Wanhong Zheng, Megan Cavrak, Hannah Bowles, Yongjia Deng, Sijin Wen, Si Gao, Laura Lander, James Berry, Erin L Winstanley
{"title":"10-year retention of a comprehensive treatment model of buprenorphine for opioid use disorder.","authors":"Wanhong Zheng, Megan Cavrak, Hannah Bowles, Yongjia Deng, Sijin Wen, Si Gao, Laura Lander, James Berry, Erin L Winstanley","doi":"10.1080/10550887.2024.2315366","DOIUrl":"10.1080/10550887.2024.2315366","url":null,"abstract":"<p><strong>Background: </strong>There has been extensive research demonstrating the effectiveness of medications for opioid use disorder (MOUD) but limited investigation into its long-term retention rate.</p><p><strong>Objective: </strong>Assess the long-term treatment retention of a buprenorphine-based MOUD clinic with additional stratifications by age and gender.</p><p><strong>Methods: </strong>This retrospective study analyzed 10-years of data from a MOUD clinic in West Virginia that served 3,255 unique patients during the study period (2009-2019). Retention was measured by summation of total treatment days with a new episode of care defined as re-initiating buprenorphine treatment after 60+ consecutive days of nonattendance. Kaplan-Meier survival analysis, with the log-rank test, was used to compare retention by gender and age.</p><p><strong>Results: </strong>The mean age was 38 (SD = 10.6) and 95% were non-Hispanic white. Irrespective of treatment episode, 56.8% of patients were retained ≥ 90 days, and the overall median time in treatment was 112 days. Considering only the first treatment episode, 48.4% of 3,255 patients were retained at least 90 days and the overall median was 77 days. Female patients had <i>a</i> ≥ 90 day retention rate of 52.2% for the first admission and 60.1% for multiple admissions, both significantly higher than those of male subjects (44.1% and 53.0%). Additionally, patients ≤ 24 years old had the lowest rate of treatment retention, while patients aged ≥ 35 had the highest.</p><p><strong>Conclusions: </strong>This study adds to the limited data regarding long-term retention in MOUD. Our findings indicate gender and age were highly correlated with retention in MOUD treatment.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"44-51"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Apolinario de Oliveira Botelho, Francieli Bernardo Ribeiro, Jéssica Soares Machado, Daiane Cristini Barbosa de Souza
{"title":"Functional connectivity alterations in individuals with gaming disorder assessed by functional magnetic resonance imaging: a systematic review.","authors":"Apolinario de Oliveira Botelho, Francieli Bernardo Ribeiro, Jéssica Soares Machado, Daiane Cristini Barbosa de Souza","doi":"10.1080/10550887.2024.2322861","DOIUrl":"10.1080/10550887.2024.2322861","url":null,"abstract":"<p><p>Neuroimaging has continually advanced, playing a crucial role in the accurate diagnosis of various brain pathologies and disorders. This integrative review aimed to identify the main changes in brain connections found in fMRI scans of individuals with Internet Gaming Disorder (IGD). The data collection method involved searching for the terms \"Magnetic Resonance Imaging\", \"Psychological Dependence\" and \"Internet Addiction Disorder\" in the PubMed and Embase databases. Studies published between 2020 and January 2023 were included and manually analyzed through the virtual environment created in the \"Rayyan\" software, compiling a total of 18 scientific studies. The main findings reveal changes such as significant increases or decreases in functional connectivity in certain regions of the brain. Some potential negative impacts on the uncontrolled use of technologies among the young population were evaluated, such as the loss of inhibitory control in decision-making, transforming leisure into dependence, and although the IGD understands the associated risks and harms, it faces difficulties in resisting the desire to stop playing. This situation emphasizes the need for more long-term studies that can be comparative between different age groups. Conclusion, the brain regions with the most significant changes in functional connectivity in individuals with IGD symptoms are the prefrontal cortex, fronto-parietal regions, frontal gyrus, insula lobe, cingulate cortex and striatum. The lack of comprehensive knowledge about the effects of video game addiction across different age groups is a significant concern. Therefore, it is essential to carry out research that evaluates the impact of these technologies on different stages of human development.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"4-11"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O Trent Hall, Parker Entrup, Anthony King, Michael Vilensky, Craig J Bryan, Julie Teater, Julie Niedermier, Chelsea M Kaplan, Jessica A Turner, Stephanie Gorka, Steven E Harte, David A Williams, Daniel J Clauw
