Natural and Life Sciences Communications最新文献

Effects of Occlusion Cuff Pressures for Determining Brachial Artery Flow-Mediated Dilation in Healthy Thai Adults 闭塞袖带压力对确定泰国健康成人肱动脉血流介导的扩张的影响

Natural and Life Sciences Communications Pub Date : 2024-08-09 DOI: 10.12982/nlsc.2024.050

Kanpiraya Nithitsuttibuta, Jaruta Kunritt, Suchart Kiatwattanacharoen, Sainatee Pratanaphon

{"title":"Effects of Occlusion Cuff Pressures for Determining Brachial Artery Flow-Mediated Dilation in Healthy Thai Adults","authors":"Kanpiraya Nithitsuttibuta, Jaruta Kunritt, Suchart Kiatwattanacharoen, Sainatee Pratanaphon","doi":"10.12982/nlsc.2024.050","DOIUrl":"https://doi.org/10.12982/nlsc.2024.050","url":null,"abstract":"Variability in cuff occlusion pressure used during flow-mediated dilation (FMD) measurement may cause differences in FMD results and discomfort sensation. The objective of this study was to compare FMD data and sensations of pain and numbness using three levels of occlusion cuff pressures commonly used for FMD assessment in healthy adults. A within-subject design was conducted in 12 healthy adults aged 20-40 years. FMD was measured using brachial artery Doppler ultrasound at three different occlusion pressures: 25 and 50 mmHg above systolic blood pressure (SBP) and 200 mmHg. Pain and numbness were recorded using the Numeric Pain Rating Scale and the Visual Analog Scale, respectively, at baseline and every minute during the 5-minute occlusion and 3 minutes after cuff deflation. The results showed that %FMD and mean blood flow velocity after using cuff pressure at 25 mmHg above SBP (10.11 ± 2.58% and 11.52 ± 3.96 cm/s) were comparable to those of 50 mmHg above SBP (10.08 ± 2.70% and 12.54 ± 4.31 cm/s) and at 200 mmHg (10.15 ± 2.74% and 12.28 ± 4.30 cm/s) (all P >0.05). The pain intensity was significantly greater at 200 mmHg compared to 25 mmHg at the first, second, and fourth minutes during occlusion (all P <0.05). The numbness scale was not different among the three pressure conditions. In conclusion, the minimum occlusion pressure above SBP by 25 mmHg generated an insignificant FMD response compared to the other two cuff pressures, caused minor pain, and may be the favorable pressure for determining endothelium-dependent FMD in healthy Thai adults.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"66 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stigma and Discrimination Towards People Living With HIV/AIDS Among Myanmar Migrants in Chiang Mai Province, Thailand 泰国清迈府缅甸移民对艾滋病毒/艾滋病感染者的羞辱和歧视

Natural and Life Sciences Communications Pub Date : 2024-07-24 DOI: 10.12982/nlsc.2024.048

Kyaw Soe Thant, A. Thongprachum, Sineenart Chautrakarn, Pannawich Chantaklang, S. Chariyalertsak

{"title":"Stigma and Discrimination Towards People Living With HIV/AIDS Among Myanmar Migrants in Chiang Mai Province, Thailand","authors":"Kyaw Soe Thant, A. Thongprachum, Sineenart Chautrakarn, Pannawich Chantaklang, S. Chariyalertsak","doi":"10.12982/nlsc.2024.048","DOIUrl":"https://doi.org/10.12982/nlsc.2024.048","url":null,"abstract":"HIV remains a significant public health concern among migrants in Thailand, a central migration hub in Southeast Asia. Reducing HIV-related discrimination is a major goal of Thailand’s National Strategy to End AIDS: 2017-2030. The study aimed to examine the level of stigma towards people living with HIV and associated factors among Myanmar migrants. A cross-sectional study was conducted among Myanmar migrants in Chiang Mai province from October to December 2023. A total of 424 migrants attending hospital health screening and community gatherings were recruited by a convenience sampling method. Average age of participants was 29.92 ± 7.9 years, married (56.8%), and primary or lower education (67.5%). 85.1% had discriminatory attitudes toward people living with HIV/AIDS. Significant factors associated with discriminatory attitudes included being of Shan ethnicity (aOR=2.419) and having a low education level (aOR=2.559). HIV preventive strategies should include inclusive health education and accessible health care that are culturally sensitive among migrants.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Analysis of Conserved B-Cell Epitopes in DENV NS1 Protein for Enhanced Rapid Diagnostic Tests Development in Indonesia 全面分析印度尼西亚用于强化快速诊断检测开发的 DENV NS1 蛋白中的保守 B 细胞表位

