Natural and Life Sciences Communications最新文献_第2页

The Effectiveness of Herbal Poultice in Relieving Pain and Flexibility in Osteoarthritis Patients 草药膏对缓解骨关节炎患者疼痛和灵活性的效果

Natural and Life Sciences Communications Pub Date : 2024-05-16 DOI: 10.12982/nlsc.2024.031

Nunthiya Srikaew, Natthaphol Phewkham, Sucharat Tungsukruthai, Kusuma Sriyakul, Parunkul Tungsukruthai, Pratya Phetkate, Chuntida Kamalashiran, Piracha Jumpa-ngern

{"title":"The Effectiveness of Herbal Poultice in Relieving Pain and Flexibility in Osteoarthritis Patients","authors":"Nunthiya Srikaew, Natthaphol Phewkham, Sucharat Tungsukruthai, Kusuma Sriyakul, Parunkul Tungsukruthai, Pratya Phetkate, Chuntida Kamalashiran, Piracha Jumpa-ngern","doi":"10.12982/nlsc.2024.031","DOIUrl":"https://doi.org/10.12982/nlsc.2024.031","url":null,"abstract":"Knee osteoarthritis (OA) is a chronic condition that causes joint degradation and primarily affects the elderly, reducing their quality of life and physical movements. The objective of this study was to determine the efficacy of Thai herbal poultice in relieving pain in OA patients. A single-blind, randomized controlled trial was conducted amongst OA patients at Integrative medicine clinic, Chulabhorn International College of Medicine, Thammasat University, Thailand. Participants were randomly allocated to the Thai herbal poultice or the diclofenac gel group (N=30). The main outcomes were evaluated using visual analog scale (VAS), isokinetic testing, goniometer, and knee injury and osteoarthritis outcome scores (KOOS) at different time assessment. Data were analyzed by the paired t-test and analysis of variance (ANOVA). Thai herbal poultice and diclofenac group showed a significant difference in both the VAS pain scores, extension and flexion as well as KOOS scores (P < 0.01 in both groups). In addition, when compared to diclofenac group, Thai herbal poultice group were significantly improve pain score at the sixth time point following the intervention (P < 0.01). Furthermore, no patients have experienced allergic reactions to therapies. In conclusion, Thai herbal poultice showed more efficiency in reducing pain scores than diclofenac gel without causing undesirable side effects.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"56 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140970997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spa Product Containing Plumeria acuminataand and Pandanus amaryllifolius Absolute for Antioxidant and Anti-wrinkle Activity: In vitro and In vivo Testing 含有梅花和露珠的水疗产品的抗氧化和抗皱活性：体外和体内测试

Natural and Life Sciences Communications Pub Date : 2024-05-14 DOI: 10.12982/nlsc.2024.033

Kunthida Taisakun, S. Chansakaow, Worrapan Poomanee, P. Leelapornpisid

{"title":"Spa Product Containing Plumeria acuminataand and Pandanus amaryllifolius Absolute for Antioxidant and Anti-wrinkle Activity: In vitro and In vivo Testing","authors":"Kunthida Taisakun, S. Chansakaow, Worrapan Poomanee, P. Leelapornpisid","doi":"10.12982/nlsc.2024.033","DOIUrl":"https://doi.org/10.12982/nlsc.2024.033","url":null,"abstract":"This study investigated the biological activities of Plumeria acuminata absolute (PLA), Pandan amaryllifolius absolute (PDA), and the essential oil blends (EOB2, EOB5) combining PLA, PDA, and other essential oils. It also aimed to identify the selected EOB for GC-MS analysis, develop this EOB into a cream, and determine its stability. Additionally, clinical evaluations were conducted to evaluate the cream’s efficacy on skin moisture, wrinkles, and irritation. PLA, PDA, and EOB2 exhibited potent anti-oxidants and anti-aging effects. They effectively showed free radicals scavenging (DPPH, ABTS), inhibiting lipid peroxidation, and suppressing hyaluronidase and collagenase activities. Due to its superior stability, EOB2 was selected for subsequent analysis. It demonstrated a potent inhibitory activity against MMP-2 enzymes. From GC-MS analysis, limonene was identified as the main component in EOB2. The 1.5%EOB cream maintained excellent stability under accelerated conditions. From the clinical study tested in 20 healthy volunteers after 8 weeks of twice diary application, it was found that the cream containing 1.5%EOB2 did not cause any skin irritation and significantly improved skin hydration. It also showed statistically significant decreases in wrinkle area, wrinkle depth, and skin roughness compared to the baseline. In conclusion, cream containing EOB could be a promising cosmeceutical or spa product for anti-aging purposes.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"113 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of Age Estimation Method Using Dental Radiographs of Permanent Mandibular Second Molars in a Southern Thailand Population 泰国南部人口使用下颌第二恒磨牙牙科 X 射线照片估算年龄的准确性

