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Examining Comorbid Psychopathology Symptoms as Predictors of Family Based Treatment for Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa in a Real-World Setting. 在现实世界中,对青少年神经性厌食症和非典型神经性厌食症进行以家庭为基础治疗的共病精神病理症状的研究
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-02 DOI: 10.1002/erv.70124
Daniel Wilson, Hilary Grimmer, Renata A Mendes, Jenna Irwin, Julie Atherton, Richard Litster, Jacinda White, Natalie J Loxton
{"title":"Examining Comorbid Psychopathology Symptoms as Predictors of Family Based Treatment for Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa in a Real-World Setting.","authors":"Daniel Wilson, Hilary Grimmer, Renata A Mendes, Jenna Irwin, Julie Atherton, Richard Litster, Jacinda White, Natalie J Loxton","doi":"10.1002/erv.70124","DOIUrl":"https://doi.org/10.1002/erv.70124","url":null,"abstract":"<p><strong>Background: </strong>For adolescents with Anorexia Nervosa (AN) or Atypical Anorexia Nervosa (AAN), Family Based Treatment (FBT) is an effective treatment. However, outcomes remain suboptimal, making investigations into predictors of outcome important. Most prior research into FBT has focussed on parental and family factors as predictors.</p><p><strong>Objective: </strong>The current study aimed to identify predictors of FBT for adolescents with AN and AAN in a real-world setting, specifically focussed on comorbid patient psychopathology as a predictor of outcome.</p><p><strong>Method: </strong>A prospective cohort of 135 young people engaging in manualised FBT (female = 92.6%, age = 14.33 years, SD = 1.54, range 11-17) at a public outpatient child and youth eating disorder (ED) service were evaluated. Measures of ED and comorbid psychopathology and BMI outcomes were evaluated pre- and post-treatment.</p><p><strong>Results: </strong>Results showed that age was a predictor of drop-out and weight gain, with older age associated with higher chance of drop-out and less weight gain. No comorbid psychopathology measure predicted drop-out or treatment outcomes.</p><p><strong>Discussion: </strong>Findings highlight the potential role of age in treatment non-completion and weight regain in FBT, suggesting the potential need for developmental considerations to FBT among this group.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parental and Peer Relationships and Their Impact on Symptom Severity in Adolescent Patients With Anorexia Nervosa. 父母和同伴关系及其对青少年神经性厌食症症状严重程度的影响。
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-27 DOI: 10.1002/erv.70072
Armita Tschitsaz, Andrea M Schumacher, Stefan Lerch, Andrea Wyssen, Marialuisa Cavelti, Ines Mürner-Lavanchy, Julian Koenig, Michael Kaess, Franziska Schlensog-Schuster
{"title":"Parental and Peer Relationships and Their Impact on Symptom Severity in Adolescent Patients With Anorexia Nervosa.","authors":"Armita Tschitsaz, Andrea M Schumacher, Stefan Lerch, Andrea Wyssen, Marialuisa Cavelti, Ines Mürner-Lavanchy, Julian Koenig, Michael Kaess, Franziska Schlensog-Schuster","doi":"10.1002/erv.70072","DOIUrl":"10.1002/erv.70072","url":null,"abstract":"<p><strong>Objective: </strong>Perceived parental relationship characteristics, such as maternal overprotection, rejection or neglect, and peer victimisation, are suggested to be more common in patients with anorexia nervosa (AN) than in healthy controls. This study compares parental and peer relationships in adolescent patients with AN to those in a clinical control group (CC; a matched group of patients with other mental disorders) and investigates their association with AN severity.</p><p><strong>Method: </strong>Self-reported parental and peer relationships were compared between adolescents with AN (n = 43) and CC (n = 127), matched for age, sex and global functioning. Multiple linear and logistic regression were used to analyse the association between parental and peer relationships and AN severity.</p><p><strong>Results: </strong>The AN group exhibited a more positive overall evaluation of parental relationships (b = 18.34, p = 0.002), particularly with fathers (b = 5.30, p = 0.028), fewer parental discrepancies (b = -7.67, p = 0.013), less peer victimisation (OR = 0.43, p = 0.030) and perpetration (OR = 0.26, p = 0.006) than the CC group. No significant associations were identified between these relationships and AN severity.</p><p><strong>Conclusions: </strong>In contrast to previous studies comparing social relationships in patients with AN and healthy controls, our findings suggest that increased positive parental and peer relationships may serve as a resource, irrespective of symptom severity.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"845-857"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapists' Attitudes and Exclusion Criteria for Prolonged Exposure and EMDR in Patients With Eating Disorders and PTSD. 进食障碍和创伤后应激障碍患者长时间暴露和EMDR的治疗师态度和排除标准。
