{"title":"Improving Biocompatibility and Mechanical Properties of Titanium Implants in Orthopedic Surgeries: The Role of Machining Depth in Enhancing Surface Interaction with Bone Tissue.","authors":"Sayyed Mohammadreza Sedehi, Mohammadreza Farahani","doi":"10.22038/ABJS.2025.83963.3830","DOIUrl":"10.22038/ABJS.2025.83963.3830","url":null,"abstract":"<p><strong>Objectives: </strong>This study comprehensively examined the influence of cutting depth during dry milling on the structural, mechanical, and biocompatibility characteristics of commercially pure titanium. The primary objective was to evaluate how variations in cutting depth can alter the crystallite size, microstrain, and wear resistance, as well as to investigate their correlation with essential biocompatibility parameters including cellular interactions, osteointegration potential, and corrosion resistance in a simulated body fluid environment. Understanding these interrelations is crucial for improving the overall performance of titanium implants used in biomedical applications.</p><p><strong>Methods: </strong>Pure titanium specimens were precisely machined at cutting depths of 0.1, 0.2, and 0.3 mm under dry conditions, ensuring that all other machining parameters remained constant. The structural characteristics were analyzed using X-ray diffraction to determine crystallite size and microstrain variations. Wear resistance was evaluated through sliding wear tests that quantified material loss, while biocompatibility performance was assessed via immersion tests in simulated body fluid. This evaluation included corrosion resistance measurements, quantification of calcium-phosphate deposition on the surface, and analysis of the initial interactions with osteoblast-like cells to determine cellular affinity and bioactivity.</p><p><strong>Results: </strong>The experimental results indicated that increasing the cutting depth led to a significant reduction in crystallite size (28, 50, and 25 nm for 0.1, 0.2, and 0.3 mm, respectively) and a corresponding increase in microstrain (0.0011, 0.0011, and 0.009). Specimens machined at cutting depths of 0.2 and 0.3 mm exhibited superior wear resistance, with lower weight losses (7.9 and 5.3 mg) compared with the 0.1 mm specimen (12.1 mg). Biocompatibility assessments revealed that higher cutting depths enhanced corrosion resistance, promoted calcium-phosphate deposition, and improved osteointegration potential.</p><p><strong>Conclusion: </strong>optimizing the cutting depth to 0.2-0.3 mm during dry milling can substantially improve both mechanical performance and biocompatibility, offering valuable guidance for implant manufacturing and long-term in vivo functionality.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 3","pages":"212-221"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afsaneh Jahani, Mohammad H Ebrahimzadeh, Ali Moradi, Fatemeh Kalalinia, Nafiseh Jirofti
{"title":"Current Concept of Bioactive Glass-loaded 3D-Printed Alginate-based Scaffolds for Bone Tissue Engineering Applications.","authors":"Afsaneh Jahani, Mohammad H Ebrahimzadeh, Ali Moradi, Fatemeh Kalalinia, Nafiseh Jirofti","doi":"10.22038/ABJS.2026.95002.4274","DOIUrl":"10.22038/ABJS.2026.95002.4274","url":null,"abstract":"<p><p>Bone is a mineralized connective tissue composed of osteoblasts, osteocytes, and osteoclasts, and its integrity is essential for structural and physiological function. Defects arising from trauma, tumors, or developmental abnormalities often require surgical reconstruction to restore normal performance. Autografts and allografts have long served as standard treatments for bone repair, however, their usefulness is restricted by limited availability, donor‑site complications, and the potential transmission of underlying diseases. These challenges have accelerated interest in bone tissue engineering (BTE) as an alternative strategy capable of enhancing regeneration while reducing postoperative risks. Advances in three‑dimensional (3D) printing have introduced powerful technique for fabrication of scaffolds with precisely controlled architectures and tunable mechanical and biological characteristics. This technology enables the creation of porous constructs that mimic the structural complexity of native bone, supporting cell infiltration, nutrient transport, and vascularization. Effective scaffolds for BTE must demonstrate biocompatibility, biodegradability, appropriate