Natural and Life Sciences Communications Pub Date : 2024-05-02 DOI: 10.12982/nlsc.2024.030

Pornpat Theerasopon, Wirin Woratanarat, Nichawan Saiwong, Namthip Netprakon, Chairat Charoemratrote, Phuwadon Duangto

{"title":"Accuracy of Age Estimation Method Using Dental Radiographs of Permanent Mandibular Second Molars in a Southern Thailand Population","authors":"Pornpat Theerasopon, Wirin Woratanarat, Nichawan Saiwong, Namthip Netprakon, Chairat Charoemratrote, Phuwadon Duangto","doi":"10.12982/nlsc.2024.030","DOIUrl":"https://doi.org/10.12982/nlsc.2024.030","url":null,"abstract":"Age estimation is an important process for identifying individuals. In 2020, Duangto et al. estimated age by assessing dental development according to the method of Demirjian on permanent mandibular second molars using a panoramic radiograph. They also developed equations and tested their accuracy in a population of northern Thailand. However, several studies have shown that age estimation methods vary in suitability and accuracy depending on genetic and environmental factors within each population group. Therefore, this research aimed to test the accuracy of dental age estimation using the equations derived from panoramic radiographs of permanent mandibular second molars in a population of southern Thailand. A total of 224 radiographs of 112 males and 112 females aged 7–14 years were used for this study. The samples were categorized into eight groups (28 radiographs per group). The study identified tooth development in stages C–G that followed the Demirjian method and converted these stages into numerical values (3–7). The researchers tested these numerical values in the Duangto et al. equations. The findings revealed that age estimation using the Duangto et al. equations was not significantly different from chronological age. The accuracy had a margin of error not exceeding one year with 95% confidence intervals. In conclusion, the age estimation equations of Duangto et al. can accurately estimate the age of persons living in southern Thailand.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"35 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141018461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluidized Bed Heat Treatment for Controlling the Lesser Grain Borer (Rhyzopertha dominica) and Sawtoothed Grain Beetle (Oryzaephilus surinamensis) on Paddy cv. Khao Dawk Mali 105 流化床热处理技术用于控制稻种上的小粒螟（Rhyzopertha dominica）和锯齿甲虫（Oryzaephilus surinamensis）。Khao Dawk Mali 105

Natural and Life Sciences Communications Pub Date : 2024-02-27 DOI: 10.12982/nlsc.2024.022

Kunlayaa Boonsa-nga, Damorn Bundhurat, Viboon Changrue, Y. Chanbang

{"title":"Fluidized Bed Heat Treatment for Controlling the Lesser Grain Borer (Rhyzopertha dominica) and Sawtoothed Grain Beetle (Oryzaephilus surinamensis) on Paddy cv. Khao Dawk Mali 105","authors":"Kunlayaa Boonsa-nga, Damorn Bundhurat, Viboon Changrue, Y. Chanbang","doi":"10.12982/nlsc.2024.022","DOIUrl":"https://doi.org/10.12982/nlsc.2024.022","url":null,"abstract":"The efficacy of fluidized bed (FDB) heating was studied for controlling stored product insects on rough rice using laboratorial heat-fluidized bed equipment, and the milling quality of rice was later examined. Rough rice cv. Khao Dawk Mali 105 (13% wb) infested with insects was treated with FDB. The lesser grain borer (Rhyzopertha dominica, Fabricius) (internal feeders) had a higher tolerance for heat than the sawtoothed grain beetle (Oryzaephilus surinamensis Linnaeus, external feeders). At a hot air velocity of 3.7 m/s at 55°C for 90 s, the mortality of the lesser grain borer treated by FDB significantly differed (P <0.05) between all stages and from the untreated control. The pulpal stage, as an FDB-tolerant stage of the lesser grain borer, was treated with 55–65 °C for 60–150 s. FDB heat treatment at 55°C for 150 s, 60°C for 90 s, and 65°C for 60 s caused 100% mortality. At a hot air velocity of 3.7 m/s at 40°C for 120 s, the mortality of the sawtoothed grain beetle significantly differed (P <0.05) between all stages and the untreated control. The egg stage, as the FDB-tolerant stage, was treated at 40–50 °C for 60–150 s. FDB heat treatment at 45°C for 150 s and 50°C for 60 s caused 100% mortality. Some of the adults that survived FDB exposure were able to reproduce, but there were significantly less progeny than in the untreated control. Heat FDB slightly affected rice quality in terms of physical and chemical properties. Keywords: Heat, Fluidized bed heat, Paddy, Stored insect pests","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"53 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140425465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study on the Effect of Hot Air and Vacuum Drying on Physiochemical Properties and antioxidant Activities of Red Dragon Fruit (Hylocereus polyrhizus) Peel 热风干燥和真空干燥对红龙果（Hylocereus polyrhizus）果皮理化性质和抗氧化活性影响的比较研究

