Maria Fusaro, Maria Cristina Mereu, Andrea Aghi, Giorgio Iervasi, Maurizio Gallieni
{"title":"维生素 K 与骨骼","authors":"Maria Fusaro, Maria Cristina Mereu, Andrea Aghi, Giorgio Iervasi, Maurizio Gallieni","doi":"10.11138/ccmbm/2017.14.1.200","DOIUrl":null,"url":null,"abstract":"<p><p>Vitamin K is mainly known as an agent involved in blood coagulation, maintaining the activity of coagulation factors in the liver. In addition, epidemiological studies suggested that a lack of vitamin K is associated with several diseases, including osteoporosis and vascular calcification. There are two main kinds of vitamin K: Phylloquinone (or PK) and Menaquinones (MKn), both act as co-enzyme of y-glutamyl carboxylase (GGCX) transforming under-carboxylated in carboxylated vitamin K dependent proteins, such as Bone Gla Protein (or Osteocalcin) and Matrix Gla Protein. Recently, Vitamin K was also identified as a ligand of the nuclear steroid and xenobiotic receptor (SXR) (in murine species Pregnane X Receptor: PXR), expressed in osteoblasts. The purpose of this literature review is to evaluate the protective role of Vitamin K in bone and vascular health.</p>","PeriodicalId":47230,"journal":{"name":"Clinical Cases in Mineral and Bone Metabolism","volume":"14 2","pages":"200-206"},"PeriodicalIF":0.0000,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726210/pdf/200-206.pdf","citationCount":"0","resultStr":"{\"title\":\"Vitamin K and bone.\",\"authors\":\"Maria Fusaro, Maria Cristina Mereu, Andrea Aghi, Giorgio Iervasi, Maurizio Gallieni\",\"doi\":\"10.11138/ccmbm/2017.14.1.200\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Vitamin K is mainly known as an agent involved in blood coagulation, maintaining the activity of coagulation factors in the liver. In addition, epidemiological studies suggested that a lack of vitamin K is associated with several diseases, including osteoporosis and vascular calcification. There are two main kinds of vitamin K: Phylloquinone (or PK) and Menaquinones (MKn), both act as co-enzyme of y-glutamyl carboxylase (GGCX) transforming under-carboxylated in carboxylated vitamin K dependent proteins, such as Bone Gla Protein (or Osteocalcin) and Matrix Gla Protein. Recently, Vitamin K was also identified as a ligand of the nuclear steroid and xenobiotic receptor (SXR) (in murine species Pregnane X Receptor: PXR), expressed in osteoblasts. The purpose of this literature review is to evaluate the protective role of Vitamin K in bone and vascular health.</p>\",\"PeriodicalId\":47230,\"journal\":{\"name\":\"Clinical Cases in Mineral and Bone Metabolism\",\"volume\":\"14 2\",\"pages\":\"200-206\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726210/pdf/200-206.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Cases in Mineral and Bone Metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.11138/ccmbm/2017.14.1.200\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/10/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Cases in Mineral and Bone Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11138/ccmbm/2017.14.1.200","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/10/25 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
众所周知，维生素 K 主要参与血液凝固，维持肝脏中凝血因子的活性。此外，流行病学研究表明，缺乏维生素 K 与多种疾病有关，包括骨质疏松症和血管钙化。维生素 K 主要有两种：植物醌（或 PK）和萘醌（MKn），二者都是 y-谷氨酰羧化酶（GGCX）的辅酶，在依赖于维生素 K 的羧化蛋白（如骨釉蛋白（或骨钙蛋白）和基质釉蛋白）中转化为欠羧化。最近，维生素 K 还被确认为在成骨细胞中表达的核类固醇和异生物受体 (SXR) （在鼠类中为孕烷 X 受体：PXR）的配体。本文献综述旨在评估维生素 K 对骨骼和血管健康的保护作用。
Vitamin K is mainly known as an agent involved in blood coagulation, maintaining the activity of coagulation factors in the liver. In addition, epidemiological studies suggested that a lack of vitamin K is associated with several diseases, including osteoporosis and vascular calcification. There are two main kinds of vitamin K: Phylloquinone (or PK) and Menaquinones (MKn), both act as co-enzyme of y-glutamyl carboxylase (GGCX) transforming under-carboxylated in carboxylated vitamin K dependent proteins, such as Bone Gla Protein (or Osteocalcin) and Matrix Gla Protein. Recently, Vitamin K was also identified as a ligand of the nuclear steroid and xenobiotic receptor (SXR) (in murine species Pregnane X Receptor: PXR), expressed in osteoblasts. The purpose of this literature review is to evaluate the protective role of Vitamin K in bone and vascular health.
期刊介绍：
The Journal encourages the submission of case reports and clinical vignettes that provide new and exciting insights into the pathophysiology and characteristics of disorders related to skeletal function and mineral metabolism and/or highlight pratical diagnostic and /or therapeutic considerations.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
