Reports of Practical Oncology and Radiotherapy最新文献

Dosimetric validation of biaxially rotational dynamic-radiation therapy using an O-ring linear accelerator. 使用o型环形直线加速器的双轴旋转动态放射治疗的剂量学验证。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.112681

Takahiro Aoyama, Tomoki Kitagawa, Yutaro Koide, Yasunori Ishiguro, Ryoma Tomoda, Shingo Hashimoto, Hiroyuki Tachibana, Takeshi Kodaira

{"title":"Dosimetric validation of biaxially rotational dynamic-radiation therapy using an O-ring linear accelerator.","authors":"Takahiro Aoyama, Tomoki Kitagawa, Yutaro Koide, Yasunori Ishiguro, Ryoma Tomoda, Shingo Hashimoto, Hiroyuki Tachibana, Takeshi Kodaira","doi":"10.5603/rpor.112681","DOIUrl":"10.5603/rpor.112681","url":null,"abstract":"Background: Biaxially rotating O-ring linear accelerators equipped with biaxially rotating gantry-ring mechanics enable non-coplanar arc delivery without the need for couch rotation. This architecture is intended to achieve conformal dose distributions and enable efficient non-coplanar delivery compared with couch-rotated techniques. However, clinical implementation requires dosimetric verification to confirm delivery accuracy. This study aimed to validate the dosimetric accuracy and treatment efficiency of a biaxially rotating O-ring linac using AAPM Task Group (TG)-119 and TG-244 test cases, with reference to TG-218 acceptance criteria.Materials and methods: In this retrospective phantom-based dosimetric validation study, 26 treatment plans were generated in RayStation based on TG-119 and TG-244 and delivered as coplanar VMAT (cVMAT) or non-coplanar VMAT [dynamic swing arc (DSA)]. Point dose measurements were performed with an A1SL ionisation chamber, and dose distribution verification was conducted using the Delta4 Phantom+. Monitor units (MU) and beam-on time (BOT) were compared between cVMAT and DSA.Results: All plans met the ±3% tolerance for absolute point-dose error (measured vs. calculated), with a mean error of -0.21% ± 1.09%. Gamma analysis (3%/2 mm, 10% threshold) showed a mean pass rate of 99.3%, exceeding the 95% threshold. Significant differences were observed in MU and BOT between cVMAT (median 862.4 MU, 104.0 s) and DSA (median 740.5 MU, 136.5 s).Conclusions: This study demonstrated dosimetric validation of a biaxially rotating O-ring linear accelerator using TG-119 and TG-244 test cases. The system achieved high accuracy in both cVMAT and DSA deliveries, supporting the dosimetric readiness for clinical implementation.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"561-568"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The smoothing factor in breast intensity-modulated radiotherapy: dosimetric impact and a predictive model of plan acceptability. 乳房调强放疗的平滑因素：剂量学影响和计划可接受性的预测模型。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.112753

Tamás Ungvári, Döme Szabó, Ádám Gáldi, Amir Hossein Bassirani, Zsófia Dankovics, Balázs Kiss, Judit Olajos, Tibor Major, Károly Tőkési

{"title":"The smoothing factor in breast intensity-modulated radiotherapy: dosimetric impact and a predictive model of plan acceptability.","authors":"Tamás Ungvári, Döme Szabó, Ádám Gáldi, Amir Hossein Bassirani, Zsófia Dankovics, Balázs Kiss, Judit Olajos, Tibor Major, Károly Tőkési","doi":"10.5603/rpor.112753","DOIUrl":"10.5603/rpor.112753","url":null,"abstract":"Background: The smoothing factor is a key planning parameter in intensity-modulated radiotherapy that affects both plan quality and deliverability. This study investigates the dosimetric impact of SF in breast radiotherapy and introduces a logistic regression-based model to predict plan acceptability.Materials and methods: IMRT plans were generated for 21 breast cancer patients using SF values from 10 to 300 (126 plans total). Dosimetric parameters included monitor units, ipsilateral lung dose (V17 Gy), planning target volume coverage, and complexity (modulation complexity score). A logistic regression model was trained using six key features to classify plan quality.Results: Plans with SF values between 100 and 150 provided the best compromise between monitor units, PTV coverage, and modulation complexity. The predictive model performed well (AUC = 0.88), with conformity index, maximum dose, and modulation complexity score emerging as the most influential predictors. It enables automated classification and supports smoothing factor selection.Conclusions: The smoothing factor strongly influences the performance of intensity-modulated radiotherapy plans. Our predictive model provides a robust tool for plan evaluation, supporting clinical decision-making and optimisation of smoothing factor in breast radiotherapy.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"530-540"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superior vena cava syndrome in non-lung primary tumours treated with palliative intent. 上腔静脉综合征在非肺原发性肿瘤姑息治疗意图。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.112680