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-25 DOI: 10.1002/erv.70073
J van der Starre, M de Jong, R A de Kleine, C V Voogt, M Schoorl, H W Hoek
{"title":"Therapists' Attitudes and Exclusion Criteria for Prolonged Exposure and EMDR in Patients With Eating Disorders and PTSD.","authors":"J van der Starre, M de Jong, R A de Kleine, C V Voogt, M Schoorl, H W Hoek","doi":"10.1002/erv.70073","DOIUrl":"10.1002/erv.70073","url":null,"abstract":"<p><strong>Objective: </strong>A significant proportion of patients with eating disorders (EDs) also meet criteria for posttraumatic stress disorder (PTSD). Guidelines recommend exposure-based treatments for PTSD, including prolonged exposure (PE) and eye movement desensitisation and reprocessing (EMDR). Investigating therapist-related factors could lead to improve their use when ED and PTSD co-occur.</p><p><strong>Method: </strong>A cross-sectional survey was conducted among 81 EDs therapists (88% female; M age = 40.4, SD = 10.4) in 2023 in the Netherlands. Hierarchical multiple regression analyses assessed predictors of excluding patients with EDs and comorbid PTSD from exposure-based treatments for PTSD.</p><p><strong>Results: </strong>Therapists held more favourable beliefs about EMDR (M = 10.5, SD = 7.5) than PE (M = 13.9, SD = 6.9), and were less likely to exclude patients with EDs and comorbid PTSD from EMDR (M = 15.5, SD = 9.3) than PE (M = 17.7, SD = 9.3) (t(80) = 3.47, p < 0.002). Beliefs about exposure-based interventions predicted the likelihood of exclusion from both PE (β = 0.56, p < 0.002) and EMDR (β = 0.69, p < 0.002).</p><p><strong>Conclusions: </strong>Therapists' beliefs influence the use of exposure-based treatments for PTSD in patients with EDs and comorbid PTSD. Addressing these beliefs in training, may support broader implementation.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"823-834"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Adults Seeking Treatment for Their Eating Disorder: An Empirical Look at Young Adults Relative to Adults Over 25. 寻求饮食失调治疗的新兴成年人:相对于25岁以上成年人的年轻人的经验观察。
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-25 DOI: 10.1002/erv.70068
Michele M Laliberte, Keisha C Gobin, Madelaine B Potechin, Kristen M Lucibello, Sarah Potter, Gillian Grant-Allen
{"title":"Emerging Adults Seeking Treatment for Their Eating Disorder: An Empirical Look at Young Adults Relative to Adults Over 25.","authors":"Michele M Laliberte, Keisha C Gobin, Madelaine B Potechin, Kristen M Lucibello, Sarah Potter, Gillian Grant-Allen","doi":"10.1002/erv.70068","DOIUrl":"10.1002/erv.70068","url":null,"abstract":"<p><strong>Aim: </strong>Emerging adults (EAs), aged 18-25, may have distinct characteristics and, therefore, treatment needs compared to adults over 25 (adults > 25) that are poorly understood.</p><p><strong>Objective: </strong>This study compares EAs to adults > 25 entering eating disorder (ED) treatment to better characterise their differences.</p><p><strong>Method: </strong>Participants were 623 individuals (332 EAs; 291 adults > 25) with anorexia nervosa, bulimia nervosa, or related OSFED, referred to outpatient ED treatment from 2004-2020. Using retrospective demographic data, assessment information, and treatment attendance, EAs were compared to adults > 25 on: demographic characteristics, high-risk behaviours, diagnostic profiles, substance use, and treatment engagement. EAs with and without prior ED treatment were compared.</p><p><strong>Results: </strong>Over half (55%) of EAs report living with family versus 14% of adults > 25. EAs reported more self-harm, ED-related theft, and greater cannabis use than adults > 25. While there were no differences in rates of comorbidity, EAs were less likely to have received treatment for comorbid illnesses. EAs without previous ED treatment were also more likely to disengage from treatment than those with prior treatment.</p><p><strong>Conclusions: </strong>EAs and adults > 25 demonstrate similar diagnostic profiles and rates of treatment drop-out. However, EAs may need individualised treatment planning for high-risk behaviours and comorbid illnesses. Recommendations for the care of EAs in adult programs are made.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"811-822"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eating Attitudes and Anthropometric Indices of Adult Women in Performance Dance: A Case-Control Study in Greece. 希腊舞蹈表演中成年女性的饮食态度和人体测量指标的病例对照研究。
