JBJS ReviewsPub Date : 2024-07-17eCollection Date: 2024-07-01DOI: 10.2106/JBJS.RVW.24.00047
Matthew Quinn, Nicholas Lemme, Patrick Morrissey, Paul Fadale, Brett D Owens
{"title":"An Update on Emerging Techniques and Considerations in Revision Anterior Cruciate Ligament Reconstruction.","authors":"Matthew Quinn, Nicholas Lemme, Patrick Morrissey, Paul Fadale, Brett D Owens","doi":"10.2106/JBJS.RVW.24.00047","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.24.00047","url":null,"abstract":"<p><p>» The rate of primary anterior cruciate ligament reconstruction (ACLR) failure in at-risk populations remains unacceptably high and necessitates thorough evaluation of native alignment and concomitant injuries.» Posterior tibial slope of >12° is a substantial risk factor of ACLR failure and should be corrected through anterior closing wedge osteotomy.» Varus malalignment of >5° exacerbates stress on the ACL graft, increases ACLR failure risks, and should be considered for correction through high tibial osteotomy at the time of revision ACLR.» Injuries to the anterolateral ligamentous complex are prevalent in ACL ruptures, and high-risk patients have shown benefit from anterolateral ligament reconstruction or lateral extra-articular tenodesis in the revision setting.» Addressing posterolateral corner, collateral ligament, and meniscal injuries, during revision ACLR, is vital to mitigate increased graft forces and optimize knee stability and functional outcomes.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-07-11eCollection Date: 2024-07-01DOI: 10.2106/JBJS.RVW.24.00070
Caleb J Bischoff, David R Woodard, Lauren Clough Pringle, Steven F DeFroda
{"title":"Imaging Modalities in the Preoperative Assessment of Femoroacetabular Impingement and Hip Dysplasia: Determining Best Practices.","authors":"Caleb J Bischoff, David R Woodard, Lauren Clough Pringle, Steven F DeFroda","doi":"10.2106/JBJS.RVW.24.00070","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.24.00070","url":null,"abstract":"<p><p>» In the last decade, significant progress has been made in understanding hip pain, especially related to femoroacetabular impingement (FAI) and hip dysplasia (HD), which collectively affect over 20% of the population.» Preoperative imaging, including plain radiographs, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US), plays a pivotal role in diagnosing FAI and HD. Imaging precision, standardized techniques, and accurate interpretation are crucial for effective treatment planning.» The continual advancements in imaging techniques, especially seen in MRI (arthrograms, application of leg traction, and delayed gadolinium-enhanced MRI of cartilage), represent important strides in the precise assessment of pathology associated with FAI and HD.» By incorporating these advancements into routine imaging protocols, healthcare providers can ensure a comprehensive understanding of hip joint dynamics, enabling more accurate diagnosis and effective management strategies for patients with FAI and HD, ultimately leading to improved clinical outcomes.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-07-11eCollection Date: 2024-07-01DOI: 10.2106/JBJS.RVW.24.00057
Paul A Rizk, Marcos R Gonzalez, Bishoy M Galoaa, Andrew G Girgis, Lotte Van Der Linden, Connie Y Chang, Santiago A Lozano-Calderon
{"title":"Machine Learning-Assisted Decision Making in Orthopaedic Oncology.","authors":"Paul A Rizk, Marcos R Gonzalez, Bishoy M Galoaa, Andrew G Girgis, Lotte Van Der Linden, Connie Y Chang, Santiago A Lozano-Calderon","doi":"10.2106/JBJS.RVW.24.00057","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.24.00057","url":null,"abstract":"<p><p>» Artificial intelligence is an umbrella term for computational calculations that are designed to mimic human intelligence and problem-solving capabilities, although in the future, this may become an incomplete definition. Machine learning (ML) encompasses the development of algorithms or predictive models that generate outputs without explicit instructions, assisting in clinical predictions based on large data sets. Deep learning is a subset of ML that utilizes layers of networks that use various inter-relational connections to define and generalize data.» ML algorithms can enhance radiomics techniques for improved image evaluation and diagnosis. While ML shows promise with the advent of radiomics, there are still obstacles to overcome.» Several calculators leveraging ML algorithms have been developed to predict survival in primary sarcomas and metastatic bone disease utilizing patient-specific data. While these models often report exceptionally accurate performance, it is crucial to evaluate their robustness using standardized guidelines.» While increased computing power suggests continuous improvement of ML algorithms, these advancements must be balanced against challenges such as diversifying data, addressing ethical concerns, and enhancing model interpretability.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-07-05eCollection Date: 2024-07-01DOI: 10.2106/JBJS.RVW.24.00064
