Jornal Brasileiro de Reproducao Assistida最新文献_第9页

Birth after low-level +20 Aneuploid Mosaic Embryo Transfer: A Case Report. 低水平 +20 非整倍体马赛克胚胎移植后出生：病例报告。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230055

Marta Ribeiro Hentschke, Aline Petracco Petzold, Isadora Badalotti-Teloken, Victória Campos Dornelles, Fabiana Mariani Wingert, Ricardo Azambuja, Maria Teresa Vieira Sanseverino, Alvaro Petracco, Mariangela Badalotti

{"title":"Birth after low-level +20 Aneuploid Mosaic Embryo Transfer: A Case Report.","authors":"Marta Ribeiro Hentschke, Aline Petracco Petzold, Isadora Badalotti-Teloken, Victória Campos Dornelles, Fabiana Mariani Wingert, Ricardo Azambuja, Maria Teresa Vieira Sanseverino, Alvaro Petracco, Mariangela Badalotti","doi":"10.5935/1518-0557.20230055","DOIUrl":"10.5935/1518-0557.20230055","url":null,"abstract":"Objective: Recently, it has been discussed whether or not mosaic embryo transfers should be performed since they might result in viable pregnancies, although they often end up being discarded. We report a case of successful pregnancy, after a mosaic embryo transfer from an in vitro matured egg and frozen PESA sperm.Case description: Tests performed on a female aged 40 years and a male aged 37 years seeking fertility treatment found she had an adequate ovarian reserve and patent fallopian tubes. He had a history of cryptorchidism and inguinal hernia repair. The spermogram showed azoospermia, and testicular ultrasound showed an atrophic left testicle and a normal right testis. The vas deferens was palpated during physical examination. Intracytoplasmic sperm injection with percutaneous epididymal sperm aspiration (PESA) was indicated. Two cycles of IVF after controlled ovarian stimulation with follitropin delta was performed. In the first cycle, seven mature eggs were inseminated, two fertilized normally, resulting in one blastocyst biopsied and analyzed by NGS with complex aneuploid results. In the second cycle, frozen sperm from PESA was used. Three eggs were inseminated on the day of the procedure (resulting in 2 blastocysts), and three in vitro matured eggs were inseminated after 24 hours (resulting in 1 blastocyst). NGS analysis showed two complex aneuploid embryos and one 40% low-level trisomy 20 aneuploid mosaicism (+20) for the post 24-hour embryo. A mosaic embryo transfer was performed, resulting in clinical pregnancy and birth of a healthy baby girl with a normal blood karyotype.Discussion: Mosaic embryo transfer is a topic for discussion. Certain levels of mosaicism do not seem to pose risks to the development of the fetus.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"203-205"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sublingual human chorionic gonadotropin as an adjuvant to ovulation induction. 舌下含服人类绒毛膜促性腺激素作为诱导排卵的辅助剂。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230068

Paula Almeida Galvão Ferreira, Luiz Augusto Giordano, Luiz Felipe Bittencourt

引用次数: 0

JBRA Assisted Reproduction - The scientific journal and the impact factor: metric and non-metric challenges for the editorial board. JBRA 辅助生殖 - 科学杂志与影响因子：编辑委员会面临的度量和非度量挑战。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230072

Maria do Carmo Borges de Souza, Paulo Franco Taitson, João Batista Alcantara Oliveira

引用次数: 0

Correlations between clinical parameters, blastocyst morphological classification and embryo euploidy. 临床参数、囊胚形态分类与胚胎整倍体的相关性。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230054

Juliano Brum Scheffer, Rafaela Friche de Carvalho, Bruno Brum Scheffer, Ana Paula de Souza Aguiar, Luiza Pinheiro Pessoa, Daniel Mendez Lozano, Renato Fanchin

