Scandinavian Journal of Pain最新文献

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Are we missing the opioid consumption in low- and middle-income countries? 我们是否忽略了中低收入国家的阿片类药物消费情况?
IF 1.5
Scandinavian Journal of Pain Pub Date : 2023-11-13 eCollection Date: 2024-01-01 DOI: 10.1515/sjpain-2023-0086
Igor Correia, Ney Meziat-Filho, Andrea D Furlan, Bruno Saragiotto, Felipe J J Reis
{"title":"Are we missing the opioid consumption in low- and middle-income countries?","authors":"Igor Correia, Ney Meziat-Filho, Andrea D Furlan, Bruno Saragiotto, Felipe J J Reis","doi":"10.1515/sjpain-2023-0086","DOIUrl":"10.1515/sjpain-2023-0086","url":null,"abstract":"<p><strong>Objectives: </strong>The rise in opioid prescriptions with a parallel increase in opioid use disorders remains a significant challenge in some developed countries (opioid epidemic). However, little is known about opioid consumption in low- and middle-income countries (LMICs). In this short report, we aim to discuss the increase in opioid consumption in LMICs by providing an update on the opioid perspective in Brazil.</p><p><strong>Methods: </strong>We analyzed opioid sales on the publicly available Brazilian Health Regulatory Agency (ANVISA) database from 2015 to 2020.</p><p><strong>Results: </strong>In Brazil, opioid sales increased 34.8 %, from 8,839,029 prescriptions in 2015 to 11,913,823 prescriptions in 2020, this represents an increase from 44 to 56 prescriptions for every 1,000 inhabitants. Codeine phosphate combined with paracetamol and tramadol hydrochloride were the most common opioids prescribed with an increase each year.</p><p><strong>Conclusions: </strong>The results suggest that opioid prescriptions are rising in Brazil in a 5 years period. Brazil may have a unique opportunity to learn from other countries and develop consistent policies and guidelines to better educate patients and prescribers and to prevent an opioid crisis.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":"24 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between psychological flexibility and daily functioning in endometriosis-related pain. 子宫内膜异位症相关疼痛患者心理灵活性与日常功能的关系。
IF 1.5
Scandinavian Journal of Pain Pub Date : 2023-10-23 eCollection Date: 2024-01-01 DOI: 10.1515/sjpain-2022-0157
Felicia T A Sundström, Amani Lavefjord, Monica Buhrman, Lance M McCracken
{"title":"Associations between psychological flexibility and daily functioning in endometriosis-related pain.","authors":"Felicia T A Sundström, Amani Lavefjord, Monica Buhrman, Lance M McCracken","doi":"10.1515/sjpain-2022-0157","DOIUrl":"10.1515/sjpain-2022-0157","url":null,"abstract":"<p><strong>Objectives: </strong>Processes of psychological flexibility (PF) are positively associated with health and wellbeing in several chronic pain disorders. However, these processes have not been investigated in endometriosis, a chronic pain disorder affecting 5-10 % of women worldwide. This study is a preliminary investigation of the associations between PF or psychological inflexibility (PI) and daily functioning in people with a primary diagnosis of endometriosis.</p><p><strong>Methods: </strong>This study is based on a secondary analysis of survey data from Swedish-speaking adult participants with chronic pain recruited online. The current study included only those reporting a diagnosis of endometriosis and significant long-term pain. All participants completed the Multidimensional Psychological Flexibility Inventory (MPFI), a measure of PF and PI, as well as other measures of PF, and measures of pain and daily functioning. Correlation and multiple regression analyses were performed to examine relations of PF and PI with measures of pain and daily functioning.</p><p><strong>Results: </strong>In general, PF facet scores from the MPFI did not correlate with pain interference but did correlate with depression, with the exception of acceptance. The overall facets of PI appeared to perform better as correlates and in regression. Established measures of PF performed in correlation and regression analyses generally as has been observed in other chronic pain populations, with significant positive associations.