Clinical Cases in Mineral and Bone Metabolism最新文献_第5页

Periostin and sclerostin levels in juvenile Paget's disease. 少年佩吉特病的骨膜蛋白和硬化蛋白水平。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.2.269

Stergios A Polyzos, Polyzois Makras, Athanasios D Anastasilakis, Gesthimani Mintziori, Marina Kita, Athanasios Papatheodorou, Panagiotis Kokkoris, Evangelos Terpos

{"title":"Periostin and sclerostin levels in juvenile Paget's disease.","authors":"Stergios A Polyzos, Polyzois Makras, Athanasios D Anastasilakis, Gesthimani Mintziori, Marina Kita, Athanasios Papatheodorou, Panagiotis Kokkoris, Evangelos Terpos","doi":"10.11138/ccmbm/2017.14.2.269","DOIUrl":"https://doi.org/10.11138/ccmbm/2017.14.2.269","url":null,"abstract":"Juvenile Paget's disease (JPD) is a rare, autosomal recessive disorder featuring markedly increased serum alkaline phosphatase activity, indicative of greatly accelerated bone turnover throughout the skeleton. The main aim of this study was to evaluate circulating periostin and sclerostin levels in two adult patients with mild JPD (due to \"Balkan\" mutation). We measured periostin and sclerostin levels in a previously described woman and a newly diagnosed man with JPD, and 10 apparently healthy individuals, matched (1:5) to JPD patients for gender, age and body mass index. Sclerostin levels were similar between JPD patients and controls. Periostin levels were about 2.5 times higher in JPD patients. Periostin and sclerostin levels were negatively correlated (rs= -0.63; p=0.03). In conclusion, a trend towards higher periostin levels was observed in JPD patients, whereas sclerostin levels were similar to controls.","PeriodicalId":47230,"journal":{"name":"Clinical Cases in Mineral and Bone Metabolism","volume":"14 2","pages":"269-271"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726226/pdf/269-271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35676467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Atypical presentation of spine bone metastasis in prostate cancer mimicking Pott's disease. 模拟波特病的前列腺癌脊柱骨转移的不典型表现。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.1.239

Jérémy Flais, Guillaume Coiffier, Eric Brillet, Aleth Perdriger, Pascal Guggenbuhl

{"title":"Atypical presentation of spine bone metastasis in prostate cancer mimicking Pott's disease.","authors":"Jérémy Flais, Guillaume Coiffier, Eric Brillet, Aleth Perdriger, Pascal Guggenbuhl","doi":"10.11138/ccmbm/2017.14.1.239","DOIUrl":"https://doi.org/10.11138/ccmbm/2017.14.1.239","url":null,"abstract":"A 55-year-old man was hospitalized for a low back pain lasting for 3 months. Spinal MRI revealed a suggestive aspect of multilevel discitis L5-S1-S2 with paravertebral abscess. A thoraco-abdominal CT scan confirmed the presence of multiple pathological lymph nodes in several locations, bilateral micronodular pulmonary infiltrate; it also showed mirror bone erosions of vertebral L5 and S1 endplates, suggestive of disseminated tuberculosis with lung involvement and lymphadenopathy. A discovertebral L5-S1 biopsy was performed confirming the diagnosis of metastatic prostatic adenocarcinoma including a tumor infiltration of the intervertebral disc, without arguments for a septic processus superimposed without tuberculosis granuloma. Although rare, cases of metastases located at the disco-vertebral junction including prostatic cancer have already been described, and should be known to the clinician. The differential diagnosis with an infectious spondylodiscitis can be difficult in some case around the vertebral disc and in case of epiduritis and soft tissues involvement on MRI sequences. Disco-vertebral biopsy remains the cornerstone of the diagnosis.","PeriodicalId":47230,"journal":{"name":"Clinical Cases in Mineral and Bone Metabolism","volume":"14 2","pages":"239-240"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726217/pdf/239-240.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35676506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hypercalcemia, necrotizing pancreatitis and bone lesions: a benign cause. 高钙血症，坏死性胰腺炎和骨损伤:良性原因。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.2.245

Conrad Rauber, Lars Kihm, Uta Merle

引用次数: 1

Spondylocarpotarsal synostosis syndrome. A rare case of short stature and congenital scoliosis. 峡部枢椎关节闭锁综合征。一个罕见的矮小和先天性脊柱侧凸的病例。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.2.258

Swayamsidha Mangaraj, Arun Kumar Choudhury, Mamata Singh, Debasish Patro, Anoj Kumar Baliarsinha

引用次数: 3

Primary central nervous system germinal center B-like diffuse large B-cell lymphoma: a case report. 原发性中枢神经生发中枢b样弥漫性大b细胞淋巴瘤1例。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.2.247

