The triglyceride-glucose index, blood glucose levels, and metabolic syndrome are associated with all-cause mortality in obesity

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-10-01 DOI:10.1016/j.dsx.2024.103146

Antonio E. Pontiroli , Lucia Centofanti , Ahmed S. Zakaria , Simona Cerutti , Michele Dei Cas , Rita Paroni , Lucia La Sala , Elena Tagliabue , Silvia Magnani , Franco Folli

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引用次数: 0

Abstract

Background

The Triglyceride-Glucose Index (TYG) has been proposed as a prognostic index for mortality in the general population, in T2DM, and in patients with cardiovascular diseases. However, data on the respective predictive roles of TYG, glucose tolerance (GT), and metabolic syndrome (MS) for mortality in obesity are lacking.

Methods

We analyzed 1359 obese patients (371 men and 988 women), aged 44.1 ± 12.64 years, followed for 14.3 ± 4.44 years. They were subdivided according to glucose tolerance, in normal glucose tolerance (NGT), impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM). We analyzed the risk of death associated with blood glucose (BG) quartiles, TYG quartiles and MS quartiles. Cox proportional-hazard models were used to evaluate the risk of death associated with independent variables that were highly statistically significant at univariate analysis.

Results

Different degrees of glucose tolerance were associated with a progressive deterioration of clinical outcomes, and increased all-cause mortality (6.3 %, 10.1 %, and 20.4 %, respectively). In all groups, age and male sex were associated with increased mortality. Higher TYG or TYG quartiles, BG or BG quartiles, and MS or MS quartiles were all associated with increased all-cause mortality in the whole cohort.

Conclusion

TYG, blood glucose and MS are risk factors for mortality in obesity, with a progressively stronger value in IFG and T2DM as compared to NGT.

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甘油三酯-葡萄糖指数、血糖水平和代谢综合征与肥胖症患者的全因死亡率有关。

背景：甘油三酯-葡萄糖指数（TYG甘油三酯-葡萄糖指数（TYG）已被提出作为普通人群、T2DM和心血管疾病患者死亡率的预后指数。然而，关于 TYG、葡萄糖耐量（GT）和代谢综合征（MS）各自对肥胖症患者死亡率的预测作用，目前还缺乏相关数据：我们对 1359 名肥胖患者（371 名男性和 988 名女性）进行了分析，他们的年龄为 44.1 ± 12.64 岁，随访时间为 14.3 ± 4.44 年。他们根据葡萄糖耐量被细分为正常葡萄糖耐量（NGT）、空腹血糖受损（IFG）和 2 型糖尿病（T2DM）。我们分析了与血糖 (BG) 四分位数、TYG 四分位数和 MS 四分位数相关的死亡风险。我们使用 Cox 比例危险模型来评估与单变量分析中具有高度统计学意义的自变量相关的死亡风险：结果：不同程度的葡萄糖耐量与临床结果的逐渐恶化和全因死亡率的增加有关（分别为 6.3%、10.1% 和 20.4%）。在所有组别中，年龄和男性与死亡率增加有关。TYG或TYG四分位数、BG或BG四分位数以及MS或MS四分位数越高，整个队列的全因死亡率越高：结论：TYG、血糖和 MS 是肥胖症患者死亡的风险因素，与 NGT 相比，IFG 和 T2DM 的风险值更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.