</p><p><strong>Conclusions: </strong>In this preliminary analysis of PF and PI in participants with endometriosis-related pain, these processes appear relevant, especially in understanding depression, but results varied along with the measures used. Specifically, when employing the MPFI, the PI facets emerged as stronger correlates. The findings underscore the potential benefit of incorporating assessments of PF and PI as process variables in endometriosis-research, but also that careful consideration should be given when selecting instruments.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hurdles and potentials when implementing internet-delivered Acceptance and commitment therapy for chronic pain: a retrospective appraisal using the Quality implementation framework. 实施互联网提供的慢性疼痛接受和承诺疗法时的障碍和潜力:使用质量实施框架的回顾性评估。
IF 1.5
Scandinavian Journal of Pain Pub Date : 2023-10-20 eCollection Date: 2024-01-01 DOI: 10.1515/sjpain-2022-0139
Nina Bendelin, Björn Gerdle, Gerhard Andersson
{"title":"Hurdles and potentials when implementing internet-delivered Acceptance and commitment therapy for chronic pain: a retrospective appraisal using the Quality implementation framework.","authors":"Nina Bendelin, Björn Gerdle, Gerhard Andersson","doi":"10.1515/sjpain-2022-0139","DOIUrl":"10.1515/sjpain-2022-0139","url":null,"abstract":"<p><strong>Objectives: </strong>Internet-delivered psychological interventions can be regarded as evidence-based practices and have been implemented in psychiatric and somatic care at primary and specialist levels. However, challenges as low adherence and poor routinization, have arisen during attempts to implement internet-delivered interventions in chronic pain settings. Internet-delivered Acceptance and Commitment Therapy (IACT) has been found to be helpful for chronic pain patients and might aid in developing pain rehabilitation services. However, the integration of IACT into standard health care has not yet been described from an implementation science perspective. The aim of this hybrid 1 effectiveness-implementation study was to evaluate the process of implementing IACT in a pain rehabilitation setting, to guide future implementation initiatives.</p><p><strong>Methods: </strong>In this retrospective study we described actions taken during an implementation initiative, in which IACT was delivered as part of an interdisciplinary pain rehabilitation program (IPRP) at a specialist level clinic. All documents relevant to the study were reviewed and coded using the Quality Improvement Framework (QIF), focusing on adoption, appropriateness and sustainability.</p><p><strong>Results: </strong>The QIF-analysis of implementation actions resulted in two categories: facilitators and challenges for implementation. Sustainability may be facilitated by sensitivity to the changing needs of a clinical setting and challenged by unfitting capacity building. Appropriateness might be challenged by an insufficient needs assessment and facilitated by aligning routines for communication with the clinic's existing infrastructure. Adoption may be facilitated by staff key champions and an ability to adapt to occurring hurdles. Possible influential factors, hypotheses and key process challenges are presented in a logic model to guide future initiatives.</p><p><strong>Conclusions: </strong>Sustainable implementation may depend on both the continuity of facilitating implementation actions and flexibility to the changing needs and interests of patients, caregivers and organization. We conclude that the use of theories, models and frameworks (TMF) as well as a logic model may ease design, planning and evaluation of an implementation process. Lastly, we suggest that IACT may be appropriate for IPRP when given before or after IPRP, focusing on psychiatric comorbidities.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-frequency, high-intensity transcutaneous electrical nerve stimulation compared with opioids for pain relief after gynecological surgery: a systematic review and meta-analysis. 与阿片类药物相比,高频、高强度经皮神经电刺激用于妇科手术后镇痛:一项系统综述和荟萃分析。
IF 1.5
Scandinavian Journal of Pain Pub Date : 2023-10-12 eCollection Date: 2024-01-01 DOI: 10.1515/sjpain-2023-0068
