Journal of Nutritional Science最新文献

{"title":"Emotional eating and mental health of nurses working in Lebanese hospitals during the double crisis.","authors":"Rosy Nahed Mitri, Zeina El-Ali, Maha Dankar","doi":"10.1017/jns.2024.63","DOIUrl":"10.1017/jns.2024.63","url":null,"abstract":"<p><p>The 2019 coronavirus (COVID-19) pandemic and strict quarantine increased the likelihood of mental symptoms and abnormal eating behaviours. This study aimed to assess the magnitude of emotional eating (EE) among nurses working in Lebanese hospitals and its association with mental health. A cross-sectional study was conducted among nurses aged between 18 and 50 years working in Lebanese hospitals during the COVID-19 outbreak and the economic crisis. A total of 303 nurses consented to participate. The mean EE score was 28.56 (±8.11). The results of this study revealed that 53.8% of the nurses reported depression, 58.1% suffered from anxiety and 95.1% experienced either moderate or severe stress. The study concluded that females (β = 8.112, P = 0.004), non-smokers (β = -4.732, P = 0.01) and depressed nurses (β = 0.596, P = 0.046) had a higher tendency towards EE. Additionally, it was found that EE was associated with weight gain (β = 6.048, P = 0.03) and increased consumption of fried foods (β = 5.223, P = 0.001). Females experienced more stress (β = 2.244, P = 0.003) and anxiety (β = 1.526, P = 0.021) than their male counterparts. With regard to mental health, depression was associated with weight gain (β = 2.402, P = 0.003) and with lower consumption of healthy foods such as nuts (β = -1.706, P = 0.009) and dishes prepared with sofrito sauce (β = -1.378, P = 0.012). These results can help the health authorities to design preparedness plans to ensure proper mental and physical well-being of nurses during any unforeseen emergencies.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e56"},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting healthful and diverse eating behaviours through an extracurricular culinary skills intervention in Philadelphia.","authors":"Matthew D Kearney, Arlene R Maheu, Madalyn Booth, Andrew B Newberg, Peter F Cronholm, Soussan Ayubcha","doi":"10.1017/jns.2024.31","DOIUrl":"10.1017/jns.2024.31","url":null,"abstract":"<p><p>In the current study we evaluated an afterschool nutrition education programme, called Vetri Cooking Lab (VCL), for promoting healthy and diverse eating habits among at-risk children in the Greater Philadelphia area. To understand potential programme impacts, we conducted a longitudinal analysis of survey data collected before and after participation in VCL. Main study included cooking confidence, cooking knowledge, changes in dietary consumption behaviours, and changes in vegetable preferences. Participants included students in grades 3-11 enrolled in VCL during the 2018-19 school year at VCL sites (n = 60) throughout Philadelphia, PA, and Camden, NJ. Eligible participants completed surveys both before and after participating in the programme. We found that students' confidence and knowledge increased (P < 0.001) after the cooking intervention. Knowledge and confidence were positively associated (<i>r</i> = 0.55; P < 0.001). Confidence was correlated with consumption behaviour changes (<i>r</i> = 0.18; P = 0.022). Confidence was positively associated with consumption changes in both our adjusted (OR = 1.81; P < 0.001) and unadjusted models (aOR = 1.88; P = 0.013). Compared to Black students, White students were more likely to report consumption changes (aOR = 5.83; P = 0.013). Hispanic/Latino participants and participants who spoke Spanish had nearly three times higher odds of consumption behaviour changes (Hispanic/Latino OR = 2.55; P = 0.007; Spanish OR = 3.04; P = 0.005). Student age and gender were not associated with behaviour changes. Our research demonstrates that programmes integrating practical cooking skills education along with nutrition, food, and cooking education can improve confidence and knowledge about healthy food choices amongst children driving an overall improvement in children's eating habits.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e57"},"PeriodicalIF":2.