Natural and Life Sciences Communications Pub Date : 2024-02-22 DOI: 10.12982/nlsc.2024.023

Hong Quan Tran, Tieu Yen Tran, Pham Ngoc Tram Giap, Phung Tien Nguyen, S. Karnjanapratum, S. Rawdkuen

{"title":"Comparative Study on the Effect of Hot Air and Vacuum Drying on Physiochemical Properties and antioxidant Activities of Red Dragon Fruit (Hylocereus polyrhizus) Peel","authors":"Hong Quan Tran, Tieu Yen Tran, Pham Ngoc Tram Giap, Phung Tien Nguyen, S. Karnjanapratum, S. Rawdkuen","doi":"10.12982/nlsc.2024.023","DOIUrl":"https://doi.org/10.12982/nlsc.2024.023","url":null,"abstract":"The red dragon fruit (Hylocereus polyrhizus) peel was subjected to freeze drying (FD), hot air drying (at 50 – 65°C) (HAD), and vacuum drying (at 50 – 65°C) (VD), in which physical properties (color, water activity, water absorption index-WAI, and microstructure), bioactive compounds (ascorbic acid, betacyanin, polyphenol, and flavonoid), and antioxidant activities (DPPH and metal chelating activities) were monitored. The results showed that the lightness (L*) of red dragon fruit peel (RDFP) decreased as HAD and VD were applied especially at higher drying temperatures. Whereas the water absorption index (WAI) of the RDFP was not affected by drying methods. The microstructure surfaces of FD-dried RDFP were smoother than those of samples dried by HAD and VD-dried RDFP. After the drying processes, the bioactive compounds and antioxidative properties of the RDFP powder decreased significantly. However, higher bioactive compounds and antioxidant activities in RDFP dried by VD compared to the samples dried by HAD at the same drying temperatures. The RDFP powder dried by VD at 55°C retaining high physiochemical and antioxidative properties could be utilized as a colorant and nutraceutical ingredient in several food products. Keywords: Red dragon fruit peel, Freeze drying, Vacuum drying, Hot air drying, Bioactive compounds, Antioxidant activity","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"19 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response Surface Methodology for Optimization of Mucilage Extraction from Dioscorea alata Tuber 响应面法优化薯蓣块茎中的黏液提取方法

Natural and Life Sciences Communications Pub Date : 2024-02-21 DOI: 10.12982/nlsc.2024.019

Dewi Fortuna, Emmy Darmawati, T. Sunarti, S. Mardjan, Siti Mariana Widayanti, N. D. Yuliana, Nanik Purwanti