Adam Piasecki, Cecilia Ögren, Sven-Egron Thörn, Alexander Olausson, Carl Johan Svensson, Birgitta Platon, Axel Wolf, Paulin Andréll
{"title":"High-frequency, high-intensity transcutaneous electrical nerve stimulation compared with opioids for pain relief after gynecological surgery: a systematic review and meta-analysis.","authors":"Adam Piasecki, Cecilia Ögren, Sven-Egron Thörn, Alexander Olausson, Carl Johan Svensson, Birgitta Platon, Axel Wolf, Paulin Andréll","doi":"10.1515/sjpain-2023-0068","DOIUrl":"10.1515/sjpain-2023-0068","url":null,"abstract":"<p><strong>Objectives: </strong>Opioids are important for postoperative analgesia but their use can be associated with numerous side effects. Transcutaneous electrical nerve stimulation (TENS) has been used for acute pain treatment and has dose-dependent analgesic effects, and therefore presents an alternative to intravenous (iv) opioids for postoperative pain relief. The aim of this meta-analysis was to compare high-frequency, high-intensity (HFHI or intense) TENS to iv opioids with regard to postoperative pain intensity, recovery time in the Post Anesthesia Care Unit (PACU) and opioid consumption after elective gynecological surgery.</p><p><strong>Methods: </strong>We searched Medline, Embase, Web of Science, Cochrane, Amed and Cinahl for RCTs and quasi-experimental studies (2010-2022), and WHO and ClinicalTrials.gov for ongoing/unpublished studies. Meta-analysis and subsequent Trial Sequential Analysis (TSA) was performed for all stated outcomes. Quality of evidence was assessed according to GRADE.</p><p><strong>Results: </strong>Only three RCTs met the inclusion criteria (362 participants). The surgical procedures involved surgical abortion, gynecologic laparoscopy and hysteroscopy. The applied TENS frequency was 80 Hz and intensity 40-60 mA. There was no difference in pain intensity according to Visual Analogue Scale (VAS) at discharge from PACU between the TENS and opioid group (MD VAS -0.15, 95 % CI -0.38 to 0.09) (moderate level of evidence). Time in PACU was significantly shorter in the TENS group (MD -15.2, 95 % -22.75 to -7.67), and this finding was manifested by TSA (high-level of evidence). Opioid consumption in PACU was lower in the TENS group (MD Morphine equivalents per patient mg -3.42, 95 % -4.67 to -2.17) (high-level of evidence).</p><p><strong>Conclusions: </strong>There was no detectable difference in postoperative pain relief between HFHI TENS and iv opioids after gynecological surgery. Moreover, HFHI TENS decreases recovery time and opioid consumption in PACU. HFHI TENS may be considered an opioid-sparing alternative for postoperative pain relief after gynecological surgery.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42021231048.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontmatter 头版头条
Scandinavian Journal of Pain Pub Date : 2023-10-01 DOI: 10.1515/sjpain-2023-frontmatter4
{"title":"Frontmatter","authors":"","doi":"10.1515/sjpain-2023-frontmatter4","DOIUrl":"https://doi.org/10.1515/sjpain-2023-frontmatter4","url":null,"abstract":"","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135850008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The incidence of post cholecystectomy pain (PCP) syndrome at 12 months following laparoscopic cholecystectomy: a prospective evaluation in 200 patients. 腹腔镜胆囊切除术后12个月胆囊切除后疼痛(PCP)综合征的发生率:对200名患者的前瞻性评估。
IF 1.5
Scandinavian Journal of Pain Pub Date : 2023-09-29 eCollection Date: 2024-01-01 DOI: 10.1515/sjpain-2023-0067
Hayun Lee, Ahmed Askar, Dipak Makanji, Khadija Ranjha, Bishow B Karki, Jade Courcol, Yuvraj Kukreja, G Niraj
{"title":"The incidence of post cholecystectomy pain (PCP) syndrome at 12 months following laparoscopic cholecystectomy: a prospective evaluation in 200 patients.","authors":"Hayun Lee, Ahmed Askar, Dipak Makanji, Khadija Ranjha, Bishow B Karki, Jade Courcol, Yuvraj Kukreja, G Niraj","doi":"10.1515/sjpain-2023-0067","DOIUrl":"10.1515/sjpain-2023-0067","url":null,"abstract":"<p><strong>Objectives: </strong>Post cholecystectomy pain syndrome can cause significant distress, impairs quality of life and exacerbations often result in emergency visits. Poorly controlled postoperative pain is a recognized cause of persistent postsurgical pain. Abdominal myofascial pain syndrome is an underdiagnosed cause of persistent pain in this cohort. The objective was to estimate the incidence of poorly controlled postoperative pain in the first 48 h after surgery and the likelihood of developing persistent pain at 12 months.