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menu provision in a young offenders institution, comparison with dietary guidelines, and previous menu allocation: a cross-sectional nutritional analysis.","authors":"Matthew Poulter, Shelly Coe, Catherine Anna-Marie Graham, Bethan Leach, Jonathan Tammam","doi":"10.1017/jns.2024.62","DOIUrl":"10.1017/jns.2024.62","url":null,"abstract":"<p><p><i>Objective:</i> This study aimed to assess and comparatively analyse two menus from a Young Offenders Institution (YOI). One menu from 2019, and one from 2022, with the objective of identifying any improvements in meeting dietary guidelines. <i>Design:</i> Cross-sectional and comparative analysis. <i>Setting:</i> United Kingdom, a YOI in Northern England. <i>Participants:</i> YOI Menus. <i>Results:</i> Analysis of 30 dietary components identified that 25 exceeded the dietary guidelines (P < 0.05) for the 2022 menu, with five failing to meet the guidelines (P < 0.05). When compared to the 2019 menu, the 2022 menu showed improvements in saturated fat, sodium, and vitamin D. Despite the improvement, vitamin D levels remained below dietary guidelines (P < 0.01). Salt and energy content were reduced in the 2022 menu (P < 0.05); however, they were still above the dietary guidelines (P < 0.01). Free sugars were significantly above dietary guidelines for both menus, with no significant change between the 2019 and 2022 menu (P = 0.12). <i>Conclusion:</i> The 2022 menu has demonstrated progress in alignment with meeting dietary guidelines, particularly in reducing calories, fat, saturated fat, salt, sodium, and chloride, as well as increasing vitamin D. Despite improvements, calories, free sugars, salt, saturated fat, sodium, and chloride are still exceeding dietary guidelines, posing as potential health risks.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e55"},"PeriodicalIF":2.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the intention of young adults to adopt genotype-based personalised advice on diet and physical activity according to perceived weight status.","authors":"Alexandra King, Mark Glaister, Kate Lawrence, Leta Pilic, Yiannis Mavrommatis","doi":"10.1017/jns.2024.50","DOIUrl":"10.1017/jns.2024.50","url":null,"abstract":"<p><p>Genotype-based dietary and physical activity advice can be delivered to young adults before unhealthy lifestyle behaviours or metabolic and physiological conditions have developed. The aim of the present study was to investigate the factors that influence the intention to adopt genotype-based personalised advice on diet and physical activity in young adults who perceive themselves to be a healthy weight versus those who perceive themselves to be overweight or obese. An online survey of 396 young adults (18-25 years) evaluated background factors (participant characteristics (including perception of body weight), psychological factors, belief composites) and constructs of the Theory of Planned Behaviour (TPB) related to the adoption of genotype-based personalised advice. The association between background factors and TPB constructs was assessed using multiple linear regression. The constructs of TPB predicted intention to adopt genotype-based personalised nutrition (<i>P</i> < 0.001, adj. <i>R</i> ^<i>2</i> = 0.54; attitude: <i>B</i> = 0.24, subjective norm: <i>B</i> = 0.25, PBC: <i>B</i> = 0.45). Background factors including belief composites, health locus of control, gender, physical activity, and food choice motives of 'health', 'price', 'familiarity', 'weight control', and 'convenience' significantly added to models of TPB constructs related to the intention to adopt personalised advice (<i>P</i> < 0.05). The influence of background factors varied between TPB constructs and differed based on participants perception of their body weight. The study provides support for the use of the TPB in understanding the intention of young adults to adopt gene-based advice for dietary and physical activity behaviour. In addition to perceived body weight, the background factors identified should help to inform and modify the delivery of advice in behaviour change interventions that seek to use genotype-based personalised advice in young adult populations.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e54"},"PeriodicalIF":2.