Ouhanamide, an Antiparasitic Linear Lipopeptide from a Marine Okeania sp. Cyanobacterium.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-05-16 DOI:10.1021/acs.jnatprod.5c00281

Mizuho Niiyama, Naoaki Kurisawa, Kairi Umeda, Ghulam Jeelani, Adnan Luthfi Agusta, Tomoyoshi Nozaki, Kiyotake Suenaga

引用次数: 0

Abstract

Ouhanamide (1), a new linear lipopeptide consisting of a long-chain fatty acid with a β-branched methyl group, was isolated from a marine Okeania sp. cyanobacterium. The overall structure was elucidated by a combination of various spectroscopic analyses, degradation reactions, and derivatizations. Ouhanamide (1) showed selective antiparasitic activity (IC₅₀ = 1.2 ± 0.1 μM against Trypanosoma brucei rhodesiense and IC₅₀ = 4.2 ± 0.9 μM against Plasmodium falciparum) without cytotoxicity at 10 μM against HeLa cells.

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海洋蓝藻属的抗寄生线状脂肽Ouhanamide。

Ouhanamide(1)是一种从海洋Okeania sp.蓝藻中分离得到的具有β-支化甲基的长链脂肪酸组成的新型线性脂肽。通过各种光谱分析，降解反应和衍生化反应的组合来阐明其总体结构。Ouhanamide(1)在10 μM下对HeLa细胞无细胞毒性，对布氏罗德西亚锥虫的IC50为1.2±0.1 μM，对恶性疟原虫的IC50为4.2±0.9 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.