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-13 DOI: 10.1002/erv.70069
Alexandra Foscolou, Konstantinos Koutoulogenis, Charalampia Amerikanou, Christina Chatzistamatiou, Eleni-Maria Stergiou, Rozanna Katsari, Anastasia Perrea, George I Panoutsopoulos, Andriana C Kaliora, Aristea Gioxari
{"title":"Eating Attitudes and Anthropometric Indices of Adult Women in Performance Dance: A Case-Control Study in Greece.","authors":"Alexandra Foscolou, Konstantinos Koutoulogenis, Charalampia Amerikanou, Christina Chatzistamatiou, Eleni-Maria Stergiou, Rozanna Katsari, Anastasia Perrea, George I Panoutsopoulos, Andriana C Kaliora, Aristea Gioxari","doi":"10.1002/erv.70069","DOIUrl":"10.1002/erv.70069","url":null,"abstract":"<p><strong>Objective: </strong>Dancers are at an increased risk of developing eating disorders and health issues. The aim of this case-control study was to compare dietary intake, anthropometric indices and eating attitudes of adult professional dancers to their age- and sex-matched non-dancer females. 170 females (cases: n = 68, controls: n = 102) were voluntarily enroled.</p><p><strong>Methods: </strong>Anthropometric, dietary characteristics and eating attitudes were derived through standard procedures. Eating Attitudes Test (EAT-26) and Eating Disorder Examination-Questionnaire (EDE-Q) were used to assess eating attitudes.</p><p><strong>Results: </strong>Female dancers were more likely to have better body composition including body weight, handgrip strength and muscle mass, p < 0.05, as compared to non-dancer females. Besides, dancers had lower energy and fat intake but higher protein intake, as well as higher intake of several micronutrients (i.e., beta-carotene, vitamin D, B6, biotin, calcium, phosphorus, magnesium, manganese) but lower intake of iron and zinc (p < 0.05) compared to non-dancers. After adjustments, dancers had 5% higher score on EDE-Q-Restraint, but non-dancers had higher eating concerns when energy intake was taken into consideration (b = 0.61 ± 0.29, p = 0.038).</p><p><strong>Conclusions: </strong>It is imperative to establish strategies to prevent eating disorders in dancers who exhibit restrictive behaviours and minimise the anxiety that women experience regarding food by establishing new social norms.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"743-748"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Change in PTSD and Complex PTSD Symptoms in Residential Treatment for Eating Disorders. 进食障碍住院治疗中PTSD和复杂PTSD症状的变化
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-23 DOI: 10.1002/erv.70075
Sinead Day, Deborah Mitchison, W Kathy Tannous, Phillipa Hay
{"title":"Change in PTSD and Complex PTSD Symptoms in Residential Treatment for Eating Disorders.","authors":"Sinead Day, Deborah Mitchison, W Kathy Tannous, Phillipa Hay","doi":"10.1002/erv.70075","DOIUrl":"10.1002/erv.70075","url":null,"abstract":"<p><strong>Objective: </strong>Trauma-related disorders are experienced by up to 50% of individuals in treatment for an eating disorder, yet research knowledge is limited as to whether trauma-related symptoms improve during eating disorder treatment. This is particularly true for complex post-traumatic stress disorder (CPTSD) and its specific symptom domains (PTSD symptoms and disturbances in self organisation [DSO]).</p><p><strong>Method: </strong>The current study included 95 individuals with eating disorders who completed measures of trauma-related symptoms and eating disorder psychopathology at admission, week 4 of treatment, discharge, and 6-month post-discharge from residential treatment.</p><p><strong>Results: </strong>Linear mixed effects models indicated that both PTSD and DSO symptom domains significantly improved over the course of residential care, adjusting for baseline eating disorder and trauma-related symptom severity. Change in PTSD symptoms from admission to follow-up was linear or quadratic, while DSO symptom trajectories exhibited cubic trends such that symptoms were slow to improve early in treatment, showed more rapid improvement later in treatment, and then slightly worsened post-discharge.