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial variation and risk factors of the dual burden of childhood stunting and underweight in India: a copula geoadditive modelling approach.","authors":"Dhiman Bhadra","doi":"10.1017/jns.2024.49","DOIUrl":"https://doi.org/10.1017/jns.2024.49","url":null,"abstract":"<p><p>India has one of the highest burdens of childhood undernutrition in the world. The two principal dimensions of childhood undernutrition, namely stunting and underweight can be significantly associated in a particular population, a fact that is rarely explored in the extant literature. In this study, we apply a copula geoadditive modelling framework on nationally representative data of 104,021 children obtained from the National Family Health Survey 5 to assess the spatial distribution and critical drivers of the dual burden of childhood stunting and underweight in India while accounting for this correlation. Prevalence of stunting, underweight and their co-occurrence among under 5 children were 35.37%, 28.63% and 19.45% respectively with significant positive association between the two (Pearsonian Chi square = 19346, P-value = 0). Some of the factors which were significantly associated with stunting and underweight were child gender (Adjusted Odds Ratio (AOR) = 1.13 (1.12) for stunting (underweight)), birthweight (AOR = 1.46 (1.64) for stunting (underweight)), type of delivery (AOR = 1.12 (1.19) for stunting (underweight)), prenatal checkup (AOR = 0.94 (0.96) for stunting (underweight)) and maternal short-stature (AOR = 2.19 (1.85) for stunting (underweight)). There was significant spatial heterogeneity in the dual burden of stunting and underweight with highest prevalence being observed in eastern and western states while northern and southern states having relatively lower prevalence. Overall, the results are indicative of the inadequacy of a \"one-size-fits-all\" strategy and underscore the necessity of an interventional framework that addresses the nutritional deficiency of the most susceptible regions and population subgroups of the country.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e52"},"PeriodicalIF":2.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal vitamin C and fish oil supplement use are associated with human milk microbiota composition in the Canadian CHILD Cohort Study.","authors":"Rana F Chehab, Kelsey Fehr, Shirin Moossavi, Padmaja Subbarao, Theo J Moraes, Piushkumar Mandhane, Russell J de Souza, Stuart E Turvey, Ehsan Khafipour, Meghan B Azad, Michele R Forman","doi":"10.1017/jns.2024.58","DOIUrl":"https://doi.org/10.1017/jns.2024.58","url":null,"abstract":"<p><p>Maternal diet may modulate human milk microbiota, but the effects of nutritional supplements are unknown. We examined the associations of prenatal diet and supplement use with milk microbiota composition. Mothers reported prenatal diet intake and supplement use using self-administered food frequency and standardised questionnaires, respectively. The milk microbiota was profiled using 16S rRNA gene sequencing. Associations of prenatal diet quality, dietary patterns, and supplement use with milk microbiota diversity and taxonomic structure were examined using Wilcoxon signed-rank tests and multivariable models adjusting for relevant confounders. A subset of 645 mothers participating in the CHILD Cohort Study (originally known as the Canadian Healthy Infant Longitudinal Development Study) provided one milk sample between 2 and 6 months postpartum and used prenatal multivitamin supplements ≥4 times a week. After adjusting for confounders, vitamin C supplement use was positively associated with milk bacterial Shannon diversity (<i>β</i> = 0.18, 95% CI = 0.05, 0.31) and <i>Veillonella</i> and <i>Granulicatella</i> relative abundance (<i>β</i> = 0.54; 95% CI = 0.05, 1.03 and <i>β</i> = 0.44; 95% CI = 0.04, 0.84, respectively), and negatively associated with <i>Finegoldia</i> relative abundance (<i>β</i> = -0.31; 95% CI = -0.63, -0.01). Fish oil supplement use was positively associated with <i>Streptococcus</i> relative abundance (<i>β</i> = 0.26; 95% CI = 0.03, 0.50). Prenatal diet quality and dietary patterns were not associated with milk microbiota composition. Prenatal vitamin C and fish oil supplement use were associated with differences in the milk microbiota composition. Future studies are needed to confirm our findings and elucidate mechanisms linking maternal supplement use to milk microbiota and child health.