Lancet Microbe最新文献_第5页

Transmission of SARS-CoV-2 in patients receiving antiviral treatment for COVID-19. 接受抗病毒治疗的COVID-19患者中SARS-CoV-2的传播

IF 20.4 1区生物学

Lancet Microbe Pub Date : 2026-03-19 DOI: 10.1016/j.lanmic.2026.101402

Daniel Pan, Ji Soo Choi, Christopher A Martin, Joshua Nazareth, Laura B Nellums, Benjamin J Cowling, Manish Pareek

引用次数: 0

Neonatal sepsis in Africa: what are we missing? 非洲新生儿败血症：我们错过了什么？

IF 20.4 1区生物学

Lancet Microbe Pub Date : 2026-03-18 DOI: 10.1016/j.lanmic.2026.101374

Luria Leslie Founou, Raspail Carrel Founou, Esmita Charani, Noella Gwanyama, Angela Dramowski, Nicholas Feasey

{"title":"Neonatal sepsis in Africa: what are we missing?","authors":"Luria Leslie Founou, Raspail Carrel Founou, Esmita Charani, Noella Gwanyama, Angela Dramowski, Nicholas Feasey","doi":"10.1016/j.lanmic.2026.101374","DOIUrl":"https://doi.org/10.1016/j.lanmic.2026.101374","url":null,"abstract":"Neonatal sepsis remains one of the most pressing public health challenges in Africa, threatening progress towards the UN Sustainable Development Goal target 3.2 of reducing neonatal mortality to 12 deaths or less per 1000 livebirths. Beyond the well recognised barriers to diagnosis, treatment, and prevention, additional and often overlooked determinants, including sociocultural norms, fragmented health systems, inequities in care, and low political will, continue to stall progress and sustain unacceptably high mortality rates. Antimicrobial-resistant infections further compound this crisis: neonatal sepsis has become a prime example of antimicrobial resistance in Africa, where neonates are at disproportionate risk. Without urgent context-appropriate actions, the region will continue to carry the greatest burden of preventable neonatal deaths. In this Personal View, we assess the growing threat of antimicrobial-resistant neonatal sepsis in Africa, identify priority health-care and health-system gaps, and appraise evidence-based interventions that remain underimplemented. We argue that political inaction and systemic neglect are the central drivers of this crisis and that sustainable progress requires a shift towards a community-centred One Health approach that integrates biomedical, environmental, and sociocultural dimensions of care. Only by uniting global and local leadership and by tailoring strategies to the diverse realities across African countries can progress be accelerated towards ending preventable neonatal deaths and a better future for all.","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":" ","pages":"101374"},"PeriodicalIF":20.4,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinically dominant AbST23 iuc3 plasmids are widespread in animal-derived Klebsiella pneumoniae. 临床上占优势的AbST23 iuc3质粒广泛存在于动物源性肺炎克雷伯菌中。

IF 20.4 1区生物学

Lancet Microbe Pub Date : 2026-03-17 DOI: 10.1016/j.lanmic.2026.101398

Qiaojun Wang, Changlong Sun, Edward J Feil, Zhiqiang Wang, Ruichao Li

引用次数: 0

The diagnostic void: how typhoid-by-default drives antimicrobial resistance in Ethiopia. 诊断空白：伤寒如何在埃塞俄比亚引发抗菌素耐药性。

IF 20.4 1区生物学

Lancet Microbe Pub Date : 2026-03-16 DOI: 10.1016/j.lanmic.2026.101363

Balew Arega, Asnake Agunie, Ayelign Derebe

{"title":"The diagnostic void: how typhoid-by-default drives antimicrobial resistance in Ethiopia.","authors":"Balew Arega, Asnake Agunie, Ayelign Derebe","doi":"10.1016/j.lanmic.2026.101363","DOIUrl":"https://doi.org/10.1016/j.lanmic.2026.101363","url":null,"abstract":"The empirical diagnosis of typhoid-by-default represents a severe failure in Ethiopia's management of febrile illnesses. This practice of diagnosing undifferentiated fever as typhoid without confirmation drives antimicrobial resistance (AMR) through a unique diagnostic ecosystem shaped by historical precedent, systemic constraints, community demand, and reliance on the outdated Widal test. This diagnostic void promotes empirical use of broad-spectrum antibiotics, selecting for resistant Salmonella enterica serotype Typhi, while contributing to the spread of AMR in commensal organisms and other pathogens. This practice contributes to a broader AMR crisis that extends beyond enteric fever, compromising the treatment of urinary, respiratory, and other common infections. The result is a self-perpetuating cycle of multisystem treatment failures, excess mortality, and economic loss. In this Personal View, we discuss the steps required to break this cycle: eliminating the Widal test, implementing validated diagnostic algorithms for febrile presentation, expanding diagnostic access, introducing typhoid vaccines, and establishing antimicrobial stewardship programmes. Addressing this issue is an urgent public health priority for both national and global AMR containment.","PeriodicalId":46633,"journal":{"name":"Lancet Microbe","volume":" ","pages":"101363"},"PeriodicalIF":20.4,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming structural barriers to tuberculosis treatment in Africa through digital technologies. 通过数字技术克服非洲结核病治疗的结构性障碍。

IF 20.4 1区生物学

Lancet Microbe Pub Date : 2026-03-13 DOI: 10.1016/j.lanmic.2026.101399

Tsegahun Manyazewal, Russell R Kempker, Zelalem Temesgen, Catherine Orrell, Esther Ngadaya, Angella Musiimenta, Lilian N Njagi, Priashni Subrayen, Yimtubezinash Woldeamanuel, Hussen Mohammed, Abebaw Fekadu, Melanie J Newport, Vincent C Marconi

引用次数: 0

Genetic platforms, bacterial hosts, and ecological contexts enable emergence and restrict dissemination of non-epidemic acquired carbapenemases. 遗传平台、细菌宿主和生态环境使非流行病获得性碳青霉烯酶的出现和传播受到限制。

IF 20.4 1区生物学

Lancet Microbe Pub Date : 2026-03-13 DOI: 10.1016/j.lanmic.2026.101396

João Pedro Rueda Furlan, Fábio Parra Sellera, Eliana Guedes Stehling, Yawen Yu, Zhi Ruan

引用次数: 0

Brazil develops and rolls out single-dose dengue vaccine. 巴西开发并推出单剂登革热疫苗。

IF 20.4 1区生物学

Lancet Microbe Pub Date : 2026-03-11 DOI: 10.1016/j.lanmic.2026.101387

Manjulika Das

引用次数: 0

Biosafety without borders: bridging the capacity gap in resource-limited laboratory settings. 无国界的生物安全：弥合资源有限的实验室环境中的能力差距。