{"title":"Significance and characteristics of patients with Ribbon-like signal hyperintensity after acute ischemic stroke.","authors":"Takeshi Miyamoto, Shu Sogabe, Masaaki Korai, Izumi Yamaguchi, Manabu Ishihara, Kenji Shimada, Yasuhisa Kanematsu, Kazutaka Kuroda, Yuki Yamamoto, Nobuaki Yamamoto, Masafumi Harada, Yuishin Izumi, Yasushi Takagi","doi":"10.2152/jmi.73.36","DOIUrl":"10.2152/jmi.73.36","url":null,"abstract":"<p><strong>Objectives: </strong>We discovered a novel finding of ribbon-like signal hyperintensity of the cerebral cortex, named the ribbon sign, after reperfusion therapy. Herein, we report the significance and clinical characteristics of ribbon signs.</p><p><strong>Materials and methods: </strong>Data from consecutive patients with acute ischemic stroke and anterior large-vessel occlusion were prospectively extracted from the Tokushima University Hospital Stroke Registry between January 2011 and March 2020. Diffusion-weighted imaging findings were retrospectively assessed in patients with acute ischemic stroke with large-vessel occlusion, with or without treatment.</p><p><strong>Results: </strong>A total of 140 patients (78 males, average age:75.7 years) were enrolled in the study. Among the patients, 113 (80.7%) underwent reperfusion therapy. Eighty-one (57.9%) patients underwent successful recanalization. The ribbon sign was more common in patients with successful recanalization than in patients with unsuccessful recanalization (53.1% vs. 8.5%, respectively;p<0.01). The ribbon sign is a specific finding after successful recanalization.</p><p><strong>Conclusions: </strong>Our study is the first to report that the ribbon sign is a specific finding in patients with acute ischemic stroke. The patients with extensive DWI lesion, including those in the cortex on adimisson, exhibited the ribbon sign after successful recanalization. J. Med. Invest. 73 : 36-43, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"36-43"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HDV Infection Status in Tokushima Prefecture Based on Histopathological Evaluation:A Single-Institution Study.","authors":"Hirohisa Ogawa, Kayu Kinouchi, Mayuko Ichimura-Shimizu, Nagisa Yawata, Zen Akazawa, Orgil Jargalsaikhan, Takaaki Koma, Shotaro Tachibana, Takeshi Kageyama, Kengo Atsumi, Yuko Miyakami, Wenhua Shao, Yu Saito, Masako Nomaguchi, Yuji Morine, Koichi Tsuneyama","doi":"10.2152/jmi.73.52","DOIUrl":"10.2152/jmi.73.52","url":null,"abstract":"<p><p>Hepatitis D virus (HDV) is a defective RNA virus requiring hepatitis B virus (HBV) for replication, and co-infection of them significantly accelerates liver inflammation, fibrosis, and hepatocarcinogenesis. Recent studies have reported that the prevalence of HDV infection is extremely high in certain regions, such as Mongolia, exceeding 50% among individuals infected with HBV. To clarify the potential presence of HDV infection in Japan, we retrospectively examined 95 surgically resected cases for HBV-related hepatocellular carcinoma (HCC) at Tokushima University Hospital between 2003 and 2023. Formalin-fixed, paraffin-embedded liver tissues were subjected to immunohistochemistry using an antibody against large and small delta antigens of HDV. Plasma samples from 12 patients were additionally tested by ELISA. As a result, none of the HBV-related HCC cases showed immunoreactivity for HDV antigens in either tumor or non-neoplastic tissues, and all available plasma samples were negative by ELISA. These findings suggest that HDV infection is either absent or extremely rare among patients with HBV-related HCC in this cohort. Our results align with prior seroprevalence estimates and provide histopathological evidence supporting minimal contribution of HDV to liver carcinogenesis in Japan, contrasting sharply with patterns in hyperendemic regions. J. Med. Invest. 73 : 52-54, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"52-54"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of the Harmony Scale for Postpartum Couples for First-time Parents.","authors":"Keiko Iida, Mari Haku","doi":"10.2152/jmi.73.176","DOIUrl":"10.2152/jmi.73.176","url":null,"abstract":"<p><p>Transitioning from a dyadic to a triadic family structure after childbirth requires substantial adaptation to maintain relationship harmony. We develop and validate the Harmony Scale for Postpartum Couples (HSPC) to assess harmony among first-time parents. The scale development proceeded in three phases. In Study 1, a conceptual framework was established, and experts evaluated content and face validity. In Study 2, item analysis and exploratory factor analysis (EFA) were conducted to refine items and construct a preliminary scale. In Study 3, psychometric properties were examined using data from 376 participants (188 couples) with infants aged 3-6 months. EFA