Journal of International Society of Preventive and Community Dentistry最新文献

{"title":"Impact of a Novel Oral Health Tracker cum Motivator Versus Conventional Education on Oral Health Behavior Among 10- to 15-Year-Old School Children in Lucknow: A Single-Blinded, Parallel Design-A Randomized Controlled Trial.","authors":"S Deepak, Gaurav Mishra, Vinay Kumar Gupta, Sumit Kumar, Aman Rajput, Mohit Kumar Kanoujia, Sreeja Gummalla, N Rinsi","doi":"10.4103/jispcd.jispcd_102_25","DOIUrl":"10.4103/jispcd.jispcd_102_25","url":null,"abstract":"<p><strong>Aim: </strong>Oral health plays a crucial role in overall well-being, particularly during childhood when positive habits are best established. Despite ongoing efforts, traditional oral health education methods often fall short in effectively influencing long-term behavior change. This study aimed to evaluate the effectiveness of a novel oral health tracker cum motivator (OHTM) in comparison to conventional educational methods for improving oral health behaviors among school-aged children in Lucknow.</p><p><strong>Materials and methods: </strong>In a single-blinded, parallel design, and RCS, 64 children were randomly assigned (computer-generated sequence; opaque sealed envelopes) to either the experimental group (OHTM) or the control group (traditional education). \"Single-blinded\" refers to outcome assessors being unaware of group allocation. Sample size was calculated using G*Power 3.1.9.7 for 80% power, <i>α</i> = 0.05, and effect size <i>d</i> = 0.31, based on Kumar <i>et al</i>. (2015). Baseline and follow-up assessments at 2 months used a 15-item theory of planned behavior (TPB)-based questionnaire and the debris index (oral hygiene index-simplified). Primary outcomes were pre-specified as knowledge scores and debris scores; no secondary outcomes were registered. Statistical analyses included paired and independent <i>t</i> tests, repeated measures analysis of variance, effect sizes (Cohen's <i>d</i>), and 95% confidence intervals (CI).</p><p><strong>Results: </strong>Post-intervention analysis revealed that the experimental group demonstrated a significantly greater improvement in both clinical and behavioral outcomes. Debris scores in the experimental group reduced from 2.06 ± 0.43 to 1.26 ± 0.36 (95% CI: -1.00 to -0.60; <i>P</i> = 0.017; <i>d</i> = 0.64), while the control group showed a reduction from 2.03 ± 0.48 to 1.48 ± 0.35 (95% CI: -0.77 to -0.33; <i>P</i> = 0.017). Knowledge scores improved from 9.09 ± 2.40 to 11.50 ± 1.48 in the experimental group (95% CI: 1.47-3.35; <i>P</i> = 0.002; <i>d</i> = 0.82), compared to 8.63 ± 1.77 to 10.34 ± 1.41 in the control group (95% CI: 0.98-2.44; <i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>The findings highlight that the OHTM significantly improved oral hygiene and knowledge compared to traditional methods. Interactive, theory-based tools showed more engagement and sustained behavior change, aligned with social cognitive theory, and the TPB. These findings suggest that such tools may be scalable in school health programs. The trial is registered with the Clinical Trials Registry-India (CTRI) under registration number CTRI/2025/03/082764.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"466-473"},"PeriodicalIF":2.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying Machine-Learning Models on Lateral Cephalogram Parameters to Classify Skeletal Classes I and III Arab Orthodontic Patients, Instead of Individualized Parameters.","authors":"Kareem Midlej, Osayd Zohud, Samir Masarwa, Eva Paddenberg-Schubert, Sebastian Krohn, Peter Proff, Nezar Watted, Fuad A Iraqi","doi":"10.4103/jispcd.jispcd_231_24","DOIUrl":"10.4103/jispcd.jispcd_231_24","url":null,"abstract":"<p><strong>Aims: </strong>The sagittal skeletal correlation involving the maxilla and mandible is commonly assessed utilizing the A point, Nasion, B point (ANB) angle and Wits appraisal. Recently, ethnicity-specific diagnostic values have been proposed to improve accuracy. This study investigates whether machine learning (ML) models can classify Arab orthodontic cases identified with skeletal class I or class III determined only by standard skeletal measurement indicators, without relying on individualized equations.</p><p><strong>Materials and methods: </strong>Lateral cephalograms from 422 Arab orthodontic patients were analyzed in this study. Five supervised ML algorithms-linear discriminant analysis, support vector machine, K-nearest neighbor, random forest, and Classification and Regression tree-were developed and evaluated utilizing a 10-fold resampling technique. This study compared full-feature models with those using limited parameter sets, such as the Wits index and Sella-Nasion-B point angle measurement. Additionally, regression models were constructed to predict ANB angle using Wits, age, and gender.