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-07-01 DOI: 10.1016/j.dsx.2024.103088

Sri V. Madhu , Paturi V. Rao , Hemraj B. Chandalia , Kesavadev Jothydev , Arvind Gupta , for Research Society for the Study of Diabetes in India

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