strength and stiffness, and the ability to promote osteogenesis and angiogenesis. Among natural polymers, alginate (Alg) has become a prominent candidate due to its inherent biocompatibility, degradability, abundance, low cost, and non‑immunogenic nature. Its versatility makes it suitable for developing customized 3D‑printed scaffolds. Additionally, bioactive glasses (BGs) are widely incorporated into composite scaffolds because their composition closely resembles the mineral phase of bone. BGs significantly enhance osteoconductivity, support mineral deposition, and can improve the mechanical resilience of polymer-based constructs. This review highlights recent progress in 3D‑printed Alg-based scaffolds for BTE, emphasizing how advanced fabrication techniques and BGs incorporation contribute to improved biological performance and structural reinforcement.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 6","pages":"380-386"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bone Fractures in People with Hemophilia.","authors":"E Carlos Rodriguez-Merchan","doi":"10.22038/ABJS.2025.85841.3907","DOIUrl":"10.22038/ABJS.2025.85841.3907","url":null,"abstract":"<p><p>The existing literature on bone fractures in people with hemophilia (PWH) states that they should be treated in the same way as in healthy individuals but with perioperative hemostasis control through intravenous infusion of the deficient coagulation factor (factor VIII in hemophilia A, factor IX in hemophilia B) at appropriate doses and for the necessary duration. It has also been found that fractures in PWH are more frequent than in normal individuals, probably due to suffering from osteoporosis. The healing time for fractures in PWH is similar to that of the general population. It should be noted that some fractures in PWH are pathological due to the presence of hemophilic pseudotumors that cause erosion of the affected bone. These fractures should also be treated as pathological fractures of any other etiology. Finally, the risk of acute compartment syndrome associated with bone fractures in PWH should never be forgotten.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 6","pages":"408-416"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Circumstances that Increase the Risk of Periprosthetic Joint Infection after Total Knee Arthroplasty.","authors":"E Carlos Rodriguez-Merchan","doi":"10.22038/ABJS.2025.91512.4145","DOIUrl":"10.22038/ABJS.2025.91512.4145","url":null,"abstract":"","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 3","pages":"167-169"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147933736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postoperative Outcomes of Total Knee Arthroplasty in Patients with Alcohol Use Disorders: A Retrospective Propensity-Matched Analysis.","authors":"Christopher Allender, Yida Liu, Senthil Sambandam","doi":"10.22038/ABJS.2026.90939.4121","DOIUrl":"10.22038/ABJS.2026.90939.4121","url":null,"abstract":"<p><strong>Objectives: </strong>Alcohol use disorder (AUD) has been associated with post-surgical complications, but previous studies were limited by national, single-database sources. The purpose of this study was to characterize differences in complications of matched cohorts of patients with versus without AUD undergoing primary total knee arthroplasty (TKA) and to evaluate the effect of AUD-associated comorbidities on the hazard of post-operative complications.</p><p><strong>Methods: </strong>A total of 6,634 patients were extracted from the TriNetX global database for patients undergoing primary TKA from 2015-2025. Univariate analysis was performed to examine the relationship between AUD and postoperative complications. A subgroup analysis was performed using the TKA/AUD cohort with surgical complications compared to AUD patients without surgical complications. Cox proportional hazards modeling evaluated the impact of comorbidities and pre-operative labs on the hazard of post-operative complications.