{"title":"Response Surface Methodology for Optimization of Mucilage Extraction from Dioscorea alata Tuber","authors":"Dewi Fortuna, Emmy Darmawati, T. Sunarti, S. Mardjan, Siti Mariana Widayanti, N. D. Yuliana, Nanik Purwanti","doi":"10.12982/nlsc.2024.019","DOIUrl":"https://doi.org/10.12982/nlsc.2024.019","url":null,"abstract":"Dioscorea alata mucilage (DAM) is a water-soluble polysaccharide and is composed of glucomannan. In this research, mucilages from D. alata were extracted using Response surface methodology (RSM) with a Central Composite Design (CCD) followed by distance-based optimality design, with three independent variables applied, i.e., temperature (4 – 60°C), time (0 – 30 h), and centrifugal speed (1.386 – 22.615×g). The maximum DAM yield was 5.89% ± 0.50%, which was obtained with an extraction temperature of 36.2°C for 13.3 h extraction time and centrifugation at 12,322×g. The regression model from RSM – CCD predicted that the maximum DAM yield was 5.47%, with R2 of 99.59% and adjusted R2 of 97.72%, which shows a significant correlation between the experimental and predicted values. The DAM is a complex material that mainly contains polysaccharides, i.e., β-pyranose forms of glucose and mannose, with low protein content. Water and oil holding capacity of the DAM powder were 8.43 g/g and 5.08 g/g, respectively, which considered as the highest compared to other similar studies. Keywords: Dioscorea alata mucilage, Extraction, Optimization, Response surface methodology, Physicochemical properties","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"6 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Properties of Propolis from Tetragonula sp. Against Subgingival Bacteria Proteolytic Activity in Periodontitis 四角虫蜂胶对牙周炎龈下细菌蛋白水解活性的生物特性

Natural and Life Sciences Communications Pub Date : 2024-02-21 DOI: 10.12982/nlsc.2024.020

Devina Nurul Isnaini, Dias Bintang Rakasiwi, Fahreza Naufaldi Putra Nawawi, Ikhsan Maulana, Ika Andriani, Arya Adiningrat

引用次数: 0

Cosmeceutical Activities of Essential Oils from the Rhizomes of Plants in the Zingiberaceae Family 姜科植物根茎中提取的精油的药用活性

Natural and Life Sciences Communications Pub Date : 2024-02-20 DOI: 10.12982/nlsc.2024.021

Pattiya Tammasorn, Watchara Kanjanakawinkul, W. Chaiyana

{"title":"Cosmeceutical Activities of Essential Oils from the Rhizomes of Plants in the Zingiberaceae Family","authors":"Pattiya Tammasorn, Watchara Kanjanakawinkul, W. Chaiyana","doi":"10.12982/nlsc.2024.021","DOIUrl":"https://doi.org/10.12982/nlsc.2024.021","url":null,"abstract":"The plants in the Zingiberaceae family are often rhizomatous annual or perennial herbs with considerable economic value. This study aimed to investigate the cosmeceutical activities of essential oils from the rhizomes of Hedychium coronarium J. Koenig, Curcuma caesia Roxb., and Curcuma longa L. The essential oils were obtained from hydrodistillation and subjected to investigations of antioxidant activities by 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power, and ferric thiocyanate assay. Furthermore, the whitening properties were investigated in terms of anti-tyrosinase inhibition, whereas the anti-skin aging activities were investigated through collagenase, elastase, and hyaluronidase inhibition. The results showed that all essential oils exhibited low antioxidant, anti-elastase, and anti-collagenase activities. On the other hand, H. coronarium oil was the only essential oil in the present study, which was found to possess anti-tyrosinase activity, with the inhibition of 98.4 ± 5.5% and 30.2 ± 1.7% at the final concentration of 0.1 mg/ml, when the substrate were L-tyrosine and L-DOPA, respectively. Interestingly, it was highlighted that the anti-tyrosinase activity of H. coronarium oil was stronger than that of kojic acid, a well-known whitening agent, when the substrate was L-tyrosine. Besides, H. coronarium oil and C. longa oil exhibited promising anti-hyluronidase activities with inhibition of 83.6 ± 1.0% and 82.9 ± 2.2%, respectively, which were comparable to that of epigallocatechin gallate (100.0 ± 0.0%). All essential oil induced irritations in the HET-CAM test at the tested concentration of 5 mg/ml in 10% dimethyl sulfoxide in olive oil. Therefore, H. coronarium oil was suggested as an attractive ingredient in cosmeceutical products for whitening and anti-aging.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"41 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140449018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antifungal Effect and Durability of Chitosan Oligosaccharide Coating on Heat-cured Polymethylmethacrylate Surface 壳聚糖寡糖涂层对热固化聚甲基丙烯酸甲酯表面的抗真菌效果和耐久性能

Natural and Life Sciences Communications Pub Date : 2024-01-02 DOI: 10.12982/nlsc.2024.004

Pattaraporn Buanpech, P. Chaijareenont, P. Wanachantararak, Patcharawan Silthampitag