Yasir AlShehri, Panayiotis D Megaloikonomos, Michael E Neufeld, Lisa C Howard, Nelson V Greidanus, Donald S Garbuz, Bassam A Masri
{"title":"Cementless Total Knee Arthroplasty: A State-of-the-Art Review.","authors":"Yasir AlShehri, Panayiotis D Megaloikonomos, Michael E Neufeld, Lisa C Howard, Nelson V Greidanus, Donald S Garbuz, Bassam A Masri","doi":"10.2106/JBJS.RVW.24.00064","DOIUrl":"10.2106/JBJS.RVW.24.00064","url":null,"abstract":"<p><p>» The demographic profile of candidates for total knee arthroplasty (TKA) is shifting toward younger and more active individuals.» While cemented fixation remains the gold standard in TKA, the interest is growing in exploring cementless fixation as a potentially more durable alternative.» Advances in manufacturing technologies are enhancing the prospects for superior long-term biological fixation.» Current research indicates that intermediate to long-term outcomes of modern cementless TKA designs are comparable with traditional cemented designs.» The selection of appropriate patients is critical to the success of cementless fixation techniques in TKA.» There is a need for high-quality research to better understand the potential differences and relative benefits of cemented vs. cementless TKA systems.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Appropriateness and Quality of Composite Endpoint Use and Reporting in Spine Surgery: A Systematic Review.","authors":"Markian Pahuta, Mohamed Sarraj, Varun Muddaluru, Pranjan Gandhi, Fawaz Alshaalan, Jason Busse, Daipayan Guha, Mohit Bhandari","doi":"10.2106/JBJS.RVW.24.00039","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.24.00039","url":null,"abstract":"<p><strong>Background: </strong>A composite endpoint (CEP) is a measure comprising 2 or more separate component outcomes. The use of these constructs is increasing. We sought to conduct a systematic review on the usage, quality of reporting, and appropriate use of CEPs in spine surgery research.</p><p><strong>Methods: </strong>A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Articles reporting randomized controlled trials of a spine surgery intervention using a CEP as a primary outcome were included. We assessed the quality of CEP reporting, appropriateness of CEP use, and correspondence between CEP treatment effect and component outcome treatment effect in the included trials.</p><p><strong>Results: </strong>Of 2,321 initial titles, 43 citations were included for analysis, which reported on 20 unique trials. All trials reported the CEP construct well. In 85% of trials, the CEP design was driven by US Food and Drug Administration guidance. In the majority of trials, the reporting of CEP results did not adhere to published recommendations: 43% of tests that reported statistically significant results on component outcomes were not statistically significant when adjusted for multiple testing. 67% of trials did not meet appropriateness criteria for CEP use. In addition, CEP treatment effect tended to be 6% higher than the median treatment effect for component outcomes.</p><p><strong>Conclusion: </strong>Given that CEP analysis was not appropriate for the majority of spine surgery trials and the inherent challenges in the reporting and interpretation of CEP analysis, CEP use should not be mandated by regulatory bodies in spine surgery trials.</p><p><strong>Level of evidence: </strong>Level I. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-07-05eCollection Date: 2024-07-01DOI: 10.2106/JBJS.RVW.24.00048
Ashley B Anderson, Jason M Souza, Lisa Prasso, Shannon Ford, Julio A Rivera, Louise Hassinger, Tawnee Sparling, Jonathan A Forsberg, Benjamin K Potter
{"title":"Team Approach: Osseointegration Amputation Surgery.","authors":"Ashley B Anderson, Jason M Souza, Lisa Prasso, Shannon Ford, Julio A Rivera, Louise Hassinger, Tawnee Sparling, Jonathan A Forsberg, Benjamin K Potter","doi":"10.2106/JBJS.RVW.24.00048","DOIUrl":"10.2106/JBJS.RVW.24.00048","url":null,"abstract":"<p><p>» The purpose of this article was to review the multidisciplinary, team-based approach necessary for the optimal management of patients with limb loss undergoing osseointegration surgery.» In this study, we describe the interdisciplinary process of screening, counseling, and surgical and rehabilitation considerations with an emphasis on principles rather than specific implants or techniques.» Integrated perioperative management and long-term surveillance are crucial to ensure the best possible outcomes.» We hope this model will service as an implant-agnostic guide to others seeking to development an osseointegration center of excellence.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-07-05eCollection Date: 2024-07-01DOI: 10.2106/JBJS.RVW.24.00022
