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Connecting the Practice of Modern Qualitative and Quantitative NMR Analysis with Its Theoretical Foundation.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-03-09 DOI: 10.1021/acs.jnatprod.4c01013
Lucy Botros, Yang Liu, Charlotte Corbett, Dan Sørensen, Christina Szabo, Anton Bzhelyansky, Matthias Niemitz, Petrus Korhonen, Guido F Pauli, Patrick Giraudeau, G Joseph Ray
{"title":"Connecting the Practice of Modern Qualitative and Quantitative NMR Analysis with Its Theoretical Foundation.","authors":"Lucy Botros, Yang Liu, Charlotte Corbett, Dan Sørensen, Christina Szabo, Anton Bzhelyansky, Matthias Niemitz, Petrus Korhonen, Guido F Pauli, Patrick Giraudeau, G Joseph Ray","doi":"10.1021/acs.jnatprod.4c01013","DOIUrl":"10.1021/acs.jnatprod.4c01013","url":null,"abstract":"<p><p>This Perspective seeks to reconnect the current practice of nuclear magnetic resonance (NMR) spectroscopy in chemical structure and quantitative (qNMR) analysis with its roots in classical physics and quantum mechanics (QM). Rationales for this approach are derived from various angles, including focused reviews of the key parameters of the nuclear resonance phenomenon, the structural information richness of NMR spectra, and significant progress in both computational and spectrometer hardware. This provides collective reasoning for the reintegration of computational quantum mechanical spectral analysis (QMSA) into the contemporary practice of NMR spectral interpretation. Retethering operator-dependent visual <i>phenotypic</i> with QM-driven computational <i>genotypic</i> analysis yields more objective and accurate information by taking advantage of QM as the foundational reference point for NMR. Powerful computational tools for compound <i>genotyping</i> are available and evolve rapidly toward automation. In addition to enhancing the rigor and reproducibility of structure elucidation of new and the dereplication of known compounds, QM anchoring enables competent resolution of peak overlap, with resulting benefits in qNMR and low-field/benchtop NMR analysis. Furthermore, examination of common definitions and documentation practices shows that an evolutionary reconciliation of NMR terminology helps resolve ambiguities: shifting from <i>phenotypic</i> peak focus to <i>genotypic</i> QM-based pattern analysis is not only the logical next step when communicating structures of natural products and other molecules reproducibly but also a timely approach, as it yields QMSA-verified data for evolving knowledge bases for molecules of biomedical relevance.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"877-888"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curvisetone─A Male-Specific Tricyclic nor-Diterpenoid from the Springtail Sinella curviseta.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-03-12 DOI: 10.1021/acs.jnatprod.4c01432
Anton Möllerke, Stefan Schulz
{"title":"Curvisetone─A Male-Specific Tricyclic <i>nor</i>-Diterpenoid from the Springtail <i>Sinella curviseta</i>.","authors":"Anton Möllerke, Stefan Schulz","doi":"10.1021/acs.jnatprod.4c01432","DOIUrl":"10.1021/acs.jnatprod.4c01432","url":null,"abstract":"<p><p>The structure determination and occurrence of curvisetone (<b>1</b>), a tricyclic nor-diterpenoid from the tiny Collembola <i>Sinella curviseta</i>, is reported. Utilizing NMR analysis and mass spectrometry, we identified curvisetone's unique carbon skeleton and its occurrence in various sex and life stages. Curvisetone, carrying an unprecedented carbon tricyclic ring system, is an example of the distinct terpene usage of Collembola, which differentiates them from other arthropods.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"857-861"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical and Structural Insights of the N-Methyltransferase CyaF in Cyanogramide Biosynthesis.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-03-07 DOI: 10.1021/acs.jnatprod.4c01391
Ruijie Chen, Qingbo Zhang, Liping Zhang, Chunyan Fang, Hanning Zhu, Weiming Zhu, Changsheng Zhang, Yiguang Zhu