Natural and Life Sciences Communications Pub Date : 2024-07-23 DOI: 10.12982/nlsc.2024.049

Y. Messe, S. Wibowo, Hery Wijayanto, W. Artama, Fajar Sofyantoro, Nastiti Wijayanti

{"title":"Comprehensive Analysis of Conserved B-Cell Epitopes in DENV NS1 Protein for Enhanced Rapid Diagnostic Tests Development in Indonesia","authors":"Y. Messe, S. Wibowo, Hery Wijayanto, W. Artama, Fajar Sofyantoro, Nastiti Wijayanti","doi":"10.12982/nlsc.2024.049","DOIUrl":"https://doi.org/10.12982/nlsc.2024.049","url":null,"abstract":"Dengue virus (DENV) constitutes a formidable public health threat within tropical and subtropical regions. The escalation of cases in Southeast Asia, notably Indonesia, is a matter of considerable concern. Timely identification of DENV infection remains imperative for efficient disease management. The non-structural protein-1 (NS1), distinguished by its heightened immunogenicity and early detectability during infection, stands as a pivotal target for diagnostic modalities. The current investigation delves into the exploration of B-cell epitopes within Indonesian DENV NS1 protein isolates, with the overarching objective of enhancing the sensitivity and specificity of early detection systems, such as the Rapid Diagnostic Test (RDT). This study has successfully delineated five B-cell epitopes that exhibit conservation across DENV serotypes within Indonesian isolates (accessions number: QBB90021.1, QBE90252.1, QBB90023.1, and UDW38833.1). These epitopes were discerned through comprehensive screening leveraging the IEDB platforms. Noteworthy variations in antigenicity, allergenicity, and toxicity profiles were observed among these identified epitopes. Molecular docking analysis substantiated a robust binding affinity between the predicted epitope and the B-cell receptor. The ensuing in silico protein-peptide docking analyses offer valuable insights into potential B-cell epitopes on the Indonesian DENV NS1 protein. The identified epitopes, particularly the SQHNYRPGY epitope characterized by its antigenic potency and non-allergenic attributes, hold promise for advancing the development of sensitive and specific RDTs tailored for DENV detection in the Indonesian context. However, it is imperative to underscore the requisite for subsequent experimental validation to affirm the efficacy of these epitopes in diagnostic applications.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"32 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141813282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Early Protein Damage-Associated Molecular Pattern (DAMPs) Candidates from Cardiac Cells Subjected to an In Vitro Myocardial Ischemic Injury 从体外心肌缺血损伤的心脏细胞中鉴定早期蛋白质损伤相关分子模式 (DAMP) 候选者

Natural and Life Sciences Communications Pub Date : 2024-07-03 DOI: 10.12982/nlsc.2024.047

S. Kumphune, N. Paiyabhroma, Porrnthanate Seenak, Worawat Songjang, A. Jiraviriyakul, Noppadon Jumroon, Panyupa Pankhong, Siriwan Thaisakun, Narumon Phaonakrop, S. Roytrakul, N. Nernpermpisooth

{"title":"Identification of Early Protein Damage-Associated Molecular Pattern (DAMPs) Candidates from Cardiac Cells Subjected to an In Vitro Myocardial Ischemic Injury","authors":"S. Kumphune, N. Paiyabhroma, Porrnthanate Seenak, Worawat Songjang, A. Jiraviriyakul, Noppadon Jumroon, Panyupa Pankhong, Siriwan Thaisakun, Narumon Phaonakrop, S. Roytrakul, N. Nernpermpisooth","doi":"10.12982/nlsc.2024.047","DOIUrl":"https://doi.org/10.12982/nlsc.2024.047","url":null,"abstract":"Damage-associated molecular patterns (DAMPs) are intracellular molecules that are released from cells that undergo injury. Protein-DAMPs are abundant biomolecules that could potentially be a novel biomarker for pathology. Myocardial ischemia injury is a causative process for ischemic heart disease, which is now the leading cause of global deaths. Early diagnosis is necessary to save patient lives, so the discovery of new early cardiac biomarkers is crucial. Here, we examined the protein-DAMPs expression in ischemic buffer collected from adult ventricular myocytes cells subjected to various timepoints of simulated ischemia (sI). Adult ventricular myocytes cells (AC-16) were subjected to sublethal simulated ischemia (sI) by treatment with ischemic buffer for 5, 10, 20, and 30 minutes (I5, I10, I20, and I30, respectively). After simulated ischemia was achieved, the ischemic buffer was collected and determined for proteins profiling by Shotgun proteomics approach. Cell viability was reduced in a time dependent manner in ischemia. Targeted proteomics reveals 21 proteins found to highly increase in early ischemic injury and can still be detected until 30 minutes of ischemia. Lactotransferrin (LTF) was determined to be the protein with the greatest impact, exhibiting both fast and sustained release throughout the whole study time. The present study identified the protein damage associated molecular pattern (DAMPs) released specifically from ischemia-induced cardiomyocytes injury, which could potentially be candidates to be early biomarkers for myocardial ischemic injury. Further studies should be focused on in vivo validation of potential protein markers that could be used in practical clinical applications.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"110 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological Properties of Poly (vinyl alcohol)/Gelatin contained Indonesian Carbonated Hydroxyapatite Abalone Nanofibrous Scaffold by Electrospinning 电纺丝法制备含印尼碳酸羟基磷灰石鲍鱼纳米纤维支架的聚（乙烯醇）/明胶形态学特性