</p><p><strong>Results: </strong>Full-feature models achieved up to 97% accuracy, whereas reduced models maintained high performance (up to 91%) using Wits, S-N-B, and S-N-Pg angles. A marked positive association (<i>r</i> = 0.55, <i>P</i> < 0.01) was found shared by Wits and ANB in class III patients. The best regression model (<i>R</i> ² = 0.57) predicted ANB using the formula: ANB = 4.37 + (0.47 × Wits) + (1.07 × gender) + (0.04 × age).</p><p><strong>Conclusions: </strong>ML models can effectively classify skeletal classes I and III malocclusions in Arab subjects using basic cephalometric data, offering a reliable alternative to individualized assessment tools.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"474-484"},"PeriodicalIF":2.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Salivary Properties Between Different Degrees of Caries Level in Children Aged Below 72 Months: A Cross-sectional Study.","authors":"Paulina N Gunawan, Endang W Bachtiar, Boy M Bachtiar, Mochamad Fahlevi Rizal","doi":"10.4103/jispcd.jispcd_66_25","DOIUrl":"10.4103/jispcd.jispcd_66_25","url":null,"abstract":"<p><strong>Aim: </strong>Early childhood caries (ECC) remain prevalent in many developing countries, including Indonesia. Salivary factors, such as flow rate, pH, and nitric oxide (NO) concentration, are potential indicators of caries risk. The study aimed to compare unstimulated whole saliva (UWS) flow rate, salivary pH, and nitrite ion concentration among caries-free (CF), ECC, or severe ECC (S-ECC) children.</p><p><strong>Materials and methods: </strong>Thirty-one children aged 36-71 months visiting the Pedodontic Department at the Specialized Teeth and Mouth Hospital, University of Indonesia, were categorized into CF, ECC, and S-ECC groups. The UWS flow rate was measured by volume per minute, salivary pH with a universal pH indicator strip, and NO concentration using the Griess reaction.</p><p><strong>Results: </strong>The median UWS flow rate was highest in the CF group (0.38 mL/min) and lower in the ECC (0.29 mL/min) and S-ECC (0.33 mL/min) groups. Median salivary pH was 7.00 in CF, ECC, and S-ECC, while NO concentrations were 70.14 µM (CF), 71.04 µM (ECC), and 90.59 µM (S-ECC). None of the differences were statistically significant (<i>P</i> > 0.05). The correlation coefficients were UWS flow rate and def-t scores, <i>r</i> = -0.267, salivary pH and def-t, <i>r</i> = -0.066; and NO concentration and def-t, <i>r</i> = 0.169.</p><p><strong>Conclusions: </strong>Although trends in the salivary flow rate, pH, and NO concentration were observed, no significant differences were found among caries groups. The small sample size, non-standardized collection, and imprecise pH measurements may have limited the findings. These preliminary studies may support future research on salivary markers in caries risk assessment.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"460-465"},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GCF NLRP3 as a Biomarker for Assessing Endodontic Treatment Outcomes in Symptomatic Irreversible Pulpitis: A Comparative Nonrandomized, Observational Cross-Sectional Study.","authors":"Neha Neha, Dax Abraham, Anjana Goyal, Alpa Gupta, Rajat Sharma, Rajeev Kumar Malhotra","doi":"10.4103/jispcd.jispcd_31_25","DOIUrl":"10.4103/jispcd.jispcd_31_25","url":null,"abstract":"<p><strong>Aim: </strong>Biomarker-based evaluation of endodontic outcomes offers an objective alternative to traditional clinical assessments. The human nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing-3 (NLRP3) inflammasome is emerging as a potential indicator in inflammatory dental conditions. The aim was to correlate changes in pain levels with gingival crevicular fluid (GCF) levels of the NLRP3 inflammasome in patients with symptomatic irreversible pulpitis (SIP), before and after nonsurgical endodontic treatment.</p><p><strong>Materials and methods: </strong>This nonrandomized matched comparative study included 15 SIP patients (45 teeth: involved, adjacent, and contralateral) and 15 healthy controls (15 teeth). GCF samples were analyzed via enzyme-linked immunosorbent assay. Pain was assessed using the Heft Parker visual analog scale (HP-VAS). Data were analyzed using linear mixed models, the Wilcoxon signed-rank test, and the Spearman correlation.</p><p><strong>Results: </strong>Baseline GCF-NLRP3 levels were significantly higher in SIP-affected teeth (4.33 ± 0.98 ng/mL) than in controls (1.34 ± 0.45 ng/mL; <i>P</i> < 0.001). A significant difference was observed between involved and contralateral teeth (mean difference = 2.96; 95% CI = 2.28-3.65). Post-treatment levels in both involved and adjacent teeth decreased (<i>P</i> < 0.05). HP-VAS scores also showed a significant reduction (median difference: 69; <i>P</i> < 0.001). The reduction in the NLRP3 inflammasome activity was significantly correlated with pain reduction, with <i>P</i> value (<0.001) after the treatment (<i>r</i> = 0.686; 95% CI = 0.22-0.91).