</p><p><strong>Conclusion: </strong>These findings indicate that symptoms related to both PTSD and CPTSD may improve with eating disorder residential treatment, even without trauma-focused interventions. However, despite this, trauma-related symptoms are likely to remain severe post-treatment. Individuals with this comorbidity may therefore benefit from greater incorporation of trauma-informed care in specialist eating disorder services as well as trauma-focused therapies as part of stepdown care.</p><p><strong>Trial registration: </strong>The study was prospectively registered on the Australian and New Zealand Clinical Trials Registry in November 2021, registration number ACTRN12621001651875.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"805-810"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathological Eating Patterns in Adults Displaying Obsessive-Compulsive Symptoms: A Scoping Review. 显示强迫性症状的成人病理饮食模式:范围综述
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-23 DOI: 10.1002/erv.70071
Sonay Kucukterzi-Ali, Amanda K Ludlow, Roberto Gutierrez, Naomi A Fineberg, Tim M Gale
{"title":"Pathological Eating Patterns in Adults Displaying Obsessive-Compulsive Symptoms: A Scoping Review.","authors":"Sonay Kucukterzi-Ali, Amanda K Ludlow, Roberto Gutierrez, Naomi A Fineberg, Tim M Gale","doi":"10.1002/erv.70071","DOIUrl":"10.1002/erv.70071","url":null,"abstract":"<p><strong>Aim: </strong>Numerous studies have now shown that those with eating disorders have statistically higher rates of obsessive-compulsive disorder (OCD). However, much less is known about the eating behaviours of adults with OCD. This scoping review aimed to identify and synthesise the existing literature describing pathological eating behaviours in adults with OCD and/or obsessive-compulsive (OC) symptoms.</p><p><strong>Method: </strong>The databases PubMed, Scopus, ScienceDirect and PsychNet were searched in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.</p><p><strong>Results: </strong>Fifty-nine studies met the eligibility criteria and were included in this review. There was a high occurrence of eating disorders identified in both adults with a diagnosis of OCD and in those with elevated OC symptoms. The literature appears inconclusive as to which eating disorders most commonly co-occur alongside OCD. Furthermore, it was noted that a number of adults with OCD and those with elevated OC symptoms showed high levels of eating behaviours falling below clinical thresholds, including behaviours synonymous with avoidant-restrictive food intake disorder and orthorexia nervosa.</p><p><strong>Conclusions: </strong>Future research needs to identify underlying factors for these problematic eating behaviours in OCD to adapt current treatment modalities to meet this group's needs. Addressing particular subsets of adults with OCD and/or OC symptoms, such as those with co-occurring anxiety and mood disorders, may be key to understanding who are most at risk.</p><p><strong>Trail registration: </strong>The scoping review was registered on OSF: https://osf.io/s8kan.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"780-804"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Caloric Realimentation and Mental and Physical Well-Being in Patients With Extreme Anorexia Nervosa. A Prospective Study. 极端神经性厌食症患者的高热量摄入与身心健康。前瞻性研究。
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-25 DOI: 10.1002/erv.70074
Ulrich Voderholzer, Juliane Silbernagl, Verena Haas, Ulrich Cuntz, Silke Naab, Norbert Quadflieg
{"title":"High-Caloric Realimentation and Mental and Physical Well-Being in Patients With Extreme Anorexia Nervosa. A Prospective Study.","authors":"Ulrich Voderholzer, Juliane Silbernagl, Verena Haas, Ulrich Cuntz, Silke Naab, Norbert Quadflieg","doi":"10.1002/erv.70074","DOIUrl":"10.1002/erv.70074","url":null,"abstract":"<p><strong>Objective: </strong>While high caloric realimentation (HCR) is increasingly recommended for quick weight restoration of patients with anorexia nervosa (AN), the development of AN-specific psychopathology and somatic symptoms during HCR have so far insufficiently been studied.</p><p><strong>Method: </strong>Patients hospitalised for the treatment of AN received oral realimentation starting with 2000 kcal under close medical monitoring and a substitution regimen. Weekly over the initial 6 weeks of treatment, assessments included body weight, drive for thinnesss, body dissatisfaction, depression, and somatic symptoms.