</p><p><strong>Results: </strong>Patients with AUD had a significantly higher risk of acute renal failure, respiratory failure, delirium, transfusion, joint infection, wound dehiscence, superficial skin and soft tissue infection, infection following procedure, periprosthetic fracture around the knee joint, and revision arthroplasty. The cohort of TKA/AUD patients with surgical complications had a significantly higher percentage of diabetes, tobacco use, essential hypertension, depression, anxiety, bipolar disorder, and atrial fibrillation than the cohort without surgical complications. These patients also had significantly lower preoperative hemoglobin, albumin, and alanine aminotransferase (ALT), and a higher international normalized ratio (INR) than patients without complications. The Cox proportional hazards model showed a significantly increased hazard of post-operative complications for hypertension, hemoglobin of 6 - 10 g/dL, and albumin of 2.5 - 3 g/dL in a cohort of patients with AUD.</p><p><strong>Conclusion: </strong>AUD has a significant effect on both medical and surgical complications following primary TKA at 30 days, 90 days, 1 year, and 5 years post-operatively. Certain preoperative labs can predict the risk of postoperative complications. This data supports a multidisciplinary approach to optimize care for high-risk individuals.</p><p><strong>Level of evidence: </strong>III.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 9","pages":"607-615"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unicompartmental Knee Arthroplasty: Mobile-bearing or Fixed-bearing?","authors":"Rodriguez-Merchan E Carlos","doi":"10.22038/ABJS.2025.91153.4129","DOIUrl":"10.22038/ABJS.2025.91153.4129","url":null,"abstract":"","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 2","pages":"88-89"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lessons Learned from the Certified Mulligan Concept® Practitioner Exam.","authors":"Mohammadreza Pourahmadi, Ismail Ebrahimi Takamjani","doi":"10.22038/abjs.2026.94131.4243","DOIUrl":"10.22038/abjs.2026.94131.4243","url":null,"abstract":"<p><p>The Mulligan Concept® is taught worldwide through structured courses that aim to equip physical therapists with hands-on techniques to enhance movement and alleviate pain in individuals with musculoskeletal disorders. To obtain certification as a Certified Mulligan Concept® Practitioner (CMP), participants are required to successfully complete a formal examination following course completion. This paper outlines the essential information and preparatory considerations that candidates should be aware of prior to undertaking the certification examination.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 2","pages":"154-158"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammadreza Razzaghof, Sina Esmaeili, Mehdi Rezaee, Masoud Kazemifard, Ghasem Daneshgar, Sm Javad Mortazavi
{"title":"Cross-Cultural Adaptation, Validity, and Reliability of the Persian Translation of the Merle d'Aubigné-Postel Score.","authors":"Mohammadreza Razzaghof, Sina Esmaeili, Mehdi Rezaee, Masoud Kazemifard, Ghasem Daneshgar, Sm Javad Mortazavi","doi":"10.22038/ABJS.2026.90335.4097","DOIUrl":"10.22038/ABJS.2026.90335.4097","url":null,"abstract":"<p><strong>Objectives: </strong>The Merle d'Aubigné--Postel (MDP) score is a widely used patient-reported outcome measure (PROM) for assessing hip function for pain, walking ability, and mobility. Despite its widespread international use, no validated Persian version has been available to date. This study aimed to translate and culturally adapt the MDP score into Persian and evaluate its reliability and validity in Persian-speaking patients undergoing total hip arthroplasty (THA).</p><p><strong>Methods: </strong>Following Guillemin et al. guidelines, Persian translation was done using a forward--backward process, followed by expert review and pretesting with 20 patients to ensure clarity and cultural relevance. The adapted instrument was validated in 103 Persian-speaking patients who had undergone THA with at least one year of follow-up. Internal consistency (Cronbach's alpha), test--retest reliability (intraclass correlation coefficient [ICC]), construct validity (correlation with the Harris Hip Score [HHS]), criterion validity (correlation with HHS and the Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), and content validity (floor and ceiling effects) were evaluated. Inter-rater reliability for mobility was assessed by three orthopedic residents.</p><p><strong>Results: </strong>The Persian MDP score demonstrated high internal consistency (α= 0.74) and excellent test--retest reliability (ICC= 0.95; 95%CI: 0.91--0.98). Inter-rater reliability for mobility was excellent (ICC= 0.89; 95%CI: 0.82--0.94). Construct validity was supported by strong domain-specific correlations (e.g., MDP pain vs. HHS pain: r= 0.73; 95%CI: 0.62--0.81). Criterion validity was confirmed by strong correlations with WOMAC (r= 0.745; 95%CI: 0.65--0.82) and HHS (r= 0.753; 95%CI: 0.66--0.83). Content validity showed no floor effect (0%) and an acceptable ceiling effect (14.5%).