{"title":"Correlations between clinical parameters, blastocyst morphological classification and embryo euploidy.","authors":"Juliano Brum Scheffer, Rafaela Friche de Carvalho, Bruno Brum Scheffer, Ana Paula de Souza Aguiar, Luiza Pinheiro Pessoa, Daniel Mendez Lozano, Renato Fanchin","doi":"10.5935/1518-0557.20230054","DOIUrl":"10.5935/1518-0557.20230054","url":null,"abstract":"Objective: The aim of the present study was to evaluate clinical and embryo parameters to predict embryo ploidy.Methods: In this retrospective analysis, we studied 838 biopsied day-5 blastocysts from 219 patients in the period from May 2021 to July 2022. All embryos were morphologically classified before biopsy and were divided into two groups according to genetic test results. Euploid embryos (299) were compared with aneuploid embryos (539) based on maternal age, anti-Mullerian hormone, antral follicle count, and embryo morphology.Results: Maternal age (36.2±3.0) of euploid embryos was lower than maternal age (37.1±2.5) of aneuploid embryos (p<0.0001). AMH levels were higher (3.9±1.2) in the group of euploid embryos than in the group of aneuploid embryos (3.6±1.3, p<0.0001). However, the AFC was not different in the group of euploid embryos (15.3±6.0) compared to the group of aneuploid embryos (14.5±5.9, p=0.07). The presence of aneuploidy was negatively correlated with top embryo quality (embryos 4AA and 4AB). All euploid embryos (299) were top quality versus 331 of 539 (61.49%) aneuploid embryos (p<0.0001).Conclusions: We found that euploid embryos were associated with lower maternal age, higher AMH levels, and higher quality embryos.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"54-58"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of patients seeking fertility care in a low-income setting. 在低收入环境中寻求生育护理的患者特征。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230073

Miriam Tarrash, Olutunmike Kuyoro, Randi H Goldman, Christine Mullin

{"title":"Characteristics of patients seeking fertility care in a low-income setting.","authors":"Miriam Tarrash, Olutunmike Kuyoro, Randi H Goldman, Christine Mullin","doi":"10.5935/1518-0557.20230073","DOIUrl":"10.5935/1518-0557.20230073","url":null,"abstract":"Objective: Patients face challenges accessing fertility treatment due to barriers such as financial burdens, delayed referral to Reproductive Endocrinologists (REI), low medical literacy, language barriers and numerous other health disparities. Medicaid in New York offers coverage for office visits, blood tests, hysterosalpingograms (HSGs), and pelvic ultrasounds for infertility. The aim of this study is to delineate the characteristics of this underserved population and determine their ability to complete the initial fertility workup.Methods: This was a retrospective study of all patients seeking fertility care at a single resident/fellow REI clinic in New York from September 2020 - January 2022.Results: During the study period, 87 patients (avg age = 35.2y) sought care at the resident/fellow clinic over 126 appointments. The majority of patients had Medicaid insurance and most primary languages spoken included English (70.1%), Spanish (21.8%), and Bengali (3.4%). Documented Race was comprised of mostly Other (46%), African American (21.8%), Asian (17.2%), and White (11.5%). The majority of patients completed a lab workup (70-80%). Fewer patients underwent a scheduled HSG (59.8%) and patients' partners completed a semen analysis (SA) (27.6%). Overall, there was a significant difference in the ability to complete the initial infertility workup (lab tests vs. HSG vs. SA) across all groups regardless of age, insurance type, primary language spoken, race and ethnicity (p<0.05).Conclusions: Completing the fertility workup, particularly the male partner workup and imaging studies, can present challenges for underserved patients with infertility. Understanding which patient characteristics and societal factors restrict access to fertility care requires further investigation to improve access to fertility care in underserved communities.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"59-65"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression, anxiety, and stress in infertile couples during the COVID-19 pandemic: the consequences we face. 2019冠状病毒病大流行期间不孕夫妇的抑郁、焦虑和压力:我们面临的后果

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230018

Anamarija Bogović, Ana-Meyra Potkonjak, Ivka Djaković, Hrvojka Soljačić Vraneš

{"title":"Depression, anxiety, and stress in infertile couples during the COVID-19 pandemic: the consequences we face.","authors":"Anamarija Bogović, Ana-Meyra Potkonjak, Ivka Djaković, Hrvojka Soljačić Vraneš","doi":"10.5935/1518-0557.20230018","DOIUrl":"10.5935/1518-0557.20230018","url":null,"abstract":"Objective: Postponing assisted reproductive technology treatment can cause pronounced mental health problems. The aim of this study was to examine the level of depression, anxiety, stress, and overall infertility-related distress experienced by infertile couples during the pandemic, as well as the differences between men and women in the examined variables and the correlations between them.Methods: A total of 131 participants were included in the study, 65 men and 66 women. They were selected based on their responses in the Fertility Problems Inventory (FPI); the Depression, Anxiety, and Stress Scale-21 (DASS-21); and a general data questionnaire provided to them at the time of IVF.Results: The levels of depression, anxiety, and stress in women and men resided within the normal range. Depression (p<0.05), anxiety (p<0.01), stress (p<0.01), and social concern (p<0.05) were more pronounced among women. Significant correlations were found between depression, anxiety, stress, and global stress and its three dimensions: social concern, sexual concern, and relationship concern.Conclusions: During the pandemic, women undergoing assisted reproductive technology treatment experienced significantly higher levels of depression, anxiety, stress, and overall infertility-related stress than men. Furthermore, depression, anxiety, and stress were apparently correlated with overall infertility-related stress.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"9-12"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial hydatidiform mole and coexisting fetus after frozen embryo transplantation: a case report. 冷冻胚胎移植后部分水胎记和并存胎儿：病例报告。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230069