</p><p><strong>Conclusion: </strong>GCF-NLRP3 levels can serve as a reliable biomarker for evaluating endodontic treatment outcomes in SIP, reflecting both local inflammation and patient-reported pain. Integrating GCF-NLRP3 monitoring may enhance the diagnostic accuracy and inform treatment planning. Future studies should assess longitudinal trends and therapeutic thresholds. GCF-NLRP3 could be a promising biomarker for assessing the outcome of endodontic treatment. This finding opens up new possibilities for improving the efficacy of endodontic procedures and, ultimately, patient care.</p><p><strong>Clinical trial registration: </strong>The clinical study was registered under the clinical trial registry-India www.ctri.nic.in (CTRI/2023/07/055526) on July 24, 2023. The supporting document can be produced through requisition mail to the corresponding author.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"415-425"},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Artificial Intelligence in Detecting Oral Potentially Malignant Disorders and Oral Cancer: A Meta-Analysis of Imaging-Based Studies (2015-2024).","authors":"M Nayana, J Avinash, M Y Jayachandra, Padma K Bhat, Subodh Kumar, Lipsa Bhuyan","doi":"10.4103/jispcd.jispcd_116_25","DOIUrl":"10.4103/jispcd.jispcd_116_25","url":null,"abstract":"<p><strong>Aim: </strong>Oral cancer is a leading cause of cancer-related morbidity, especially in low-resource settings. Early detection of oral potentially malignant disorders (OPMDs) is key to reducing disease burden. This study was carried out to evaluate the diagnostic accuracy of AI-assisted imaging tools in the detection of OPMDs and oral cancer in community and clinical settings.</p><p><strong>Materials and methods: </strong>We searched PubMed, IEEE Xplore, Scopus, and Web of Science (2015-2024) for studies using AI to detect OPMDs or oral cancer from images, reporting sensitivity and specificity. A random-effects meta-analysis was conducted. Quality was assessed using QUADAS-2. Summary receiver operating characteristic curves were generated to evaluate the global performance.</p><p><strong>Results: </strong>From 1092 articles screened, 35 studies met inclusion criteria. These studies evaluated >15,000 images using clinical photography, histopathology, optical coherence tomography, and autofluorescence. Pooled sensitivity was 0.919% (95% CI: 0.89-0.94), specificity 0.879 (95% CI: 0.84-0.91), area under curve 0.9758, and diagnostic odds ratio 131.63. Deep learning methods-particularly convolutional neural networks-consistently demonstrated superior performance.</p><p><strong>Conclusion: </strong>AI-assisted diagnostic systems demonstrate high accuracy and potential for scalable, non-invasive screening of OPMDs and oral cancer. Integration into public health programs, particularly in underserved settings, could significantly improve early detection outcomes. Mobile-compatible platforms represent a viable public health tool for oral cancer control.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"391-401"},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Recurrent Herpes Labialis among Dentistry Students: A Cross-Sectional Survey in Egypt.","authors":"Dalia Ghalwash, Sara Abd El Wahed, Al Hassan Diab","doi":"10.4103/jispcd.jispcd_120_25","DOIUrl":"10.4103/jispcd.jispcd_120_25","url":null,"abstract":"<p><strong>Aim: </strong>Recurrent herpes labialis (RHL) is a common viral infection with significant psychosocial and clinical implications. Dental students are particularly vulnerable due to stress and frequent patient contact, yet data on their epidemiology in Egyptian cohorts are scarce. The study aimed to determine the prevalence, recurrence patterns, and associated risk factors of RHL among dentistry students in Egypt.</p><p><strong>Materials and methods: </strong>A cross-sectional survey was conducted among 559 dentistry students at the British University in Egypt. A structured, self-administered questionnaire captured sociodemographic data, history of RHL episodes, frequency, severity, and triggering factors. Data were analyzed using descriptive statistics and Chi-square tests; associations between risk factors and RHL were further explored using logistic regression to estimate adjusted odds ratios (AOR) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>RHL prevalence was 28.3% (158/559). A total of 35.4% reported one episode/year, and 3.2% reported six or more. Stress (65.8%), common cold (51.3%), and low immunity (29.7%) were the most frequently reported triggers. Most symptoms were mild (52.5%) or moderate (39.9%). Quality of life was negatively impacted in 81.7% of cases, with significant associations to stress, symptom severity, and recurrence frequency (<i>P</i> < 0.05). Multivariable regression identified family history as the only independent predictor of RHL (AOR = 7.07, 95% CI: 4.40-11.35, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>RHL is highly prevalent among Egyptian dental students, with stress and sun exposure emerging as key risk factors. These findings highlight the need for targeted preventive strategies and awareness programs in dental institutions. Longitudinal studies are recommended to further clarify causality and recurrence patterns.