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Applied Biochemistry and Biotechnology最新文献

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UCHL3 Promotes Triple-Negative Breast Cancer Metastatic Potential Through Enhancing Cell Migration and Invasion. UCHL3通过增强细胞迁移和侵袭促进三阴性乳腺癌转移潜能。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-07 DOI: 10.1007/s12010-026-05645-6
Qi Xu, Wenli Yang, Chengxia Li, Mao Yang, Xianyu Zhu, Wenjun Wang, Yan Lin, Zhonglin Gan, Tao He, Xiaoping Wu, Xuesen Li
{"title":"UCHL3 Promotes Triple-Negative Breast Cancer Metastatic Potential Through Enhancing Cell Migration and Invasion.","authors":"Qi Xu, Wenli Yang, Chengxia Li, Mao Yang, Xianyu Zhu, Wenjun Wang, Yan Lin, Zhonglin Gan, Tao He, Xiaoping Wu, Xuesen Li","doi":"10.1007/s12010-026-05645-6","DOIUrl":"https://doi.org/10.1007/s12010-026-05645-6","url":null,"abstract":"<p><p>Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3), a key deubiquitinating enzyme of the UCH family, has been implicated in DNA repair in breast cancer; however, its role in regulating cell migration and invasion in triple-negative breast cancer (TNBC) remains poorly understood. The expression pattern of UCHL3 across breast cancer subtypes was analyzed using TCGA data. In TNBC cells, UCHL3 mRNA levels were quantified by qRT-PCR, while its protein expression and epithelial-mesenchymal transition (EMT) markers (Vimentin, N-cadherin, SNAIL, E-cadherin, α-SMA, TWIST) were assessed by Western blot. Functional assays included: MTT and EdU incorporation assays for proliferation; wound healing and Transwell migration assays for migratory capacity. Transcriptomic changes induced by UCHL3 knockdown were profiled via RNA sequencing. Additionally, an in vivo mice model was used to evaluate the pro-invasive effects of UCHL3 overexpression in TNBC. UCHL3 was significantly overexpressed in TNBC and correlated with poor patient prognosis. Functional studies revealed that UCHL3 enhances the proliferative capacity of TNBC cells. Furthermore, UCHL3 was demonstrated to promote TNBC cell migration and invasion through modulation of epithelial-mesenchymal transition (EMT) markers. Mechanistically, knockdown of UCHL3 attenuated activation of invasion- and migration-related signaling pathways in TNBC cells. Pharmacological inhibition of UCHL3 effectively suppressed TNBC cell migration and invasion in vitro. In vivo studies further confirmed that UCHL3 overexpression drives metastatic progression of TNBC in mice. UCHL3 is significantly upregulated in TNBC and drives tumor progression by promoting cell proliferation and activating EMT-mediated migration and invasion. These findings identify UCHL3 as a potential therapeutic target for TNBC treatment.</p>","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the Anti-inflammatory Effects of a Delivery System Based on Alginate Hydrogels Enriched with Bioactive Compounds from Marine Sponge Dysidea robusta. 富海绵体藻酸盐水凝胶的抗炎作用分析。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-06 DOI: 10.1007/s12010-026-05684-z
Homero Garcia-Motta, Cintia Cristina Santi Martignago, Mirian Bonifacio, Dalete Christine da Silva Souza, Lais Caroline Souza-Silva, Beatriz Soares-Silva, Anabella Patricia Rosso, Isabelly Bertochi Veroneze, Marcelo Assis, Fernando Carlos Giacomelli, Sandra Andrea Cruz, João Henrique Ghilardi Lago, Renata Granito, Lívia Assis, Alessandra Mussi Ribeiro, Ana Claudia Muniz Rennó