Jinran Li, Xiaoli Sun

{"title":"Partial hydatidiform mole and coexisting fetus after frozen embryo transplantation: a case report.","authors":"Jinran Li, Xiaoli Sun","doi":"10.5935/1518-0557.20230069","DOIUrl":"10.5935/1518-0557.20230069","url":null,"abstract":"Hydatidiform mole and coexisting fetus is a very rare condition of which etiology is still inconclusive. It may occur after assisted reproduction, often leading to the death of normal embryos and other serious complications. We report a case of partial hydatidiform mole and coexisting fetus after frozen embryo transplantation. More than two months after the patient underwent transplantation with two blastocysts (scored 4AB and 4BC), B-ultrasound showed a single live fetus with a large dense dotted strong echo area. The patient was treated with chemotherapy after the termination of pregnancy due to persistently increased human chorionic gonadotropin levels. Many studies have described trophoblast quality as a strong predictor of pregnancy. In the case in question, in addition to partial hydatidiform mole caused by multiple sperm entering the egg, we also speculate that the condition may be related to the poor quality of the trophoblastic ectoderm of the transferred embryo. In the process of assisted reproduction, the transfer of embryos with poor trophoblastic ectoderm in multiple embryo transfers may adversely affect pregnancy outcomes.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"200-202"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frozen-thawed embryo transfer: does the addition of low-dose choriogonadotropin alfa to progesterone in the luteal phase of artificial cycles improve the endometrium and increase the chances of pregnancy? 冻融胚胎移植:在人工周期的黄体期添加低剂量绒毛膜促性腺激素是否能改善子宫内膜并增加怀孕机会?

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230053

Rodopiano de Souza Florêncio, Mylena Naves de Castro Rocha, Vinicius Alves de Oliveira, Marta Curado Carvalho Franco Finotti

{"title":"Frozen-thawed embryo transfer: does the addition of low-dose choriogonadotropin alfa to progesterone in the luteal phase of artificial cycles improve the endometrium and increase the chances of pregnancy?","authors":"Rodopiano de Souza Florêncio, Mylena Naves de Castro Rocha, Vinicius Alves de Oliveira, Marta Curado Carvalho Franco Finotti","doi":"10.5935/1518-0557.20230053","DOIUrl":"10.5935/1518-0557.20230053","url":null,"abstract":"Objective: Primary: To evaluate the effect of low doses of recombinant hCG (choriogonadotropin alfa) in the luteal phase of frozen-thawed embryo transfers (FET) of artificial cycles on the chances of pregnancy in patients aged ≤38years. Secondary: To assess the chances of pregnancy in the FET groups of artificial cycles using micronized vaginal progesterone (VP) versus injectable intramuscular progesterone (IMP) and the chances of pregnancy in type-1 embryo transfers (two top embryos).Methods: This retrospective cohort study included 122 cycles of FET and compared two groups of patients aged 38 years or younger, one given hCG in the luteal phase and one not administered hCG.Results: The clinical pregnancy rates (CPR) in the control and hCG groups were 45% and 45.16%, respectively (p=0.9999). The live birth rates (LBR) were 33.33% and 32.25%, respectively, (p=0.99909). The CPR in the VP group (83 patients) was 46.89% versus 41.02% in the IMP group, (p=0.5459). The LBR was 33.73% in the VP group and 30.76% in the IMP group (39 patients), (p=0.7559).Conclusions: The CPR and LBR of patients undergoing FET in groups prescribed and not prescribed low doses of recombinant hCG were similar. No significant difference was found between patients given VP or IMP.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"33-38"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of selenium and vitamin C on the fertility of male rats given penconazole. 硒和维生素C对给予戊康唑雄性大鼠生育能力的保护作用。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20230042

