International Journal of Occupational and Environmental Medicine最新文献_第4页

Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers. 水泥仓库工人脱落颊细胞的基因组不稳定性。

International Journal of Occupational and Environmental Medicine Pub Date : 2020-01-01 DOI: 10.15171/ijoem.2020.1744

Lalu Krishna, Ursula Sampson, Panthapulaykal Theru Annamala, Kumudam Malati Unni, Bhaskarapillai Binukumar, Alex George, Ranjith Sreedharan

{"title":"Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers.","authors":"Lalu Krishna, Ursula Sampson, Panthapulaykal Theru Annamala, Kumudam Malati Unni, Bhaskarapillai Binukumar, Alex George, Ranjith Sreedharan","doi":"10.15171/ijoem.2020.1744","DOIUrl":"https://doi.org/10.15171/ijoem.2020.1744","url":null,"abstract":"Background: Workers in cement warehouses of Kerala are enduring long-standing exposure to cement dust, which is considered genotoxic.Objective: To evaluate the extent of genotoxicity and cytotoxicity caused due to exposure of cement dust among those working in cement warehouses.Methods: The study included 82 cement warehouse workers and 82 age-matched individuals with no exposure to cement dust. Exfoliated buccal micronucleus cytome assay (BMCyt) was performed to analyze the genotoxic and cytotoxic effects caused by inhalation of cement dust.Results: The frequency of various genotoxic and cytotoxic end markers (micronucleated cells [2-fold increase, p<0.001], nuclear buds [4-fold increase, p<0.001], binucleated cells [4-fold increase, p<0.001], karyorrhectic cells [2-fold increase, p<0.001], pyknotic cells [3-fold increase, p<0.001], and karyolytic cells [2-fold increase, p<0.001]) were higher in the exposed workers compared with unexposed group. Increase of these parameters represented an increased level of chromosomal damage, nuclear disintegration and increased cell death among exposed group compared with unexposed group.Conclusion: Continuous exposure to cement dust results in increased frequency of nuclear aberrations and cellular apoptosis. This may lead to defects in genome maintenance, accelerated ageing, increased chance of oral cancer and neurodegenerative disorders in those occupationally exposed to cement dust.","PeriodicalId":46545,"journal":{"name":"International Journal of Occupational and Environmental Medicine","volume":"11 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/55/ijoem-11-33.PMC7024590.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37515768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels 50hz不同强度电磁场对血清IL-9、IL-10和TNF-α水平的影响

International Journal of Occupational and Environmental Medicine Pub Date : 2020-01-01 DOI: 10.15171/ijoem.2020.1572

H. Mahaki, N. Jabarivasal, K. Sardarian, A. Zamani

{"title":"Effects of Various Densities of 50 Hz Electromagnetic Field on Serum IL-9, IL-10, and TNF-α Levels","authors":"H. Mahaki, N. Jabarivasal, K. Sardarian, A. Zamani","doi":"10.15171/ijoem.2020.1572","DOIUrl":"https://doi.org/10.15171/ijoem.2020.1572","url":null,"abstract":"Background: Extremely low-frequency electromagnetic fields (ELF-EMFs) are abundantly produced in modern societies. In recent years, interest in the possible effects of ELF-EMFs on the immune system has progressively increased. Objective: To examine the effects of ELF-EMFs with magnetic flux densities of 1, 100, 500, and 2000 µT on the serum levels of interleukin (IL)-9, IL-10, and tumor necrosis factor-alpha (TNF-α). Methods: 80 adult male rats were exposed to ELF-EMFs at a frequency of 50 Hz for 2 h/day for 60 days. The serum cytokines were measured at two phases of pre- and post-stimulation of the immune system by human serum albumin (HSA). Results: Serum levels of IL-9 and TNF-α, as pro-inflammatory cytokines, were decreased due to 50 Hz EMFs exposure compared with the controls in the pre- and post-stimulation phases. On the contrary, exposures to 1 and 100 µT 50 Hz EMFs increased the levels of antiinflammatory cytokine, and IL-10 only in the pre-stimulation phase. In the post-stimulation phase, the mean level of serum IL-10 was not changed in the experimental groups. Conclusion: The magnetic flux densities of 1 and 100 µT 50 Hz EMFs had more immunological effects than EMFs with higher densities. Exposure to 50 Hz EMFs may activate anti-inflammatory effects in rats, by down-modulation of pro-inflammatory cytokines (IL-9 and TNF-α) and induction of the anti-inflammatory cytokine (IL-10).","PeriodicalId":46545,"journal":{"name":"International Journal of Occupational and Environmental Medicine","volume":"11 1","pages":"24 - 32"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42381439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Tenth Anniversary of The IJOEM. IJOEM 十周年。

