Jurnal Sains dan Kesehatan最新文献

{"title":"Analisis Hidrokuinon dalam Krim Pemutih Wajah yang Beredar di Kota Bangkinang dengan Metode Kromatografi Lapis Tipis","authors":"Kony Putriani, Lovera Anggraini, Fitri Cindy Fricilia","doi":"10.25026/jsk.v6i1.2130","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.2130","url":null,"abstract":"Hydroquinone is an ingredient or preparation to overcome skin hyperpigmentation on the outside of the body. Hydroquinone is prohibited from use in cosmetics that can cause oochronosis, which is skin spots like sand and bluish brown in color, people with oochronosis will feel itchy and burning on the skin. The study aims to determine the presence or absence of Hydroquinone in face whitening creams that do not have BPOM permits circulating in Bangkinang City.  Hydroquinone examination was carried out by thin-a-layer chromatography (TLC) method using toluene mobile phase:  glacial acetic acid (80:20). Whitening cream samples were taken from as many as five different brands, and different sellers. After testing the five samples, two were positive, marked with the Rf value of the sample equal to the Rf of the control and comparison.\u0000Keywords:          Whitening Cream, Hydroquinone, KLT\u0000 \u0000Abstrak\u0000Hidrokuinon merupakan bahan atau sediaan untuk mengatasi hiperpigmentasi kulit di bagian luar tubuh. Hidrokuinon dilarang penggunaannya pada kosmetik karena menyebabkan okronosis, yaitu kulit berbintik seperti pasir dan berwarna coklat kebiruan, Pengidap okronosis akan merasa gatal dan rasa terbakar pada kulit. Penelitian ini bertujuan untuk menentukan ada atau tidaknya hidrokuinon pada krim pemutih wajah yang tidak memiliki izin Badan Penelitian Obat dan Makanan (BPOM) yang beredar di Kota Bangkinang. Pemeriksaan hidrokuinon dilakukan dengan metode Kromatografi Lapis Tipis (KLT) dengan menggunakan fase gerak toluen : asam asetat glasial (80:20). Sampel krim pemutih diambil sebanyak lima merek yang berbeda dari penjual yang berbeda, Setelah dilakukan pengujian diperoleh hasil dua sampel D dan E positif mengandung hidrokuinon yang ditandai dengan nilai Rf yang sama dengan Rf kontrol dan pembanding.\u0000Kata Kunci:     Krim Pemutih, Hidrokuinon, KL","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"94 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribusi Kasus Celah Bibir dan Langit-Langit Berdasarkan Jenis Kelamin dan Lokasi Celah di Provinsi Kalimantan Timur Tahun 2020-2022","authors":"Nida Midati Shadrina, Syahril Samad, Listiyawati Listiyawati, Cristiani Nadya Pramasari, Danial Danial","doi":"10.25026/jsk.v6i1.1777","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.1777","url":null,"abstract":"Cleft lip and cleft palate are the most common congenital malformations of the head and neck and may be associated with other congenital anomalies. The etiology of cleft lip and/or palate has been studied extensively that this anomaly is multifactorial. Risk factors for clefts include gender, genetic factors, and family history. The clinical presentation of cleft palate varies and can be classified as isolated cleft palate or cleft lip with or without a cleft palate. The disorder may involve the lips, hard palate and/or soft palate, either completely or incompletely, and unilaterally or bilaterally. The purpose of this study is to describe the distribution of cases of cleft lip and/or cleft palate based on gender and cleft location in East Kalimantan Province in 2020-2022. This type of research is a descriptive study with total sampling technique. Data were obtained from patient registration forms based on predetermined inclusion criteria. The results showed that of the 77 samples, cases of clefts were more common in males, namely 52 people (67.53%) and females, namely 25 people (32.47%). The most frequent cleft location on the left unilateral were 36 people (46.75%) compared to the right unilateral of 19 people (24.68%), or bilateral as many as 22 people (28.57%). Based on the results of this study, the distribution of cases of cleft lip and/or cleft palate mostly occurs in males, with the location of the cleft more common in the left unilateral.