Elaheh Shams, Vahideh Abdollahi, Mozhgan Harfsheno, Seyedeh Ommolbanin Ghasemian

{"title":"Protective effect of selenium and vitamin C on the fertility of male rats given penconazole.","authors":"Elaheh Shams, Vahideh Abdollahi, Mozhgan Harfsheno, Seyedeh Ommolbanin Ghasemian","doi":"10.5935/1518-0557.20230042","DOIUrl":"10.5935/1518-0557.20230042","url":null,"abstract":"Objective: Penconazole is used in agriculture and human and veterinary medicine applications. It has been included in the acute toxicity hazard category by the WHO. This study examines the protective effect of selenium and vitamin C on the fertility of male rats given penconazole.Methods: Nine groups of rats were given penconazole at concentrations of 50 and 75 mg/ml and selenium and vitamin C at concentrations of 0.5 and 100 mg/ml, respectively. Serum levels of LH and FSH were measured with ELISA kits; β-actin, GPX4, AQP7, PRM2, and BAX gene expression was evaluated with real-time PCR performed on the left testis of each rat.Results: LH, FSH, and testosterone levels were lower in the groups given penconazole (50 and 75 mg/kg). Histopathology showed that the groups given penconazole had the lowest number of spermatogonia and primary spermatocytes; these numbers were greater in the groups receiving penconazole together with selenium or vitamin C; and the highest counts were observed in separate groups given Se and vitamin C. GPX4, AQP7, PRM2 and BAX gene expression in the groups receiving penconazole was different from controls and was modulated by treatment with selenium or vitamin C.Conclusions: This study showed that antioxidant compounds have a strengthening effect on the reproductive system and can mitigate the destructive effects of chemical fungicides.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"27-32"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meiotic Spindle View improves the Outcome of IVF in Poor Responders: A Retrospective Analytical Study from an Indonesian IVF Center. 减数分裂纺锤体视图可改善反应不佳者的试管婴儿结果：印度尼西亚一家试管婴儿中心的回顾性分析研究。

IF 1.5

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI: 10.5935/1518-0557.20240006

Binarwan Halim, Hilma Putri Lubis, Ichwanul Adenin, Jesselyn Angellee, Rizky Senna Samoedra

{"title":"Meiotic Spindle View improves the Outcome of IVF in Poor Responders: A Retrospective Analytical Study from an Indonesian IVF Center.","authors":"Binarwan Halim, Hilma Putri Lubis, Ichwanul Adenin, Jesselyn Angellee, Rizky Senna Samoedra","doi":"10.5935/1518-0557.20240006","DOIUrl":"10.5935/1518-0557.20240006","url":null,"abstract":"Objective: Previous studies have shown that the meiotic spindle is not always aligned with the first polar body (PB) in metaphase II human oocytes. Polarized Light Microscopy (PLM) has been used to observe and locate the meiotic spindle to avoid disrupting it while injecting oocytes. The aim of this study is to evaluate the relationship between meiotic spindle view and IVF-ICSI outcomes in poor responder women.Methods: This study was a retrospective analytical study, carried out from January to November 2019; involving 115 poor responder women who underwent IVF-ICSI cycles at the Halim Fertility Center, Indonesia. The patients were divided into two groups: group I without meiotic spindle viewing (non-MSV) as control group, and group II with meiotic spindle viewing (MSV) as the case group. The meiotic spindles were imaged before ICSI with Oosight microscopy. Baseline characteristics and IVF-ICSI outcomes of both groups were compared.Results: Our study included 115 poor responder women with non-MSV group (71 women), and an MSV group (44 women). The results showed that there was no significant difference in the fertilization rate between the two groups (p>0.05), but the embryo cleavage rate was higher in the MSV group when compared to the non-MSV group; and there was a significant difference between the two groups (p<0.05). The fertilization rate was higher in aligned than misaligned spindle and there was a significant difference between the two groups (p<0.05). Good quality embryo was higher in MSV group than non-MSV group (59.05% vs. 63.95%).Conclusions: Meiotic spindle view might improve the outcome of IVF in poor responder women.","PeriodicalId":46364,"journal":{"name":"Jornal Brasileiro de Reproducao Assistida","volume":" ","pages":"39-46"},"PeriodicalIF":1.5,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139933529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0