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"451-459"},"PeriodicalIF":2.1,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health Literacy and Its Impact on Oral Health Promotion Behaviors in Peruvian Adults: A Multidimensional Assessment.","authors":"Teresa Angélica Evaristo-Chiyong, Manuel Antonio Mattos-Vela, Martha Cecilia Rodríguez-Vargas, Dora Noelia Gómez-Meza, Victor Fernando Lamas-Lara, Luis Alberto Cuadrao-Zavaleta","doi":"10.4103/jispcd.jispcd_115_25","DOIUrl":"10.4103/jispcd.jispcd_115_25","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate oral health literacy and its impact on oral health promotion behaviors in Peruvian adults, considering their sociodemographic characteristics.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted in 2023 with 669 adults residing in Metropolitan Lima, Peru. Oral health literacy was assessed using the condensed, validated Peruvian Spanish version of the Health Literacy in Dentistry (HeLD-14) instrument. A structured questionnaire was used to gather data on sociodemographic characteristics and self-reported oral health behaviors. The association between variables was analyzed using Poisson regression with robust variance to estimate prevalence ratios.</p><p><strong>Results: </strong>The final sample's mean oral health literacy score was 47.16, indicating an overall elevated level. Statistically significant differences were noted by age, with adults aged 18-30 having the highest scores (mean = 48.10; <i>P</i> < 0.05), and by education level, with participants having technical education scoring highest (mean = 49.02; <i>P</i> < 0.05). Tooth pain was the most frequently reported reason for dental visits (51.27%). Significant associations were found between specific literacy dimensions and behaviors: the \"support\" dimension was linked to brushing at least twice daily (adjusted PR = 1.02); the \"access\" dimension was associated with using fluoridated toothpaste (adjusted PR = 1.07); and the \"comprehension\" dimension was associated with the use of other oral hygiene accessories (adjusted PR = 1.09).</p><p><strong>Conclusion: </strong>A significant but low-impact association was identified between oral health literacy and key promotion behaviors, including toothbrushing, the use of fluoride toothpaste, and other hygiene accessories. This effect is considered minimal at an individual clinical level but may be potentially relevant for broader public health initiatives at the population level.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"442-450"},"PeriodicalIF":2.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success Rate of Dental Implants in Patients with Autoimmune Disorders: A Systematic Review and Meta-Analysis.","authors":"Raj Kiran Chitumalla, Pillai Arun Gopinathan, Faris Z Jamjoom, Swapna Munaga, Areej Alaifi, Salman Siddeeqh","doi":"10.4103/jispcd.jispcd_108_25","DOIUrl":"10.4103/jispcd.jispcd_108_25","url":null,"abstract":"<p><strong>Aim: </strong>Autoimmune disorders may affect bone metabolism and tissue healing, potentially influencing dental implant outcomes. This systematic review and meta-analysis aimed to assess implant survival and success in patients with autoimmune diseases, with particular focus on marginal bone loss (MBL) and bleeding on probing (BOP).</p><p><strong>Materials and methods: </strong>A comprehensive search of seven databases (PubMed, MEDLINE, Embase, Scopus, Web of Science, Cochrane Library, and CINAHL) was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Fourteen observational studies including 2657 participants were included. Risk of bias was assessed using ROBINS-I and Newcastle-Ottawa scale. Meta-analyses were performed using a random-effects model.</p><p><strong>Results: </strong>Implant survival rates ranged from 76.4% to 100% across autoimmune conditions. No significant differences in MBL were observed for patients with type 1 diabetes or Sjögren's syndrome compared to controls, while rheumatoid arthritis (RA) patients showed significantly increased MBL [MD = 1.60 mm; 95% confidence intervals (CI) = 1.13-2.07; <i>P</i> < 0.00001]. RA patients also had lower odds of BOP (OR = 0.13; 95% CI = 0.05-0.36; <i>P</i> < 0.0001). Overall, autoimmune conditions were associated with reduced BOP (OR = 0.24; 95% CI = 0.06-0.91; <i>P</i> = 0.04).