\u0000Keywords:          Cleft Lip and Palate, Gender, Cleft Location\u0000 \u0000Abstrak\u0000Celah bibir serta langit-langit ialah malformasi kongenital kepala dan leher yang paling umum dan mungkin berhubungan dengan anomali kongenital lainnya. Etiologi celah bibir dan/atau langit-langit telah dipelajari secara ekstensif bahwa anomali ini bersifat multifaktorial. Faktor risiko terjadinya celah yaitu seperti, jenis kelamin, faktor genetik, dan riwayat keluarga. Presentasi klinis celah mulut bervariasi dan dapat diklasifikasikan sebagai celah langit-langit terisolasi atau celah bibir dengan ataupun tanpa celah langit-langit. Kelainan tersebut dapat melibatkan bibir, langit-langit keras dan/atau langit-langit lunak, baik secara lengkap atau tidak lengkap, serta unilateral atau bilateral. Tujuan penelitian ini adalah menggambarkan distribusi kasus celah bibir dan/atau celah langit-langit menurut jenis kelamin serta lokasi celah di Provinsi Kalimantan Timur pada tahun 2020-2022. Jenis penelitian ini ialah penelitian deskriptif dengan teknik total sampling. Hasil penelitian memperlihatkan bahwa dari 77 sampel, kasus celah lebih kerap dialami laki-laki yakni 52 orang (67,53%) dan perempuan yakni 25 orang (32,47%). Lokasi celah paling sering terjadi pada unilateral kiri berjumlah 36 orang (46,75%) dibandingkan dengan unilateral kanan sebanyak 19 orang (24,68%), ataupun bilateral sebanyak 22 orang (28,57%). Berdasarkan hasil penelitian ini, distribusi kasus celah bibir dan/atau celah langit-langit sebagian besar terjadi pada laki","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulasi dan Uji Aktivitas Nanoemulsi Spray Gel Propolis sebagai Antijamur terhadap Candida albicans","authors":"Baiq Aluh Nurfatimah, Fatya Kamila Putri, Adila Rizkika, Early Windary Suhayatman, Sucilawaty Ridwan","doi":"10.25026/jsk.v6i1.2121","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.2121","url":null,"abstract":"Aphthous stomatitis is inflammation of the oral mucosa, which can cause pain and discomfort. Thrush can be caused by Candida albicans. So, this research aims to make a nanoemulsion spray gel preparation that can treat the Candida albicans fungus. The method was to formulate propolis nanoemulsion and gel base with variations of Carbopol, followed by physical properties testing such as organoleptic test, pH, viscosity, spreadability and adhesivity, particle size, and index polydispersity. Furthermore, the antifungal activity of the preparation was tested against Candida albicans. The results showed that formulation 2 had better antifungal activity where the diameter of the inhibitory force was 22,33±0,58(p?0,05). This research concludes that formula 2 nanoemulsion spray gel preparations showed the optimum preparation based on physical properties evaluation and showed the diameter inhibitory of 22,33±0,58 mm.\u0000Keywords:          nanoemulsion, spray, gel, propolis\u0000 \u0000Abstrak\u0000Sariawan atau Stomatitis aphtosa adalah inflamasi pada bagian mukosa mulut yang dapat menimbulkan rasa sakit dan tidak nyaman. Sariawan dapat disebabkan oleh Candida albicans. Sehingga tujuan dilakukannya penelitian ini yaitu melakukan pembuatan sediaan nanoemulsi spray gel yang dapat mengatasi jamur Candida albicans. Metode yang digunakan yaitu dengan memformulasikan nanoemulsi propolis dan basis gel dengan variasi 3 variasi formula carbopol sebagai gelling agent. Selanjutnya dilakukan uji evaluasi fisik sediaan meliputi organoleptik, pH, daya sebar lekat, viskositas, ukuran partikel, dan indeks polidispersitas. Selanjutnya dilakukan uji aktivitas antijamur terhadap Candida albicans. Hasilnya didapatkan bahwa formula 2 merupakan formula paling optimum berdasarkan evaluasi fisik. Formula ini memiliki aktivitas antijamur dengan diameter daya hambat sebesar 22,33±0,58 (p?0,05. Kesimpulan dari penelitian ini yaitu formula 2 sediaan nanoemulsi spray gel merupakan formula paling optimum berdasarkan evaluasi fisik serta memiliki aktivitas terhadap jamur Candida albicans dengan zona hambat sebesar 22,33±0,58 mm.