血清脂质过氧化潜能作为 2 型糖尿病患者冠状动脉疾病风险分级的生物标志物

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-10-01 DOI:10.1016/j.dsx.2024.103143

Kavya Sugur , Swetha N. Kempegowda , Sunil K. Shambu , Manjappa Mahadevappa , Vinay K. Kengegowda , Jadeppa Gowda , Rajesh K. Thimmulappa

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引用次数: 0

摘要

目的我们研究了用于冠状动脉疾病（CAD）风险分层的 2 型糖尿病（T2D）患者血清脂质过氧化潜能，作为全身氧化应激水平的估计值。方法我们前瞻性地招募了患者，并根据糖尿病和CAD严重程度[Gensini评分<20，非显著性CAD；Gensini评分>20，显著性CAD]将他们分为四个亚组：非显著性CAD的非糖尿病患者、非显著性CAD的糖尿病患者、显著性CAD的非糖尿病患者和显著性CAD的糖尿病患者。对血脂概况、HbA1c、空腹血糖和氧化低密度脂蛋白进行了评估。新开发的检测方法可估算血清脂质过氧化潜能值。结果与无明显CAD的非糖尿病患者相比，严重CAD患者的循环氧化低密度脂蛋白水平明显较高，但在四个亚组中未观察到明显差异。与患有非明显 CAD 的非糖尿病患者相比，患有非明显 CAD 的糖尿病患者的血清脂质过氧化潜能明显升高。耐人寻味的是，与患有明显 CAD 的糖尿病患者和非糖尿病患者相比，患有非明显 CAD 的糖尿病患者的血清脂质过氧化潜能值明显升高。血糖控制不佳和血液总抗氧化能力降低是导致非显著性 CAD 组糖尿病患者血清脂质过氧化潜能值升高的主要因素。这项研究表明，"血清脂质过氧化潜能 "测定可用于对 T2D 患者的 CAD 进行风险分级。

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Serum lipid peroxidation potential as a biomarker for risk-stratification of coronary artery disease in patients with type 2 diabetes mellitus

Aim

We examined the serum lipid peroxidation potential as an estimate of systemic oxidative stress levels in people with type 2 diabetes (T2D) for coronary artery disease (CAD) risk stratification.

Methods

We prospectively recruited patients and categorized them into four subgroups based on diabetes and severity of CAD [Gensini score <20, non-significant CAD; Gensini score >20, significant CAD]: non-diabetics with non-significant CAD, diabetics with non-significant CAD, non-diabetics with significant CAD and diabetics with significant CAD. Lipid profile, HbA1c, fasting blood glucose, and oxidized LDL were assessed. A newly developed assay estimated serum lipid peroxidation potential.

Results

Circulatory oxidized LDL levels were significantly higher in patients with severe CAD compared to non-diabetics with non-significant CAD, however no significant differences were observed across the four subgroups. Diabetics with non-significant CAD demonstrated significantly elevated serum lipid peroxidation potential compared to non-diabetics with non-significant CAD. Intriguingly, serum lipid peroxidation potential was markedly elevated in diabetics with non-significant CAD compared to both diabetics and non-diabetics with significant CAD. Poor glycemic control and reduced blood total antioxidant capacity were the primary factors contributing to increased serum lipid peroxidation potential in diabetics with non-significant CAD group.

Conclusions

We found that people with T2D who are associated with non-significant CAD are more vulnerable to oxidative stress than those with significant CAD. The study demonstrates the application of 'serum lipid peroxidation potential' assay for risk-stratification of CAD in people with T2D.

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.