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Applied Biochemistry and Biotechnology最新文献

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Hyaluronic Acid Increase Anti-Inflammatory and Regenerative Effects of Adipose-Derived Mesenchymal Stem Cells in an Interstitial Cystitis Rat Model. 透明质酸增加间质性膀胱炎大鼠模型中脂肪来源的间充质干细胞的抗炎和再生作用。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-16 DOI: 10.1007/s12010-026-05677-y
Amal F Dawood, Rashad Qasem Ali Othman, Baker M Albow, Elryah I Ali, Abdelnaser A Badawy, Mahmoud Abdel-Maboud, Nada Ashraf, Intisar I Ali, Raghda W Magar, Mamdouh Eldesoqui
{"title":"Hyaluronic Acid Increase Anti-Inflammatory and Regenerative Effects of Adipose-Derived Mesenchymal Stem Cells in an Interstitial Cystitis Rat Model.","authors":"Amal F Dawood, Rashad Qasem Ali Othman, Baker M Albow, Elryah I Ali, Abdelnaser A Badawy, Mahmoud Abdel-Maboud, Nada Ashraf, Intisar I Ali, Raghda W Magar, Mamdouh Eldesoqui","doi":"10.1007/s12010-026-05677-y","DOIUrl":"https://doi.org/10.1007/s12010-026-05677-y","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UHPLC-MS/MS-based Untargeted Metabolomics Reveals Changes in Metabolites of Ligusticum chuanxiong During Irradiation. UHPLC-MS/MS-based非靶向代谢组学揭示川芎代谢产物在辐照过程中的变化
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-16 DOI: 10.1007/s12010-026-05629-6
Xin Jia, Peng Gao, Yan Wang, Yi Fu, Pan Xu, Min Huang
{"title":"UHPLC-MS/MS-based Untargeted Metabolomics Reveals Changes in Metabolites of Ligusticum chuanxiong During Irradiation.","authors":"Xin Jia, Peng Gao, Yan Wang, Yi Fu, Pan Xu, Min Huang","doi":"10.1007/s12010-026-05629-6","DOIUrl":"https://doi.org/10.1007/s12010-026-05629-6","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volatile Fatty Acid Production from Baijiu Distillers' Grains Via Anaerobic Fermentation with Rumen Microbes: Performance and Mechanism. 瘤胃微生物厌氧发酵白酒酒糟生产挥发性脂肪酸的性能及机理
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-15 DOI: 10.1007/s12010-026-05694-x
Xue Tao, Zhangping Du, Xianchen Wang, Longyi Lv, Guangming Zhang, Jinsong Liang, Wenxiu Zou
{"title":"Volatile Fatty Acid Production from Baijiu Distillers' Grains Via Anaerobic Fermentation with Rumen Microbes: Performance and Mechanism.","authors":"Xue Tao, Zhangping Du, Xianchen Wang, Longyi Lv, Guangming Zhang, Jinsong Liang, Wenxiu Zou","doi":"10.1007/s12010-026-05694-x","DOIUrl":"https://doi.org/10.1007/s12010-026-05694-x","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering and Partial Characterization of an Anti-IL-23/Anti-TNF-α Bispecific Domain Antibody Fused to Human Serum Albumin Domain for Inflammatory Disease Therapy. 融合人血清白蛋白结构域的抗il -23/抗tnf -α双特异性结构域抗体的工程设计和部分表征
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-15 DOI: 10.1007/s12010-026-05702-0
Sandeep, Suraj H Shinde, Sakeel Ahmed, Shyam Sunder Sharma, Abhay H Pande
{"title":"Engineering and Partial Characterization of an Anti-IL-23/Anti-TNF-α Bispecific Domain Antibody Fused to Human Serum Albumin Domain for Inflammatory Disease Therapy.","authors":"Sandeep, Suraj H Shinde, Sakeel Ahmed, Shyam Sunder Sharma, Abhay H Pande","doi":"10.1007/s12010-026-05702-0","DOIUrl":"https://doi.org/10.1007/s12010-026-05702-0","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Biosynthesis of Phenolics and Antioxidants by Marine Endophyte Penicillium rubens: Optimization and Bioactivity Evaluation. 海洋内生真菌黄本青霉促进酚类和抗氧化剂的生物合成：优化和生物活性评价。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-14 DOI: 10.1007/s12010-026-05688-9
Jeyamanikandan Venkatachalam, Veronica Shalini Jeyadoss, Senthamil Selvi Poongavanam
{"title":"Enhanced Biosynthesis of Phenolics and Antioxidants by Marine Endophyte Penicillium rubens: Optimization and Bioactivity Evaluation.","authors":"Jeyamanikandan Venkatachalam, Veronica Shalini Jeyadoss, Senthamil Selvi Poongavanam","doi":"10.1007/s12010-026-05688-9","DOIUrl":"https://doi.org/10.1007/s12010-026-05688-9","url":null,"abstract":"<p><p>Marine-derived endophytic fungi have long been recognised as valuable sources of therapeutic metabolites. In the present study, the endophyte Penicillium rubens strain PrubVJ was studied for optimised production of bioactive compounds using Response Surface Methodology (RSM). Experimental data predicted that incubation time was identified as the most influential variable, with maximum protein yield (190 mg/L) observed at day 20, antioxidant activity (74%) at 10-15 days and total phenolics (1,724 ± 19 µg GAE g⁻¹ DW) at day 25. The optimal fermentation conditions (25 °C, pH 3.6, 4 g/L salinity, 10 days incubation) with a desirability of 0.92, yielding 158 ± 1.325 mg/L protein, 1,798 ± 18 µg GAE g⁻¹ DW