Aniwat Berpan, Kyrhatii Trikhirhisthit, Kullathorn Thephamongkhol, Wasu Tanasoontrarat

{"title":"Superior vena cava syndrome in non-lung primary tumours treated with palliative intent.","authors":"Aniwat Berpan, Kyrhatii Trikhirhisthit, Kullathorn Thephamongkhol, Wasu Tanasoontrarat","doi":"10.5603/rpor.112680","DOIUrl":"10.5603/rpor.112680","url":null,"abstract":"Background: This study aimed to evaluate the effects of systemic treatment on the overall survival (OS) of patients with superior vena cava (SVC) syndrome caused by neoplasms other than lung and haematological cancers.Materials and methods: Patient data were collected retrospectively. Cox proportional hazards regression was used to analyse the associations between variables and time to death.Results: Twenty-four patients were identified. The median follow-up time was 36 months. The median OS of patients receiving upfront systemic treatment and radiotherapy were 252 and 150 days (p = 0.298), and the 1-year OS rates were 20% and 22.7%, respectively. Patients treated with and without steroids had 1-year OS rates of 30.8% and 10.1% and median OS of 154 and 224 days, respectively (p = 0.426). The median OS of patients treated with and without loop diuretics was 114 and 252 days (p = 0.004), and the 1-year OS rates were 0% and 33.6%, respectively. In multivariable analysis, significant independent factors included upfront systemic therapy [hazard ratio (HR) = 0.022; 95% confidence interval (CI): 0.001-0.413], loop diuretics (HR = 12.364; 95% CI: 2.093-73.032), male sex (HR = 9.746; 95% CI: 1.478-64.276), visceral metastases (HR = 96.265; 95% CI: 5.437-1704.39), and previous systemic treatment for nonmetastatic disease (HR = 0.072; 95% CI: 0.005-0.955).Conclusions: In multivariable analysis, systemic treatment was associated with improved survival. However, this finding remains exploratory because of the small sample size and model instability. Loop diuretics were associated with increased mortality, and steroids showed no benefit in improving survival.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"520-529"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The optimal approach to the primary treatment of uveal melanoma: a narrative review. 葡萄膜黑色素瘤初级治疗的最佳方法：叙述性回顾。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.113324

Adam Deja, Emilia Żurowska, Piotr Milecki, Iwona Rospond-Kubiak

{"title":"The optimal approach to the primary treatment of uveal melanoma: a narrative review.","authors":"Adam Deja, Emilia Żurowska, Piotr Milecki, Iwona Rospond-Kubiak","doi":"10.5603/rpor.113324","DOIUrl":"10.5603/rpor.113324","url":null,"abstract":"Background: Uveal melanoma is the most common primary intraocular malignancy in adults. Current management emphasises local tumour control and globe preservation, while survival remains largely determined by metastatic disease. Several eye-preserving radiotherapy modalities have replaced enucleation in many cases. This narrative review summarises indications, outcomes, and toxicity profiles of definitive local treatment strategies for primary uveal melanoma.Materials and methods: A nonsystematic literature review was conducted in accordance with SANRA guidelines. Publications from 2015-2025 were identified via PubMed using keywords related to uveal melanoma and radiotherapy. Landmark data from the COMS and recommendations from the National Comprehensive Cancer Network (NCCN) were included to provide clinical context. Studies addressing primary tumour management were eligible, while those focusing exclusively on metastatic disease were excluded.Results: Five-year local control rates exceed 90% across modalities for tumours of comparable size. Plaque brachytherapy remains the most widely used technique, offering survival outcomes equivalent to enucleation, with isotope selection varying by region. fSRT provides excellent local control for posterior or large tumours unsuitable for plaque placement, particularly with hypofractionated regimens such as 50 Gy in 5 fractions. PBT offers highly conformal dose distribution and is advantageous for large or posterior tumours, although access is limited. Despite improved local control, metastatic outcomes remain poor; ongoing trials of adjuvant tebentafusp may influence future systemic strategies.Conclusions: Treatment should be individualised within a multidisciplinary setting. Brachytherapy remains the standard for small and medium tumours, while fSRT and PBT are effective alternatives when plaque therapy is not feasible.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"591-598"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment outcomes in head and neck cancer presenting with synchronous primaries - case series. 头颈癌的治疗结果呈现同步的原发病例系列。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.112208