{"title":"Antifungal Effect and Durability of Chitosan Oligosaccharide Coating on Heat-cured Polymethylmethacrylate Surface","authors":"Pattaraporn Buanpech, P. Chaijareenont, P. Wanachantararak, Patcharawan Silthampitag","doi":"10.12982/nlsc.2024.004","DOIUrl":"https://doi.org/10.12982/nlsc.2024.004","url":null,"abstract":"This study aimed to investigate the antifungal effect against Candida albicans (ATCC® 10231) and the durability of chitosan oligosaccharide (COS) coated on heat-polymerized polymethylmethacrylate (PMMA). The various concentrations of COS solution, 0.5, 1 and 2-fold of minimum fungicidal concentration (0.5, 1 and 2 MFC) were prepared and applied to PMMA specimens treated with sandblasting (SB), application of 3-aminopropyltriethoxysilane (APS), and a combination of both procedures (SB&APS). The toothbrush abrasion test was done to evaluate the remaining COS (n=10). The antifungal effect was determined through the colony count method (n=3). The number of fungal colonies was recorded at 16 and 48 hours. Data were analyzed using two-way and one-way ANOVA at the 95% confidence level. The result of the toothbrush abrasion test revealed that COS concentration and surface treatment affected coating durability. APS and SB&APS groups showed a high percentage of COS and significantly differed from SB groups (P = 0.00). For the antifungal effect, coatings with 1 MFC and 2 MFC demonstrated no difference, but coating with 0.5 MFC differed from others (P = 0.00). At 16 and 48 hours, PMMA coated with 1 MFC and 2 MFC by APS and SB&APS methods inhibited C.albicans. COS can be coated onto PMMA using APS and can inhibit C.albicans. With further development, this method could be applied to treat denture stomatitis alternatively to conventional antifungal drugs. Keywords: Candida albicans, Chitosan, Oligochitosan, Polymethylmethacrylate, Silanes","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"60 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artocarpus lakoocha Roxb. and Oxyresveratrol Inhibits Interleukin 6 Secretion Related with Insulin Resistance in 3T3-L1 Adipocytes 白藜芦醇抑制 3T3-L1 脂肪细胞中与胰岛素抵抗有关的白细胞介素 6 分泌

Natural and Life Sciences Communications Pub Date : 2024-01-02 DOI: 10.12982/nlsc.2024.005

Saowalak Yomlar, Kanittaporn Trisat, Nanteetip Limpeanchob

{"title":"Artocarpus lakoocha Roxb. and Oxyresveratrol Inhibits Interleukin 6 Secretion Related with Insulin Resistance in 3T3-L1 Adipocytes","authors":"Saowalak Yomlar, Kanittaporn Trisat, Nanteetip Limpeanchob","doi":"10.12982/nlsc.2024.005","DOIUrl":"https://doi.org/10.12982/nlsc.2024.005","url":null,"abstract":"Chronic low-grade inflammation plays an important role in insulin resistance and the development of type 2 diabetes in obese people. Adipocytes, the most abundant cell type in adipose tissue, could produce various types of cytokines responsible for chronic inflammation. The purpose of the present study was to investigate the preventive effect of oxyresveratrol and Puag-Haad, which is the oxyresveratrol-enriched aqueous extract from Artocarpus lakoocha Roxb., on the inflammation and insulin resistance demonstrated by adipocytes. The release of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, were monitored to evaluate the inflammatory status of the adipocyte cells during the 3T3-L1 adipocytes maturation period. Intracellular lipid accumulation and glucose uptake were measured to assess adipogenicity and insulin sensitivity status of mature adipocytes, respectively. The results showed that 3T3-L1 adipocytes substantially secreted IL-6 but not TNF-α, IL-1β. Further, IL-6 secretion was correlated with lipid quantity accumulated in the adipocytes. Oxyresveratrol and Puag-Haad predominantly exhibited anti-inflammatory activity in a dose-dependent manner, inhibiting IL-6 release but showed less effect on lipid accumulation. 3T3-L1 adipocytes treated with Puag-Haad (40 µg/mL) for 15 days showed significant decreases in fat accumulation and IL-6 secretion and promoted the glucose uptake. These outcomes indicate an improvement in insulin sensitivity. Taken all together, the data indicates that Puag-Haad is an interesting natural substance that should be further studied for its preventive effect on obese-mediated inflammation and the consequences of insulin resistance and type 2 diabetes. Keywords: Artocarpus lakoocha Roxb., Oxyresveratrol, Pro-inflammatory cytokine, Insulin resistance, Adipocyte","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"134 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139453239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0