Malaysian Journal of Medical Sciences最新文献

筛选
英文 中文
A Scoping Review of Intervention Implementation for Self-Care Skills among Children with Developmental Delay. 对发育迟缓儿童自理能力干预措施实施情况的范围审查。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.6
Noor Amiera Alias, Masne Kadar, Farahiyah Wan Yunus, Katie Cremin
{"title":"A Scoping Review of Intervention Implementation for Self-Care Skills among Children with Developmental Delay.","authors":"Noor Amiera Alias, Masne Kadar, Farahiyah Wan Yunus, Katie Cremin","doi":"10.21315/mjms2024.31.4.6","DOIUrl":"10.21315/mjms2024.31.4.6","url":null,"abstract":"<p><p>Difficulties with self-care skills are frequently observed in children with developmental delays. Given the scarcity of robust evidence backing self-care interventions for this group, this scoping review is designed to aggregate existing literature on the implementation of such interventions. Therefore, this scoping review aims to collate literature on the nature of self-care intervention implementation to increase understanding of the current practice and inform future research directions. This scoping review endeavoured to explore the body of literature concerning the existence of self-care interventions and their implementation strategies in children who have developmental delays. Relevant studies were identified by searching through the following databases: Web of Science (W0S), Scopus, ASEAN Citation Index (ACI), CINAHL EBSCO and PubMed. Six types of interventions using various approaches were identified. Occupational therapists mainly manage intervention providers with multidisciplinary co-facilitator and parents' involvement. Whilst session information varied, some evidence suggests that at least 30 min per session, minimum once per week up to twice per week, ranging from 10 to 23 sessions, may be sufficient. Intervention plans should be tailored to each child's unique needs, taking into account the variety of available interventions. Collaboration among occupational therapists, parents, educators and health professionals in home programmes enhances self-care intervention outcomes. These results are set to inform future research and practice, paving the way for enhanced support and improved outcomes for children with developmental delays.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comorbidities and Monitoring in Patients with Chronic Hepatitis B on Nucleos(t)ide Analogues Attending a Tertiary Hospital in Malaysia, Southeast Asia: A Critical Perspective. 在东南亚马来西亚一家三甲医院就诊的使用核苷酸类似物的慢性乙型肝炎患者的并发症和监测:关键视角。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.12
Kizito Eneye Bello, Itodo Janefrancis Kelechi, Zakari A David, Adejo Patience Omebije, Rafidah Hanim Shueb, Nazri Mustaffa
{"title":"Comorbidities and Monitoring in Patients with Chronic Hepatitis B on Nucleos(t)ide Analogues Attending a Tertiary Hospital in Malaysia, Southeast Asia: A Critical Perspective.","authors":"Kizito Eneye Bello, Itodo Janefrancis Kelechi, Zakari A David, Adejo Patience Omebije, Rafidah Hanim Shueb, Nazri Mustaffa","doi":"10.21315/mjms2024.31.4.12","DOIUrl":"10.21315/mjms2024.31.4.12","url":null,"abstract":"<p><strong>Background: </strong>Chronic hepatitis B (CHB) is a significant global public health concern in Malaysia. It is a potentially life-threatening liver disease caused by the hepatitis B virus (HBV), which can lead to long-term complications such as cirrhosis, liver failure and hepatocellular carcinoma. In managing CHB, nucleos(t)ide analogues (NAs) have become the preferred treatment due to their ability to suppress viral replication and prevent disease progression. The question of liver-associated comorbidities related to patients with CHB on NAs remains unresolved in Malaysia despite the impending burden of CHB in the country. This study intends to address this and related aspects.</p><p><strong>Method: </strong>We assessed 136 CHB patients on NAs in one centre, the Hospital Universiti Sains Malaysia. Demographic and epidemiological data on the treatment, concomitant disease and monitoring strategies were collected and analysed.