identified 15 items across four factors:[Intimacy with partner], [Physical・Social Health], [Mental Health], and [Self-Efficacy in Parenting]. The overall Cronbach's α for the scale was .825, indicating good internal consistency. Construct validity was supported by confirmatory factor analysis indices (GFI = .908, AGFI = .869, CFI = .880, RMSEA = .083). The final 15-items, four-factors HSPC demonstrated reliable and valid performance for evaluating couple harmony during the early postpartum period. This concise instrument provides comprehensive assessment of couple harmony, supports early identification of relational difficulties, and can inform targeted interventions to promote healthy family functioning, parental well-being, and infant health. J. Med. Invest. 73 : 176-185, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"176-185"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Significance of the geriatric nutrition risk index (GNRI) in colorectal cancer surgery patients.","authors":"Toshiaki Yoshimoto, Takuya Tokunaga, Toshihiro Nakao, Chie Takasu, Hideya Kashihara, Yuma Wada, Yukako Takehara, Katsuki Miyazaki, Masaaki Nishi","doi":"10.2152/jmi.73.101","DOIUrl":"10.2152/jmi.73.101","url":null,"abstract":"<p><strong>Background: </strong>Japan's aging population presents significant healthcare challenges, particularly in colorectal cancer care, where nutritional assessment is vital for improving outcomes. This study evaluated the prognostic value of the geriatric nutritional risk index (GNRI) in patients undergoing curative colorectal cancer surgery.</p><p><strong>Methods: </strong>We retrospectively analyzed 113 patients with stage II / III colorectal cancer who underwent curative surgery. Patients were categorized into GNRI Low (≤ 92) and High (> 92) groups. Clinicopathological characteristics, immunonutritional indicators, postoperative complications, and survival outcomes were compared.</p><p><strong>Results: </strong>The GNRI Low group (24.8%) had significantly older age, lower BMI, poorer ASA classification, frailty, and larger tumor size compared with the GNRI High group. Immunonutritional indicators, including albumin, CRP, NLR, and PNI, were also worse in the GNRI Low group. However, no significant difference in perioperative complications was observed between the groups. Five-year OS was 76.0% in GNRI Low versus 89.2% in GNRI High (p = 0.05), and 5-year DFS was 53.8% versus 74.2% (p = 0.04).</p><p><strong>Conclusion: </strong>Low GNRI was associated with poor prognosis in colorectal cancer patients, despite no increase in surgical complications. Preoperative nutritional assessment using GNRI may help identify high-risk patients and support targeted interventions. J. Med. Invest. 73 : 101-105, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"101-105"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eye Discomfort and Blurred Vision Preceding Oculomotor Nerve Palsy in a Warning Headache:A Case Report.","authors":"Shigeomi Yokoya, Hideki Oka","doi":"10.2152/jmi.73.257","DOIUrl":"10.2152/jmi.73.257","url":null,"abstract":"<p><p>Cerebral aneurysms can present with warning headaches before rupture or during minor leaks. Internal carotid artery-posterior communicating artery (IC-PC) aneurysms are among the few aneurysms for which the clinical observation of growth and associated symptoms is possible. Enlargement or morphological changes may worsen oculomotor nerve (ON) palsy, intensified headache, or orbital pain, indicating an impending rupture that requires urgent intervention. Notably, blurred vision with eye discomfort preceding ON palsy during impending rupture is rarely reported. Herein, we present a case highlighting this phenomenon. A 74-year-old woman with hypertension and migraines with aura presented with a 14-day history of gradual-onset left frontal headache. Despite the initial normal neurological findings and no evidence of subarachnoid hemorrhage on computed tomography, she later developed blurred vision and left eye discomfort without objective ON palsy. Her symptoms were initially attributed to migraines. Two days later, the patient developed ptosis and was diagnosed with complete ON palsy. Magnetic resonance angiography revealed a left IC-PC aneurysm, and urgent direct clipping confirmed rupture of the aneurysm. The patient recovered without complications. Blurred vision with eye discomfort during a warning headache may indicate early ON dysfunction and impending aneurysm rupture. Early recognition and vascular evaluation are crucial to prevent catastrophic outcomes. J. Med. Invest. 73 : 257-259, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"257-259"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiroki Sato, Saki Saijo, Kota Miyoshi, Masaki Terazawa, Shotaro Otani, Konomi Moriwaki, Kazuki Momota, Takuya Takashima, Toshiyuki Nunomura, Manabu Ishihara, Taiga Itagaki, Jun Oto
