Lancet Microbe最新文献

{"title":"COVID-19 origins: plain speaking is overdue","authors":"","doi":"10.1016/j.lanmic.2024.07.016","DOIUrl":"10.1016/j.lanmic.2024.07.016","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666524724002064/pdfft?md5=c0f0f7fd2139af6b8894a66faec7c0c2&pid=1-s2.0-S2666524724002064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the entire landscape of antifungal immune response to COVID-19-associated pulmonary aspergillosis","authors":"","doi":"10.1016/S2666-5247(24)00076-4","DOIUrl":"10.1016/S2666-5247(24)00076-4","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666524724000764/pdfft?md5=0472ccbd03a7b4794ebc2450285def10&pid=1-s2.0-S2666524724000764-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity and safety of beta variant COVID-19 vaccine AZD2816 and AZD1222 (ChAdOx1 nCoV-19) as primary-series vaccination for previously unvaccinated adults in Brazil, South Africa, Poland, and the UK: a randomised, partly double-blinded, phase 2/3 non-inferiority immunobridging study","authors":"","doi":"10.1016/S2666-5247(24)00078-8","DOIUrl":"10.1016/S2666-5247(24)00078-8","url":null,"abstract":"<div><h3>Background</h3><p>AZD2816 is a variant-adapted COVID-19 vaccine that expresses the full-length SARS-CoV-2 beta variant spike protein but is otherwise similar to AZD1222 (ChAdOx1 nCoV-19). This study aimed to evaluate the safety and immunogenicity of AZD1222 or AZD2816 (or both) primary-series vaccination in a cohort of adult participants who were previously unvaccinated.</p></div><div><h3>Methods</h3><p>In this phase 2/3, randomised, multinational, active-controlled, non-inferiority, immunobridging study, adult participants previously unvaccinated for COVID-19 were enrolled at 16 study sites in Brazil, South Africa, Poland, and the UK. Participants were stratified by age, sex, and comorbidity and randomly assigned 5:5:5:2 to receive a primary series of AZD1222 (AZD1222 group), AZD2816 (AZD2816 [4-week] group), or AZD1222-AZD2816 (AZD1222-AZD2816 group) at 4-week dosing intervals, or AZD2816 at a 12-week interval (AZD2816 [12-week] group) and evaluated for safety and immunogenicity through 180 days after dose 2. Primary outcomes were safety (rates of solicited adverse events occurring during 7 days and unsolicited adverse events occurring during 28 days after each dose) and immunogenicity (non-inferiority of pseudovirus neutralising antibody geometric mean titre [GMT], GMT ratio margin of 0·67, and seroresponse rate, rate difference margin of –10%, recorded 28 days after dose 2 with AZD2816 [4-week interval] against beta <em>vs</em> AZD1222 against ancestral SARS-CoV-2) in participants who were seronegative at baseline. This trial is registered with ClinicalTrials.gov, <span><span>NCT04973449</span><svg><path></path></svg></span>, and is completed.</p></div><div><h3>Findings</h3><p>Between July 7 and Nov 12, 2021, 1449 participants were assigned to the AZD1222 group (n=413), the AZD2816 (4-week) group (n=415), the AZD1222-AZD2816 group (n=412), and the AZD2816 (12-week) group (n=209). Ten (2·6%) of 378 participants who were seronegative at baseline in the AZD1222 group, nine (2·4%) of 379 in the AZD2816 (4-week) group, eight (2·1%) of 380 in the AZD1222-AZD2816 group, and 11 (5·8%) of 191 in the AZD2816 (12-week) group had vaccine-related unsolicited adverse events. Serious adverse events were recorded in one (0·3%) participant in the AZD1222 group, one (0·3%) in the AZD2816 (4-week) group, two (0·5%) in the AZD1222-AZD2816 group, and none in the AZD2816 (12-week) group. Co-primary immunogenicity endpoints were met: neutralising antibody GMT (ratio 1·19 [95% CI 1·08–1·32]; lower bound greater than 0·67) and seroresponse rate (difference 1·7% [–3·1 to 6·5]; lower bound greater than –10%) at 28 days after dose 2 were non-inferior in the AZD2816 (4-week) group against beta versus in the AZD1222 group against ancestral SARS-CoV-2. Seroresponse rates were highest with AZD2816 against beta (12-week interval 94·3% [95% CI 89·4–97·3]; 4-week interval 85·7% [81·5–89·2]) and with AZD1222 (84·6% [80·3–88·2]) against ancestral SARS-CoV-2.