Liam O'Connell, Niall O'Dwyer, Frances Duane, Sinead Brennan, John Armstrong, Nazmy El Beltagi, Oleksandr Boychak, Dymphna McGettigan, Orla McArdle

{"title":"Treatment outcomes in head and neck cancer presenting with synchronous primaries - case series.","authors":"Liam O'Connell, Niall O'Dwyer, Frances Duane, Sinead Brennan, John Armstrong, Nazmy El Beltagi, Oleksandr Boychak, Dymphna McGettigan, Orla McArdle","doi":"10.5603/rpor.112208","DOIUrl":"10.5603/rpor.112208","url":null,"abstract":"Background: Head and neck cancer with synchronous primary cancers is rare. There is a paucity of data on HNC with SPC regarding treatment modalities, outcomes, and combined treatment toxicities, creating a challenge for treating clinicians.Materials and methods: We retrospectively screened patients who received head and neck cancer radiotherapy in the Saint Luke's Radiation Oncology Network from July 2017 to July 2024. A synchronous primary cancer was defined as anatomically separate, not a possible metastasis of the first primary cancer and diagnosed within six months of the first primary cancer.Results: We screened 2,971 HNC patients who underwent radiotherapy of which 48 (2%) patients met the inclusion criteria. The median follow-up was 21.9 months and median age was 65 years. The most common SPC sites were lung (46%), oesophageal (13%), then prostate, colon and thyroid (all 6%). The median overall survival for all patients was 28 months. Forty-two (88%) patients completed definitive treatment for both cancers. The median overall survival of patients who completed definitive treatment for both cancers was 30.2 months vs. 5.5 months among patients who did not (p < 0.001). Ten patients had simultaneous radiotherapy to both cancers with overlapping radiotherapy fields and nine of them finished definitive treatment to both cancers.Conclusions: Patients with HNC and a synchronous primary can be treated curatively to both cancers with a median overall survival of over 2 years. Simultaneous radiotherapy for both cancers can be completed with acceptable toxicity rates even in the setting of overlapping radiation fields.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"469-478"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of radiotherapy planning images using colour blindness filters. 利用色盲滤光片分析放疗计划图像。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.112214

Felipe Beraldo da Cruz, Alessa Maschio, Maria Eduarda Nascimento Andrade, Ana Paula Perini, Roseane Eloiza Máximo Silva, Lucio Pereira Neves

{"title":"Analysis of radiotherapy planning images using colour blindness filters.","authors":"Felipe Beraldo da Cruz, Alessa Maschio, Maria Eduarda Nascimento Andrade, Ana Paula Perini, Roseane Eloiza Máximo Silva, Lucio Pereira Neves","doi":"10.5603/rpor.112214","DOIUrl":"10.5603/rpor.112214","url":null,"abstract":"Background: Colour vision deficiency (CVD), or colour blindness, affects the interpretation of colours and poses a significant risk in clinical settings that rely on colour-coded information. This study aims to quantitatively assess the impact of CVD on the interpretation of radiotherapy treatment planning images, in which isodose curves and target volumes are represented by a specific colour spectrum.Materials and methods: By applying simulated filters for deuteranopia, protanopia, and tritanopia to a set of radiotherapy images, a quantitative analysis framework was developed using Python. This framework evaluates not only global changes but also functional and perceptual integrity through advanced metrics: Intersection over Union (IoU) for spatial accuracy of the planning target volume (PTV), structural similarity index (SSIM) for overall image structure, and CIEDE2000 (Delta E) for perceptual colour difference.Results: Our results demonstrate that deuteranopia and protanopia consistently lead to a complete failure in identifying the red-coded PTV (IoU = 0.0) across all tested images, despite the overall image structure remaining deceptively intact (SSIM > 0.98). The Delta E metric confirmed a massive perceptual shift in color for these conditions, with values ranging from 22.15 to 29.93. In contrast, tritanopia showed significantly better PTV identification (IoU ranging from 0.7256 to 0.9493) and lower perceptual colour differences (Delta E ranging from 4.47 to 11.64).Conclusions: These findings quantify a severe clinical risk, highlighting the urgent need for color-accessible radiotherapy planning software to ensure patient safety.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"554-560"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smells like beam spirit - a radiotherapy multiverse of (super) humans in white coats: seven radiotherapy phenotypes that suggest we may be closer to superheroes than we think. 闻起来像光束精神——一个由穿着白大褂的（超级）人类组成的放射治疗多重宇宙：七种放射治疗表型表明，我们可能比我们想象的更接近超级英雄。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.112211