\u0000Kata Kunci:         nanoemulsi, spray, gel, propolis","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Tingkat Pengetahuan dengan Sikap terhadap Penggunaan Antibiotik Amoxicillin di Kampung X, Kabupaten Purwakarta","authors":"Herma Yulika, Marselina Marselina","doi":"10.25026/jsk.v6i1.1992","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.1992","url":null,"abstract":"Antibiotics are drugs that are used to deal with bacterial infections or are bacteriostatic, which prevents the occurrence of bacteria. Amoxicillin is the most well-known antibiotic used by people without a doctor’s prescription. The aim of this study is to analyze the relationship between the level of knowledge and the attitude towards the use of antibiotics Amoxicillin. This research is a quantitative study with cross-sectional approach carried out on 58 respondents in Kampung X  Purwakarta. Questionnaire that has been tested for validity and reliability, SPSS univariat and bivariat analysis chi-square test square. The result of this study is obtained a value (p = 0,000) which means there is a meaningful relationship between the level of knowledge and attitude towards the use of antibiotics Amoxicillin. Respondents whose level of knowledge is less good and have a less good attitude are at risk of using an antibiotic Amoxicillin that does not comply with the rules of use. A good level of knowledge can reduce the adverse impact on the use of antibiotic Amoxicillin that does not comply with the rules of use.\u0000Keywords:          Education, Age,  Pharmacy\u0000 \u0000Abstrak\u0000Antibiotik merupakan obat yang digunakan untuk mengatasi infeksi bakteri atau bersifat bakteriostatik yaitu menghambat terjadinya perkembangbiakan bakteri. Antibiotik Amoxicillin merupakan antibiotik yang paling banyak dikenal sekaligus dipergunakan oleh masyarakat tanpa resep dokter. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara tingkat pengetahuan dengan sikap terhadap penggunaan antibiotik Amoxicillin. Menggunakan penelitian kuantitatif yang dilakukan pada 58 responden di Kampung X Kabupaten Purwakarta. Menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya, Diuji  menggunakan SPSS analisis univariat dan bivariat serta uji chi-square kuadrat. Dari penelitian ini didapatkan hasil  dengan nilai (p = 0,000) yang artinya terdapat hubungan bermakna antara tingkat pengetahuan dengan sikap terhadap penggunaan antibiotik Amoxicillin. Responden yang tingkat pengetahuannya kurang baik dan memiliki sikap yang kurang baik berisiko menggunakan antibiotik Amoxicillin yang tidak sesuai dengan aturan pakai. Tingkat pengetahuan yang baik dapat mengurangi dampak negatif penggunaan antibiotik Amoxicillin yang tidak sesuai aturan pakai.\u0000Kata Kunci:         Pendidikan, Usia, Apotek","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"2014 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis Biaya dengan Efektifitas dan Rasionalitas Pengobatan Serangan Asma di Rumah Sakit X Gresik","authors":"Amelia Lorensia, Marthy Meliana Ariyanti Jalmav, Sugeng Haryoko","doi":"10.25026/jsk.v6i1.2179","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.2179","url":null,"abstract":"Asthma is a major global problem. The annual economic burden of asthma is very large. These cost increases are caused by poor asthma management and management and an imbalance between the large number of health workers. This study aims to analyze the cost and effectiveness of treating asthma attacks at X Hospital Gresik by involving 23 respondents. This research is a non-experimental study which is retrospective in nature. As research material is medical record data of patients with asthma at the Petrokimia Hospital, during the 2020-2022 period. The location of the research was Pertokimia Hospital. The independent variable in this study is the therapy used. The dependent variable in this study is the total cost of treatment for treatment outcomes (hospitalization and improvement in asthma symptoms). Data collection was carried out through observation of patient medical records. Data analysis with Shapiro Wilk. The results of the difference test showed that there was no significant difference between classroom costs and total costs (P=0.513) and there was no significant difference between severity costs and total costs (P=0.275) in asthma patients. The number of cases of irrationality of treatment in all subjects (100%) with a total of 178 cases. There is no significant difference between real costs and INA-CBGs rates, total costs based on room class and severity level.