International Journal of Occupational and Environmental Medicine Pub Date : 2020-01-01 DOI: 10.15171/ijoem.2020.1894

Farrokh Habibzadeh

引用次数: 0

Introduction to Occupational Health Hazards 职业健康危害概论

International Journal of Occupational and Environmental Medicine Pub Date : 2020-01-01 DOI: 10.15171/ijoem.2020.1889

R. Mehrdad

引用次数: 2

Subcellular Organelle Toxicity Caused by Arsenic Nanoparticles in Isolated Rat Hepatocytes. 砷纳米颗粒在离体大鼠肝细胞中引起的亚细胞器毒性

International Journal of Occupational and Environmental Medicine Pub Date : 2020-01-01 DOI: 10.15171/ijoem.2020.1614

Rashid Jahangirnejad, Mehdi Goudarzi, Heibatullah Kalantari, Hossein Najafzadeh, Mohsen Rezaei

{"title":"Subcellular Organelle Toxicity Caused by Arsenic Nanoparticles in Isolated Rat Hepatocytes.","authors":"Rashid Jahangirnejad, Mehdi Goudarzi, Heibatullah Kalantari, Hossein Najafzadeh, Mohsen Rezaei","doi":"10.15171/ijoem.2020.1614","DOIUrl":"10.15171/ijoem.2020.1614","url":null,"abstract":"Background: Arsenic, an environmental pollutant, is a carcinogenic metalloid and also an anticancer agent.Objective: To evaluate the toxicity of arsenic nanoparticles in rat hepatocytes.Methods: Freshly isolated rat hepatocytes were exposed to 0, 20, 40, and 100 μM of arsenic nanoparticles and its bulk counterpart. Their viability, reactive oxygen species level, glutathione depletion, mitochondrial and lysosomal damage, and apoptosis were evaluated.Results: By all concentrations, lysosomal damage and apoptosis were clearly evident in hepatocytes exposed to arsenic nanoparticles. Evaluation of mitochondria and lysosomes revealed that lysosomes were highly damaged.Conclusion: Exposure to arsenic nanoparticles causes apoptosis and organelle impairment. The nanoparticles have potentially higher toxicity than the bulk arsenic. Lysosomes are highly affected. It seems that, instead of mitochondria, lysosomes are the first target organelles involved in the toxicity induced by arsenic nanoparticles.","PeriodicalId":46545,"journal":{"name":"International Journal of Occupational and Environmental Medicine","volume":"11 1","pages":"41-52"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/94/ijoem-11-41.PMC7024596.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37515769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphism of Glutathione S-transferase Genes and the Risk of Toxic Liver Damage in Petrochemical Workers. 石油化工工人谷胱甘肽s -转移酶基因多态性与中毒性肝损害风险

International Journal of Occupational and Environmental Medicine Pub Date : 2020-01-01 DOI: 10.15171/ijoem.2020.1771

Elvira Timeryanovna Valeeva, Guzel Fanisovna Mukhammadiyeva, Akhat Barievich Bakirov

{"title":"Polymorphism of Glutathione S-transferase Genes and the Risk of Toxic Liver Damage in Petrochemical Workers.","authors":"Elvira Timeryanovna Valeeva, Guzel Fanisovna Mukhammadiyeva, Akhat Barievich Bakirov","doi":"10.15171/ijoem.2020.1771","DOIUrl":"10.15171/ijoem.2020.1771","url":null,"abstract":"Background: Exposure to numerous chemicals, including industrial ones, may result in liver damage. The body susceptibility to the environmental hazards largely depends on the activity of the enzymes in the xenobiotic detoxification system. Function abnormalities of such enzymes due to genetic variations would increase the risk of developing various diseases.Objective: To elucidate the relationship between polymorphism in glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and the risk of toxic liver damage in a group of petrochemical workers.Methods: This study was conducted on 72 workers with toxic liver injury, 156 healthy workers, and 322 healthy individuals without history of occupational exposure to chemicals. Genotyping of the GSTP1 rs1695 gene polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Polymerase chain reaction (PCR) was used to perform genotyping of the GSTM1 and GSTT1 genes polymorphism.Results: There was a significant difference in genotype frequencies of the GSTP1 rs1695 gene polymorphism among the groups studied. The distribution of Val/Val genotype of the GSTP1 rs1695 gene polymorphism had a higher incidence in healthy workers compared with patients with toxic liver damage (p=0.036). No significant association was found between the GSTM1 and GSTT1 polymorphisms and toxic liver damage.Conclusion: The GSTP1 rs1695 gene polymorphism can play a protective role in the development of toxic liver damage in petrochemical workers.","PeriodicalId":46545,"journal":{"name":"International Journal of Occupational and Environmental Medicine","volume":"11 1","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/ce/ijoem-11-53.PMC7024595.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37515770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia. 农药暴露与脐血IGF-1水平和低出生体重之间的关系:印度尼西亚布雷比斯的病例对照研究