{"title":"Analysis of the Anti-inflammatory Effects of a Delivery System Based on Alginate Hydrogels Enriched with Bioactive Compounds from Marine Sponge Dysidea robusta.","authors":"Homero Garcia-Motta, Cintia Cristina Santi Martignago, Mirian Bonifacio, Dalete Christine da Silva Souza, Lais Caroline Souza-Silva, Beatriz Soares-Silva, Anabella Patricia Rosso, Isabelly Bertochi Veroneze, Marcelo Assis, Fernando Carlos Giacomelli, Sandra Andrea Cruz, João Henrique Ghilardi Lago, Renata Granito, Lívia Assis, Alessandra Mussi Ribeiro, Ana Claudia Muniz Rennó","doi":"10.1007/s12010-026-05684-z","DOIUrl":"https://doi.org/10.1007/s12010-026-05684-z","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paris Saponin VII Inhibits Ferroptosis through USP7/SLC7A11 to Alleviate Metabolic-associated Fatty Liver Disease in Rats. 巴黎皂苷VII通过USP7/SLC7A11抑制铁沉，减轻大鼠代谢相关脂肪肝疾病
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-06 DOI: 10.1007/s12010-026-05656-3
Wei Liu, Xiangfang Li, Chunhai Hu, Huangyan Zhang, Yuqian Wu, Zongqiang Hu
{"title":"Paris Saponin VII Inhibits Ferroptosis through USP7/SLC7A11 to Alleviate Metabolic-associated Fatty Liver Disease in Rats.","authors":"Wei Liu, Xiangfang Li, Chunhai Hu, Huangyan Zhang, Yuqian Wu, Zongqiang Hu","doi":"10.1007/s12010-026-05656-3","DOIUrl":"https://doi.org/10.1007/s12010-026-05656-3","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and Validation of the Breast Cancer Diagnostic Biomarker SVEP1 and Its Relationship With CD8 + T Cell Activation Using Bioinformatics and Machine Learning. 利用生物信息学和机器学习技术鉴定和验证乳腺癌诊断生物标志物SVEP1及其与CD8 + T细胞活化的关系。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-02 DOI: 10.1007/s12010-026-05676-z
Yaojun Song, Baoya Wang, Shanshan Liu, Wenjuan Yan, Yanru Fan
{"title":"Identification and Validation of the Breast Cancer Diagnostic Biomarker SVEP1 and Its Relationship With CD8 + T Cell Activation Using Bioinformatics and Machine Learning.","authors":"Yaojun Song, Baoya Wang, Shanshan Liu, Wenjuan Yan, Yanru Fan","doi":"10.1007/s12010-026-05676-z","DOIUrl":"https://doi.org/10.1007/s12010-026-05676-z","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Synthesis, Stability, and Fungicidal Mechanisms of Polyphenol-Derived Silver Nanoparticles from Vietnamese Robusta Coffee Husk. 越南罗布斯塔咖啡壳中多酚衍生银纳米颗粒的绿色合成、稳定性和杀真菌机理。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-02 DOI: 10.1007/s12010-026-05685-y
Thi Huyen Nguyen, Tu Quy Phan, Manh Dung Doan, Van Chung Do, Van Anh Ngo, Anh Dzung Nguyen, Van Bon Nguyen
{"title":"Green Synthesis, Stability, and Fungicidal Mechanisms of Polyphenol-Derived Silver Nanoparticles from Vietnamese Robusta Coffee Husk.","authors":"Thi Huyen Nguyen, Tu Quy Phan, Manh Dung Doan, Van Chung Do, Van Anh Ngo, Anh Dzung Nguyen, Van Bon Nguyen","doi":"10.1007/s12010-026-05685-y","DOIUrl":"https://doi.org/10.1007/s12010-026-05685-y","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data-Driven Bioprocess Optimization: Lipase Production by Aspergillus Niger ATCC 1004 in COCOA and Palm Oil Byproducts Based Solid State Fermentation. 数据驱动的生物工艺优化：尼日尔曲霉ATCC 1004在可可和棕榈油副产品中固体发酵生产脂肪酶。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-01 DOI: 10.1007/s12010-026-05681-2
Eliézer Luz do Espirito Santo, Bruno Henrique Leão Pimentel, Igor Carvalho Fontes Sampaio, Thiago Pereira das Chagas, Erik Galvão Paranhos da Silva, Marcelo Franco, Julieta Rangel de Oliveira