</p><p><strong>Result: </strong>Patients on NAs aged 50 years old-70 years old had the highest proportion of CHB (45.59%), with males representing 61.03% of that age group. There was a statistical significance in CHB acquisition and presence of comorbidities at <i>P ></i> 0.005. Our cohort displayed seven comorbidities (diabetes, obesity, rheumatoid diseases, renal impairment, spontaneous bacterial peritonitis, hypertension, non-hepatocellular malignancies and carcinoma); hypertension had the highest incidence (69.12%), while renal impairment had the lowest incidence (8.09%). Whole blood count, liver function and creatinine tests were the major monitoring tests used in over 90% of the cohort compared to viral load (6.1%).</p><p><strong>Conclusion: </strong>Diabetes, hypertension and obesity were independent risk factors for acquiring liver cirrhosis and hepatocellular carcinoma. Malaysian CHB patients treated with NAs have several comorbidities that could affect disease outcomes. Therefore, careful monitoring is required.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association between Drug-Related Problems and Length of Stay of Type 2 Diabetes Mellitus Patients. 药物相关问题与 2 型糖尿病患者住院时间之间的关联。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.13
Niken Larasati, Satibi Satibi, Susi Ari Kristina, Lutfan Lazuardi
{"title":"The Association between Drug-Related Problems and Length of Stay of Type 2 Diabetes Mellitus Patients.","authors":"Niken Larasati, Satibi Satibi, Susi Ari Kristina, Lutfan Lazuardi","doi":"10.21315/mjms2024.31.4.13","DOIUrl":"10.21315/mjms2024.31.4.13","url":null,"abstract":"<p><strong>Introduction: </strong>Drug-related problems (DRPs) are treatment-related occurrences that affect therapeutic efficacy. In a previous study, approximately 279 out of 330 (84.5%) patients with type 2 diabetes mellitus (T2DM) had experienced at least one DRP, including non-optimal drug effects (<i>n</i> = 240, 52.7%) and indications without medication (<i>n =</i> 137, 30.1%). Patients who were hospitalised for 5-10 days had the highest number of DRPs. Therefore, this study investigates the association between DRPs and length of stay (LoS) in patients with T2DM.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from January 2020 to May 2023 at Rumah Sakit Akademik, Universitas Gadjah Mada, Yogyakarta, Indonesia. Clinical pharmacists reviewed electronic health data to examine DRPs. The Fisher's exact test evaluated the association between DRPs and LoS.</p><p><strong>Results: </strong>A total of 60.7% (<i>n</i> = 17) of the participants were females, with the majority falling into the age group ≥ 65 years old (<i>n</i> = 11, 29.7%). A significant portion experienced LoS > 7 days (<i>n</i> = 17, 60.7%). Antidiabetic monotherapy was predominant, and the categories of DRPs included adverse drug reaction (<i>n =</i> 15, 40.5%), dosage too high (<i>n</i> = 6, 16.2%), wrong drug (<i>n</i> = 6, 16.2%), non-adherence (<i>n</i> = 4, 10.8%), need for additional therapy (<i>n =</i> 4, 10.8%) and dosage too low (<i>n =</i> 2, 5.4%). A significant association was observed between non-adherence and LoS (<i>P =</i> 0.016). The possibility of experiencing LoS of 1-7 days increased by 3.43 times with improved non-adherence (OR = 3.43; 95% CI: 1.83, 6.39). In this context, non-adherence refers to DRPs associated with the non-compliance of patients with the prescribed treatment plan.</p><p><strong>Conclusion: </strong>This study concludes that non-adherence was significantly associated with hospital LoS.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Lactate and D-Dimer as Mortality Predictors of Paediatric Multiple Organ Dysfunction Syndrome: A Prospective Study in a Low-Middle Income Country. 评估乳酸和 D-二聚体作为儿科多器官功能障碍综合征死亡率预测指标的作用:一项在中低收入国家开展的前瞻性研究。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.10
Phuong Minh Nguyen, Khai Viet Tran, Hung Viet Phan, Khai Quang Tran, Duc Long Tran, Huong Thien Mai, Thu Minh Pham Vo, Tho Kieu Anh Pham, Ly Cong Tran
{"title":"Evaluating Lactate and D-Dimer as Mortality Predictors of Paediatric Multiple Organ Dysfunction Syndrome: A Prospective Study in a Low-Middle Income Country.","authors":"Phuong Minh Nguyen, Khai Viet Tran, Hung Viet Phan, Khai Quang Tran, Duc Long Tran, Huong Thien Mai, Thu Minh Pham Vo, Tho Kieu Anh Pham, Ly Cong Tran","doi":"10.21315/mjms2024.31.4.10","DOIUrl":"10.21315/mjms2024.31.4.10","url":null,"abstract":"<p><strong>Background: </strong>Multiple Organ Dysfunction Syndrome (MODS) is a complex medical condition characterised by dysfunction across multiple organs. With limited information available on mortality prediction in the paediatric population, particularly in low-middle income countries, this study evaluates the mortality predicting capabilities of lactate, D-dimer, and their combination.