Xiaoqing Wang

引用次数: 2

Vitamin K and bone. 维生素 K 与骨骼

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.1.200

Maria Fusaro, Maria Cristina Mereu, Andrea Aghi, Giorgio Iervasi, Maurizio Gallieni

引用次数: 0

The LARO-MEN1 study: a longitudinal clinical experience with octreotide Long-Acting Release in patients with Multiple Endocrine Neoplasia type 1 Syndrome. LARO-MEN1研究:奥曲肽长效释放治疗多发性内分泌肿瘤1型综合征的纵向临床经验

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.1.123

Federica Cioppi, Luisella Cianferotti, Laura Masi, Francesca Giusti, Maria Luisa Brandi

{"title":"The LARO-MEN1 study: a longitudinal clinical experience with octreotide Long-Acting Release in patients with Multiple Endocrine Neoplasia type 1 Syndrome.","authors":"Federica Cioppi, Luisella Cianferotti, Laura Masi, Francesca Giusti, Maria Luisa Brandi","doi":"10.11138/ccmbm/2017.14.1.123","DOIUrl":"10.11138/ccmbm/2017.14.1.123","url":null,"abstract":"Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumoral syndrome, featured by a combination of neoplasms of various endocrine and nonendocrine tissues. Approximately 33% of MEN1-related deaths are due to the malignant behaviour of well-differentiated neuroendocrine tumors (NETs), for which a preventive surgical treatment is not feasible. Somatostatin analogues (SSA) have been employed in the treatment of NETs in the stage of advanced or metastatic disease, in order to control the growth and secretion of tumor lesions. A longitudinal, open label study named \"LARO-MEN1\" was undertaken in order to assess whether early medical treatment with long-acting SSA could act as a preventive approach in small MEN1-related gastroenteropancreatic (GEP) NETs. Thirty consecutive patients affected by MEN1 were screened and 8 patients with small (<2 cm) NETs and abnormal laboratory values of at least one of the GEP hormones were administered octreotide acetate slow-release formulation (LAR) (10 mg i.m. every 28 days). Octreotide LAR was effective in decreasing GEP hormones and overall safe in the majority of patients up to six years of treatment, maintaining the disease stable also in terms of tumor size. The positive outcomes of this study in MEN1 patients reinforce the results obtained in advanced NETs on the use of SSA, opening to the opportunity for preventive use of octreotide LAR, aimed to delay or even avoid surgery in these patients.","PeriodicalId":47230,"journal":{"name":"Clinical Cases in Mineral and Bone Metabolism","volume":"14 2","pages":"123-130"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726195/pdf/123-130.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35675628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Adipose stem cells for bone tissue repair. 脂肪干细胞用于骨组织修复。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.1.217

Simone Ciuffi, Roberto Zonefrati, Maria Luisa Brandi

引用次数: 51

Clinical management of osteoporotic vertebral fracture treated with percutaneous vertebroplasty. 经皮椎体成形术治疗骨质疏松性脊椎骨折的临床管理。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.1.161

Anna Capozzi, Giovanni Scambia, Alessandro Pedicelli, Maurizio Evangelista, Roberto Sorge, Stefano Lello

{"title":"Clinical management of osteoporotic vertebral fracture treated with percutaneous vertebroplasty.","authors":"Anna Capozzi, Giovanni Scambia, Alessandro Pedicelli, Maurizio Evangelista, Roberto Sorge, Stefano Lello","doi":"10.11138/ccmbm/2017.14.1.161","DOIUrl":"10.11138/ccmbm/2017.14.1.161","url":null,"abstract":"Our study demonstrated percutaneous vertebroplasty (PVP) is an effective procedure to rapidly reduce back pain in patients affected by acute osteoporotic vertebral compression fractures (OVCFs) assessed by MRI. We confirmed in our sample, femoral bone density impacts more deeply than vertebral T-score and/or BMD on bone strenght, as it is less affected by any interferences. We interestingly found the presence of previous osteoporotic fragility fractures and chronic glucocorticoids therapy should especially negatively influence bone health of our patients. On the other hand, even if both FRAX scores for major osteoporotic fractures and for femoral fractures seemed to globally define a population at major risk for fragility fractures, our analysis is retrospectively done. We choose and suggest a multidisciplinary medical management of these patients, considering OP is a multifactorial disease and OVCFs usually produce lots of different important consequences on general health.","PeriodicalId":47230,"journal":{"name":"Clinical Cases in Mineral and Bone Metabolism","volume":"14 2","pages":"161-166"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726202/pdf/161-166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35676082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-articular therapy in hip osteoarthritis. 髋关节骨关节炎的关节内治疗。

Clinical Cases in Mineral and Bone Metabolism Pub Date : 2017-05-01 Epub Date: 2017-10-25 DOI: 10.11138/ccmbm/2017.14.1.179

Alberto Migliore, Silvia Anichini

引用次数: 10