</p><p><strong>Methods: </strong>The patients undergoing laparoscopic cholecystectomy at a tertiary unit were consented for participation in a prospective service evaluation. A telephone review was performed at three, six and twelve months after surgery. Incidence of poorly controlled pain in the first 48 h after surgery was assessed. Patients with persistent pain were referred to the pain clinic.</p><p><strong>Results: </strong>Over a six-month period, 200 patients were assessed. Eleven patients were excluded (5.5 %). Twelve patients were lost to follow-up (6.6 %, 12/189). Patient satisfaction with acute postoperative pain management was low in 40 % (76/189). Poorly controlled postoperative pain was reported by 36 % (68/189) of patients. Incidence of persistent pain was 29 % (54/189) at 12 months post-surgery. Over half of patients with persistent pain (63 %, 34/54) reported poorly controlled postoperative pain. A somatic source was diagnosed in 54 % (29/54) with post cholecystectomy pain syndrome.</p><p><strong>Conclusions: </strong>Poorly controlled postoperative pain was reported by a third of patients. Persistent pain was present in 29 % at twelve months post-surgery. Abdominal myofascial pain syndrome should be considered as a differential diagnosis in post cholecystectomy pain syndrome.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41120171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability, construct validity, and factorial structure of a Swedish version of the medical outcomes study social support survey (MOS-SSS) in patients with chronic pain. 瑞典版慢性疼痛患者医疗结果研究社会支持调查(MOS-SSS)的可靠性、构建有效性和因子结构。
IF 1.5
Scandinavian Journal of Pain Pub Date : 2023-09-18 eCollection Date: 2024-01-01 DOI: 10.1515/sjpain-2023-0002
Hanna Ljungvall, Lisa Ekselius, Pernilla Åsenlöf
{"title":"Reliability, construct validity, and factorial structure of a Swedish version of the medical outcomes study social support survey (MOS-SSS) in patients with chronic pain.","authors":"Hanna Ljungvall, Lisa Ekselius, Pernilla Åsenlöf","doi":"10.1515/sjpain-2023-0002","DOIUrl":"10.1515/sjpain-2023-0002","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to examine the psychometric properties of a Swedish version of the Medical Outcomes Study Social Support Survey (MOS-SSS).</p><p><strong>Methods: </strong>Standard forward-backward translation was used. A cross-sectional survey was conducted among treatment seeking individuals with chronic pain included in a clinical cohort. Internal consistency was measured with Cronbach's α, test-retest reliability was examined with intraclass correlation, confirmatory factor analyses was used for examining factor structure, and correlations between the MOS-SSS and selected health validity measures were used for testing concurrent validity hypotheses.</p><p><strong>Results: </strong>182 participants were included in the study. Internal consistency measured with Cronbach's alpha was acceptable for all subscales and for the total support index of the MOS-SSS. Test-retest reliability was moderate - good for the different subscales, and was good for the overall support index. The original four factor model of the MOS-SSS was confirmed, and the concurrent validity hypotheses were also confirmed; however, the associations were weaker than expected.</p><p><strong>Conclusions: </strong>The Swedish version of the MOS-SSS was found psychometrically sound and offers a systematic assessment of social support in specialized pain care.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10609996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low back-pain among school-teachers in Southern Tunisia: prevalence and predictors. 突尼斯南部学校教师腰痛的患病率和预测因素。
IF 1.6
Scandinavian Journal of Pain Pub Date : 2023-09-18 Print Date: 2023-10-26 DOI: 10.1515/sjpain-2023-0023
Mouna Baklouti, Houda Ben Ayed, Nouha Ketata, Hanen Maamri, Raouf Karray, Jihene Jdidi, Yosra Mejdoub, Mondher Kassis, Sourour Yaich, Jamel Dammak
