JBJS ReviewsPub Date : 2024-01-05eCollection Date: 2024-01-01DOI: 10.2106/JBJS.RVW.23.00135
Charlotte M J M Pott, Huub H de Klerk, Simone Priester-Vink, Denise Eygendaal, Michel P J van den Bekerom
{"title":"Treatment Outcomes of Simple Elbow Dislocations: A Systematic Review of 1,081 Cases.","authors":"Charlotte M J M Pott, Huub H de Klerk, Simone Priester-Vink, Denise Eygendaal, Michel P J van den Bekerom","doi":"10.2106/JBJS.RVW.23.00135","DOIUrl":"10.2106/JBJS.RVW.23.00135","url":null,"abstract":"<p><strong>Background: </strong>The treatment of simple elbow dislocations (SEDs) has become more functional last decade with a tendency to shorter immobilization of the elbow, whereas simultaneously, surgical stabilization has been promoted by some authors. The primary aim of this study was to systematically review the literature and analyze the outcomes and complications of different treatment options for acute and persistent SEDs, including operative and nonoperative treatments with varying immobilization periods.</p><p><strong>Methods: </strong>A literature search was performed based on the online medical databases MEDLINE, Embase, and the Cochrane databases. Articles presenting patients with a SED were eligible for inclusion. When an SED persists for >3 weeks, it is categorized as persistent. Various outcome measures were assessed, including the range of motion (ROM), patient-reported outcome measures, and complication rates. To get insight into the severity of complications, all complications were categorized as minor or major. The Methodological Index for Nonrandomized Studies was used to assess the methodological quality of nonrandomized studies. The risk of bias in the randomized studies was assessed with the Cochrane risk-of-bias tool.</p><p><strong>Results: </strong>A total of 37 articles were included with 1,081 dislocated elbows (1,078 patients). A fair quality of evidence was seen for the nonrandomized studies and a low risk of bias for the randomized study. Nonoperative treatment was administered to 710 elbows, with 244 elbows treated with early mobilization, 239 with 1- to 3-week immobilization, and 163 with ≥3-week immobilization. These groups showed a ROM flexion-extension arc (ROM F/E) of 137, 129, and 131°, respectively. Surgical treatment as open reduction and ligament repair or reconstruction was performed in 228 elbows and showed a ROM F/E of 128°. All persistent SEDs were treated surgically and showed a ROM F/E of 90°.</p><p><strong>Conclusion: </strong>The early mobilization treatment showed the most consistent satisfactory outcomes in the literature compared with the other treatment options. Nevertheless, there remains ambiguity regarding which patients would benefit more from surgery than nonoperative treatment.</p><p><strong>Level of evidence: </strong>Level IV. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"12 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-22eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00163
Nickelas Huffman, Ignacio Pasqualini, Peter Surace, Robert M Molloy, Nicolas S Piuzzi, Matthew E Deren
{"title":"Diagnosis, Treatment, and Outcomes of Crystalline Arthropathy in the Setting of Total Knee Arthroplasty: A Critical Analysis Review.","authors":"Nickelas Huffman, Ignacio Pasqualini, Peter Surace, Robert M Molloy, Nicolas S Piuzzi, Matthew E Deren","doi":"10.2106/JBJS.RVW.23.00163","DOIUrl":"10.2106/JBJS.RVW.23.00163","url":null,"abstract":"<p><p>» Emerging evidence suggests the prevalence of crystalline arthropathy (CA) in the setting of total knee arthroplasty (TKA) is increasing, and diagnosis of CA is often intricate because of symptom overlap with other common postoperative complications such as periprosthetic joint infection (PJI). Consequently, an accurate and timely diagnosis becomes pivotal in guiding the choice of treatment.» CA includes gout and calcium pyrophosphate deposition (CPPD) disease, and accurate diagnosis in patients with prior TKA requires a multifaceted approach. The diagnosis algorithm plays a critical role in determining the appropriate treatment approach.» Management of CA typically involves a conservative strategy, encompassing the administration of nonsteroidal anti-inflammatory drugs, colchicine, and steroids, regardless of whether patients have undergone prior TKA.» There is conflicting evidence on the effect CA has on the surgical outcomes in postoperative TKA patients. While these patients may expect excellent functional outcomes and pain relief, they may be at a higher risk of complications such as infections, medical complications, and revision procedures.» Additional research is required to fully comprehend the impact of CA on postoperative TKA outcomes and to establish effective strategies for enhancing patient care and optimizing long-term joint function.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138886229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-20eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00145