</p><p><strong>Methods: </strong>This prospective study involved paediatric patients admitted to the paediatric intensive care unit (PICU) of the largest central children's hospital in the Mekong Delta region, Vietnam, from 2019 to 2021. The discriminative ability and calibration of both individual and combined tests were assessed using the receiver operating characteristic (ROC) curves and the Hosmer-Lemeshow goodness-of-fit test.</p><p><strong>Results: </strong>Among the patients studied, 63.1% did not survive. Lactate and D-dimer concentrations were significantly higher in the non-survivor group (<i>P</i> < 0.001). The area under the curve (AUC) values for lactate, D-dimer and the combined lactate-D-dimer test were 0.742, 0.775 and 0.804, respectively, with the combination showing the highest AUC value, though without statistical significance. Specific thresholds for lactate, D-dimer and the combination yielded sensitivities of 75.5%, 71.7%, and 66.0%, respectively. All three tests showed no statistically significant differences between observed and predicted mortality in the Hosmer-Lemeshow test (all <i>P-</i>values > 0.05).</p><p><strong>Conclusion: </strong>Lactate and D-dimer levels showed a significant association with mortality, along with good discrimination and calibration abilities. These results highlight the utility of lactate and D-dimer as effective predictors in paediatric MODS, particularly in resource-limited settings, and their role in improving patient outcomes.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally Invasive Intervention for Trigeminal Neuralgia. 三叉神经痛的微创介入治疗。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.20
Muhammad Ihfaz Ismail, Song Yee Ang, Diana Noma Fitzrol, Zaitun Zakaria
{"title":"Minimally Invasive Intervention for Trigeminal Neuralgia.","authors":"Muhammad Ihfaz Ismail, Song Yee Ang, Diana Noma Fitzrol, Zaitun Zakaria","doi":"10.21315/mjms2024.31.4.20","DOIUrl":"10.21315/mjms2024.31.4.20","url":null,"abstract":"","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Healthcare Professionals Disagree: Finding the Right Balance. 当医护人员意见不一致时:找到正确的平衡。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.19
Yusrita Zolkefli
{"title":"When Healthcare Professionals Disagree: Finding the Right Balance.","authors":"Yusrita Zolkefli","doi":"10.21315/mjms2024.31.4.19","DOIUrl":"10.21315/mjms2024.31.4.19","url":null,"abstract":"<p><p>Healthcare disagreements are common, but recognising the causes is essential to reaching a moral consensus. The article describes the challenges associated with resolving the disagreements. Therefore, a systematic and timely team-based discussion, ethics consultation with ethicists and the hospital ethics committee, active participation of all members' discussions, and scheduled debriefings are pragmatic ways to find balance when healthcare professionals disagree. Teams need these attempts to build consensus and make moral decisions. It also fosters harmony, prioritises patient and team interests and, most importantly, keeps the team intact.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological Profiles of Male Adolescents in Kelantan, Malaysia Practicing Taekwondo and Wushu. 马来西亚吉兰丹州练习跆拳道和武术的男性青少年的生理特征。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.14
Nur Fadhilah Ain Adanan, Foong Kiew Ooi, Norsuriani Samsudin
{"title":"Physiological Profiles of Male Adolescents in Kelantan, Malaysia Practicing Taekwondo and Wushu.","authors":"Nur Fadhilah Ain Adanan, Foong Kiew Ooi, Norsuriani Samsudin","doi":"10.21315/mjms2024.31.4.14","DOIUrl":"10.21315/mjms2024.31.4.14","url":null,"abstract":"<p><strong>Background: </strong>Martial arts training is beneficial for improving physical fitness but the improvements can vary according to the type of martial art performed. This study investigated lung function, aerobic and anaerobic capacity, flexibility, muscular strength and power among male adolescents who were sedentary or who practiced taekwondo or wushu.</p><p><strong>Methods: </strong>A total of 30 male adolescents living in the Kelantan state in Malaysia who were between 14 years old and 20 years old were enrolled and divided into three groups: i) sedentary (control), ii) taekwondo and iii) wushu. Each participant underwent a lung function test, 20 m shuttle run, Wingate anaerobic test and a Sit and Reach test, as well as tests of standing long jump power, handgrip, back and leg strength.