International Journal of Occupational and Environmental Medicine Pub Date : 2020-01-01 DOI: 10.15171/ijoem.2020.1809

Sigit Ambar Widyawati, Suhartono Suhartono, Maria Mexitalia, Ariawan Soejoenoes

{"title":"The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia.","authors":"Sigit Ambar Widyawati, Suhartono Suhartono, Maria Mexitalia, Ariawan Soejoenoes","doi":"10.15171/ijoem.2020.1809","DOIUrl":"10.15171/ijoem.2020.1809","url":null,"abstract":"Background: Birth weight is very important for long-term physical, mental, health, and brain development. Pesticide exposure is thought to interfere with fetal growth, among others, through disruption of the function of the insulin-like growth hormone-1 (IGF-1) hormone.Objective: To analyze the relationship between exposure to pesticides during pregnancy and low-birth weight (LBW) through the disruption of the IGF-1 hormone.Methods: In a case-control study, babies born with LBW (birth weight <2500 g) and those born later with normal birth weight (=2500 g) at 2 hospitals in Brebes were chosen as cases and controls, respectively. Maternal pesticide exposure was measured by interview using a questionnaire. Umbilical serum IGF-I level was tested using the ELISA method.Results: There was a significant relationship between pesticide exposure during pregnancy and LBW (OR 6.8; 95% CI 2.0 to 22.9) and low umbilical serum IGF-1 levels (OR 3.6; 95% CI 1.2 to 11.1). There was a significant relationship between low umbilical serum IGF-1 levels and LBW (OR 8.9; 95% CI 2.4 to 32.1).Conclusion: There was a significant relationship between pesticide exposure during pregnancy and LBW through the umbilical serum IGF-1 reduction pathway.","PeriodicalId":46545,"journal":{"name":"International Journal of Occupational and Environmental Medicine","volume":"11 1","pages":"15-23"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/71/ca/ijoem-11-15.PMC7024592.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37515767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Shared Decision Making: Ethical Aspects within Occupational and Environmental Medicine. 共同决策:职业和环境医学中的伦理方面。

International Journal of Occupational and Environmental Medicine Pub Date : 2019-12-05 DOI: 10.1097/JOM.0000000000001778

引用次数: 0

Authors' Response to "Evidence Does Not Support Exposure to Cosmetic Talc as a Cause of Malignant Mesothelioma". 作者对“证据不支持接触化妆品滑石粉是恶性间皮瘤的原因”的回应。

International Journal of Occupational and Environmental Medicine Pub Date : 2019-12-05 DOI: 10.1097/JOM.0000000000001790

J. Moline, Kristin G Bevilacqua, R. Gordon

引用次数: 0

RESPONSE to the Relationship of the Amount of Physical Therapy to Time Lost from Work and Costs in the Workers' Compenstion System. 工伤补偿制度中物理治疗量与旷工时间和费用关系的回应。

International Journal of Occupational and Environmental Medicine Pub Date : 2019-12-05 DOI: 10.1097/JOM.0000000000001758

Nina Leung, X. Tao, E. Bernacki

{"title":"RESPONSE to the Relationship of the Amount of Physical Therapy to Time Lost from Work and Costs in the Workers' Compenstion System.","authors":"Nina Leung, X. Tao, E. Bernacki","doi":"10.1097/JOM.0000000000001758","DOIUrl":"https://doi.org/10.1097/JOM.0000000000001758","url":null,"abstract":"W e appreciate the opportunity to respond to the concerns raised by Leung et al. We are delighted that our research has garnered interest and intellectual discussion among the research community. Several concerns were raised by Leung et al regarding the provider types associated with current procedural terminology codes as listed in Appendix A of the previously published article. Our manuscript does not focus on specific provider types and instead focuses on the outcomes related to billable, physical methods for the treatment of injury. Similar methodologies in assessing ‘‘physical therapy’’ on healthcare utilization and cost has been applied in previous studies. We agree that effective physical therapy services may differ between providers and our article was careful to avoid generalizing to specific practitioners and as such, does not assess variations in care by provider types. Another issue discussed in the comment related to the categorization of physical therapy visits among claimants without services (zero visits) and those with one to three visits. Significant differences were not observed for claim characteristics and","PeriodicalId":46545,"journal":{"name":"International Journal of Occupational and Environmental Medicine","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83078857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0