</p><p><strong>Results: </strong>In 46 patients (mean age 27.57 years, 2 males, 44 females), the body mass index increased from 12.6 (SD 1.1) at baseline to 14.4 (SD 1.0) kg/m<sup>2</sup> (p < 0.001) at week 6 (d = 2.57). Drive for thinnesss did not change (28.9 [SD 10.2] to 27.7 [SD 10.8]; p = 0.102), while body dissatisfaction increased slightly from 37.3 (SD 7.8) to 39.1 (SD 9.2; p = 0.019; d = 0.41). Depression and somatic symptoms decreased significantly (p < 0.001) with large effect sizes (d = 1.09, d = 0.90, respectively). No case of refeeding syndrome was encountered.</p><p><strong>Discussion: </strong>HCR was medically safe and associated with a decrease in depressive and somatic symptoms at only slight increase in body dissatisfaction. Fast realimentation brings patients with extreme AN quickly out of a weight range dangerous to their health.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"835-844"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy, Safety and Tolerability of Lisdexamfetamine Dimesylate Treatment Compared With Placebo in Adults With Binge-Eating Disorder: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. 与安慰剂相比,利地氨苯他明二甲基磺酸治疗暴食症的有效性、安全性和耐受性:随机对照试验的系统评价和荟萃分析
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-21 DOI: 10.1002/erv.70070
Maurício Prätzel Ellwanger, Beatriz Westphalen Pomianoski, Daniela Lopes Vieira, Manuela Pozza Ellwanger, Vírgilio Astori, Mateus Frizzo Messinger
{"title":"Efficacy, Safety and Tolerability of Lisdexamfetamine Dimesylate Treatment Compared With Placebo in Adults With Binge-Eating Disorder: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.","authors":"Maurício Prätzel Ellwanger, Beatriz Westphalen Pomianoski, Daniela Lopes Vieira, Manuela Pozza Ellwanger, Vírgilio Astori, Mateus Frizzo Messinger","doi":"10.1002/erv.70070","DOIUrl":"10.1002/erv.70070","url":null,"abstract":"<p><strong>Introduction: </strong>Binge-Eating Disorder (BED) causes significant psychosocial impairment and comorbidities like obesity, depression, and anxiety. Given the limited effectiveness of current treatments, Lisdexamfetamine dimesylate (LDX), approved for Attention-Deficit/Hyperactivity Disorder- ADHD and BED in the U.S., may provide a promising alternative by enhancing impulse control and targeting reward pathways.</p><p><strong>Objective: </strong>This study aims to assess the efficacy, safety, and tolerability of LDX compared with placebo in adults with BED.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase and Cochrane databates for randomised controlled trials (RCTs). We used a random-effects model with a 95% confidence interval (CI) to pool the data. Outcomes analysed included binge-eating frequency, Yale-Brown Obsessive-Compulsive Scale for Binge-Eating (Y-BOCS-BE), weight change, treatment-emergent adverse events (TEAEs), and discontinuation rates. Sensitivity analyses were performed to assess heterogeneity. This systematic review and meta-analysis was prospectively registered in PROSPERO (CRD42024619617).</p><p><strong>Results: </strong>Five RCTs were included in this meta-analysis, encompassing a total of 988 participants. LDX significantly reduced binge-eating days per week by an average of 1.29 days and decreased obsessive-compulsive behaviours by 6.16 points on the Y-BOCS-BE scale, compared with placebo. Additionally, LDX led to a significant weight reduction with an average decrease of 1.31 standardised mean differences (SMD). Diarrhoea was identified as a significant side effect not previously acknowledged in guidelines (RR = 4.06). Discontinuation rates were comparable between LDX and placebo.</p><p><strong>Conclusion: </strong>LDX demonstrates significant efficacy in reducing binge-eating behaviours and associated obsessive-compulsive symptoms in patients with BED, with a tolerable safety profile. These findings support the clinical use of LDX for managing BED.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":"770-779"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal Trends in the Epidemiology of Eating Disorders Between 2000 and 2022: A Danish Register Study of Their Incidence and Comorbidities. 2000年至2022年间饮食失调流行病学的时间趋势:丹麦对其发病率和合并症的登记研究
IF 3.4 2区 心理学
European Eating Disorders Review Pub Date : 2026-05-01 Epub Date: 2025-12-16 DOI: 10.1002/erv.70061
Nadia Micali, Helena L Davies, Heidi Jeannet Graff, Laust H Mortensen, Emilie R Hegelund
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