Ali Lari, Ali Esmaeil, Yousef AlSalem, Fahad Alabbad, Maged Shahin, Ahmed Aoude
{"title":"Comparative Outcomes and Failure Rates of Total Femur Replacement in Oncologic and Nononcologic Indications: A Systematic Review and Meta-analysis.","authors":"Ali Lari, Ali Esmaeil, Yousef AlSalem, Fahad Alabbad, Maged Shahin, Ahmed Aoude","doi":"10.2106/JBJS.RVW.24.00022","DOIUrl":"10.2106/JBJS.RVW.24.00022","url":null,"abstract":"<p><strong>Background: </strong>Total femur replacement (TFR) has become increasingly significant as a salvage procedure for both oncologic reconstruction and complex nononcologic conditions such as revision arthroplasty. Despite its effectiveness in limb salvage, TFR is associated with high complication and failure rates, which vary depending on the underlying indication.</p><p><strong>Methods: </strong>This systematic review and meta-analysis adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of MEDLINE, EMBASE, Web of Science, and Cumulative Index to Nursing and Allied Health Literature databases was conducted, focusing on studies that reported outcomes of TFR in oncologic and nononcologic cases. Primary outcomes included failure mode and rates according to the Henderson classification, functional outcomes scores, and mobility status. Data were analyzed using random-effects models and generalized linear mixed models.</p><p><strong>Results: </strong>A total of 35 studies involving 1,002 patients were included. The majority of TFRs were performed for oncologic reasons (63.7%). The mean Musculoskeletal Tumor Society (MSTS) score was 66%, with a limb salvage rate of 89%. The meta-analysis revealed a combined failure rate of 34%. For type 4 failures (infection), nononcologic patients exhibited a significantly higher rate at 18% (95% confidence interval [CI], 12%-26%, I2 = 46%, p < 0.01) compared with 8% in oncologic patients (95% CI, 6%-12%, I2 = 0%). Regarding combined types 1 to 4 failures, oncologic patients had a rate of 20% (95% CI, 25%-52%, I2 = 60%), whereas nononcologic patients faced a higher rate of 37% (95% CI, 12%-26%, I2 = 63%) (p < 0.05), indicating a significant difference. There were no significant differences in the MSTS score. In addition, there were no notable differences when comparing failure modes 1, 2, and 3 independently. Mobility analysis showed that approximately 70% of patients required walking aids after surgery.</p><p><strong>Conclusion: </strong>TFR offers a valuable limb salvage option in both oncologic and nononcologic scenarios, despite its high failure rates. Although functional outcomes were similar between groups, the higher failure rate in nononcologic cases and the poor overall quality of evidence warrant further comprehensive assessments into predictors of outcomes to optimize results.</p><p><strong>Level of evidence: </strong>Level III. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 7","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-06-24eCollection Date: 2024-06-01DOI: 10.2106/JBJS.RVW.24.00036
Olivia K Blaber, Mikalyn T DeFoor, Zachary A Aman, Emily R McDermott, Nicholas N DePhillipo, Jonathan F Dickens, Travis J Dekker
{"title":"Lack of Consensus on the Management of Medial Collateral Ligament Tears in the Setting of Concomitant Anterior Cruciate Ligament Injury: A Critical Analysis.","authors":"Olivia K Blaber, Mikalyn T DeFoor, Zachary A Aman, Emily R McDermott, Nicholas N DePhillipo, Jonathan F Dickens, Travis J Dekker","doi":"10.2106/JBJS.RVW.24.00036","DOIUrl":"10.2106/JBJS.RVW.24.00036","url":null,"abstract":"<p><p>» There is no clear agreement on the optimal timing or superior type of fixation for medial collateral ligament (MCL) tears in the setting of anterior cruciate ligament (ACL) injury.» Anatomic healing of medial knee structures is critical to maintain native knee kinematics, supported by biomechanical studies that demonstrate increased graft laxity and residual valgus rotational instability after ACL reconstruction (ACLR) alone in the setting of concomitant ACL/MCL injury.» Historically, most surgeons have favored treating acute combined ACL/MCL tears conservatively with MCL rehabilitation, followed by stress radiographs at 6 weeks after injury to assess for persistent valgus laxity before performing delayed ACLR to allow for