{"title":"Biochemical and Structural Insights of the <i>N</i>-Methyltransferase CyaF in Cyanogramide Biosynthesis.","authors":"Ruijie Chen, Qingbo Zhang, Liping Zhang, Chunyan Fang, Hanning Zhu, Weiming Zhu, Changsheng Zhang, Yiguang Zhu","doi":"10.1021/acs.jnatprod.4c01391","DOIUrl":"10.1021/acs.jnatprod.4c01391","url":null,"abstract":"<p><p><i>N</i>-Methyltransferases involved in indole methylation have seldom been discovered in natural product biosynthesis. This study focuses on the enzyme CyaF, which catalyzes a critical <i>N</i>-methylation step of indole in the β-carboline skeleton during cyanogramide biosynthesis. Seven β-carboline analogues (<b>3</b>-<b>9</b>) were isolated from the recombinant strain <i>Streptomyces coelicolor</i> YF11/<i>cyaABC</i>, including three new compounds (<b>5</b>-<b>7</b>). <i>In vitro</i> assays revealed CyaF's substrate flexibility. The crystal structure of the CyaF/<i>S</i>-adenosyl-L-homocysteine (SAH) complex, combined with the AlphaFold-predicted model and site-directed mutagenesis, elucidated the catalytic mechanism and structural features that enable CyaF to accommodate diverse substrates, highlighting its potential for biocatalytic applications.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"715-722"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total Synthesis of (-)- and (+)-Talaroenamine B and Diphenylene Derivatives.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-03-09 DOI: 10.1021/acs.jnatprod.5c00144
Zhenzhen Zhang, Wei Li, Miaomiao Chai, Bing Wang, Xiaomin Zhang, Dehai Li, Xueqian He, Zhenhui Wang
{"title":"Total Synthesis of (-)- and (+)-Talaroenamine B and Diphenylene Derivatives.","authors":"Zhenzhen Zhang, Wei Li, Miaomiao Chai, Bing Wang, Xiaomin Zhang, Dehai Li, Xueqian He, Zhenhui Wang","doi":"10.1021/acs.jnatprod.5c00144","DOIUrl":"10.1021/acs.jnatprod.5c00144","url":null,"abstract":"<p><p>The first total synthesis of (±)-talaroenamine B was achieved through a concise four-step procedure. The key feature of this synthetic strategy lies in a one-pot reaction involving I (III)-mediated oxidative dearomatization to construct a racemic cyclohexanedione unit, followed by imination using a chiral auxiliary to afford a separable mixture of diastereoisomers. A further acid-catalyzed substitution reaction of aniline with the diastereoisomers led to the natural product (-)-talaroenamine B and its enantiomer (+)-talaroenamine B. Additionally, virtual screening was utilized to expand the chemo-diversity of talaroenamines, and (±)-talaroenamine B diphenylene derivatives <b>6</b>-<b>11</b> were obtained by replacing aniline with selected aniline derivatives in the final step of synthesis. The structures of the synthetic compounds were elucidated using NMR, HRESIMS, and electronic circular dichroism (ECD) data. Compound <b>6b</b> displayed an acetylcholinesterase (AChE) inhibitory effect with an IC<sub>50</sub> value of 4.5 μM, as well as cytotoxicity against the K562 cell line with an IC<sub>50</sub> value of 5.6 μM.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"842-849"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-03-14 DOI: 10.1021/acs.jnatprod.5c00086
Jian-Yu Liu, Yi-Jing Song, Peng-Jie Li, Yang Gao, Mei-Yan Wei, Chang-Lun Shao
{"title":"Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer.","authors":"Jian-Yu Liu, Yi-Jing Song, Peng-Jie Li, Yang Gao, Mei-Yan Wei, Chang-Lun Shao","doi":"10.1021/acs.jnatprod.5c00086","DOIUrl":"10.1021/acs.jnatprod.5c00086","url":null,"abstract":"<p><p>Bladder cancer is a common malignancy known for its high recurrence rate and poor survival rate. New strategies are urgently needed to reduce recurrence and improve prognosis. Arf1 and BMX are potential targets associated with the prognosis of bladder cancer. In this study, niacin ester derivatives of brefeldin A were synthesized by introducing nicotinic acid moieties at the 4-OH and 7-OH positions. Notably, the 4-monoester derivative, CHNQD-01228 (<b>2</b>), could significantly inhibit the proliferation of T24 cells (IC<sub>50</sub> = 0.22 μM) in a time-dependent manner. Furthermore, it dose-dependently inhibited