Angel Montero, Ovidio Hernando Requejo, Raúl Hernanz de Lucas, Javier Serrano

{"title":"Smells like beam spirit - a radiotherapy multiverse of (super) humans in white coats: seven radiotherapy phenotypes that suggest we may be closer to superheroes than we think.","authors":"Angel Montero, Ovidio Hernando Requejo, Raúl Hernanz de Lucas, Javier Serrano","doi":"10.5603/rpor.112211","DOIUrl":"10.5603/rpor.112211","url":null,"abstract":"Background: Radiotherapy is a technically precise yet deeply human medical specialty, often underrepresented in narrative depictions of oncology. Like modern superhero stories, radiotherapy practice blends idealism, responsibility, moral ambiguity, and human limitation. This work explores the professional behaviours, cultural identities, and interpersonal dynamics within radiotherapy departments through a satirical but recognisable framework.Materials and methods: We conducted a qualitative, narrative-based observational study informed by long-term clinical experience in radiotherapy practice. Using thematic synthesis, reflective ethnography, and humour as analytical tools, recurrent professional behaviours and attitudes were identified and distilled into archetypal personas representing common patterns within the radiotherapy workforce.Results: Seven archetypal radiotherapy phenotypes emerged, each embodying characteristic strengths, flaws, and decision-making styles. These personas illustrate tensions between evidence and action, precision and pragmatism, idealism and compromise, as well as the balance between technical excellence and human factors. Collectively, they provide an accessible framework to describe the social and cognitive ecology of contemporary radiotherapy practice.Conclusions: This satirical taxonomy highlights the diversity, complexity, and humanity of professionals working in radiotherapy. By framing the specialty as a \"multiverse\" of flawed yet committed heroes, the study offers an engaging perspective on clinical culture, professional identity, and self-awareness. Ultimately, it argues that maintaining humour and humility may be as essential to radiotherapy practice as technical precision.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"576-581"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative dosimetric analysis of flattening-filter and flattening-filter-free photon beams in radiotherapy based on TRS-398 calibration protocol. 基于TRS-398标定方案的放疗中滤平与无滤平光子束的剂量学比较分析。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.111980

Sakinah Sakinah, Primasari Cahya Wardhani, Arie Chintya Martania, Wahyu Dwi Lestari