phenolics, and 84.9% antioxidant activity were predicted from the RSM model. Experimental validation under these conditions achieved protein yield of 190 mg/L, phenolics of 1,724 µg GAE g⁻¹ DW, and 74% antioxidant activity, confirming the reliability and robustness of the model. The developed quadratic models exhibited strong statistical reliability with stochastic parameters such as F-value and p-value, and coefficients of determination (R², adjusted R² and predicted R²) above 80% for all responses, validating model adequacy. Collectively, these findings establish P. rubens strain PrubVJ as a promising microbial platform, providing a reliable framework for optimising fungal fermentation. This study recommends the optimized strategy for large-scale pharmaceutical bioprocessing of fungal metabolites, to reduce production costs and accelerate the discovery of novel bioactive metabolites with pharmaceutical relevance, particularly for anticancer, antimicrobial, and antioxidant applications.</p>","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Tumor-Promoting Role of ADM in Bladder Cancer and its Mediated Mechanisms of Cell Death via PKR and STAT1. ADM在膀胱癌中的促瘤作用及其通过PKR和STAT1介导的细胞死亡机制
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-14 DOI: 10.1007/s12010-026-05691-0
Xiaowen Sun, Qianyu Qi, Xue Ding, Xiaonen Wang, Shuai Shao, Dapeng Ding, Yang Liu
{"title":"The Tumor-Promoting Role of ADM in Bladder Cancer and its Mediated Mechanisms of Cell Death via PKR and STAT1.","authors":"Xiaowen Sun, Qianyu Qi, Xue Ding, Xiaonen Wang, Shuai Shao, Dapeng Ding, Yang Liu","doi":"10.1007/s12010-026-05691-0","DOIUrl":"https://doi.org/10.1007/s12010-026-05691-0","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescence Based Epinephrine Detection Using CeCr@CQDs. Towards Advanced Biomolecule Sensing with Smartphone Sensing. 利用CeCr@CQDs荧光法检测肾上腺素。利用智能手机实现先进的生物分子传感。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-14 DOI: 10.1007/s12010-026-05686-x
Bindu Dhuva, Jyoti Duhan, Sangeeta Obrai
{"title":"Fluorescence Based Epinephrine Detection Using CeCr@CQDs. Towards Advanced Biomolecule Sensing with Smartphone Sensing.","authors":"Bindu Dhuva, Jyoti Duhan, Sangeeta Obrai","doi":"10.1007/s12010-026-05686-x","DOIUrl":"https://doi.org/10.1007/s12010-026-05686-x","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic Engineering for Biotechnological Production of Bioactive Methylated Flavonoids and Stilbenes: Progress and Perspectives. 生物技术生产生物活性甲基化黄酮类和二苯乙烯的代谢工程：进展与展望。
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-11 DOI: 10.1007/s12010-026-05658-1
Santosh Kumar Shrestha, Tae-Jin Oh
{"title":"Metabolic Engineering for Biotechnological Production of Bioactive Methylated Flavonoids and Stilbenes: Progress and Perspectives.","authors":"Santosh Kumar Shrestha, Tae-Jin Oh","doi":"10.1007/s12010-026-05658-1","DOIUrl":"https://doi.org/10.1007/s12010-026-05658-1","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147661941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-155-3p in Systemic Lupus Erythematosus: Association with Immune Activation and Renal-Related Parameters. miR-155-3p在系统性红斑狼疮中：与免疫激活和肾脏相关参数的关联
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-11 DOI: 10.1007/s12010-026-05663-4
Mohamed M Sadaty, Rana Mohamed, Emad El-Zayat, Salma M Mekhemer, Amira El-Ansary, Nahla O Mousa
{"title":"miR-155-3p in Systemic Lupus Erythematosus: Association with Immune Activation and Renal-Related Parameters.","authors":"Mohamed M Sadaty, Rana Mohamed, Emad El-Zayat, Salma M Mekhemer, Amira El-Ansary, Nahla O Mousa","doi":"10.1007/s12010-026-05663-4","DOIUrl":"https://doi.org/10.1007/s12010-026-05663-4","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147661964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-Producing Reducing Sugars, Furfural and Xylo-Oligosaccharides from Reeds via Effective Pretreatment by Ternary Deep Eutectic Solvent Lactic Acid:Cetyltrimethylammonium Bromide:CuCl₂. 深度共熔三元溶剂预处理芦苇中还原糖、糠醛和低聚木糖的研究
IF 3.3 4区 生物学
Applied Biochemistry and Biotechnology Pub Date : 2026-04-07 DOI: 10.1007/s12010-026-05682-1
Zhenyao Zhao, Yu-Cai He
{"title":"Co-Producing Reducing Sugars, Furfural and Xylo-Oligosaccharides from Reeds via Effective Pretreatment by Ternary Deep Eutectic Solvent Lactic Acid:Cetyltrimethylammonium Bromide:CuCl₂.","authors":"Zhenyao Zhao, Yu-Cai He","doi":"10.1007/s12010-026-05682-1","DOIUrl":"https://doi.org/10.1007/s12010-026-05682-1","url":null,"abstract":"","PeriodicalId":465,"journal":{"name":"Applied Biochemistry and Biotechnology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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