</p></div><d","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666524724000788/pdfft?md5=ee743bc27f7f5c27b492e984497667b8&pid=1-s2.0-S2666524724000788-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of large language models in fighting emerging outbreaks: lights and shadows.","authors":"Alberto Rizzo, Enrico Mensa, Andrea Giacomelli","doi":"10.1016/j.lanmic.2024.07.017","DOIUrl":"https://doi.org/10.1016/j.lanmic.2024.07.017","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bedaquiline: what might the future hold?","authors":"Emily S Shaw, Neil G Stoker, Jessica L Potter, Helgard Claassen, Alasdair Leslie, Conor D Tweed, Chen-Yuan Chiang, Francesca Conradie, Hanif Esmail, Christoph Lange, Lancelot Pinto, Oxana Rucsineanu, Derek J Sloan, Grant Theron, Phumeza Tisile, Teck Chuan Voo, Robin M Warren, Limakatso Lebina, Marc Lipman","doi":"10.1016/S2666-5247(24)00149-6","DOIUrl":"https://doi.org/10.1016/S2666-5247(24)00149-6","url":null,"abstract":"<p><p>Tuberculosis drug development has stagnated for decades, so the recent availability of bedaquiline is welcome. Bedaquiline-containing regimens, now the first-line therapy recommended by WHO, have transformed the treatment of drug-resistant tuberculosis, offering safer and more effective oral treatment options. However, key obstacles need to be overcome to ensure global access and prevent the rapid development of resistance against this promising class of drugs. In this Personal View, building on an international workshop held in 2023, we evaluate the current evidence and suggest possible ways forward, recognising the tension between increasing use and slowing the rise of resistance. We also discuss problems in accessing bedaquiline-containing regimens, the potential widening of their use beyond drug-resistant tuberculosis, and lessons for utilising new drugs as they are developed.</p>","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing epidemiological patterns in human avian influenza virus infections.","authors":"Mei Kang, Hai-Peng Li, Jia Tang, Xin-Yu Wang, Li-Fang Wang, Guy Baele, Jia-Tao Lou, Philippe Lemey, Shuo Su","doi":"10.1016/S2666-5247(24)00158-7","DOIUrl":"https://doi.org/10.1016/S2666-5247(24)00158-7","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropouche fever outbreak in Brazil: an emerging concern in Latin America.","authors":"Ranjit Sah, Shriyansh Srivastava, Sachin Kumar, Pougang Golmei, Sk Abdul Rahaman, Rachana Mehta, Carolina Ferraz, Vasso Apostolopoulos, Alfonso J Rodriguez-Morales","doi":"10.1016/S2666-5247(24)00136-8","DOIUrl":"https://doi.org/10.1016/S2666-5247(24)00136-8","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for high-resolution observational cohort studies to understand the natural history of tuberculosis.","authors":"Leyla Larsson, Claire J Calderwood, Rishi K Gupta, Celso Khosa, Katharina Kranzer","doi":"10.1016/S2666-5247(24)00140-X","DOIUrl":"https://doi.org/10.1016/S2666-5247(24)00140-X","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-assisted HIV case finding in Ukraine","authors":"Ed Holt","doi":"10.1016/S2666-5247(24)00077-6","DOIUrl":"10.1016/S2666-5247(24)00077-6","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666524724000776/pdfft?md5=8f8ef2d1ec8d4b344de040e9ab239b00&pid=1-s2.0-S2666524724000776-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of IncX3 plasmids in bacteria","authors":"Yu Feng ,&nbsp;Zhiyong Zong","doi":"10.1016/S2666-5247(24)00050-8","DOIUrl":"10.1016/S2666-5247(24)00050-8","url":null,"abstract":"","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":null,"pages":null},"PeriodicalIF":20.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666524724000508/pdfft?md5=7085591cb8c809410aada0ecaf4c31fd&pid=1-s2.0-S2666524724000508-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}