</p><p><strong>Results: </strong>Relative to the sedentary control group, the wushu group had significantly higher values than the sedentary control group for fat free mass (<i>P</i> = 0.047), explosive leg power (<i>P</i> < 0.001), aerobic capacity (<i>P</i> < 0.001), forced expiratory volume in 1 s (FEV<sub>1</sub>) (<i>P</i> = 0.021) and Wingate anaerobic capacity (<i>P</i> < 0.05). The taekwondo group also showed significantly greater values than the sedentary control group for explosive leg power (<i>P</i> = 0.018), forced vital capacity (FVC) (<i>P</i> = 0.014) and FEV<sub>1</sub> (<i>P</i> < 0.001). The wushu group exhibited significantly higher explosive leg power (<i>P</i> = 0.010) and Wingate anaerobic capacity parameters including mean power (<i>P</i> = 0.001), anaerobic capacity (<i>P</i> < 0.001) and anaerobic power (<i>P</i> = 0.002) than the taekwondo group.</p><p><strong>Conclusion: </strong>Engagement of male adolescents in wushu and taekwondo was associated with improved physiological profiles compared to those who were in the sedentary control group. Practice of wushu could result in greater explosive leg power and anaerobic capacities than taekwondo.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychometric Evaluation of the Abdominal Bloating Social Support Scale. 腹胀社会支持量表的心理计量学评估
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.11
Nurzulaikha Abdullah, Yee Cheng Kueh, Garry Kuan, Mung Seong Wong, Yeong Yeh Lee
{"title":"Psychometric Evaluation of the Abdominal Bloating Social Support Scale.","authors":"Nurzulaikha Abdullah, Yee Cheng Kueh, Garry Kuan, Mung Seong Wong, Yeong Yeh Lee","doi":"10.21315/mjms2024.31.4.11","DOIUrl":"10.21315/mjms2024.31.4.11","url":null,"abstract":"<p><strong>Background: </strong>Abdominal bloating (AB) is a common, bothersome symptom that negatively affects most adults. Although social support may help people suffering from AB, limited validated questionnaire is available. This study aimed to validate the newly developed Abdominal Bloating Social Support (SS-Bloat) scale for the Malaysian context.</p><p><strong>Method: </strong>We conducted a cross-sectional study in which we used purposive sampling and a self-administered questionnaire. Based on the literature review, experts' input and in-depth interviews, new items were generated for SS-Bloat scale. Content validity was assessed by experts and pre-tested with 30 individuals with AB. Construct validity was determined based on exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Reliability was determined based on Cronbach's alpha and composite reliability (CR).</p><p><strong>Results: </strong>During the development stage, eight items were generated for SS-Bloat scale and remained the same after content validity and pre-testing. A total of 152 participants with a mean age of 31.27 years old (68.3% female, 32.7% male) completed the questionnaire. Based on the EFA, three problematic items were removed. The total variance explained was 35.6% with acceptable reliability (α = 0.66). The model was then tested using CFA. The initial model did not fit the data well. After several model re-specifications, the final measurement model of SS-Bloat scale fit the data well with acceptable fit indices (comparative fit index [CFI] = 0.994 and Tucker-Lewis index [TLI] = 0.984). The CR was satisfactory with value of 0.84.</p><p><strong>Conclusion: </strong>SS-Bloat scale was deemed valid and reliable for assessing the level of social support among AB patients. The questionnaire can be useful for both research studies and clinical purposes, as it is easy to use.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Scoping Review on Cucumis melo and Its Anti-Cancer Properties. 瓜果及其抗癌特性的范围界定综述
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.5
Raja Siti Syazana Raja Soh, Hermizi Hapidin, Mohamad Zahid Kasiram