{"title":"Low back-pain among school-teachers in Southern Tunisia: prevalence and predictors.","authors":"Mouna Baklouti, Houda Ben Ayed, Nouha Ketata, Hanen Maamri, Raouf Karray, Jihene Jdidi, Yosra Mejdoub, Mondher Kassis, Sourour Yaich, Jamel Dammak","doi":"10.1515/sjpain-2023-0023","DOIUrl":"10.1515/sjpain-2023-0023","url":null,"abstract":"<p><strong>Objectives: </strong>In the professional environment, low back pain (LBP) is a multifactorial symptomatology, despite scientific and technological advances in the design and the arrangement of increasingly ergonomic workstations. Teachers are not exempt from this risk, due to prolonged sitting or standing. In light of this, this study aimed to estimate LBP prevalence among teachers in Southern Tunisia and to identify their determinants.</p><p><strong>Methods: </strong>It was a cross-sectional study including a representative sample of teachers from secondary, middle, and primary schools in Sfax, Tunisia, conducted during the period March-April 2021. LBP intensity was assessed using a visual analog scale from 1 to 10. A severe LBP was defined as VAS≥7.</p><p><strong>Results: </strong>Among the participants, 292 teachers were females (55.6 %). The median age was 48 years (Interquartile Range (IQR)=[41-53] years). Overall, 377 teachers had a severe LBP, with a global prevalence of 71.8 %. Multivariate analysis showed that independent determinants of LBP among teachers were female gender (Adjusted Odds Ratio (AOR)=2.81;p<0.001), age ≥30 (AOR=5.68;p=0.009), chronic diseases (AOR=2.52;p<0.001), working at primary schools (AOR=1.75;p=0.033), working for ≥4 h per day (AOR=2.41;p=0.005), inadequate ergonomic conditions at work (AOR=1.78;p=0.008) and distance home-school ≥10 km (AOR=2.27;p=0.003).</p><p><strong>Conclusions: </strong>This study demonstrated that LBP among teachers was alarmingly high. Different individual, ergonomic, and occupational factors were predictors of this symptom. Thus, development of rational strategies for LBP prevention among teachers and the improvement of working conditions are urgently needed.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":"687-693"},"PeriodicalIF":1.6,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10261228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial. 口服吗啡对实验诱发的瘙痒和疼痛的影响:一项随机、双盲、安慰剂对照试验。
IF 1.6
Scandinavian Journal of Pain Pub Date : 2023-09-15 Print Date: 2023-10-26 DOI: 10.1515/sjpain-2023-0034
Hiroai Okutani, Silvia Lo Vecchio, Nadia Ammitzbøll, Asbjørn Mohr Drewes, Lars Arendt-Nielsen
{"title":"Effects of oral morphine on experimentally evoked itch and pain: a randomized, double-blind, placebo-controlled trial.","authors":"Hiroai Okutani, Silvia Lo Vecchio, Nadia Ammitzbøll, Asbjørn Mohr Drewes, Lars Arendt-Nielsen","doi":"10.1515/sjpain-2023-0034","DOIUrl":"10.1515/sjpain-2023-0034","url":null,"abstract":"<p><strong>Objectives: </strong>Pain and itch share similar neuronal networks; hence, it is difficult to explain why opioids can relieve pain but provoke itching. The present human volunteer study aimed to investigate the similarities and differences in responses to experimentally provoked pain and itching to explore the underlying fundamental mechanisms.</p><p><strong>Methods: </strong>Twenty-four healthy volunteers were enrolled in this single-center, randomized, double-blind, placebo-controlled, parallel-group trial. Three volar forearms and two mandibular areas were marked, and participants randomly received morphine (20 mg) or identical placebo tablets. Heat, cold, and pressure pain thresholds, and vasomotor responses were assessed at baseline and after oral morphine administration. Itch provocations were induced by intradermal application of 1 % histamine or a topical cowhage (non-histaminergic itch) to a marked area of the skin. The participants were subsequently asked to rate their itching and pain intensities. The assessments were repeated for all marked areas.