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e53"},"PeriodicalIF":2.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to college student food access: a scoping review examining policies, systems, and the environment.","authors":"Matthew J Landry, Rebecca L Hagedorn-Hatfield, Victoria A Zigmont","doi":"10.1017/jns.2024.25","DOIUrl":"https://doi.org/10.1017/jns.2024.25","url":null,"abstract":"<p><p>College student food insecurity (FI) is a public health concern. Programming and policies to support students have expanded but utilisation is often limited. The aim of this study was to summarise the barriers to accessing college FI programming guided by the social ecological model (SEM) framework. A scoping review of peer-reviewed literature included an electronic search conducted in MEDLINE, ERIC, and PubMed databases, with a secondary search in Google Scholar. Of the 138 articles identified, 18 articles met eligibility criteria and were included. Articles primarily encompassed <i>organisational</i> (17/18) level barriers, followed by <i>individual</i> (15/18), <i>relationship</i> (15/18), <i>community</i> (9/18), and <i>policy</i> (6/18) levels. <i>Individual</i> barriers included seven themes: <i>Knowledge of Process, Awareness, Limited Time or Schedules, Personal Transportation, Internal Stigma, Perception of Need, and Type of Student</i>. Four relationship barriers were identified: <i>External Stigma</i>, <i>Comparing Need</i>, <i>Limited Availability Causes Negative Perceptions</i>, and <i>Staff</i>. Ten barrier themes comprised the organisational level: <i>Application Process</i>, <i>Operational Process</i>, <i>Location</i>, <i>Hours of Operation</i>, <i>Food Quality</i>, <i>Food Quantity</i>, <i>Food Desirability or Variety of Food</i>, <i>Marketing Materials</i>, <i>Awareness of the Program,</i> and <i>COVID-19 Restrictions</i>. Two barrier themes were identified at the <i>community</i> level, <i>Public Transportation</i> and <i>Awareness of SNAP</i>, while one barrier theme, <i>SNAP Eligibility and Process</i>, encompassed the <i>policy</i> level. Higher education stakeholders should seek to overcome these barriers to the use of food programmes as a means to address the issue of college FI. This review offers recommendations to overcome these barriers at each SEM level.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e51"},"PeriodicalIF":2.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human immunodeficiency virus exposed child feeding and maternal enriching factors.","authors":"Birhan Desalegn, Misgan Legesse, Fassikaw Kebede Bizuneh","doi":"10.1017/S204867902400051X","DOIUrl":"https://doi.org/10.1017/S204867902400051X","url":null,"abstract":"<p><p>Globally, each year 1.3 million neonates acquire human immunodeficiency virus during pregnancy, labour, and breastfeeding time. Replacing breastfeeding with recommended safe infant feeding practices significantly reduces the risk of transmission, nearly eliminating it. This study aimed to assess Human immunodeficiency virus exposed child feeding among 314 mothers with infants under 24 months old. Participants were selected using a systematic random sampling technique, and data were collected through a semi-structured questionnaire. Bivariable and multivariable logistic regression analyses employed to identify determinants for safe infant feeding. During interviews, the mean age of women was 32.35 years (standard deviation±4.5), and infants were 10.8(±3.951) months. The overall safe infant feeding was 67.2% (95% CI: 61.7, 72.9), with a mean knowledge score. By the study's end, 9 infants (2.89%) were confirmed to be infected with virus based on dried blood sample test. Maternal promoting factors for safe infant practice included infant age 25-35 years (adjusted odd ratio (aOR) =2.9) completing high school education (adjusted odd ratio = 9.2), having a good knowledge score for infant feeding (adjusted odd ratio = 8.2), and urban residency (adjusted odd ratio = 2.2). On the other hand, being married made it 83% less likely for safe infant feeding practices (adjusted odd ratio = 0.17) compared to those never in a union. Two in three mothers practiced safe infant feeding for their HIV-exposed infants, with a mean knowledge score of 70.3%. Therefore, healthcare providers give accurate information and counselling services to make informed decisions about infant safe feeding.