T24 cell migration and colony formation, induced G1 phase arrest, and triggered apoptosis. Based on molecular modeling, CHNQD-01228 was evaluated to exhibit high binding affinity toward both Arf1 and BMX proteins. Further verification was conducted using cellular thermal shift assays and drug affinity responsive target stability assays. It suppressed the AKT/p-AKT and STAT3/p-STAT3 signaling pathways by targeting BMX in T24 cells, eliminated bladder cancer stem cells, and activated antitumor immunity via Arf1 inhibition. <i>In vivo</i> data further demonstrated that the dual-target inhibitor exhibited a potential antitumor efficacy against MB49 allograft tumors (TGI = 51.0%) and thus represents a promising therapeutic strategy for bladder cancer.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"830-841"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-03-02 DOI: 10.1021/acs.jnatprod.4c01424
Jiří Ferenczei, Vilém Blahout, Hana Dvořáková, Andrea Brancale, Petra Cuřínová, Magdaléna Labíková, Michal Kohout, Vladimír Setnička, Pavla Perlíková
{"title":"Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates.","authors":"Jiří Ferenczei, Vilém Blahout, Hana Dvořáková, Andrea Brancale, Petra Cuřínová, Magdaléna Labíková, Michal Kohout, Vladimír Setnička, Pavla Perlíková","doi":"10.1021/acs.jnatprod.4c01424","DOIUrl":"10.1021/acs.jnatprod.4c01424","url":null,"abstract":"<p><p>The recent popularity of indoor farming has brought about problems with parasites spreading among pollinator colonies. The natural product callunene (<b>1</b>) can be used in the prophylaxis of bumblebees against <i>Crithidia</i> infection. Here, we report the synthesis of callunene (<b>1</b>), its enantioseparation, and a method for analyzing its optical purity. The approach was applied to determine the configuration of callunene extracted from heather honey. The proposed method is also applicable to the analysis of mixtures of diastereomers obtained during callunene synthesis, which allows the stereospecificity of individual reaction steps to be determined.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"723-731"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total Synthesis and Structural Revision of (±)-Mauritamide B.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-28 Epub Date: 2025-02-21 DOI: 10.1021/acs.jnatprod.5c00019
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
{"title":"Total Synthesis and Structural Revision of (±)-Mauritamide B.","authors":"Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita","doi":"10.1021/acs.jnatprod.5c00019","DOIUrl":"10.1021/acs.jnatprod.5c00019","url":null,"abstract":"<p><p>Mauritamide B (<b>1a</b>) is a taurine-connected cyclic guanidino-bromopyrrole alkaloid originally isolated from the marine sponge <i>Agelas linnaei</i>. To date, the total synthesis of taurine-connected guanidino-bromopyrrole alkaloids, including this compound, has not yet been reported. Herein, a total synthesis of (±)-mauritamide B (<b>1b</b>) was achieved by oxidation of 2-aminoimidazole of dihydro-sventrin (<b>10</b>) using activated carbon and air in the presence of taurine. The synthetic precursor of <b>10</b>, 4-(3-aminopropyl)-2-aminoimidazole (<b>22</b>), was synthesized via our original route. The NMR data of the obtained product agreed with that reported for mauritamide B (<b>1a</b>). However, a detailed analysis of the NMR data of synthetic (±)-mauritamide B (<b>1b</b>) including <sup>1</sup>H-<sup>15</sup>N HSQC spectrum revealed the need for a structural revision of the reported structure for mauritamide B (<b>1b</b>).</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"806-814"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-27 DOI: 10.1021/acs.jnatprod.5c00059
Alexander F Perhal, Patrik F Schwarz, Thomas Linder, Marko D Mihovilovic, Michael Schnürch, Verena M Dirsch