{"title":"Data-Driven Bioprocess Optimization: Lipase Production by Aspergillus Niger ATCC 1004 in COCOA and Palm Oil Byproducts Based Solid State Fermentation.","authors":"Eliézer Luz do Espirito Santo, Bruno Henrique Leão Pimentel, Igor Carvalho Fontes Sampaio, Thiago Pereira das Chagas, Erik Galvão Paranhos da Silva, Marcelo Franco, Julieta Rangel de Oliveira","doi":"10.1007/s12010-026-05681-2","DOIUrl":"https://doi.org/10.1007/s12010-026-05681-2","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Engineered β-glucosidase from Bacteroides Thetaiotaomicron for Production of Rubusoside from Stevioside. 从甜菊糖苷中提取工程β-葡萄糖苷酶的研究。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-01 DOI: 10.1007/s12010-026-05669-y
Yuan Liao, Kai Chen, Hafza Altaf, Jiajie Ding, Liping Zhu, Honghua Jia, Yan Li
{"title":"An Engineered β-glucosidase from Bacteroides Thetaiotaomicron for Production of Rubusoside from Stevioside.","authors":"Yuan Liao, Kai Chen, Hafza Altaf, Jiajie Ding, Liping Zhu, Honghua Jia, Yan Li","doi":"10.1007/s12010-026-05669-y","DOIUrl":"https://doi.org/10.1007/s12010-026-05669-y","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding Geniposide's Mechanism: From miR-208a-3p/SMAD5 Modulation To Osteoblast Proliferation and Differentiation. 解码Geniposide的机制：从miR-208a-3p/SMAD5调控到成骨细胞增殖和分化
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-01 DOI: 10.1007/s12010-026-05631-y
Na Zhang, ShuangShuang Yin, Long Fang, Yi Xu
{"title":"Decoding Geniposide's Mechanism: From miR-208a-3p/SMAD5 Modulation To Osteoblast Proliferation and Differentiation.","authors":"Na Zhang, ShuangShuang Yin, Long Fang, Yi Xu","doi":"10.1007/s12010-026-05631-y","DOIUrl":"https://doi.org/10.1007/s12010-026-05631-y","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of a GH11 Xylanase from Endophytic Chaetomium globosum DX-THS3 with Excellent pH Stability and its Role in Enhancing Lignocellulose Degradation. 具有良好pH稳定性的内生球形毛囊DX-THS3 GH11木聚糖酶的特性及其在促进木质纤维素降解中的作用。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-03-31 DOI: 10.1007/s12010-026-05679-w
Runzhen Ji, Qijing Hua, Yamin Dong, Du Zhu, Yiwen Xiao, Boliang Gao
{"title":"Characterization of a GH11 Xylanase from Endophytic Chaetomium globosum DX-THS3 with Excellent pH Stability and its Role in Enhancing Lignocellulose Degradation.","authors":"Runzhen Ji, Qijing Hua, Yamin Dong, Du Zhu, Yiwen Xiao, Boliang Gao","doi":"10.1007/s12010-026-05679-w","DOIUrl":"https://doi.org/10.1007/s12010-026-05679-w","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SASH1 Inhibits Gastric Cancer Progression by Regulating YAP1-Mediated Metabolic Reprogramming. SASH1通过调控yap1介导的代谢重编程抑制胃癌进展
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-03-31 DOI: 10.1007/s12010-026-05621-0
Ting Qiu, Shujuan Gao, Lingjuan Zhang, Chunying Yan, Lu Niu, Guisheng Liu, Ping Wang, Yifei Lyu
{"title":"SASH1 Inhibits Gastric Cancer Progression by Regulating YAP1-Mediated Metabolic Reprogramming.","authors":"Ting Qiu, Shujuan Gao, Lingjuan Zhang, Chunying Yan, Lu Niu, Guisheng Liu, Ping Wang, Yifei Lyu","doi":"10.1007/s12010-026-05621-0","DOIUrl":"https://doi.org/10.1007/s12010-026-05621-0","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147579920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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