</p><p><strong>Conclusion: </strong>Dental implants demonstrate favorable survival in autoimmune patients, although RA and diabetes may increase MBL risk. Tailored treatment planning and follow-up are essential. Further high-quality studies are needed to confirm disease-specific risks.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"402-414"},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Multi-Strain Probiotic on Secretory Immunoglobulin-A Levels in Patients with Complete Edentulism: A Quasi-Experimental Study.","authors":"Harsimran Kaur, Pankaj Dhawan, Shakila Mahesh, Navdha Gupta","doi":"10.4103/jispcd.jispcd_36_25","DOIUrl":"10.4103/jispcd.jispcd_36_25","url":null,"abstract":"<p><strong>Aim: </strong>Secretory immunoglobulin-A (sIgA) plays a crucial role in the immune response and in protecting the oral mucosa as part of the body's defense system. Periodontitis, caries, fungal infections, and halitosis are among the most common oral illnesses treated with probiotics today. The study analyzes the outcome of multi-strain probiotics on the levels of sIgA in completely edentulous patients.</p><p><strong>Materials and methods: </strong>A total of 52 participants who were fully edentulous and wearing removable complete denture prosthesis were recruited for the research. The subjects were split into two groups. Patients in Group I (experimental) were given the multi-strain probiotic Lee-Biotic (Leeford Healthcare Ltd.), whereas those in Group II (control) did not receive any probiotic prescriptions. The enzyme-linked immunosorbent assay (ELISA) was employed to assess sIgA levels at baseline, 2 months later, and 3 months later. The collected data were statistically analyzed.</p><p><strong>Results: </strong>The mean baseline sIgA levels were 1.032 mg/mL in the probiotic group and 0.432 mg/mL in the non-probiotic group (<i>P</i> < 0.05). After 3 months, the probiotic group exhibited a significant increase to 2.254 mg/mL, whereas the non-probiotic group reached 1.213 mg/mL. The probiotic group showed a statistically significant increase (<i>P</i> < 0.05) in sIgA levels over the 3-month period, indicating a strong immunological response. In contrast, the non-probiotic group showed a modest increase, suggesting that the non-probiotic supplement has a limited effect.</p><p><strong>Conclusion: </strong>Commercially available multi-strain probiotic supplements increased the levels of sIgA in edentulous patients who were old denture wearers. Multi-strain probiotics have been shown to increase sIgA levels. This enhancement may contribute to improved oral immunity and reduced susceptibility to oral infections in the denture wearer population.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"435-441"},"PeriodicalIF":2.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Association Between Periodontal Inflammation and Serum Aspartate Aminotransferase: Findings From a Longitudinal Study Among the Japanese Older Population.","authors":"Fania Chairunisa, Sachiko Takehara, Kaname Nohno, Hiroshi Ogawa","doi":"10.4103/jispcd.jispcd_86_25","DOIUrl":"10.4103/jispcd.jispcd_86_25","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to investigate whether periodontal inflammation is associated with elevation of aspartate aminotransferase serum (AST) levels, which serve as a marker for inflammation or injury in particular organs, focusing on older adults.</p><p><strong>Materials and methods: </strong>This 3-year longitudinal study, part of the Niigata Elderly Study cohort, included a total of 233 individuals aged 77 years. As the main exposure, periodontal inflamed surface area (PISA) was calculated from all teeth except the third molar and then categorized into quartiles. AST was measured from the vessel blood sample and observed by the changes between baseline and follow-up examination as the outcome. Positive AST serum changes indicated deteriorated conditions. The highest PISA quartile group was selected to examine the correlation with the elevated AST group using logistic regression analysis.</p><p><strong>Results: </strong>During the 3-year follow-up examination, 86 participants (36.9%) developed an elevated AST level. The PISA highest quartile group was significantly associated with changes in cumulative AST serum levels (OR 2.191; 95% CI 1.148-4.181) after adjusting for covariates.</p><p><strong>Conclusion: </strong>This finding suggests that periodontal inflammation in older adults is more likely to develop AST elevation over 3 years. Therefore, assessment and treatment for periodontitis are still important to prevent any deterioration in future health conditions.</p>","PeriodicalId":47247,"journal":{"name":"Journal of International Society of Preventive and Community Dentistry","volume":"15 5","pages":"426-434"},"PeriodicalIF":2.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12617981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}