{"title":"Central sensitization in alcohol use disorder: correlates of pain, addiction and health-related quality of life.","authors":"O Trent Hall, Parker Entrup, Anthony King, Michael Vilensky, Craig J Bryan, Julie Teater, Julie Niedermier, Chelsea M Kaplan, Jessica A Turner, Stephanie Gorka, Steven E Harte, David A Williams, Daniel J Clauw","doi":"10.1080/10550887.2023.2237396","DOIUrl":"10.1080/10550887.2023.2237396","url":null,"abstract":"<p><strong>Background: </strong>Central sensitization is an important mechanism underlying many chronic pain conditions. Chronic pain and alcohol use disorder (AUD) are highly comorbid. Despite great scientific interest in brain mechanisms linking chronic pain and AUD, progress has been impeded by difficulty assessing central sensitization in AUD.</p><p><strong>Objective: </strong>The present study is the first to employ a validated surrogate measure to describe central sensitization in a clinical sample with AUD.</p><p><strong>Methods: </strong>Participants with AUD (<i>n</i> = 99) were recruited from an academic addiction treatment center. A well-established surrogate measure of central sensitization, The American College of Rheumatology Fibromyalgia Survey Criteria (ACRFMS) was administered. Participants also responded to questions about quality of life (RAND-36), and AUD. Descriptive analyses and Spearman's rho correlations were performed.</p><p><strong>Results: </strong>Chronic pain and evidence of central sensitization were prevalent. Greater central sensitization was associated with worse health-related quality of life. Participants higher in central sensitization expressed greater endorsement of pain as a reason for AUD onset, maintenance, escalation, treatment delay, and relapse.</p><p><strong>Conclusion: </strong>The present study bolsters prior assertions that AUD and chronic pain might compound one another <i>via</i> progressive sensitization of shared brain circuitry. These results may inform future mechanistic research and precision AUD treatment.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"32-43"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9851398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophie Paroz, Martine Monnat, Francesco Panese, Michael Saraga, Jean-Bernard Daeppen
{"title":"Caring for patients with substance use disorders: a qualitative investigation of difficulties encountered by hospital-based clinicians.","authors":"Sophie Paroz, Martine Monnat, Francesco Panese, Michael Saraga, Jean-Bernard Daeppen","doi":"10.1080/10550887.2023.2227307","DOIUrl":"10.1080/10550887.2023.2227307","url":null,"abstract":"<p><p><b>Background:</b> Caring for patients with substance use disorders (SUD) is held in low regard and many clinicians resist treating them. To address this situation, numerous research projects assessed training program gaps and professional attitudes. In contrast, this study explored the actual clinical difficulties that a variety of hospital-based professionals encounter when treating patients with SUD. <b>Methods:</b> Qualitative multiple method design including: (1) individual semi-structured interviews with SUD experts and educators; (2) video-elicited, cross self-confrontation interviews with clinicians working in a specialist addiction unit; (3) paired semi-structured interviews with clinicians working in non-specialist units. Participants were recruited within one university hospital. Data collected at stages (1) and (3) relied on an interview guide and were analyzed using conventional content analyses. Data collected at stage (2) consisted of discussions of video recorded clinical interviews and were analyzed based on a participatory approach. <b>Results:</b> Twenty-three clinicians from seven hospital units participated. Forty-four difficulties were reported that we classified into six categories: knowledge-based; moral; technical; relational; identity-related; institutional. We identified seven cross-category themes as key features of SUD clinical complexity: exacerbation of patient characteristics; multiplication of medical issues; hybridity and specificity of medical discipline; experiences of stalemate, adversity, and role reversal. <b>Conclusions:</b> Our study, providing a comprehensive analysis of the difficulties of caring for patients with SUD, reveals a highly challenging clinical practice for a diversity of healthcare providers. They represent a complementary approach to addressing resistance as an important feature of a complex clinical system, and valuable material to discussing professional preparedness.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"12-23"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9692930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heather Webber, Jessica Badawi, Douglas Calvillo, Jin Yoon, Michael Weaver, Scott Lane, Joy Schmitz