{"title":"Comparative dosimetric analysis of flattening-filter and flattening-filter-free photon beams in radiotherapy based on TRS-398 calibration protocol.","authors":"Sakinah Sakinah, Primasari Cahya Wardhani, Arie Chintya Martania, Wahyu Dwi Lestari","doi":"10.5603/rpor.111980","DOIUrl":"10.5603/rpor.111980","url":null,"abstract":"Background: In external beam radiotherapy, delivering an accurate radiation dose is essential to ensure treatment effectiveness while minimising harm to surrounding healthy tissue. In Indonesia, the adoption of flattening-filter-free (FFF) technology remains limited, making its evaluation highly relevant for supporting more equitable radiotherapy services nationwide. The FFF technique offers advantages such as higher dose rates, shorter treatment time, and reduced head scatter, providing opportunities for faster and more precise treatment. This study compares the output dose deviations between flattening-filter (FF) and FFF modes using the IAEA TRS-398 dosimetry protocol.Materials and methods: Measurements were performed using a Varian TrueBeam linear accelerator with 6 MV and 10 MV FF beams and a 6 MV FFF beam. Absolute dose calibration was conducted with a calibrated ionisation chamber and electrometer in a water phantom at a reference depth of 10 cm. Data were collected from April to August 2025, with five repeated measurements for each energy.Results: The results showed dose deviations of 0.908% (6 MV), 0.876% (10 MV), and 0.020% (6 FFF), which are all within the ±2% allowed by TRS-398. Among the evaluated modes, the FFF beam demonstrated the highest output stability.Conclusions: Both FF and FFF photon beams meet the TRS-398 standards for how accurate the radiation dose should be. But, the FFF mode is more stable, so it could be used more in hospitals, especially for very precise radiotherapy. These results show that FFF technology can make radiotherapy better, especially in places where the newest equipment is not available.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"541-548"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-chemoradiotherapy temporal lesion in nasopharyngeal SCC: when radionecrosis mimics tumor progression. 放化疗后鼻咽鳞状细胞癌颞叶病变：放射性坏死模拟肿瘤进展。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.111332

Matheus de Lima Ruffini, Adolfo Moraes de Souza, Luís Eduardo de Mello Maronez, Lilian Gonçalves Campos, Juliana Avila Duarte

引用次数: 0

Multicentre study of inoperable HPV-negative head and neck cancer: a persistent real-world challenge. 不可手术的hpv阴性头颈癌的多中心研究：一个持续的现实世界的挑战。

IF 1.7

Reports of Practical Oncology and Radiotherapy Pub Date : 2026-08-01 eCollection Date: 2026-01-01 DOI: 10.5603/rpor.112755

Marek Slavik, Iveta Selingerova, Jakub Cvek, Dukagjin M Blakaj, Tomas Blazek, Lukáš Knybel, Zuzana Zdeblova Cermakova, Jan Cincibuch, Tomas Novotny, Petr Burkon, Pavel Slampa, Tomas Kazda, Martin Dolezel

{"title":"Multicentre study of inoperable HPV-negative head and neck cancer: a persistent real-world challenge.","authors":"Marek Slavik, Iveta Selingerova, Jakub Cvek, Dukagjin M Blakaj, Tomas Blazek, Lukáš Knybel, Zuzana Zdeblova Cermakova, Jan Cincibuch, Tomas Novotny, Petr Burkon, Pavel Slampa, Tomas Kazda, Martin Dolezel","doi":"10.5603/rpor.112755","DOIUrl":"10.5603/rpor.112755","url":null,"abstract":"Background: HPV-negative head and neck squamous cell carcinoma (HNSCC) has a poorer prognosis than HPV-positive tumours, yet real-world outcomes remain understudied. This study analyses a multicentre cohort of HPV-negative HNSCC patients, including those over 65 years of age.Materials and methods: This retrospective study included HPV-negative HNSCC patients treated with definitive radiotherapy (RT) or chemoradiotherapy (CRT) between 2015 and 2020. RT protocols included standard fractionation (70 Gy, 35 fractions), simultaneous integrated boost (69.96 Gy, 33 fractions), or concomitant boost (72.5 Gy, 50 fractions).Results: Among 225 patients (62 over 65 years), 138 (61%) received CRT. Local progression occurred in 83 (37%), and 177 (79%) died. Median overall survival (OS) was 23.1 months, with 3-year OS and local control (LC) rates of 37% and 35%, respectively. ECOG predicted outcomes (p < 0.001 for OS, p = 0.040 for LC), while comorbidity burden and disease stage were significant only for OS (p < 0.001 and p = 0.006). CRT improved OS over RT alone (p = 0.059). Older patients more often had hypopharyngeal/laryngeal tumours (p = 0.033), received CRT less frequently (29% vs. 74%, p < 0.001), and chemotherapy did not affect outcomes.Conclusions: Real-world outcomes for inoperable HPV-negative HNSCC remain poor. Personalized approaches are needed to improve care for this challenging population.","PeriodicalId":47283,"journal":{"name":"Reports of Practical Oncology and Radiotherapy","volume":"31 4","pages":"479-491"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0