</p><p><strong>Conclusion: </strong>The Persian MDP score is a valid and reliable instrument for assessing outcomes after THA in Persian-speaking patients. Its simplicity and strong psychometric properties support its use in clinical and research settings. However, the observed ceiling effect should be considered for excellent postoperative outcomes.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 8","pages":"518-526"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Double Nerve Transfer Versus Triple Nerve Transfer for Elbow Flexion Restoration in C5-C6 Traumatic Brachial Plexus Injuries.","authors":"Reza Shahryar Kamrani, Mohammadreza Hozhabrbayan, Kasra Mirzaei, Hesam Alitaleshi, Dorsa Ghorban Sarvi, Shervin Mossavarali","doi":"10.22038/ABJS.2025.87587.3964","DOIUrl":"10.22038/ABJS.2025.87587.3964","url":null,"abstract":"<p><strong>Objectives: </strong>This preliminary study compares two nerve transfer techniques for restoring elbow function in patients with C5-C6 brachial plexus injuries. The double nerve transfer (Oberlin II) involves the transfer of fascicles from the ulnar and median nerves to the biceps and brachialis muscles. In contrast, the triple nerve transfer (Oberlin III) includes an additional transfer from the radial nerve to the brachioradialis muscle.</p><p><strong>Methods: </strong>Nine patients with C5-C6 traumatic brachial plexus injuries were included in the study and followed for five years after nerve transfer surgery. Four patients underwent the Oberlin III technique, while five received the Oberlin II procedure. Outcomes assessed included the range of motion in the elbow and shoulder joints, hand grip strength, elbow flexion strength, elbow flexion velocity, and brachioradialis muscle bulk.</p><p><strong>Results: </strong>All patients achieved an MRC grade of 4 for elbow flexion strength. Brachioradialis muscle bulk was recovered in the Oberlin III group, which also demonstrated a higher elbow flexion velocity (P = 0.032). Additionally, higher mean values were observed in the Oberlin III group for elbow flexion strength (in both supination and pronation) and QuickDASH scores. However, no statistically significant differences were found for these outcomes.</p><p><strong>Conclusion: </strong>The Oberlin III technique was associated with the recovery of brachioradialis muscle bulk and improved elbow flexion velocity. These preliminary findings suggest potential functional benefits, highlighting the need for further investigation in larger cohorts.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 3","pages":"179-184"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikolaos E Koukoulias, Evangelia Germanou, Dimitris Koukoulias
{"title":"No Risk of Tunnel Convergence in Combined ACL Reconstruction and Transtibial Lateral Meniscus Posterior Root Tear Repair. A Technical Note.","authors":"Nikolaos E Koukoulias, Evangelia Germanou, Dimitris Koukoulias","doi":"10.22038/abjs.2025.88483.4013","DOIUrl":"10.22038/abjs.2025.88483.4013","url":null,"abstract":"<p><p>Lateral meniscus posterior root tears are frequently identified during anterior cruciate ligament reconstruction. These tears are associated with increased knee instability and altered biomechanics in knees deficient in the anterior cruciate ligament, leading to potential cartilage degeneration and compromised graft function if left untreated. Repairing lateral meniscus posterior root tears during anterior cruciate ligament reconstruction improves knee stability and biomechanics, while also yielding better patient-reported outcomes. The transtibial pullout technique is a popular and reliable method for repairing lateral meniscus posterior root tears. However, it poses a substantial risk of tibial tunnel convergence, which may complicate the surgery and compromise the clinical result. We describe a simple and reproducible technique that enables anatomic anterior cruciate ligament reconstruction and lateral meniscus posterior root tear repair with no risk of tibial tunnel convergence.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":"14 3","pages":"222-227"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}