full knee range of motion, and reduce the risk of postoperative stiffness and arthrofibrosis.» However, with the advancement of early mobilization and aggressive physical therapy protocols, acute surgical management of MCL tears in the setting of ACL injury can have benefits of avoiding residual laxity and further intra-articular damage, as well as earlier return to sport.» Residual valgus laxity from incomplete MCL healing at the time of ACLR should be addressed surgically, as this can lead to an increased risk of ACLR graft failure.» The treatment of combined ACL/MCL injuries requires an individualized approach, including athlete-specific factors such as level and position of play, timing of injury related to in-season play, contact vs. noncontact sport, and anticipated longevity, as well as consideration of the tear pattern, acuity of injury, tissue quality, and surgeon familiarity with the available techniques.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-06-18eCollection Date: 2024-06-01DOI: 10.2106/JBJS.RVW.24.00035
Dev Laungani, Joshua R Porto, Lucas Haase, Kira Smith, Raymond Chen, Robert Gillespie
{"title":"Tranexamic Acid in Total Shoulder Arthroplasty: A Scoping Review of Current Practices and Future Directions.","authors":"Dev Laungani, Joshua R Porto, Lucas Haase, Kira Smith, Raymond Chen, Robert Gillespie","doi":"10.2106/JBJS.RVW.24.00035","DOIUrl":"10.2106/JBJS.RVW.24.00035","url":null,"abstract":"<p><strong>Background: </strong>The effectiveness of tranexamic acid (TXA) as an antifibrinolytic agent in total shoulder arthroplasty (TSA) is well documented; however, there remains considerable practice variability concerning the optimal route of administration and dosing protocols concerning the medication's use. Our aim was to conduct a scoping review of the literature regarding the efficacy of various methods of TXA administration in TSA and to identify knowledge gaps that may be addressed.</p><p><strong>Methods: </strong>A scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. The PubMed and MEDLINE electronic databases were searched to identify all articles published before March 2023 investigating the administration of TXA in TSA. Randomized controlled trials and cohort studies were included, and data were extracted to capture information regarding intervention details and related outcomes such as blood loss, transfusion needs, and complication rates.</p><p><strong>Results: </strong>A total of 15 studies were included in this review. All selected studies used either intravenous (IV) or topical TXA, with 1 study also including a combined approach of both topical and IV TXA. Of the studies that used an IV approach, the most commonly reported favorable outcomes were a reduction in blood volume loss, reduction in hemoglobin or hematocrit change, and decreased drain output. Dosing varied significantly between all identified studies because some used a standard dosing amount in grams or milligrams for all treatment group participants, whereas others used weight-based dosing amounts. All studies that used a weight-based dosing regimen as well as studies using a standard dosing amount between 1,000 and 5,000 mg reported favorable outcomes for postoperative blood loss.</p><p><strong>Conclusion: </strong>Both IV and topical TXA clearly demonstrate favorable perioperative hematologic profiles in TSA. Although both approaches have demonstrated a successful association with decreased blood loss and transfusion requirements, there is no definitive benefit to choosing one over the other. Furthermore, the use of oral TXA either in combination or isolation warrants further study in TSA because of its comparable efficacy profiles and significantly lower associated costs of application.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2024-06-18eCollection Date: 2024-06-01DOI: 10.2106/JBJS.RVW.24.00061
Michel A Arcand, Dominique Poulin, Edward J Testa, Nicholas J Lemme
{"title":"Testosterone: A Review for Orthopaedic Surgeons.","authors":"Michel A Arcand, Dominique Poulin, Edward J Testa, Nicholas J Lemme","doi":"10.2106/JBJS.RVW.24.00061","DOIUrl":"10.2106/JBJS.RVW.24.00061","url":null,"abstract":"<p><p>» Testosterone replacement treatment (TRT) and anabolic androgenic steroid (AAS) use is common and possibly increasing.» Diagnosing and treating hypogonadism in men is controversial.» Hypogonadism and the use of AASs seem to have a detrimental effect on the musculoskeletal system. The current literature on TRT and the musculoskeletal system shows an increased risk of tendon injury.» There may be a role for testosterone supplementation in the postoperative period.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}