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e49"},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using co-design to identify intervention components to address unhealthy dietary and activity behaviours in New Zealand South Asians.","authors":"Sherly Parackal, Sumera Saeed Akhtar, Sivamanoj Yadav, Rachel Brown","doi":"10.1017/jns.2024.48","DOIUrl":"10.1017/jns.2024.48","url":null,"abstract":"<p><p>There is an urgent need to develop sustainable and impactful interventions to mitigate the high risk of diet-related non-communicable diseases (diet-NCDs) in South Asians living in high-income countries. The current study using a co-design methodology aimed to identify community-led intervention components (solutions) to address barriers and enablers of disease-promoting dietary and physical activity behaviours in New Zealand South Asians. Data were collected from South Asian immigrants aged 25-59 years via three focus group discussions (n = 21) and 10 telephone or face-to-face interviews between 2018 and 2019. The thematic analysis resulted in identifying 22 barrier and enabler codes and 12 solution codes which were summarised under five themes. The key solutions (intervention components) to mitigate the identified target behaviours were providing recipes for using local vegetables in South Asian cuisine, information on the nutritional quality of frozen vegetables and canned lentils, simple home gardening techniques, the saturated fat content of dairy foods, interpreting nutrition labels, optimal portion sizes of foods, and framing low-fat messages positively. Similarly, group-based activities with peer support such as walking, cultural dancing and community sports like cricket, football, and tennis were the identified solutions to increase physical activity levels. The identified solutions for health promoting dietary habits and physical activity levels could be part of any targeted multicomponent health promoting programme to reduce the risk of diet-NCDs in South Asian immigrants.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e47"},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary cholesterol increases body levels of oral administered vitamin D₃ in mice.","authors":"Julia Kühn, Alexandra Schutkowski, Lina-Maria Rayo-Abella, Mikis Kiourtzidis, Anika Nier, Corinna Brandsch, Gabriele I Stangl","doi":"10.1017/jns.2024.32","DOIUrl":"https://doi.org/10.1017/jns.2024.32","url":null,"abstract":"<p><p>Vitamin D and cholesterol share the same intestinal transporters. Thus, it was hypothesized that dietary cholesterol adversely affects vitamin D uptake. The current studies investigated the influence of cholesterol on the availability of oral vitamin D. First, 42 wild-type mice received a diet with 25 µg/kg labelled vitamin D₃ (vitamin D₃-d₃), supplemented with either 0% (control), 0.2%, 0.4%, 0.6%, 0.8%, 1.0% or 2.0% cholesterol for four weeks to investigate vitamin D uptake. In a second study, 10 wild-type mice received diets containing 0% (control) or 1% cholesterol over four weeks to determine cholesterol-induced changes in bile acids. Finally, we investigated the impact of cholesterol versus bile acids on vitamin D uptake in Caco-2 cells. Surprisingly, dietary cholesterol intake was associated with 40% higher serum levels of vitamin D₃-d₃ and 2.3-fold higher vitamin D₃-d₃ concentrations in the liver compared to controls. The second study showed that cholesterol intake resulted in higher concentrations of faecal bile acids (control: 3.55 ± 1.71 mg/g dry matter; 1% dietary cholesterol: 8.95 ± 3.69 mg/g dry matter; <i>P</i> < 0.05) and changes in the bile acid profile with lower contents of muricholic acids (<i>P</i> < 0.1) and higher contents of taurodeoxycholic acid (<i>P</i> < 0.01) compared to controls. <i>In-vitro</i> analyses revealed that taurocholic acid (<i>P</i> < 0.001) but not cholesterol increased the cellular uptake of vitamin D by Caco-2 cells. To conclude, dietary cholesterol seems to improve the bioavailability of oral vitamin D by stimulating the release of bile acids and increasing the hydrophobicity of bile.</p>","PeriodicalId":47536,"journal":{"name":"Journal of Nutritional Science","volume":"13 ","pages":"e50"},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}