{"title":"A Scoping Review on Cucumis melo and Its Anti-Cancer Properties.","authors":"Raja Siti Syazana Raja Soh, Hermizi Hapidin, Mohamad Zahid Kasiram","doi":"10.21315/mjms2024.31.4.5","DOIUrl":"10.21315/mjms2024.31.4.5","url":null,"abstract":"<p><p><i>Cucumis melo</i> L., better known by its popular cultivar cantaloupe, is an economically significant crop in the Cucurbitaceae family. Melon peel and seeds have shown medicinal potential due to their numerous biological qualities, including anti-inflammatory, anti-cancer, antibacterial, hepatoprotective and immunomodulatory effects to treat cardiovascular disease, diabetes and oedema. This scoping review aims to broaden the research scope on the cancer-fighting abilities of melon extract and its half maximal inhibitory concentration (IC<sub>50</sub>). Three databases which are Scopus, ScienceDirect and PubMed were used to locate relevant publications utilising the keywords 'melon', '<i>Cucumis melo</i>', 'inhibitory activity', 'cancer' and 'anti-cancer'. The Preferred Reporting Items for Systematic and Meta-analyses extension for Scoping Review (PRISMA-ScR) framework was used in conducting this study. Out of 904 articles, 14 articles met the inclusion criteria and were used in this analysis. These articles were published in English between 2000 and 2023 with full text accessibility, specifically addressed the fruit cantaloupe (<i>Cucumis melo</i> L.) or melon and reported on any type of cancer. <i>Cucumis melo</i> extract showed promising anti-cancer action in both in vitro and in vivo investigations on eight different cancer types: cervical, colon, prostate, leukaemia, multiple myeloma, breast, hepatoma and ovarian cancer. A thorough analysis shows that some of the IC<sub>50</sub> values were significantly low, especially in cases of colon and prostate cancer, indicating a significant anti-cancer effect. The substantial anti-cancer benefits of <i>Cucumis melo</i> fruit extracts point to the necessity for additional investigation into their potential for cancer therapy on each form of cancer.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cord Blood 25-Hydroxyvitamin D Level is Correlated with a Risk for Atopic Dermatitis: Systematic Review and Meta-Analysis. 脐带血 25-羟维生素 D 水平与特应性皮炎风险相关:系统回顾与元分析》。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-08-01 Epub Date: 2024-08-27 DOI: 10.21315/mjms2024.31.4.4
Dedianto Hidajat, Abiyyu Didar Haq, Cut Warnaini, Hamsu Kadriyan
{"title":"Cord Blood 25-Hydroxyvitamin D Level is Correlated with a Risk for Atopic Dermatitis: Systematic Review and Meta-Analysis.","authors":"Dedianto Hidajat, Abiyyu Didar Haq, Cut Warnaini, Hamsu Kadriyan","doi":"10.21315/mjms2024.31.4.4","DOIUrl":"10.21315/mjms2024.31.4.4","url":null,"abstract":"<p><p>Although Indonesia is located in an equatorial region with adequate year-round sun exposure, the prevalence of 25-hydroxyvitamin D (25[OH]D) deficiency is as high as 90%. Mothers are especially vulnerable to deficiencies due to changes in their gastrointestinal system. Previous studies have reported a correlation between the 25[OH]D status of mothers with atopic dermatitis (AD) and their offspring. However, studies investigating maternal cord blood 25[OH]D levels and the incidence of AD have yielded controversial results due to its variability. As such, this systematic review and meta-analysis aimed to evaluate the correlation between maternal cord blood 25[OH]D levels and the risk for AD. In accordance with Preferred Reporting System for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the PubMed, Cochrane Library and ScienceDirect databases were searched for relevant observational studies and a meta-analysis was performed to obtain odds ratios (OR) and corresponding 95% confidence intervals (CI). Nine studies were included in the qualitative synthesis, five of which were included in the quantitative synthesis. Meta-analysis revealed that cord blood 25[OH]D levels < 50 nmol/L were associated with a 60% higher risk for the development of AD (OR = 1.60; 95% CI: 1.15, 2.22; I<sup>2</sup> = 0%; <i>P</i> < 0.05). However, qualitative synthesis revealed a variety of cord blood 25[OH]D measurements and different methods of diagnosing AD in each study. Based on the current analysis, maternal cord blood 25[OH]D levels were significantly correlated with the risk for AD. Therefore, studies investigating 25[OH]D supplementation in pregnant women and its efficacy in decreasing the risk for AD are needed, especially in tropical and equatorial countries. This study also serves as a proof of concept that cord blood 25[OH]D levels can be used as a more affordable predictive parameter for AD.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信