Natural and Life Sciences Communications Pub Date : 2024-06-11 DOI: 10.12982/nlsc.2024.037

M. Sari, Nilam Cahyati, Yusril Yusuf

{"title":"Morphological Properties of Poly (vinyl alcohol)/Gelatin contained Indonesian Carbonated Hydroxyapatite Abalone Nanofibrous Scaffold by Electrospinning","authors":"M. Sari, Nilam Cahyati, Yusril Yusuf","doi":"10.12982/nlsc.2024.037","DOIUrl":"https://doi.org/10.12982/nlsc.2024.037","url":null,"abstract":"One strategy for dealing with bone defects is replicating and reconstructing artificial bone for bone tissue engineering (BTE) application, known as the scaffold. Bone consists of an extracellular matrix (ECM) which, at the nanoscale, has a fibrous structure that can be replicated in synthetic scaffolds using an electrospinning method. This work describes the analysis of the morphological properties of Poly (vinyl alcohol) (PVA)/Gelatin contained Indonesian carbonated hydroxyapatite (CHA) abalone nanoparticle scaffold by electrospun nanofiber. CHA nanoparticles were produced using a co-precipitation method, and nanofibrous PVA/Gelatin/CHA 5 wt% scaffold was fabricated by electrospinning. The synthesized CHA produced the same condition as B-type CHA, ensured by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometer (XRD), and differential scanning calorimetry (DSC), and energy-dispersive X-ray spectroscopy (EDS) tests. The morphological properties of PVA/Gelatin/CHA are analyzed using Scanning Electron Microscopy (SEM). The SEM image indicated that PVA/Gelatin nanofiber tended to have a fine morphology without beads. The agglomeration of the PVA/Gelatin/CHA 5 wt% nanofiber scaffold can be neglected because it is still on the sub-micron scale (1 μm–100 nm). Moreover, adding CHA 5 wt% in the PVA/Gelatin matrix decreased the average fiber diameter. The diameter fiber results are within the fiber diameter range (100–450 nm) in native bone ECM. Therefore, PVA/Gelatin/CHA 5 wt% has the potential to serve as an alternative scaffold material for BTE application.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"34 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Reasons and Perspectives Behind Decisions to Forego Hospital Births Among Remote Rural Populations in Bokeo Province, Lao PDR 探讨老挝博胶省偏远农村人口决定放弃住院分娩的原因和观点

Natural and Life Sciences Communications Pub Date : 2024-06-07 DOI: 10.12982/nlsc.2024.040

Krissana Kapheak, Nonthaphat Theerawasttanasiri, Potchara Khumphoo, Chansy Chayaseng, Phouangphet Bounmaseng, Ninrat Pangsri, Jukkrit Wungrath