\u0000Keywords:          Asthma, direct costs, length of treatment, rationality\u0000 \u0000Abstrak\u0000Asma merupakan masalah besar global, Beban ekonomi penyakit asma pertahunya sangat besar. Pembengkakan biaya tersebut disebabkan oleh penanganan dan pengendalian asma yang buruk dan tidak seimbang antara tenaga kesehatan yang cukup besar. Penelitian ini bertujuan untuk menganalisis biaya dan efektivitas pengobatan serangan asma di Rumah Sakit X Gresik dengan melibatkan 23 responden. Penelitian ini termasuk dalam penelitian non eksperimental yang bersifat retrospektif. Sebagai bahan penelitian adalah data rekam medik pasien dengan penyakit asma di Rumah Sakit Petrokimia, selama periode 2020-2022. Lokasi penelitian dilakukan di Rumah Sakit Pertokimia. Variabel bebas dalam penelitian ini adalah terapi yang digunakan. Variabel tergantung dalam penelitian ini yaitu total biaya penggobatan outcome pengobatan (rawat inap dan perbaikan gejala asma). pengumpulan data dilakukan dengan melalui pengamatan terhadap rekam medis pasien. Analisa data dengan Shapiro Wilk. Hasil uji beda menunjukkan tidak terdapat perbedaan yang signifikan antara biaya ruang kelas dengan biaya total (P=0,513) dan tidak terdapat perbedaan yang signifikan antara biaya keparahan dengan biaya total (P=0,275) pada pasien asma. Jumlah kasus ketidakrasionalitas pengbatan pada semua subjek (100%) dengan total kasus 178. Tidak ada perbedaan signifikan antara biaya riil dengan tarif INA-CBGs, total biaya berdasarkan kelas kamar dan tingkat keparahan.\u0000Kata Kunci:         Asma, biaya langsung, lama perawatan, rasionalitas","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Catechin Content in Green and Black Tea (Camellia sinensis L.) by UV-Vis Spectrophotometric Method","authors":"Umi Nafisah, Aptika Oktaviana Trisna Dewi, Anes Aisna Hana Lulu","doi":"10.25026/jsk.v6i1.2166","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.2166","url":null,"abstract":"Tea is one of the most commonly consumed beverages around the world. The chemical compounds contained in tea have a good effect on health because they contain polyphenolic compounds, catechins. This study examined the catechin compound content of black tea and green tea from Karanganyar (A) and Malang (B). This research aims to determine the differences in catechin levels in black and green tea types in Malang, East Java, and Karanganyar, Central Java plantations. The research method used was experimental. Identification of catechin content was done using UV-Vis Spectrophotometry method. Tea is extracted by brewing, 4 grams of green tea is brewed using distilled water for 6 minutes, while 5.6 grams of black tea is brewed using distilled water for 10 minutes with the comparison used is pure catechin solution. The results obtained for green tea Karanganyar (A) had a catechin content of 3.61±0.083%, green tea Malang (B) had a level of 2.97±0.037%, black tea Karanganyar (A) had a level of 3.14±0.065%, and black tea Malang (B) had a level of 1.60±0.009%. It is concluded that the catechin content of green tea is higher than black tea, and of the two samples, the high catechin content comes from Karanganyar (A).\u0000Keywords:          catechins, green tea, black tea, malang, karanganyar","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"21 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potensi Penghambatan Enzim Tirosinase dengan Ekstrak Etanol Daun Kopasanda (Chromolaena Odorata L.)","authors":"Astuti Amin, Besse Hardianti, Subehan Lallo, Wahyu Hendrari","doi":"10.25026/jsk.v6i1.2120","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.2120","url":null,"abstract":"The need for skin care is increasing. One indicator of skin health is the brightness of skin color. Tyrosinase enzyme can darken skin color due to its activity against melanin biosynthesis. Skin color will also change when exposed to UV rays, even at a more severe level can cause cancer. The purpose of