{"title":"Successful treatment for collagen vascular disease-related respiratory failure with inhaled nitric oxide as a bridging therapy:A case report.","authors":"Hiroki Sato, Saki Saijo, Kota Miyoshi, Masaki Terazawa, Shotaro Otani, Konomi Moriwaki, Kazuki Momota, Takuya Takashima, Toshiyuki Nunomura, Manabu Ishihara, Taiga Itagaki, Jun Oto","doi":"10.2152/jmi.73.270","DOIUrl":"10.2152/jmi.73.270","url":null,"abstract":"<p><strong>Background: </strong>Inhaled nitric oxide (iNO) is approved in Japan for perioperative pulmonary hypertension and persistent pulmonary hypertension in newborns;however, its role in non-cardiac respiratory failure is unclear.</p><p><strong>Case presentation: </strong>A 47-year-old woman with Sjögren's syndrome developed severe acute type I respiratory failure due to collagen vascular disease. Despite high-FIO2 ventilation, her PaO2/FIO2 ratio remained <80, and extracorporeal membrane oxygenation (ECMO) was considered. Administration of iNO at 10 ppm improved oxygenation, with a rapid increase in PaO2/FIO2 ratio. This response allowed time for steroid pulse therapy, rituximab, plasma exchange, and pleural drainage, which stabilized the patient's condition without ECMO. Notably, the temporal association between iNO initiation and rapid oxygenation improvement suggests that pulmonary vascular dysfunction was a major contributor to hypoxemia. Subsequent stabilization with immunosuppressive therapy highlights the role of iNO as a bridging therapy rather than a definitive treatment.</p><p><strong>Conclusion: </strong>In this case, iNO may have served as a bridging therapy, improving oxygenation until immunosuppressive treatment was effective. iNO may serve as a useful interim measure for avoiding ECMO in collagen vascular disease-associated respiratory failure, particularly when pulmonary hypertension is suspected. J. Med. Invest. 73 : 270-273, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"270-273"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Positive End-expiratory Pressure on Sevoflurane Washout Times from Anesthesia Workstations.","authors":"Yuki Ishikawa, Michiko Kinoshita, Katsuya Tanaka","doi":"10.2152/jmi.73.111","DOIUrl":"10.2152/jmi.73.111","url":null,"abstract":"<p><p>This study examined the effect of positive end-expiratory pressure (PEEP) on sevoflurane washout from anesthesia workstations using a test lung model. Two workstations (Perseus A500 and Carestation 650) were tested with fresh gas flows (FGF) of 2-8 L / min at PEEP levels of 0 and 8 cmH2O. Washout time was the interval for sevoflurane concentration to fall from 8% to 0%. In the Perseus A500, PEEP prolonged washout at 2 L / min (2562 [92] s vs. 2266 [17] s, p = 0.027), 4 L / min (1397 [36] s vs. 1275 [32] s, p = 0.012), and 6 L / min (756 [8] s vs. 533 [34] s, p = 0.006), but not at 8 L / min (115 [2] s vs. 113 [2] s, p = 0.23). In the Carestation 650, washout was prolonged at 2 L / min (5254 [229] s vs. 4447 [113] s, p = 0.013), 4 L / min (3597 [101] s vs. 2911 [230] s, p = 0.022), and 6 L / min (1816 [94] s vs. 1492 [115] s, p = 0.021), but not at 8 L / min (252 [3] s vs. 212 [35] s, p = 0.187). Our findings indicated that PEEP delayed anesthetic washout most at lower FGFs, which warrants caution in low-flow anesthesia. J. Med. Invest. 73 : 111-115, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"111-115"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aki Takahashi, Yukie Iwasa, Riitta Suhonen, Mika Ueta, Akemi Nakano, Naomi Hase, Miyuki Kawahara, Yukiyo Miki, Kozue Miki, Hidehiro Shibahashi, Hiroyo Shikone, Rie Manabe, Tomoko Sasai, Miki Yokota, Chikako Kane
{"title":"Development and Validation of the Japanese Version of the Individualized Care Scale-Nurse (JICS-Nurse).","authors":"Aki Takahashi, Yukie Iwasa, Riitta Suhonen, Mika Ueta, Akemi Nakano, Naomi Hase, Miyuki Kawahara, Yukiyo Miki, Kozue Miki, Hidehiro Shibahashi, Hiroyo Shikone, Rie Manabe, Tomoko Sasai, Miki Yokota, Chikako Kane","doi":"10.2152/jmi.73.121","DOIUrl":"10.2152/jmi.73.121","url":null,"abstract":"<p><strong>Background: </strong>Individualized nursing care is essential for patient-centered practice, yet few validated instruments exist in Japan for assessment from the nurse's perspective.</p><p><strong>Purpose: </strong>This study aimed to develop and validate the Japanese version of the Individualized Care Scale-Nurse (JICS-Nurse) in acute care hospitals.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted with nurses and midwives in Japan. Item analysis, exploratory and confirmatory factor analyses were performed. Internal consistency was assessed with Cronbach's alpha, test-retest reliability with Pearson's correlations and intraclass correlation coefficients (ICC), and concurrent validity with correlations to the Self-assessment Scale for Nursing Practice for Person-Centered Care (SSNP-PCC).