{"title":"Exploring Reasons and Perspectives Behind Decisions to Forego Hospital Births Among Remote Rural Populations in Bokeo Province, Lao PDR","authors":"Krissana Kapheak, Nonthaphat Theerawasttanasiri, Potchara Khumphoo, Chansy Chayaseng, Phouangphet Bounmaseng, Ninrat Pangsri, Jukkrit Wungrath","doi":"10.12982/nlsc.2024.040","DOIUrl":"https://doi.org/10.12982/nlsc.2024.040","url":null,"abstract":"Maternal mortality remains high among marginalized rural populations in Laos. Remote mountain villages in Bokeo Province typify persistent health access divides facing minor subgroups amidst infrastructure gaps and scattered habitation. This study explores complex drivers behind shunning hospital births using focused rural ethnography. Between October and November 2023, this qualitative study interviewed 40 participants including pregnant women, postpartum women, and their relatives across 5 villages in Bokeo Province regarding barriers to hospital births. Open-ended discussions aimed to elucidate motivations and barriers embedded in their decision to avoid formal delivery care, despite mortality awareness. Transcriptions from Lao were translated to Thai, maintaining cultural nuances. Thematic analysis identified patterns in women’s attitudes and barriers to hospital childbirth. A collaborative coding process revealed constraints on access, affordability, and autonomy, explaining why vulnerable groups often forego hospital births despite risks. The result founded that prohibitive transportation deficiencies including impassable roads, exorbitant driver fees and unreliable conveyance options were primary obstacles. Prohibitive direct and indirect costs compounded struggles for impoverished families. Restrictive traditions persisted among certain ethnicities. Discrimination fears and hospital foreignness also provoked wariness among a minority. Multidimensional geographical, financial and sociocultural barriers intersect to obstruct rural groups from accessible emergency obstetric care in Laos. Infrastructural strengthening, financial protection and public education can relieve these pronounced constraints denying the marginalized realization of maternal health rights.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141375823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Particulate Matter Deposition Efficiency and Air Quality Improvement by Vertical Shrub and Climber Walls 评估垂直灌木和攀缘植物墙的颗粒物质沉积效率和空气质量改善情况

Natural and Life Sciences Communications Pub Date : 2024-06-07 DOI: 10.12982/nlsc.2024.038

Pamon Pumas

引用次数: 0

Fabrication of Silver Nanoparticles Using Acalypha paniculata Extract, AI-Based Interaction Analysis and Its Activity Explication 利用刺五加提取物制造银纳米粒子、基于人工智能的交互分析及其活性阐释

Natural and Life Sciences Communications Pub Date : 2024-06-06 DOI: 10.12982/nlsc.2024.035

Elumalai A., Irfan Navabshan

{"title":"Fabrication of Silver Nanoparticles Using Acalypha paniculata Extract, AI-Based Interaction Analysis and Its Activity Explication","authors":"Elumalai A., Irfan Navabshan","doi":"10.12982/nlsc.2024.035","DOIUrl":"https://doi.org/10.12982/nlsc.2024.035","url":null,"abstract":"This study showcases eco-friendly silver nanoparticle synthesis using Acalypha paniculata herb and its biological activity. Artificial Intelligence (AI) tools are used to analyze the interaction between phytoconstituent and silver ion to find the capping and nanoparticle fabricating phytoconstituents. Ethanolic extract was added to silver nitrate solution and irradiated under sunlight until the formation of silver nanoparticles. These particles were sedimented, characterised by spectral technique and biological activity was measured. Finally, a Computational simulation algorithm was used to visualize the interactions of phytoconstituent and silver nanoparticles. Ultra Violet (UV)-visible spectrum revealed a visible peak at 420nm in the brownish solution, Dynamic Light Scattering (DLS) size of 54.7nm, spherical crystalline morphology of the nanoparticle by Transmission Electron Microscope (TEM) and X-Ray Diffraction (XRD) analysis. The synthesized silver nanoparticle antagonised Escherichia coli, and Bacillus cereus and showed the Minimum Inhibitory Concentration (MIC) of 65 µg/mL, and 78 µg/mL respectively and Minimum Bacterial Concentration (MBC) of 52.5 µg/mL for B.cereus and 61.5µg/mL for E.coli. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals IC50 was found to be 97.414 µg/mL and it revealed the dose-dependent antioxidant activity of phyto-capped silver particles. The cytotoxicity of fabricated nanoparticles was studied on Vero cells and the results indicate that IC50 of 47.28 µg/mL. Furthermore, an AI-based study concludes that Alloaromadendrene adsorbed highly by the Silver (Ag) ion compared to the nitrate with an affinity of -30.6755 kcal/mol. This research introduces an innovative, cost-effective method for stable Acalypha paniculata Silver Nanoparticles (AP-AgNPs) fabrication, crucial for diverse biomedical uses.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"30 52","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimising High-Pressure Processing (HPP) for Optimal Total Phenolic and Flavonoid Content in Kelulut (Stingless Bee) Honey 优化高压加工（HPP）以优化克鲁鲁（无刺蜂）蜂蜜中的总酚类和类黄酮含量

Natural and Life Sciences Communications Pub Date : 2024-05-20 DOI: 10.12982/nlsc.2024.034