this study was to determine the tyrosinase enzyme inhibitory activity of ethanol extract of copasanda leaves of Chromolaena odorata L. C. odorata leaves are weeds from the Asteraceae family which contain several compounds such as tannins, phenols, flavonoids, saponins, and steroids. In this study, the ethanol extract of C. odorata leaves was tested in inhibiting tyrosinase enzyme activity based on the percent inhibition. Determination of tyrosinase enzyme inhibitory activity using UV-Vis spectrometer at a wavelength of 495 nm, done by calculating the IC50 value with kojic acid as a positive control. The results showed that the IC50 value of the tyrosinase enzyme inhibition activity test, kojic acid as a positive control amounted to 27,472 mg L-1 (very strong), the sample of ethanol extract of C. odorata leaves amounted to 81,546 mg L-1 (very strong). The ethanol extract of C. odorata leaves has an inhibitory effect on tyrosinase enzyme which is used as a potential source material for natural antimelagenic compounds.\u0000Keywords:          Chromolaena odorata L., tyrosinase enzyme, Weeds\u0000 \u0000Abstrak\u0000Kebutuhan akan perawatan kulit semakin meningkat. Salah satu indikator kesehatan kulit adalah kecerahan kulit warna kulit. Enzim tirosinase dapat menggelapkan warna kulit karena aktivitasnya melawan biosintesis melanin. Warna kulit juga akan berubah ketika terpapar sinar UV, bahkan pada tingkat yang lebih parah dapat menyebabkan kanker. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas penghambatan enzim tirosinase dari ekstrak etanol daun kopasanda Chromolaena odorata L. Daun C. odorata merupakan tumbuhan gulma dari family Asteraceae yang mengandung beberapa senyawa seperti tannin, fenol, flavonoid, saponin, dan steroid. Pada penelitian ini dilakukan pengujian terhadap ekstrak etanol daun C. odorata dalam menghambat aktivitas enzim tirosinase berdasarkan persen penghambatannya. Penentuan aktivitas penghambatan enzim tirosinase menggunakan alat Spektrometer UV-Vis pada panjang gelombang 495 nm, dilakukan dengan menghitung nilai IC50 dengan asam kojic sebagai kontrol positif. Hasil penelitian menunjukkan bahwa nilai IC50 dari uji aktivitas penghambatan enzim tirosinase, asam kojic sebagai kontrol positif sebesar 27,472 mg L-1 (sangat kuat), sampel ekstrak etanol daun C.odorata  sebesar  81,546 mg L-1 (sangat kuat). Ekstrak etanol daun C. odorata memiliki efek penghambatan terhadap enzim tirosinase yang digunakan sebagai bahan sumber potensial senyawa antimelagenik alami.\u0000Kata Kunci:         Chromolaena odorata L, enzim tirosinase, Gulma","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"2007 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Cathelicidin in Dermatology Skin","authors":"Diana Kurnia Apriani, R. Dwiyana, A. Chaerunisaa","doi":"10.25026/jsk.v6i1.1883","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.1883","url":null,"abstract":"Acne, Atopic Dermatitis, Psoriasis and Rosacea are examples of chronic inflammatory skin conditions. One characteristic of many skin disorders is the dysregulation of innate immunity in the skin. Acne, Atopic Dermatitis, Psoriasis, and Rosacea all have problems with the expression, function, or processing of the key innate immune effector molecule in the skin, cathelicidin LL-37. Cathelicidin induction can be altered to treat Acne and Atopic Dermatitis, which lessens the efficiency of the antimicrobial barrier. However, cathelicidin is overexpressed in Psoriasis and Rosacea. The most recent research on cathelicidin LL-37’s involvement in the etiology of inflammatory skin disorders will be included in this review. Since cathelicidin LL-37 may one day be employed as a therapeutic target, many cutting-edge therapy methods for the disease will be discussed.