{"title":"Identification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist.","authors":"Alexander F Perhal, Patrik F Schwarz, Thomas Linder, Marko D Mihovilovic, Michael Schnürch, Verena M Dirsch","doi":"10.1021/acs.jnatprod.5c00059","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.5c00059","url":null,"abstract":"<p><p>The G-protein coupled bile acid receptor 1 (GPBAR1 or TGR5) is the major cell membrane receptor for bile acids regulating metabolic and immunological functions. Its pharmacological modulation has been shown to alleviate inflammatory diseases, such as type 2 diabetes and atherosclerosis. The naturally occurring lignan leoligin and structural analogues have shown anti-inflammatory effects in vitro. However, the underlying molecular targets are still unknown. In this study, we identify the natural product-inspired synthetic structural analogue of leoligin, LT-188A (<b>1</b>), as a novel nonsteroidal TGR5 agonist. LT-188A (<b>1</b>) induced cyclic adenosine monophosphate (cAMP) accumulation and cAMP response element (CRE)-dependent luciferase activity in a concentration- and TGR5-dependent manner. Consistently, LT-188A (<b>1</b>) inhibited activation of the pro-inflammatory transcription factor nuclear factor κB (NFκB) only in TGR5 expressing cells. In macrophages, LT-188A (<b>1</b>) reduced the expression levels of pro-inflammatory cytokines and the production of nitric oxide (NO) as determined by qPCR and the Griess assay, respectively. We showed that LT-188A (<b>1</b>) decreased the levels of production of these inflammatory mediators in macrophages. In conclusion, we demonstrate that LT-188A (<b>1</b>) is a novel natural product-inspired TGR5 agonist with promising anti-inflammatory in vitro bioactivity in relevant cellular assays representing a promising tool compound with potential for further development.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium Okeania sp.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-27 DOI: 10.1021/acs.jnatprod.5c00095
Shunya Tojo, Noriyuki Natsume, Taiki Niino, Arihiro Iwasaki, Kiyotake Suenaga, Osamu Ohno, Toshiaki Teruya
{"title":"Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium <i>Okeania</i> sp.","authors":"Shunya Tojo, Noriyuki Natsume, Taiki Niino, Arihiro Iwasaki, Kiyotake Suenaga, Osamu Ohno, Toshiaki Teruya","doi":"10.1021/acs.jnatprod.5c00095","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.5c00095","url":null,"abstract":"<p><p>A novel 19-membered cyclic depsipeptide, hedopeptolide (<b>1</b>), was isolated from <i>Okeania</i> sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide (<b>1</b>) inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral Optical Sensing of Amino Acids with 2-Trifluoromethyl Benzaldehyde for Ophiopogon japonicus Authentication.
IF 3.3 2区 生物学
Journal of Natural Products Pub Date : 2025-03-26 DOI: 10.1021/acs.jnatprod.4c01389
Xijian Wu, Zijie Su, Biling Huang, Xin Peng, Xing Zhang, Shaohua Huang
{"title":"Chiral Optical Sensing of Amino Acids with 2-Trifluoromethyl Benzaldehyde for <i>Ophiopogon japonicus</i> Authentication.","authors":"Xijian Wu, Zijie Su, Biling Huang, Xin Peng, Xing Zhang, Shaohua Huang","doi":"10.1021/acs.jnatprod.4c01389","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.4c01389","url":null,"abstract":"<p><p>The detection and analysis of chiral molecules have long been challenging in analytical chemistry. This study introduces a novel approach that utilizes 2-trifluoromethyl benzaldehyde as a small-molecule probe capable of forming a stable Schiff base with chiral amino acids in aqueous solution under alkaline conditions. The amino acid Schiff bases present a strong Cotton effect and UV absorption at wavelengths exceeding 260 nm, enabling chiral analysis, including assignment of absolute configuration, enantiomeric composition, and total concentration. An application of this method was the authentication of the herbal medicine <i>Ophiopogon japonicus</i>. Using principal component analysis and orthogonal partial least squares discriminant analysis, we successfully differentiated <i>O. japonicus</i> samples collected in two distinct locations with 20 samples. This rapid and convenient method offers a new approach to quality control of herbal medicine.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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