{"title":"Preliminary examination of orexin receptor antagonism with suvorexant in individuals with Methamphetamine use disorder: a case series study.","authors":"Heather Webber, Jessica Badawi, Douglas Calvillo, Jin Yoon, Michael Weaver, Scott Lane, Joy Schmitz","doi":"10.1080/10550887.2024.2434298","DOIUrl":"10.1080/10550887.2024.2434298","url":null,"abstract":"<p><p><b>Background:</b> No FDA-approved medications for methamphetamine (MA) use disorder (MUD) are available. Suvorexant (SUVO), a dual orexin receptor antagonist that is FDA approved for insomnia treatment, reduces MA self-administration and MA-induced reinstatement responding in preclinical studies. SUVO may also reduce MA use by targeting substance use risk factors, including insomnia, stress, cue reactivity, and craving. This case series study assessed the (1) feasibility and safety of administering suvorexant in a sample of individuals with MUD; and (2) preliminary effects of suvorexant on objective and subjective measures of sleep, stress, and cue reactivity/craving. <b>Method:</b> Participants (<i>n</i> = 3) were randomized to receive 1 week of SUVO or placebo using a within-subject, crossover design with a 1-week washout period between doses. Participants completed self-report (sleep quality, stress), behavioral (cold pressor task), and physiological measures (heart rate, electroencephalogram) during all three weeks. Participants wore a Fitbit to monitor sleep throughout the study. <b>Results:</b> Participants completed all study visits and tasks. One report of severe drowsiness and of severe headache were made; no other severe side effects were associated with SUVO. SUVO improved total sleep time and resulted in lower resting-state alpha power, but was mixed for subjective sleep quality. SUVO administration was associated with increased overall brain reactivity to cues that was not specific to MA cues and also reduced stress, though self-reported stress demonstrated mixed results. <b>Conclusion:</b> Suvorexant was safe and tolerable in a MUD sample. Future research may benefit from investigating SUVO in a well-controlled study with a larger sample.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valerie A Earnshaw, Ginnie Sawyer-Morris, Braeden Kelly, Zachary K Collier, Xueli Qiu, Aimee Shadwick, Jessica Hulsey
{"title":"enCompass: evaluation of a community-based substance use disorder stigma intervention.","authors":"Valerie A Earnshaw, Ginnie Sawyer-Morris, Braeden Kelly, Zachary K Collier, Xueli Qiu, Aimee Shadwick, Jessica Hulsey","doi":"10.1080/10550887.2024.2431374","DOIUrl":"10.1080/10550887.2024.2431374","url":null,"abstract":"<p><strong>Introduction: </strong>Stigma within communities is pervasive and a barrier to substance use disorder (SUD) treatment. The current proof-of-concept study evaluated <i>enCompass</i>, a community-based SUD knowledge and stigma intervention.</p><p><strong>Methods: </strong>In 2021, 22 <i>enCompass</i> trainings were offered to community members in partnership with the Ohio Governor's RecoveryOhio initiative to 22 Ohio counties with high numbers of overdose deaths. Participants of the current study included 492 individuals who completed surveys measuring knowledge of SUD treatment and medication, and SUD stigma (i.e., stereotypes, prejudice, discrimination), before and after the intervention. Implementation-related outcomes (i.e., acceptability, appropriateness, feasibility) were also measured after the intervention.</p><p><strong>Results: </strong>Participants' knowledge increased, and their SUD stigma decreased, from before to after the intervention. Participants strongly agreed that the intervention was acceptable, appropriate, and feasible.</p><p><strong>Discussion: </strong>Although more testing with longitudinal, randomized designs is needed, preliminary results suggest that <i>enCompass</i> is a promising community-based SUD knowledge and stigma intervention.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A survey of quit vaping strategies and relapse triggers for maintaining youth and young adult vaping abstinence in Canada.","authors":"Mohammed Al-Hamdani, Myles Davidson, Steven Smith","doi":"10.1080/10550887.2024.2440185","DOIUrl":"https://doi.org/10.1080/10550887.2024.2440185","url":null,"abstract":"<p><strong>Objectives: </strong>To examine whether various quit strategies and relapse triggers are associated with maintenance period in a sample of people who quit vaping.</p><p><strong>Method: </strong>Young Canadians who used to vape (<i>N</i> = 772) completed an online survey on maintenance period, quit strategies, and relapse triggers. Logistic regression was employed to variables associated with maintenance period.</p><p><strong>Results: </strong>People with past vaping history who quit unassisted or through eliminating social influences were more likely to achieve long-term maintenance. Those who quit through thinking about health improvements, distraction techniques, or self-restriction were less likely to achieve long-term maintenance. Other substance use or sensory vaping cues as relapse triggers were less likely to be experienced for those in long-term maintenance. Using very high concentrations of nicotine prior to quitting, and being unemployed were associated with lower likelihood for long-term maintenance.