\u0000Keywords:          Antimicrobial Peptide, Cathelicidin, Dermatology Skin","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"10 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pengetahuan terhadap Perilaku Penggunaan Obat Antihipertensi di Kelurahan Sungai Miai Banjarmasin","authors":"Nurul Mardiati, Anis Hikmah Syabana, W. Wahyudi","doi":"10.25026/jsk.v6i1.1399","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.1399","url":null,"abstract":"A circulatory system problem that surpasses 120/80 mmHg is known as hypertension. To ensure patient health, it is crucial to understand how antihypertensive medications should be used and how to behave while taking them. In the Sungai Miai Village of Banjarmasin, this study attempts to ascertain the impact of knowledge on the behaviour of antihypertensive drugs. This study is a non-experimental cross-sectional descriptive analytic study. Accidental sampling was employed to get the data, utilizing instruments in the form of questionnaires, depending on inclusion and exclusion criteria. 48 respondents (48%), the majority of hypertensive patients with good knowledge, and 43 respondents, the majority of hypertensive patients with good behaviour, provided the results (43 percent). In Sungai Miai Village, Banjarmasin, information has an impact on how people take antihypertensive medications.\u0000Keywords:  Antihypertention, Knowledge, Behavior\u0000 \u0000Abstrak\u0000Hipertensi merupakan gangguan sistem peredaran darah di atas nilai normal yang melebihi 120/ 80 mmHg. Pengetahuan tentang pemakaian obat antihipertensi dan perilaku pemakaian obat antihipertensi ialah perihal yang penting untuk mencapai kesehatan penderita. Riset ini bertujuan buat mengetahui pengaruh pengetahuan terhadap perilaku obat antihipertensi di Kelurahan Sungai Miai Banjarmasin. Riset ini merupakan riset deskriptif analitik non-eksperimental, desain cross sectional. Pengambilan data yang digunakan merupakan accidental sampling berdasarkan kriteria inklusi serta eksklusi dengan instrumen berbentuk kuesioner. Hasil riset yang didapat kebanyakan penderita hipertensi dengan pengetahuan baik ialah sebanyak 48 responden (48%), serta kebanyakan penderita hipertensi dengan perilaku baik sebanyak 43 responden (43%). Terdapat pengaruh pengetahuan terhadap perilaku pemakaian obat antihipertensi di Kelurahan Sungai Miai Banjarmasin.\u0000Kata Kunci: Antihipertensi, Pengetahuan, Perilaku","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"26 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in Vitro Approach: Antibacterial Activity of Sansevieria trifasciata Prain. Leaves with Chemometric Analysis","authors":"Henny Kasmawati, N. A. Sida, A. Arfan, Wa Ode Dian Indrayanti, Arman Rusman","doi":"10.25026/jsk.v6i1.2087","DOIUrl":"https://doi.org/10.25026/jsk.v6i1.2087","url":null,"abstract":"Exploration the antibacterial activity of S.trifasciata Prain. is still limited, therefore this study aims to assess the antibacterial activity of extracts and ethyl acetate fractions of Sansevieria trifasciata Prain. The S.trifasciata leaves was macerated with ethanol 96%, then fractionated using the trituration method with ethyl acetate. The treatment group was divided into positive control group (PC) using ciprofloxacin, negative control (NC) using DMSO, extract, ethyl acetate fraction 5% (ET5%), 10% (ET10%), 20% (ET20%), 40% (ET40 %). Data were analyzed statistically by ANOVA and chemometrically with PCA. The inhibition zone for S.aureus bacteria in each sample is 26.69; 1.40; 23.32;2.82; 6.23; 11.11; 20.15 mm, respectively, E.coli is 26.65;0.63;22.65;3.61;7.11;11.44;21.15 mm respectively, P. aeruginosa is 27.40; 0.00; 23.23; 2.74;7.03;11.69;21.36 mm respectively. Percent inhibition of extract, ET5%, ET10%, ET20%, ET40% on S. aureus bacteria is 82.16; 5.31; 18.12; 36.39; 70.38% respectively, E.coli is 82.67; 11.13; 24.31; 40.56; 76.99% respectively, P. aeruginosa 84.85; 10.01; 25.65; 42.68; 77.98% respectively. Extract and ethyl acetate fraction have significant potential as antibacterial (p<0.05). The results of PCA chemometric analysis showed that the extract and ET40% had similar inhibition zone area to the positive control ciprofloxacin. The extract and the ethyl acetate fraction 40% are promising for development as antibacterials.\u0000Keywords:          Sansevieria trifasciata Prain., chemometric, bacterial","PeriodicalId":473028,"journal":{"name":"Jurnal Sains dan Kesehatan","volume":"21 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140412747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}