Charalambos P Charalambous, Emadeldin M Ahmed, Fatima Kayali, Hritik Nautiyal, Kenan Kuršumović, Paul M Sutton
{"title":"Vancomycin Graft Presoaking in Anterior Cruciate Ligament Reconstruction Surgery Is Associated with a Lower Risk of Graft Rerupture as Compared With No Vancomycin Presoaking: Systematic Review and Meta-analysis.","authors":"Charalambos P Charalambous, Emadeldin M Ahmed, Fatima Kayali, Hritik Nautiyal, Kenan Kuršumović, Paul M Sutton","doi":"10.2106/JBJS.RVW.23.00145","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.23.00145","url":null,"abstract":"<p><strong>Background: </strong>To determine whether there is any difference in graft rerupture rates and clinical outcomes between cases having vancomycin graft presoaking vs. no vancomycin presoaking in anterior cruciate ligament (ACL) reconstruction (ACLR).</p><p><strong>Methods: </strong>Systematic review and meta-analysis. PubMed, Embase, CINAHL, and Cochrane CENTRAL were searched. Full published studies reporting on the relation between vancomycin graft presoaking and rates of graft rerupture and/or clinical outcomes in ACLR surgery vs. no vancomycin graft presoaking were included. Data extraction and quality appraisal were performed. Meta-analysis was conducted using a random effects model. The study's protocol was prospectively registered with PROSPERO (CRD42021290608).</p><p><strong>Results: </strong>The literature search identified 907 records. After removing duplicates and those not meeting inclusion criteria, 8 studies were included. Meta-analysis showed that the estimated risk of hamstring graft rerupture was lower in cases presoaked with vancomycin vs. those having no presoaking (3.2% vs. 6.2% rerupture rate, risk ratio [RR] = 0.507, 95% CI, 0.39-0.737, p < 0.001). Similarly, the estimated risk of graft rerupture was lower in cases presoaked with vancomycin vs. those having no presoaking when the analysis included various ACL graft types (2.7% vs. 3.9% rerupture rate, RR = 0.557, 95% confidence interval [CI], 0.403-0.771, p < 0.001). Meta-analysis also showed that vancomycin graft presoaking was associated with similar International Knee Documentation Committee scores as compared with no presoaking when looking at hamstring grafts (estimated mean difference 0.112, 95% CI, -2.359 to 2.582, p = 0.929) or when considering various graft types (estimated mean difference 0.933, 95% CI, -0.140 to 2.006, p = 0.088).</p><p><strong>Conclusion: </strong>Vancomycin graft presoaking is a safe practice and does not compromise ACL graft rerupture rates or clinical outcomes.</p><p><strong>Level of evidence: </strong>Level IV. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-20eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00171
Carol D Morris, Lauren B Banks, Valerie A Fitzhugh, Kevin C McGill, Curtiland Deville
{"title":"Team Approach: Extremity Soft Tissue Sarcoma.","authors":"Carol D Morris, Lauren B Banks, Valerie A Fitzhugh, Kevin C McGill, Curtiland Deville","doi":"10.2106/JBJS.RVW.23.00171","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.23.00171","url":null,"abstract":"<p><p>» Synovial sarcoma is a soft tissue sarcoma that most commonly presents in the extremity in a periarticular location.» As the history and physical examination of patients with synovial sarcoma can overlap considerably with those of patients with non-oncologic orthopedic conditions, it is important that orthopedic surgeons maintain a high level of suspicion when caring for patients with extremity masses.» Soft tissue sarcomas are best treated using a team approach. Early recognition and referral to a multidisciplinary sarcoma team are crucial to ensure the best clinical outcome for the patient.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-15eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00156
Emily Arciero, Josephine R Coury, Alexandra Dionne, Justin Reyes, Joseph M Lombardi, Zeeshan M Sardar