Muhammad Faiz Razali, B. Talip, N. Adzahan, A. Sulaiman, Azeman Samiun, Noor Akhmazillah Mohd Fauzi

{"title":"Optimising High-Pressure Processing (HPP) for Optimal Total Phenolic and Flavonoid Content in Kelulut (Stingless Bee) Honey","authors":"Muhammad Faiz Razali, B. Talip, N. Adzahan, A. Sulaiman, Azeman Samiun, Noor Akhmazillah Mohd Fauzi","doi":"10.12982/nlsc.2024.034","DOIUrl":"https://doi.org/10.12982/nlsc.2024.034","url":null,"abstract":"High-pressure processing (HPP) has the potential to enhance the total phenolic and flavonoid content (TPC and TFC) in Kelulut honey (KH). However, KH’s inherent variability possesses challenges in optimising these phytochemicals. This study hence explores the optimisation of KH through HPP, focusing on TPC and TFC. The Face-centered Central Composite Design (FC-CCD), involving two factors with three levels each (pressure of 200, 400, and 600 MPa, and time of 5, 10, and 15 min), was applied to investigate two response variables (total phenolic and flavonoid content). The optimisation identified the optimal parameters as 200 MPa for 15 min, with a desirability of 0.986, indicating precise modeling. Compared to other pressures (400 and 600 MPa) at common processing time (15 minutes), 200 MPa recorded higher TPC and TFC with differences of 25.71% to 30.92% and 13.78% to 14.19%, respectively. A verification step revealed that HPP-KH at 200 MPa for 15 minutes yielded a TPC of 15.278 ± 0.525 mg GAE/100 g and a TFC of 38.274 ± 1.980 mg RE/100 g, indicating the precise accuracy of the quadratic modeling. However, this discovery contradicts the consensus that pressures above 500 MPa increase TPC and TFC. Consequently, it underscores the need for tailored high-pressure strategies in KH processing, offering essential insights for industry applications and further research endeavors.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141120929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Overjet Severity and Skeletal Divergence on the Perioral Soft Tissue Area 过咬合严重程度和骨骼发散对口周软组织面积的影响

Natural and Life Sciences Communications Pub Date : 2024-05-16 DOI: 10.12982/nlsc.2024.032

Kulnipa Punyanirun, Chairat Charoemratrote

{"title":"Impact of Overjet Severity and Skeletal Divergence on the Perioral Soft Tissue Area","authors":"Kulnipa Punyanirun, Chairat Charoemratrote","doi":"10.12982/nlsc.2024.032","DOIUrl":"https://doi.org/10.12982/nlsc.2024.032","url":null,"abstract":"Overjet (OJ) and skeletal divergence affect the perioral soft tissue. However, no previous study has investigated the combined effects on perioral soft tissue, which includes the upper lip (UL), lower lip (LL), and chin projection. We explored the impact of OJ severity and skeletal divergence on the perioral soft tissue. Lateral cephalograms of 133 untreated skeletal Class II adult patients were allocated into three categories according to the degree of skeletal divergence: hypodivergence (Hypo), normodivergence (Normo), and hyperdivergence (Hyper). Furthermore, OJ was classified as normal OJ (NOJ), moderately excessive OJ (MEOJ), and severely excessive OJ (SEOJ). A matrix of skeletal divergence and OJ variables produced the following groups: NOJ-Hypo, MEOJ-Hypo, SEOJ-Hypo, NOJ-Normo, MEOJ-Normo, SEOJ-Normo, NOJ-Hyper, MEOJ-Hyper, and SEOJ-Hyper. The skeletal, dental, and soft tissue parameters were measured. Statistical analyses showed that increased hyperdivergence and OJ severity corresponded with a more retruded mandibular perioral soft tissue (MPST), except for the Pog’ in the SEOJ-Hypo group, which was insignificantly more prominent than the MEOJ-Hypo group. Unlike the LL, the UL was similar among the groups. Multiple regression indicated that greater OJ and skeletal divergence significantly influenced MPST retrusion and increased vermilion lower lip thickness (VLLT) while independently affecting deeper mentolabial sulcus depth (MSD) and a more obtuse lip-chin-throat angle (P < 0.05). The effect of OJ was most significant at the LL and gradually decreased down to the chin; conversely, divergence increased downwards. The SEOJ-Hyper group displayed the greatest retruded MPST, thickest VLLT, and deepest MSD, which highlighted the combined effect of OJ and divergence.","PeriodicalId":471315,"journal":{"name":"Natural and Life Sciences Communications","volume":"45 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0