</p><p><strong>Results: </strong>Valid responses from 536 of 705 invited participants were analyzed. A three-factor structure consistent with the original version was supported. CFA showed good fit for JICS-A and an overall acceptable fit for JICS-B, Internal consistency was high (α=.94), while test-retest reliability was moderate (ICC=.54 for JICS-A, .51 for JICS-B). Strong correlations with SSNP-PCC supported concurrent validity (r=.78 and r=.72;p<.001).</p><p><strong>Conclusions: </strong>The JICS-Nurse demonstrated reliability and validity and may be a useful tool for assessing individualized nursing care in Japanese acute care hospitals. J. Med. Invest. 73 : 121-128, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"121-128"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Full-endoscopic interspinous cleaning surgery for chronic low back pain associated with Baastrup's disease:a technical note and case series.","authors":"Yutaro Kanda, Ryota Mio, Fumiaki Makiyama, Kozaburo Mizutani, Masashi Kumon, Hiroshi Kageyama, Saori Soeda, Kosuke Sugiura, Masatoshi Morimoto, Hiroaki Manabe, Fumitake Tezuka, Kazuta Yamashita, Junzo Fujitani, Koichi Sairyo","doi":"10.2152/jmi.73.68","DOIUrl":"10.2152/jmi.73.68","url":null,"abstract":"<p><p>Chronic low back pain due to impingement of two adjacent spinous processes has been called Baastrup's disease. The diagnosis can be confirmed by interspinous infiltration of local anesthetic. However, little evidence regarding its pathology and treatment exists. Considering previous reports and our cases, three pathologies including impingement caused by contact between two adjacent spinous processes, inflammation and synovitis at the interspinous ligament, and inflammation and synovitis in the tissue surrounding the interspinous area are needed to be addressed. Conservative treatment with an interspinous steroid injection has been reported, as has surgery consisting of partial resection of the spinous processes or installation of an interspinous spacer. Thus, surgical strategy should include partial resection of the spinous processes causing impingement, removal of the interspinous inflammatory bursitis, and radiofrequency ablation of the surrounding tissue. Another surgical option that can achieve these strategies is a minimally invasive full-endoscopic procedure, which we refer to as \"full-endoscopic interspinous cleaning surgery.\" Briefly, the bony surface on the spinous processes is removed by the drill and the surrounding tissues are ablated using a bipolar radiofrequency device. This report describes the surgical technical presentation and the clinical outcomes for 3 cases based on the pathologies.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"68-73"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between subjective emotions and food choice behavior in the general Japanese population:An internet panel survey.","authors":"Mariko Nakamoto, Shoko Kawatake, Asuka Oda, Haruki Kunitomi, Akiko Nakamoto, Tohru Sakai","doi":"10.2152/jmi.73.241","DOIUrl":"10.2152/jmi.73.241","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to clarify the association between subjective emotions and food choice behavior in Japanese adults aged 18 years or older.</p><p><strong>Methods: </strong>Five hundred Japanese adults completed an online questionnaire. We collected data on the participants' characteristics, lifestyle, and changes in food group selection under normal conditions and six emotional states (anger, disgust, fear, happiness, sadness, and surprise). We calculated the dietary balance score (DBS) based on the frequency of intake for 10 food groups. Estimated mean DBS and intake frequency of its components during each emotional state were assessed using generalized estimating equations.</p><p><strong>Results: </strong>More than half of participants (59.6%) reported that their food selection usually changed according to their emotional state. The DBS score was lower in all six emotional states than in the normal state in both sexes. Sadness decreased intake frequency of the DBS components in both sexes. Additionally, the frequency of confectionery and beverage intake during happiness increased compared to the normal state in both sexes. Conversely, the frequency of confectionery intake during sadness decreased compared to the normal state in both sexes.</p><p><strong>Conclusion: </strong>Emotions, especially sadness and happiness, may affect the frequency of food group intake and dietary balance in Japanese adults. J. Med. Invest. 73 : 241-250, February, 2026.</p>","PeriodicalId":46910,"journal":{"name":"JOURNAL OF MEDICAL INVESTIGATION","volume":"73 1.2","pages":"241-250"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}