{"title":"Optimizing Preoperative Chronic Pain Management in Elective Spine Surgery Patients: A Narrative Review of Outcomes with Opioid and Adjuvant Pain Therapies.","authors":"Emily Arciero, Josephine R Coury, Alexandra Dionne, Justin Reyes, Joseph M Lombardi, Zeeshan M Sardar","doi":"10.2106/JBJS.RVW.23.00156","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.23.00156","url":null,"abstract":"<p><p>» Chronic preoperative opioid use negatively affects outcomes after spine surgery, with increased complications and reoperations, longer hospital stays, decreased return-to-work rates, worse patient-reported outcomes, and a higher risk of continued opioid use postoperatively.» The definition of chronic opioid use is not consistent across studies, and a more specific and consistent definition will aid in stratifying patients and understanding their risk of inferior outcomes.» Preoperative weaning periods and maximum dose thresholds are being established, which may increase the likelihood of achieving a meaningful improvement after surgery, although higher level evidence studies are needed.» Spinal cord stimulators and intrathecal drug delivery devices are increasingly used to manage chronic back pain and are equivalent or perhaps even superior to opioid treatment, although few studies exist examining how patients with these devices do after subsequent spine surgery.» Further investigation is needed to determine whether a true mechanistic explanation exists for spine-related analgesia related to spinal cord stimulators and intrathecal drug delivery devices.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-15eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00040
Michael Beverly, David W Murray
{"title":"Hydraulic Joint Function and Osteoarthritis.","authors":"Michael Beverly, David W Murray","doi":"10.2106/JBJS.RVW.23.00040","DOIUrl":"10.2106/JBJS.RVW.23.00040","url":null,"abstract":"<p><p>» This review of bone perfusion work introduces a new field of subchondral physiology.» Intraosseous pressure (IOP) measured through an intraosseous needle reflects conditions only at the needle tip rather than being a constant for the whole bone.» Measurements of IOP in vitro and in vivo, with and without proximal vascular occlusion, show that at rest, bone is perfused at normal physiological pressures.» A subtraction perfusion range or bandwidth at the needle tip offers a better measure of bone health than a single IOP.» With ordinary loads, very great subchondral pressures are generated.» Subchondral tissues are relatively delicate but are microflexible with bone fat being essentially liquid at body temperature.» Collectively, the subchondral tissues transmit load mainly through hydraulic pressure to the trabeculae and cortical shaft.» White vascular marks on normal magnetic resonance imaging scans are present but are lost in early osteoarthritis.» Histological studies confirm the presence of those vascular marks and also choke valves capable of supporting hydraulic pressure load transmission.» Osteoarthritis seems to be at least partly a vasculomechanical disease.» Understanding subchondral physiology will be key to better classification, control, prognosis, and treatment of osteoarthritis.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10720793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-15eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00178
Ignacio Pasqualini, Nickelas Huffman, Sarah F Keller, John P McLaughlin, Robert M Molloy, Matthew E Deren, Nicolas S Piuzzi
{"title":"Team Approach: Bone Health Optimization in Orthopaedic Surgery.","authors":"Ignacio Pasqualini, Nickelas Huffman, Sarah F Keller, John P McLaughlin, Robert M Molloy, Matthew E Deren, Nicolas S Piuzzi","doi":"10.2106/JBJS.RVW.23.00178","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.23.00178","url":null,"abstract":"<p><p>» Bone health optimization (BHO) has become an increasingly important consideration in orthopaedic surgery because deterioration of bone tissue and low bone density are associated with poor outcomes after orthopaedic surgeries.» Management of patients with compromised bone health requires numerous healthcare professionals including orthopaedic surgeons, primary care physicians, nutritionists, and metabolic bone specialists in endocrinology, rheumatology, or obstetrics and gynecology. Therefore, achieving optimal bone health before orthopaedic surgery necessitates a collaborative and synchronized effort among healthcare professionals.» Patients with poor bone health are often asymptomatic and may present to the orthopaedic surgeon for reasons other than poor bone health. Therefore, it is imperative to recognize risk factors such as old age, female sex, and low body mass index, which predispose to decreased bone density.» Workup of suspected poor bone health entails bone density evaluation. For patients without dual-energy x-ray absorptiometry (DXA) scan results within the past 2 years, perform DXA scan in all women aged 65 years and older, all men aged 70 years