</p><p><strong>Conclusions: </strong>It is important to consider quit strategies, relapse triggers, and nicotine use prior to quitting in vaping cessation programing as they are related to maintenance period.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurobiology, psychotherapeutic interventions, and emerging therapies in addiction: a systematic review.","authors":"Christopher Lomas","doi":"10.1080/10550887.2024.2440184","DOIUrl":"https://doi.org/10.1080/10550887.2024.2440184","url":null,"abstract":"<p><p>Substance use disorders (SUDs) represent a major challenge in psychiatric treatment, with significant relapse rates despite various psychotherapeutic interventions. This systematic review explores the neurobiological underpinnings of addiction and examines the efficacy of psychotherapies, such as Cognitive Behavioral Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), Mindfulness-Based Relapse Prevention (MBRP), and emerging therapies in treating SUDs. Additionally, the study assesses how emerging biomarkers and neuroimaging data could enhance therapeutic outcomes by guiding personalized treatments. Neurobiological markers, such as prefrontal-limbic connectivity, mesolimbic dopaminergic dysregulation, and glutamate transmission deficits, are shown to significantly influence treatment efficacy. For example, prefrontal cortex hypoactivity and amygdala hyperactivity correlate with poor impulse control and emotional regulation, making these individuals more responsive to CBT and EMDR. Similarly, dopaminergic dysfunction in the mesolimbic pathway is closely tied to reward-seeking behavior where Transcranial Magnetic Stimulation (TMS) may offer therapeutic benefits. Epigenetic modifications, primarily those affecting the glucocorticoid receptor (GR), highlight the role of stress in relapse suggesting that trauma-focused therapies can be effective for individuals with high stress vulnerability. This review finds that integrating neurobiological insights with clinically validated psychometric assessments could significantly improve treatment stratification. Future research should focus on aligning diagnostic systems, such as the DSM-5, with neurobiological markers and psychological tells to facilitate more precise and personalized interventions, potentially transforming addiction treatment outcomes.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-19"},"PeriodicalIF":1.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The influence of technology: Internet gambling among college students.","authors":"Xiaozheng Zhu","doi":"10.1080/10550887.2024.2404733","DOIUrl":"https://doi.org/10.1080/10550887.2024.2404733","url":null,"abstract":"<p><p>Adolescent gambling, internet gambling among college students, and the impact of school bullying collectively form a complex web of challenges that significantly influence the well-being of today's youth. As technology continues to evolve, the accessibility of online platforms has heightened concerns regarding the occurrence and impact of online gambling among college students. This quantitative research investigates the interconnected dynamics of adolescent gambling prevention strategies, internet gambling among high school and college students, and the role of school bullying. Utilizing a purposive sampling technique, 800 valid responses were collected from a total distribution of 850 questionnaires (500 high school, and 300 college students). The data, analyzed using SPSS statistical software, yielded significant findings. The study validates a negative correlation between effective adolescent gambling prevention strategies and problematic gambling prevalence. It also reveals higher psychological distress and a negative correlation between academic performance and internet gambling frequency among college students engaged in internet gambling. Furthermore, a positive association exists between school bullying experience and adolescents' engagement in both offline and online gambling behaviors. Demographic factors such as socioeconomic status and ethnicity were found to moderate the relationship between adolescent gambling prevention strategies and gambling prevalence. A research novelty is introduced, demonstrating a positive correlation between exposure to pro-gambling advertisements on digital platforms and the frequency and severity of internet gambling among college students. This study offers insightful perspectives on the complex dynamics of adolescent behaviors, guiding the creation of specific prevention strategies and emphasizing the influence of digital advertising on internet gambling.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-15"},"PeriodicalIF":1.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}