</p><p><strong>Results: </strong>Morphine caused analgesia, as assessed by the significant modulation of cold and pressure pain thresholds (p<0.05). There were no significant differences in histaminergic or non-histaminergic itch or pain intensity between the morphine and placebo groups. Superficial blood perfusion (vasomotor response) following histamine provocation was significantly increased by morphine (p<0.05) in both areas. No correlation was found between the provoked itch intensity and analgesic efficacy in any area or group.</p><p><strong>Conclusions: </strong>Oral administration of morphine caused analgesia without modulating itch intensities but increased neurogenic inflammation in response to histamine, suggesting that different opioid mechanisms in histaminergic and non-histaminergic neurons evoke neurogenic inflammation.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":"743-750"},"PeriodicalIF":1.6,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential effect of walking on quantitative sensory testing, pain catastrophizing, and perceived stress: an exploratory study. 步行对定量感觉测试、疼痛灾难和感知压力的潜在影响:一项探索性研究。
IF 1.6
Scandinavian Journal of Pain Pub Date : 2023-09-12 Print Date: 2023-10-26 DOI: 10.1515/sjpain-2023-0039
Anna Houmøller Rasmussen, Lærke Kjeldgaard Petersen, Mette Kaasgaard Sperling, Maria Møller Bertelsen, Michael Skovdal Rathleff, Kristian Kjær-Staal Petersen
{"title":"The potential effect of walking on quantitative sensory testing, pain catastrophizing, and perceived stress: an exploratory study.","authors":"Anna Houmøller Rasmussen, Lærke Kjeldgaard Petersen, Mette Kaasgaard Sperling, Maria Møller Bertelsen, Michael Skovdal Rathleff, Kristian Kjær-Staal Petersen","doi":"10.1515/sjpain-2023-0039","DOIUrl":"10.1515/sjpain-2023-0039","url":null,"abstract":"<p><strong>Objectives: </strong>Studies suggest that a range of pain mechanisms, such as poor quality of sleep, perceived stress, pain catastrophizing or pain sensitivity, are likely to enhance clinical pain. Animal studies suggest that these pain mechanisms can be modulated by increasing physical activity, but human data are needed to support this hypothesis. This exploratory study aimed to investigate the changes in pain mechanisms after a simple self-directed walking program of 8-weeks. Additionally, this exploratory study investigated the interaction between changes over time in assessments of poor quality of sleep, perceived stress, pain catastrophizing or pain sensitivity and how these changes interacted with each other.</p><p><strong>Methods: </strong>This prospective cohort study included 30 healthy subjects who were assessed at baseline and 4- and 8-weeks after initiating the walking program (30 min walking/day for 8 weeks). Self-report outcomes included: Pain Catastrophizing Scale (PCS), the Perceived Stress Scale (PSS) and Pittsburgh Sleep Quality Index. Pressure pain thresholds, temporal summation of pain and conditioned pain modulation (CPM) were assessed using cuff algometry.</p><p><strong>Results: </strong>Twenty-four subjects completed all the visits (age: 42.2, SD: 14.9, 16 females). PCS and PSS significantly decreased at the 8-week's visit compared to baseline (p<0.05). No significant differences were seen for an improvement in quality of sleep (p=0.071) and pain sensitivity (p>0.075) when comparing the 8-week's visit to the baseline visit. Changes in pain mechanisms comparing baseline and 8-weeks data were calculated and regression analyses found that an improvement in PCS was associated with an improvement in CPM (R<sup>2</sup>=0.197, p=0.017) and that a higher adherence to the walking program was associated with a larger improvement in PCS (R<sup>2</sup>=0.216, p=0.013).</p><p><strong>Conclusions: </strong>The current exploratory study indicates that a simple self-directed walking program of 8-weeks can improve pain catastrophizing thoughts, perceived stress. Higher adherence to the walking program were associated with an improvement in pain catastrophizing and an improvement in pain catastrophizing was associated with an increase in conditioned pain modulation.</p>","PeriodicalId":47407,"journal":{"name":"Scandinavian Journal of Pain","volume":" ","pages":"751-758"},"PeriodicalIF":1.6,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10554817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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