and older, and women younger than 65 years or men younger than 70 years with concurrent risk factors for poor bone health. All women and men presenting with a fracture secondary to low-energy trauma should receive DXA scan and bone health workup; for fractures secondary to high-energy trauma, perform DXA scan and further workup in women aged 65 years and older and men aged 70 years and older.» Failure to recognize and treat poor bone health can result in poor surgical outcomes including implant failure, periprosthetic infection, and nonunion after fracture fixation. However, collaborative healthcare teams can create personalized care plans involving nutritional supplements, antiresorptive or anabolic treatment, and weight-bearing exercise programs, resulting in BHO before surgery. Ultimately, this coordinated approach can enhance the success rate of surgical interventions, minimize complications, and improve patients' overall quality of life.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-11eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00140
Michael S Ramos, Ignacio Pasqualini, Peter A Surace, Robert M Molloy, Matthew E Deren, Nicolas S Piuzzi
{"title":"Arthrofibrosis After Total Knee Arthroplasty: A Critical Analysis Review.","authors":"Michael S Ramos, Ignacio Pasqualini, Peter A Surace, Robert M Molloy, Matthew E Deren, Nicolas S Piuzzi","doi":"10.2106/JBJS.RVW.23.00140","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.23.00140","url":null,"abstract":"<p><p>» Arthrofibrosis after total knee arthroplasty (TKA) is the new formation of excessive scar tissue that results in limited ROM, pain, and functional deficits.» The diagnosis of arthrofibrosis is based on the patient's history, clinical examination, absence of alternative diagnoses from diagnostic testing, and operative findings. Imaging is helpful in ruling out specific causes of stiffness after TKA. A biopsy is not indicated, and no biomarkers of arthrofibrosis exist.» Arthrofibrosis pathophysiology is multifactorial and related to aberrant activation and proliferation of myofibroblasts that primarily deposit type I collagen in response to a proinflammatory environment. Transforming growth factor-beta signaling is the best established pathway involved in arthrofibrosis after TKA.» Management includes both nonoperative and operative modalities. Physical therapy is most used while revision arthroplasty is typically reserved as a last resort. Additional investigation into specific pathophysiologic mechanisms can better inform targeted therapeutics.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-11eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00157
Luke Zabawa, Apurva S Choubey, Brett Drake, Joel Mayo, Alfonso Mejia
{"title":"Dementia and Hip Fractures: A Comprehensive Review of Management Approaches.","authors":"Luke Zabawa, Apurva S Choubey, Brett Drake, Joel Mayo, Alfonso Mejia","doi":"10.2106/JBJS.RVW.23.00157","DOIUrl":"https://doi.org/10.2106/JBJS.RVW.23.00157","url":null,"abstract":"<p><p>» The elderly population is the fastest growing demographic, and the number of dementia cases in the United States is expected to double to 10 million by 2050.» Patients with dementia are at 3× higher risk of hip fractures and have higher morbidity and mortality after hip fractures.» Hip fracture patients with dementia benefit from early analgesia and timely surgical fixation of fracture.» Early and intensive inpatient rehabilitation is associated with improved postoperative outcomes in patients with dementia.» Coordination of care within a \"orthogeriatric\" team decreases mortality, and fracture liaison services show potential for improving long-term outcomes in hip fracture patients with dementia.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JBJS ReviewsPub Date : 2023-12-11eCollection Date: 2023-12-01DOI: 10.2106/JBJS.RVW.23.00175
Timothy R Buchanan, Victoria E Bindi, Ettienne Caban-Klepac, Keegan M Hones, Thomas W Wright, Bradley S Schoch, Joseph J King, Kevin A Hao
{"title":"Mitigating Fracture of the Acromion and Scapular Spine After Reverse Shoulder Arthroplasty: A Critical Analysis Review of Patient and Surgical Risk Factors.","authors":"Timothy R Buchanan, Victoria E Bindi, Ettienne Caban-Klepac, Keegan M Hones, Thomas W Wright, Bradley S Schoch, Joseph J King, Kevin A Hao","doi":"10.2106/JBJS.RVW.23.00175","DOIUrl":"10.2106/JBJS.RVW.23.00175","url":null,"abstract":"<p><strong>Level of evidence: </strong>Level V. Narrative Review. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":47098,"journal":{"name":"JBJS Reviews","volume":"11 12","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}